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Open AccessCommunication

Regioselective Monobromination of Phenols with KBr and ZnAl–BrO3–Layered Double Hydroxides

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310004, China
Authors to whom correspondence should be addressed.
Academic Editor: Narciso M. Garrido
Molecules 2020, 25(4), 914;
Received: 19 January 2020 / Revised: 15 February 2020 / Accepted: 16 February 2020 / Published: 18 February 2020
(This article belongs to the Special Issue New Synthetic Methods for Organic Compounds)
The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl–BrO3–layered double hydroxides (abbreviated as ZnAl–BrO3–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols. View Full-Text
Keywords: phenol; bromination; regioselecitvity phenol; bromination; regioselecitvity
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MDPI and ACS Style

Wang, L.; Feng, C.; Zhang, Y.; Hu, J. Regioselective Monobromination of Phenols with KBr and ZnAl–BrO3–Layered Double Hydroxides. Molecules 2020, 25, 914.

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