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Article

Ulva intestinalis Protein Extracts Promote In Vitro Collagen and Hyaluronic Acid Production by Human Dermal Fibroblasts

1
Equipe BCBS (Biotechnologies et Chimie des Bioressources pour la Santé), La Rochelle Université, UMR CNRS 7266 LIENSs, Avenue Michel Crépeau, 17042 La Rochelle, France
2
SEPROSYS, Séparations, Procédés, Systèmes, 12 Rue Marie-Aline Dusseau, 17000 La Rochelle, France
*
Author to whom correspondence should be addressed.
Academic Editors: Raffaele Capasso and Lorenzo Di Cesare Mannelli
Molecules 2020, 25(9), 2091; https://doi.org/10.3390/molecules25092091
Received: 1 April 2020 / Revised: 19 April 2020 / Accepted: 21 April 2020 / Published: 30 April 2020
(This article belongs to the Special Issue Plant Extracts: Biological and Pharmacological Activity)
With the increase in life expectancy, reducing the visible signs of skin aging has become a major issue. A reduction in collagen and hyaluronic acid synthesis by fibroblasts is a feature of skin aging. The green seaweed, Ulva intestinalis, is an abundant and rich source of nutrients, especially proteins and peptides. The aim of this study was to assess the potential cosmetic properties of a protein fraction from Ulva intestinalis (PROT-1) containing 51% of proteins and 22% of polysaccharides, and its enzymatic peptide hydrolysates on human dermal fibroblasts. PROT-1 was extracted using a patented acid- and solvent-free process (FR2998894 (B1)). The biochemical characterization and chromatographic analysis showed a main set of proteins (25 kDa). To demonstrate the anti-aging potential of PROT-1, fibroblast proliferation and collagen and hyaluronic acid production were assessed on fibroblast cell lines from donors aged 20 years (CCD-1059Sk) and 46 years (CCD-1090Sk). PROT-1 induced a significant increase in collagen and hyaluronic acid production per cell, and a reduction in cell proliferation without increasing cell mortality. These effects were reversed after protein hydrolysis of PROT-1, showing the central role of proteins in this promising anti-aging property. View Full-Text
Keywords: Ulva intestinalis; seaweed proteins; human dermal fibroblast; collagen; hyaluronic acid; anti-aging Ulva intestinalis; seaweed proteins; human dermal fibroblast; collagen; hyaluronic acid; anti-aging
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MDPI and ACS Style

Bodin, J.; Adrien, A.; Bodet, P.-E.; Dufour, D.; Baudouin, S.; Maugard, T.; Bridiau, N. Ulva intestinalis Protein Extracts Promote In Vitro Collagen and Hyaluronic Acid Production by Human Dermal Fibroblasts. Molecules 2020, 25, 2091. https://doi.org/10.3390/molecules25092091

AMA Style

Bodin J, Adrien A, Bodet P-E, Dufour D, Baudouin S, Maugard T, Bridiau N. Ulva intestinalis Protein Extracts Promote In Vitro Collagen and Hyaluronic Acid Production by Human Dermal Fibroblasts. Molecules. 2020; 25(9):2091. https://doi.org/10.3390/molecules25092091

Chicago/Turabian Style

Bodin, Justine, Amandine Adrien, Pierre-Edouard Bodet, Delphine Dufour, Stanislas Baudouin, Thierry Maugard, and Nicolas Bridiau. 2020. "Ulva intestinalis Protein Extracts Promote In Vitro Collagen and Hyaluronic Acid Production by Human Dermal Fibroblasts" Molecules 25, no. 9: 2091. https://doi.org/10.3390/molecules25092091

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