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Open AccessArticle

Arginine: New Insights into Growth Performance and Urinary Metabolomic Profiles of Rats

by Guangmang Liu 1,2,*, Xianjian Wu 1,2, Gang Jia 1,2, Xiaoling Chen 1,2, Hua Zhao 1,2, Jing Wang 3, Caimei Wu 1,2 and Jingyi Cai 1,2
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China
Maize Research Institute, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(9), 1142;
Received: 17 June 2016 / Revised: 6 August 2016 / Accepted: 25 August 2016 / Published: 29 August 2016
(This article belongs to the Section Metabolites)
Arginine regulates growth performance, nutrient metabolism and health effects, but the underlying mechanism remains unknown. This study aims to investigate the effect of dietary arginine supplementation on rat growth performance and urinary metabolome through 1H-NMR spectroscopy. Twenty rats were randomly assigned to two groups supplemented with 0% or 1.0% l-arginine for 4 weeks. Urine samples were analyzed through NMR-based metabolomics. Arginine supplementation significantly increased the urine levels of 4-aminohippurate, acetate, creatine, creatinine, ethanolamine, formate, hippurate, homogentisate, indoxyl sulfate, and phenylacetyglycine. Conversely, arginine decreased the urine levels of acetamide, β-glucose, cirtulline, ethanol, glycine, isobutyrate, lactate, malonate, methymalonate, N-acetylglutamate, N-methylnicotinamide, and propionate. Results suggested that arginine can alter common systemic metabolic processes, including energy metabolism, amino acid metabolism, and gut microbiota metabolism. Moreover, the results also imply a possible physiological role of the metabolism in mediating the arginine supplementation-supported growth of rats. View Full-Text
Keywords: arginine; metabolism; metabolomic profiles; urine arginine; metabolism; metabolomic profiles; urine
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MDPI and ACS Style

Liu, G.; Wu, X.; Jia, G.; Chen, X.; Zhao, H.; Wang, J.; Wu, C.; Cai, J. Arginine: New Insights into Growth Performance and Urinary Metabolomic Profiles of Rats. Molecules 2016, 21, 1142.

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