Next Article in Journal
Synthesis, Acidity and Antioxidant Properties of Some Novel 3,4-disubstituted-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives
Next Article in Special Issue
Trimethyl Lock: A Stable Chromogenic Substrate for Esterases
Previous Article in Journal
Substitutions of Fluorine Atoms and Phenoxy Groups in the Synthesis of Quinoxaline 1,4-di-N-oxide Derivatives
Previous Article in Special Issue
Antiparkinson Prodrugs
Article Menu

Export Article

Open AccessArticle
Molecules 2008, 13(1), 96-106;

Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin

Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland
Author to whom correspondence should be addressed.
Received: 14 December 2007 / Revised: 16 January 2008 / Accepted: 16 January 2008 / Published: 18 January 2008
(This article belongs to the Special Issue Prodrugs)
Full-Text   |   PDF [101 KB, uploaded 18 June 2014]   |  


Two-, three- and four-arm, star-shaped poly(ε-caprolactone) andpoly(D,L-lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide weresynthesized via ring-opening polymerization of cyclic esters in the presence of glycerol,penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst.Thus obtained oligomers were successfully used in the synthesis of novel macromolecularprodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated bymeans of MALDI-TOF MS, NMR and IR studies. View Full-Text
Keywords: aliphatic polyesters; ring-opening polymerization; macromolecular prodrugs; aliphatic polyesters; ring-opening polymerization; macromolecular prodrugs;

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Sobczak, M.; Witkowska, E.; Olędzka, E.; Kolodziejski, W. Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin. Molecules 2008, 13, 96-106.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top