A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental Section
3.1. General Information
3.2. 1,4-bis(tert-Butoxycarbonylmethyl)-1,4,7-triazacyclononane (3)
3.3. Ethyl 2-(3-Hydroxy-2-oxopyridin-1(2H)-yl) Acetate (8)
3.4. Ethyl 2-(3-(Benzyloxy)-2-oxopyridin-1(2H)-yl) Acetate (9a)
3.5. 2-(3-(Benzyloxy)-2-oxopyridin-1(2H)-yl)acetic Acid (9b)
3.6. 3-(Benzyloxy)-1-(2-hydroxyethyl)pyridin-2(1H)-one (10)
3.7. 3-(Benzyloxy)-1-(2-hydroxyethyl)pyridin-2(1H)-one (10)
3.8. 3-(Benzyloxy)-1-(2-chloroethyl)pyridin-2(1H)-one (4)
3.9. tert-Butyl-2,2'-(7-(2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)ethyl)-1,4,7-triazonane-1,4-diyl) Diacetate (11)
3.10. 2,2'-(7-(2-(3-Hydroxy-2-oxopyridin-1(2H)-yl)ethyl)-1,4,7-triazonane-1,4-diyl) Diacetic Acid (HE-NO2A, 1)
3.11. Methyl 3-(3-Hydroxy-2-oxopyridin-1(2H)-yl) Propanoate (12)
3.12. Methyl 3-(3-(Benzyloxy)-2-oxopyridin-1(2H)-yl) Propanoate (13a)
3.13. 3-(3-(Benzyloxy)-2-oxopyridin-1(2H)-yl) Propanoic Acid (13b)
3.14. 3-(Benzyloxy)-1-(3-hydroxypropyl) Pyridin-2(1H)-one (14)
3.15. 3-(Benzyloxy)-1-(3-hydroxypropyl) Pyridin-2(1H)-one (14)
3.16. 9-(Benzyloxy)-3,4-dihydro-2H-pyrido[2,1-b][1,3]oxazin-5-ium Methanesulfonate (15)
3.17. tert-Butyl-2,2'-(7-(3-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)propyl)-1,4,7-triazonane-1,4-diyl) Diacetate (16)
3.18. 2,2'-(7-(3-(3-Hydroxy-2-oxopyridin-1(2H)-yl)propyl)-1,4,7-triazonane-1,4-diyl) Diacetic Acid (HP-NO2A, 2)
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Gai, Y.; Hu, Z.; Rong, Z.; Ma, X.; Xiang, G. A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm. Molecules 2015, 20, 19393-19405. https://doi.org/10.3390/molecules201019393
Gai Y, Hu Z, Rong Z, Ma X, Xiang G. A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm. Molecules. 2015; 20(10):19393-19405. https://doi.org/10.3390/molecules201019393
Chicago/Turabian StyleGai, Yongkang, Zhongping Hu, Zhao Rong, Xiang Ma, and Guangya Xiang. 2015. "A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm" Molecules 20, no. 10: 19393-19405. https://doi.org/10.3390/molecules201019393