Next Article in Journal
Identification of Cannabis sativa L. (hemp) Retailers by Means of Multivariate Analysis of Cannabinoids
Previous Article in Journal
Phenomenological Inferences on the Kinetics of a Mechanically Activated Knoevenagel Condensation: Understanding the “Snowball” Kinetic Effect in Ball Milling
Previous Article in Special Issue
Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors
Open AccessReview

Combination Therapy Strategies for the Treatment of Malaria

Department of Chemistry University of Fort Hare, Alice Campus, Alice, Eastern Cape 5700, South Africa
Author to whom correspondence should be addressed.
Molecules 2019, 24(19), 3601;
Received: 13 July 2019 / Revised: 15 August 2019 / Accepted: 21 August 2019 / Published: 7 October 2019
(This article belongs to the Special Issue Chemistry & Health)
Malaria is a vector- and blood-borne infection that is responsible for a large number of deaths around the world. Most of the currently used antimalarial therapeutics suffer from drug resistance. The other limitations associated with the currently used antimalarial drugs are poor drug bioavailability, drug toxicity, and poor water solubility. Combination therapy is one of the best approaches that is currently used to treat malaria, whereby two or more therapeutic agents are combined. Different combination therapy strategies are used to overcome the aforementioned limitations. This review article reports two strategies of combination therapy; the incorporation of two or more antimalarials into polymer-based carriers and hybrid compounds designed by hybridization of two antimalarial pharmacophores. View Full-Text
Keywords: malaria; antimalarial drugs; combination therapy; hybrid compounds; polymer-based carriers malaria; antimalarial drugs; combination therapy; hybrid compounds; polymer-based carriers
Show Figures

Graphical abstract

MDPI and ACS Style

Alven, S.; Aderibigbe, B. Combination Therapy Strategies for the Treatment of Malaria. Molecules 2019, 24, 3601.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop