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Secondary Metabolites of The Endophytic Fungus Alternaria alternata JS0515 Isolated from Vitex rotundifolia and Their Effects on Pyruvate Dehydrogenase Activity

1
College of Pharmacy, Duksung Women’s University, 144 Gil 33, Dobong-gu, Seoul 01369, Korea
2
Korean medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Korea
3
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu 41061, Korea
4
Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Namgu, C5 building, room203, Pohang, Kyungbuk 37673, Korea
5
Biological Resources Assessment Division, National Institute of Biological Resources, Incheon 22689, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(24), 4450; https://doi.org/10.3390/molecules24244450
Received: 6 November 2019 / Revised: 27 November 2019 / Accepted: 3 December 2019 / Published: 4 December 2019
(This article belongs to the Section Natural Products Chemistry)
The fungal strain Alternaria alternata JS0515 was isolated from Vitex rotundifolia (beach vitex). Twelve secondary metabolites, including one new altenusin derivative (1), were isolated. The isolated metabolites included seven known altenusin derivatives (28), two isochromanones (9, 10), one perylenequinone (11), and one benzocycloalkanone (12). Their structures were determined via 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and computational electronic circular dichroism (ECD) analysis. Compounds 3 and 11 increased pyruvate dehydrogenase (PDH) activity in AD-293 human embryonic kidney cells and significantly inhibited PDH phosphorylation. The IC50 values of 3 and 11 were 32.58 and 27.82 μM, respectively. View Full-Text
Keywords: Alternaria alternata; endophytes; pyruvate dehydrogenase Alternaria alternata; endophytes; pyruvate dehydrogenase
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Lee, C.; Li, W.; Bang, S.; Lee, S.J.; Kang, N.-Y.; Kim, S.; Kim, T.I.; Go, Y.; Shim, S.H. Secondary Metabolites of The Endophytic Fungus Alternaria alternata JS0515 Isolated from Vitex rotundifolia and Their Effects on Pyruvate Dehydrogenase Activity. Molecules 2019, 24, 4450.

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