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Article

Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta

1
Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan
2
Department of Chemistry and Chemical Processing Technologies, Muğla Vocational School, Muğla Sıtkı Koçman University, 48000 Muğla, Turkey
3
Core Labs, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
4
Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Academic Editors: Krystian Marszałek, Shuyi Li, Ireneusz Kapusta and Jose Manuel Lorenzo
Molecules 2021, 26(5), 1459; https://doi.org/10.3390/molecules26051459
Received: 30 January 2021 / Revised: 21 February 2021 / Accepted: 4 March 2021 / Published: 8 March 2021
(This article belongs to the Special Issue Bioactive Compounds of Fruits, Vegetables and Mushrooms)
Mushroom polysaccharides are active medicinal compounds that possess immune-modulatory and anticancer properties. Currently, the mushroom polysaccharides krestin, lentinan, and polysaccharopeptides are used as anticancer drugs. They are an unexplored source of natural products with huge potential in both the medicinal and nutraceutical industries. The northern parts of Pakistan have a rich biodiversity of mushrooms that grow during different seasons of the year. Here we selected an edible Morchella esculenta (true morels) of the Ascomycota group for polysaccharide isolation and characterization. Polysaccharopeptides and polysaccharides from this mushroom were isolated using the green chemistry, hot water treatment method. Fourier transform infrared spectroscopy revealed the sugar nature and possible beta-glucan type structure of these polysaccharides. Antioxidant assays showed that the deproteinized polysaccharides have moderate free radical scavenging activity. These isolated polysaccharides exhibited good acetylcholinesterase (AChE) and butyryl cholinesterase (BChE) inhibition activities. Therefore, these polysaccharides may be valuable for the treatment of Alzheimer’s and Parkinson’s diseases. Further bioassays are needed to discover the true potential of M. esculenta polysaccharides for medicinal purposes. View Full-Text
Keywords: Morchella esculenta; polysaccharopeptides; anticholinesterase activity; antioxidant; tyrosinase inhibition Morchella esculenta; polysaccharopeptides; anticholinesterase activity; antioxidant; tyrosinase inhibition
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MDPI and ACS Style

Badshah, S.L.; Riaz, A.; Muhammad, A.; Tel Çayan, G.; Çayan, F.; Emin Duru, M.; Ahmad, N.; Emwas, A.-H.; Jaremko, M. Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta. Molecules 2021, 26, 1459. https://doi.org/10.3390/molecules26051459

AMA Style

Badshah SL, Riaz A, Muhammad A, Tel Çayan G, Çayan F, Emin Duru M, Ahmad N, Emwas A-H, Jaremko M. Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta. Molecules. 2021; 26(5):1459. https://doi.org/10.3390/molecules26051459

Chicago/Turabian Style

Badshah, Syed L., Anila Riaz, Akhtar Muhammad, Gülsen Tel Çayan, Fatih Çayan, Mehmet Emin Duru, Nasir Ahmad, Abdul-Hamid Emwas, and Mariusz Jaremko. 2021. "Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta" Molecules 26, no. 5: 1459. https://doi.org/10.3390/molecules26051459

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