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Combination Therapy Strategies for the Treatment of Malaria

Department of Chemistry University of Fort Hare, Alice Campus, Alice, Eastern Cape 5700, South Africa
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Molecules 2019, 24(19), 3601; https://doi.org/10.3390/molecules24193601
Received: 13 July 2019 / Revised: 15 August 2019 / Accepted: 21 August 2019 / Published: 7 October 2019
(This article belongs to the Special Issue Chemistry & Health)
Malaria is a vector- and blood-borne infection that is responsible for a large number of deaths around the world. Most of the currently used antimalarial therapeutics suffer from drug resistance. The other limitations associated with the currently used antimalarial drugs are poor drug bioavailability, drug toxicity, and poor water solubility. Combination therapy is one of the best approaches that is currently used to treat malaria, whereby two or more therapeutic agents are combined. Different combination therapy strategies are used to overcome the aforementioned limitations. This review article reports two strategies of combination therapy; the incorporation of two or more antimalarials into polymer-based carriers and hybrid compounds designed by hybridization of two antimalarial pharmacophores. View Full-Text
Keywords: malaria; antimalarial drugs; combination therapy; hybrid compounds; polymer-based carriers malaria; antimalarial drugs; combination therapy; hybrid compounds; polymer-based carriers
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MDPI and ACS Style

Alven, S.; Aderibigbe, B. Combination Therapy Strategies for the Treatment of Malaria. Molecules 2019, 24, 3601.

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