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Molecules 2017, 22(8), 1295;

An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate

Department of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, Zhejiang, China
Zhejiang Medicine Co., Ltd., Shaoxing 312000, Zhejiang, China
Authors to whom correspondence should be addressed.
Received: 19 July 2017 / Revised: 31 July 2017 / Accepted: 1 August 2017 / Published: 4 August 2017
(This article belongs to the Special Issue Advances in Spiro Compounds)
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A simple and efficient method for the synthesis of spiro[indoline-3,9′-xanthene]trione derivatives by means of condensation between isatins and 1,3-cyclohexanedione in the presence of a catalytic amount of magnesium perchlorate at 80 °C in 50% aqueous ethanol medium has been described. Notably, the present method offers desirable advantages of good yields, simplicity of workup procedure, easy purification, and reduced reaction times. View Full-Text
Keywords: aqueous; isatin; spiro[indoline-3,9′-xanthene]trione; magnesium perchlorate aqueous; isatin; spiro[indoline-3,9′-xanthene]trione; magnesium perchlorate

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, C.; Lv, C.; Liang, J.; Jin, J.; Wang, L.; Wu, C.; Shen, R. An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate. Molecules 2017, 22, 1295.

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