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Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components

by Wei Wang 1,2, Nan Li 1,2, Meng Luo 1,2, Yuangang Zu 1,2,* and Thomas Efferth 3
1
Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, China
2
Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, China
3
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz 55099, Germany
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(3), 2704-2713; https://doi.org/10.3390/molecules17032704
Received: 9 January 2012 / Revised: 20 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012
In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to α-pinene, and a little bit better than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC50) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025‰, 0.076‰ and 0.13‰ (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations. View Full-Text
Keywords: Rosmarinus officinalis L.; 1,8-cineole; α-pinene; β-pinene; antibacterial activities; cytotoxicity Rosmarinus officinalis L.; 1,8-cineole; α-pinene; β-pinene; antibacterial activities; cytotoxicity
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Wang, W.; Li, N.; Luo, M.; Zu, Y.; Efferth, T. Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components. Molecules 2012, 17, 2704-2713.

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