Adaptation Mechanisms in Therapy-Resistant Breast Cancer

Dear Colleagues,

The aim of this Topic is to report the recent findings that have increased our understanding of adaptive responses to stress, focusing on resistance to endocrine therapy in breast cancer. The usage of omics sciences to characterize cell lines and tumors has uncovered changes in genes, proteins, and other metabolites that result in metabolism adaptation to survive therapy-induced stress. Metabolite changes reflect oncogenic transformation and the remodeling of metabolic pathways, which, in addition to genes and proteins, constitute powerful biomarkers and therapeutic targets. Efforts are needed to go beyond cell line studies and plasma characterization to increase our knowledge of how therapy affects metabolic interplay in the tumor microenvironment. For this Topic, we invite authors to contribute original research, review articles, and meta analyses focusing on metabolic adaptation in hormone receptor-positive breast cancer that promotes or results from endocrine therapy resistance. We encourage the submission of articles that explore the biomarker potential of metabolic adaptations, metabolic competition/cooperation between more than one cell type, and the immune tumor microenvironment. Research on the use of novel metabolic modulators to enhance endocrine therapy, either natural or synthetic compounds, is also encouraged.

Prof. Dr. Luisa Alejandra Helguero
Dr. Iola F. Duarte
Prof. Dr. Ana M. Gil
Topic Editors

Deadline for abstract submissions: 30 April 2022.
Deadline for manuscript submissions: 31 July 2022.

Topic Board

Prof. Dr. Luisa Alejandra Helguero
E-Mail Website
Topic Editor
Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: breast cancer; steroid receptors; endocrine therapy; cell differentiation; adaptive stress responses; lipids
Dr. Iola F. Duarte Ciceco
E-Mail Website
Topic Editor
Department of Chemistry, Technological Laboratories, CICECO - Aveiro Institute of Materials, University of Aveiro, 3810-093 Aveiro, Portugal
Interests: toxicity and biological assessment of (nano)materials with biomedical applications; metabolism of immune cells and metabolic immunomodulation; metabolism of tumor cells and metabolic effects of anticancer therapies (drugs, nanomedicines, photothermal therapy); NMR spectroscopy and metabolomics
Special Issues, Collections and Topics in MDPI journals
Prof.Dr. Ana M. Gil
E-Mail Website
Topic Editor
Department of Chemistry, Technological Laboratories, CICECO - Aveiro Institute of Materials, University of Aveiro, 3810-093 Aveiro, Portugal
Interests: metabolomics of human biofluids, tissues, and cellular systems for the biochemical characterisation of diseases (mainly prenatal/newborn disorders and cancer); metabolomics testing of bio- and/or nano-materials for assessment of in vitro and in vivo biological performance; metabolomic assessment of environmental effects on human metabolism; metabolomics for the routine quality control of products and processes in the food industry
Special Issues, Collections and Topics in MDPI journals

Relevant Journals List

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomolecules
biomolecules
4.879 3.2 2011 16.29 Days 2000 CHF Submit
Cancers
cancers
6.639 4.4 2009 17.04 Days 2200 CHF Submit
Cells
cells
6.600 - 2012 15.34 Days 2000 CHF Submit
Current Oncology
curroncol
3.677 3.8 1994 19.84 Days 1600 CHF Submit
Onco
onco
- - 2021 8.01 Days 1000 CHF Submit

Published Papers

This Topic is now open for submission.
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