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Open AccessArticle

Structure Characterization and Otoprotective Effects of a New Endophytic Exopolysaccharide from Saffron

by Juan Li 1, Guimei Wu 1, Cuiying Qin 1, Wuhai Chen 1, Gang Chen 1,2,3,* and Lu Wen 1,*
1
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
2
Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Pharmaceutical University, Guangzhou 510006, China
3
Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(4), 749; https://doi.org/10.3390/molecules24040749
Received: 28 January 2019 / Revised: 16 February 2019 / Accepted: 18 February 2019 / Published: 19 February 2019
(This article belongs to the Special Issue Smart and Functional Polymers)
Saffron, a kind of rare medicinal herb with antioxidant, antitumor, and anti-inflammatory activities, is the dry stigma of Crocus sativus L. A new water-soluble endophytic exopolysaccharide (EPS-2) was isolated from saffron by anion exchange chromatography and gel filtration. The chemical structure was characterized by FT-IR, GC-MS, and 1D and 2D-NMR spectra, indicating that EPS-2 has a main backbone of (1→2)-linked α-d-Manp, (1→2, 4)-linked α-d-Manp, (1→4)-linked α-d-Xylp, (1→2, 3, 5)-linked β-d-Araf, (1→6)- linked α-d-Glcp with α-d-Glcp-(1→ and α-d-Galp-(1→ as sidegroups. Furthermore, EPS-2 significantly attenuated gentamicin-induced cell damage in cultured HEI-OC1 cells and increased cell survival in zebrafish model. The results suggested that EPS-2 could protect cochlear hair cells from ototoxicity exposure. This study could provide new insights for studies on the pharmacological mechanisms of endophytic exopolysaccharides from saffron as otoprotective agents View Full-Text
Keywords: hearing loss; saffron; endophytic exopolysaccharide; gentamicin; cochlear hair cell hearing loss; saffron; endophytic exopolysaccharide; gentamicin; cochlear hair cell
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MDPI and ACS Style

Li, J.; Wu, G.; Qin, C.; Chen, W.; Chen, G.; Wen, L. Structure Characterization and Otoprotective Effects of a New Endophytic Exopolysaccharide from Saffron. Molecules 2019, 24, 749.

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