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Cancer Targeting and Drug Delivery Using Carbon-Based Quantum Dots and Nanotubes

by Joel Pardo 1, Zhili Peng 1,2,* and Roger M. Leblanc 1,*
1
Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA
2
College of Pharmacy and Chemistry, Dali University, Dali 671000, Yunnan, China
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(2), 378; https://doi.org/10.3390/molecules23020378
Received: 19 January 2018 / Revised: 7 February 2018 / Accepted: 9 February 2018 / Published: 10 February 2018
(This article belongs to the Special Issue Targeted Drug Delivery and Nanocarriers)
Currently cancer treatment is in large part non-specific with respect to treatment. Medication is often harsh on patients, whereby they suffer several undesired side effects as a result. Carbon-based nanoparticles have attracted attention in recent years due to their ability to act as a platform for the attachment of several drugs and/or ligands. Relatively simple models are often used in cancer research, wherein carbon nanoparticles are conjugated to a ligand that is specific to an overexpressed receptor for imaging and drug delivery in cancer treatment. These carbon nanoparticles confer unique properties to the imaging or delivery vehicle due to their nontoxic nature and their high fluorescence qualities. Chief among the ongoing research within carbon-based nanoparticles emerge carbon dots (C-dots) and carbon nanotubes (CNTs). In this review, the aforementioned carbon nanoparticles will be discussed in their use within doxorubicin and gemcitabine based drug delivery vehicles, as well as the ligand-mediated receptor specific targeted therapy. Further directions of research in current field are also discussed. View Full-Text
Keywords: carbon dots; carbon nanotubes; drug delivery; doxorubicin; gemcitabine; transferrin; folic acid; hyaluronan carbon dots; carbon nanotubes; drug delivery; doxorubicin; gemcitabine; transferrin; folic acid; hyaluronan
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MDPI and ACS Style

Pardo, J.; Peng, Z.; Leblanc, R.M. Cancer Targeting and Drug Delivery Using Carbon-Based Quantum Dots and Nanotubes. Molecules 2018, 23, 378.

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