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Studies of Coumarin Derivatives for Constitutive Androstane Receptor (CAR) Activation
Article

Coumarin’s Anti-Quorum Sensing Activity Can Be Enhanced When Combined with Other Plant-Derived Small Molecules

Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences, Orenburg 460000, Russia
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Academic Editor: Maria João Matos
Molecules 2021, 26(1), 208; https://doi.org/10.3390/molecules26010208
Received: 30 November 2020 / Revised: 17 December 2020 / Accepted: 18 December 2020 / Published: 3 January 2021
(This article belongs to the Special Issue Coumarin and Its Derivatives)
Coumarins are class of natural aromatic compounds based on benzopyrones (2H-1-benzopyran-2-ones). They are identified as secondary metabolites in about 150 different plant species. The ability of coumarins to inhibit cell-to-cell communication in bacterial communities (quorum sensing; QS) has been previously described. Coumarin and its derivatives in plant extracts are often found together with other small molecules that show anti-QS properties too. The aim of this study was to find the most effective combinations of coumarins and small plant-derived molecules identified in various plants extracts that inhibit QS in Chromobacterium violaceum ATCC 31532 violacein production bioassay. The coumarin and its derivatives: 7-hydroxycoumarin, 7.8-dihydroxy-4-methylcoumarin, were included in the study. Combinations of coumarins with gamma-octalactone, 4-hexyl-1.3-benzenediol, 3.4.5-trimethoxyphenol and vanillin, previously identified in oak bark (Quercus cortex), and eucalyptus leaves (Eucalyptus viminalis) extracts, were analyzed in a bioassay. When testing two-component compositions, it was shown that 7.8-dihydroxy-4-methylcoumarin, 4-hexyl-1.3-benzendiol, and gamma-octalactone showed a supra-additive anti-QS effect. Combinations of all three molecules resulted in a three- to five-fold reduction in the concentration of each compound needed to achieve EC50 (half maximal effective concentration) against QS in C. violaceum ATCC 31532. View Full-Text
Keywords: coumarins; quorum sensing; QS inhibitors; plant-derived molecules; Chromobacterium violaceum coumarins; quorum sensing; QS inhibitors; plant-derived molecules; Chromobacterium violaceum
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MDPI and ACS Style

Deryabin, D.; Inchagova, K.; Rusakova, E.; Duskaev, G. Coumarin’s Anti-Quorum Sensing Activity Can Be Enhanced When Combined with Other Plant-Derived Small Molecules. Molecules 2021, 26, 208. https://doi.org/10.3390/molecules26010208

AMA Style

Deryabin D, Inchagova K, Rusakova E, Duskaev G. Coumarin’s Anti-Quorum Sensing Activity Can Be Enhanced When Combined with Other Plant-Derived Small Molecules. Molecules. 2021; 26(1):208. https://doi.org/10.3390/molecules26010208

Chicago/Turabian Style

Deryabin, Dmitry, Kseniya Inchagova, Elena Rusakova, and Galimzhan Duskaev. 2021. "Coumarin’s Anti-Quorum Sensing Activity Can Be Enhanced When Combined with Other Plant-Derived Small Molecules" Molecules 26, no. 1: 208. https://doi.org/10.3390/molecules26010208

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