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Open AccessArticle

Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence

1
School of Pharmacy, University of Otago, Dunedin 9056, New Zealand
2
Department of Pharmacy, University of Copenhagen, Copenhagen 2100, Denmark
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Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Molecules 2015, 20(3), 4548-4564; https://doi.org/10.3390/molecules20034548
Received: 21 January 2015 / Revised: 3 March 2015 / Accepted: 3 March 2015 / Published: 12 March 2015
Antioxidants protect against damage from free radicals and are believed to slow the ageing process. Previously, we have reported the high antioxidant activity of 70% methanolic Sonchus oleraceus L. (Asteraceae) leaf extracts. We hypothesize that S. oleraceus extracts protect cells against H2O2-induced senescence by mediating oxidative stress. Premature senescence of young WI-38 cells was induced by application of H2O2. Cells were treated with S. oleraceus extracts before or after H2O2 stress. The senescence- associated β-galactosidase (SA-β-gal) activity was used to indicate cell senescence. S. oleraceus extracts showed higher cellular antioxidant activity than chlorogenic acid in WI-38 cells. S. oleraceus extracts suppressed H2O2 stress-induced premature senescence in a concentration-dependent manner. At 5 and 20 mg/mL, S. oleraceus extracts showed better or equivalent effects of reducing stress-induced premature senescence than the corresponding ascorbic acid treatments. These findings indicate the potential of S. oleraceus extracts to be formulated as an anti-ageing agent. View Full-Text
Keywords: Sonchus oleraceus; antioxidants; leaf extracts; caffeic acid derivatives; CAA; senescence; anti-ageing Sonchus oleraceus; antioxidants; leaf extracts; caffeic acid derivatives; CAA; senescence; anti-ageing
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MDPI and ACS Style

Ou, Z.-Q.; Rades, T.; McDowell, A. Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence. Molecules 2015, 20, 4548-4564.

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