Next Article in Journal
Arginine: New Insights into Growth Performance and Urinary Metabolomic Profiles of Rats
Previous Article in Journal
Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain
Open AccessArticle

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(9), 1146; https://doi.org/10.3390/molecules21091146
Received: 20 July 2016 / Accepted: 3 August 2016 / Published: 29 August 2016
(This article belongs to the Section Natural Products Chemistry)
Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3′-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM. View Full-Text
Keywords: Tripterygium regelii; dimacrolide sesquiterpene pyridine alkaloids; anti-inflammation Tripterygium regelii; dimacrolide sesquiterpene pyridine alkaloids; anti-inflammation
Show Figures

Graphical abstract

MDPI and ACS Style

Fan, D.; Zhu, G.-Y.; Li, T.; Jiang, Z.-H.; Bai, L.-P. Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii. Molecules 2016, 21, 1146.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop