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Keywords = dimacrolide sesquiterpene pyridine alkaloids

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Article
Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii
by Dongsheng Fan, Guo-Yuan Zhu, Ting Li, Zhi-Hong Jiang and Li-Ping Bai
Molecules 2016, 21(9), 1146; https://doi.org/10.3390/molecules21091146 - 29 Aug 2016
Cited by 16 | Viewed by 6090
Abstract
Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well [...] Read more.
Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3′-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM. Full article
(This article belongs to the Section Natural Products Chemistry)
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