Next Article in Journal
Design, Synthesis and Biological Evaluation of 2-(2-Amino-5(6)-nitro-1H-benzimidazol-1-yl)-N-arylacetamides as Antiprotozoal Agents
Next Article in Special Issue
LC-ESI-MS/MS Identification of Biologically Active Phenolic Compounds in Mistletoe Berry Extracts from Different Host Trees
Previous Article in Journal
The Synthesis of 2-Aminobenzoxazoles Using Reusable Ionic Liquid as a Green Catalyst under Mild Conditions
Previous Article in Special Issue
Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(4), 515;

Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 20 February 2017 / Revised: 17 March 2017 / Accepted: 18 March 2017 / Published: 3 April 2017
(This article belongs to the Collection Bioactive Compounds)
Full-Text   |   PDF [736 KB, uploaded 3 April 2017]   |  


A new triflavanoid, kandelin B-5 (1), was isolated from the rhizomes of Smilax china L., together with six known phenylpropanoid substituted flavan-3-ols (27), nine flavonoids (816), two stilbenoids (17, 18), and two other compounds (19, 20). The structure of compound 1 was determined on the basis of 1D, 2D NMR and HR-ESI-MS data, as well as chemical method. Compounds 25, 812, 15, 17, and 19 were evaluated for anti-inflammatory activity. Only compounds 10, 15 and 17 showed slightly IL-1β expression inhibitory activities on LPS induced THP-1 cells, with inhibition rate of 15.8%, 37.3%, and 35.8%, respectively, at concentration of 50 μg/mL. View Full-Text
Keywords: Smilax china; phenolic compounds; anti-inflammatory activity Smilax china; phenolic compounds; anti-inflammatory activity

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Zhong, C.; Hu, D.; Hou, L.-B.; Song, L.-Y.; Zhang, Y.-J.; Xie, Y.; Tian, L.-W. Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity. Molecules 2017, 22, 515.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top