Micro-Nanoelectronic Systems for Diagnosis and Therapies

Dear Colleagues,

Biointegrated microelectronic systems hold immense promise as long-term, high-performance platforms for sensing and stimulating the heart, brain, and other organs with cellular-level precision over large tissue areas. These technologies are of significant interest to the cardiology, neuroscience, and biomedical communities. Despite progress, developing seamless, multiscale electronic interfaces that interact gently and effectively with living tissue remains a major challenge. Innovations such as mesh and skin electronics have demonstrated the potential of soft, tissue-like mechanics and highly miniaturized architectures to establish close, functional contact with the brain and skin, thereby enhancing biosensing capabilities. Recent breakthroughs in materials science and system integration are now enabling the creation of dynamic, adaptive interfaces that can interact with living cells and organoids in real time. Such capabilities are critical for decoding and influencing how cells coordinate activities across scales—mechanisms that underlie key processes in metabolism and disease progression. This Topic highlights recent advances in microelectronic systems engineered as diagnostic and therapeutic tools for next-generation healthcare.

Dr. Wubin Bai
Dr. Jiho Shin
Topic Editors