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Open AccessArticle

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

1
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montréal, QC H3A 0B8, Canada
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Department of Chemistry, Shahid Beheshti University G.C., Tehran 1983963113, Iran
3
Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montréal, QC H3G 1Y6, Canada
*
Authors to whom correspondence should be addressed.
Academic Editor: Jørn Bolstad Christensen
Molecules 2020, 25(4), 857; https://doi.org/10.3390/molecules25040857 (registering DOI)
Received: 21 January 2020 / Revised: 11 February 2020 / Accepted: 12 February 2020 / Published: 15 February 2020
(This article belongs to the Special Issue Dendrimers in Biomedicine)
An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl2 catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival. View Full-Text
Keywords: telodendrimer; macromolecular drug; 1,3-dipolar cycloaddition; glioblastoma telodendrimer; macromolecular drug; 1,3-dipolar cycloaddition; glioblastoma
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MDPI and ACS Style

Yazdani, H.; Kaul, E.; Bazgir, A.; Maysinger, D.; Kakkar, A. Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology. Molecules 2020, 25, 857.

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