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Oxidative Transformations of Lignans

Johan Gadolin Process Chemistry Center, Åbo Akademi University, Piispankatu 8, 20500 Turku, Finland
Author to whom correspondence should be addressed.
Academic Editor: David Barker
Molecules 2019, 24(2), 300;
Received: 16 November 2018 / Revised: 21 December 2018 / Accepted: 29 December 2018 / Published: 15 January 2019
(This article belongs to the Special Issue Lignans)


Numerous oxidative transformations of lignan structures have been reported in the literature. In this paper we present an overview on the current findings in the field. The focus is put on transformations targeting a specific structure, a specific reaction, or an interconversion of the lignan skeleton. Oxidative transformations related to biosynthesis, antioxidant measurements, and total syntheses are mostly excluded. Non-metal mediated as well as metal mediated oxidations are reported, and mechanisms based on hydrogen abstractions, epoxidations, hydroxylations, and radical reactions are discussed for the transformation and interconversion of lignan structures. Enzymatic oxidations, photooxidation, and electrochemical oxidations are also briefly reported. View Full-Text
Keywords: lignans; oxidation lignans; oxidation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Runeberg, P.A.; Brusentsev, Y.; Rendon, S.M.K.; Eklund, P.C. Oxidative Transformations of Lignans. Molecules 2019, 24, 300.

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