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Open AccessArticle

Metabolomics Research Reveals the Mechanism of Action of Astragalus Polysaccharide in Rats with Digestive System Disorders

1
School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2
College of Nursing, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
3
College of traditional Chinese medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
4
Experiment Center of Shandong University of Traditional Chinese Medicine, Jinan 250355, China
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(12), 3333; https://doi.org/10.3390/molecules23123333
Received: 24 November 2018 / Revised: 10 December 2018 / Accepted: 14 December 2018 / Published: 15 December 2018
(This article belongs to the Section Chemical Biology)
With the diversity of modern dietary lifestyles, digestive system disorders (DSD) have become a frequently occurring disease in recent years. Astragalus polysaccharide (APS) is a homogeneous polysaccharide extracted from Astragalus, which might ameliorate the digestive and absorptive functions. However, the treatment mechanisms remain unclear. In this study, rats with DSD were fed a high-fat–low-protein diet and subjected to weight-bearing swimming until exhaustion. When body weight and autonomous activities of the rats decreased, they were administered APS. After two weeks, serum metabolomics analysis based on LC-MS was performed to validate the therapeutic effect of APS and explore its mechanism. APS pharmacodynamics was determined in this study, and serum metabolomics analysis discovered and identified 16 significant, differentially produced metabolites involved in energy, amino acid, and lipid metabolism, including citric acid, lactic acid, alanine, phosphatidylcholine, phenylalanine. After treatment with APS, the levels of the above small-molecule metabolites were reversed. Our results show the efficacy of APS in DSD treatment through the regulation of perturbed metabolic pathways related to energy, amino acid, and lipid metabolism. View Full-Text
Keywords: Astragalus polysaccharide; digestive system disorders; metabolomics Astragalus polysaccharide; digestive system disorders; metabolomics
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MDPI and ACS Style

Wang, H.; Liu, A.; Zhao, W.; Zhao, H.; Gong, L.; Chen, E.; Cui, N.; Ji, X.; Wang, S.; Jiang, H. Metabolomics Research Reveals the Mechanism of Action of Astragalus Polysaccharide in Rats with Digestive System Disorders. Molecules 2018, 23, 3333.

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