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Article

Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of Plant Pathogenic Fungi

1
Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand
2
Department of Science, Faculty of Liberal Arts and Science, Kamphaeng Sean Campus, Kasetsart University, Nakhon Pathom 73140, Thailand
3
Department of Microbiology, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand
*
Author to whom correspondence should be addressed.
Academic Editors: Vincenzo Piccialli and Wenhan Lin
Molecules 2021, 26(1), 207; https://doi.org/10.3390/molecules26010207
Received: 24 November 2020 / Revised: 23 December 2020 / Accepted: 30 December 2020 / Published: 3 January 2021
A series of tetrahydro-ß-carbolines substituted with an alkyl or acyl side chain was synthesized and screened for its antifungal activity against plant pathogenic fungi (Bipolaris oryzae, Curvularia lunata, Fusarium semitectum, and Fusarium fujikuroi). The structure activity relationship revealed that the substituent at the piperidine nitrogen plays an important role for increasing antifungal activities. In this series, 2-octyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (3g) displayed potent antifungal activities with a minimum inhibitory concentration of 0.1 μg/mL, including good inhibitory activity to the radial growth of fungus at a concentration of 100 μg/mL compared to amphotericin B. View Full-Text
Keywords: tetrahydro-β-carbolines (THβCs); plant pathogenic fungi; radial growth; N-substituted THβCs tetrahydro-β-carbolines (THβCs); plant pathogenic fungi; radial growth; N-substituted THβCs
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MDPI and ACS Style

Buaban, K.; Phutdhawong, W.; Taechowisan, T.; Phutdhawong, W.S. Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of Plant Pathogenic Fungi. Molecules 2021, 26, 207. https://doi.org/10.3390/molecules26010207

AMA Style

Buaban K, Phutdhawong W, Taechowisan T, Phutdhawong WS. Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of Plant Pathogenic Fungi. Molecules. 2021; 26(1):207. https://doi.org/10.3390/molecules26010207

Chicago/Turabian Style

Buaban, Koonchira, Weerachai Phutdhawong, Thongchai Taechowisan, and Waya S. Phutdhawong. 2021. "Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of Plant Pathogenic Fungi" Molecules 26, no. 1: 207. https://doi.org/10.3390/molecules26010207

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