Topic Editors

Department of Psychiatric Genetics, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, Poland
Faculty of Psychology, Kazimierz Wielki University in Bydgoszcz, Staffa 1, 85-867 Bydgoszcz, Poland
Dr. Przemysław Zakowicz
Tadeusz Bilikiewicz Research Group for Descriptive Psychopathology, Collegium Medicum, University of Zielona Góra, 65-417 Zielona Góra, Poland

Research Advances in Psychiatric Diseases: Focusing on the Prediction of Suicide

Abstract submission deadline
closed (15 July 2025)
Manuscript submission deadline
closed (15 September 2025)
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12911

Topic Information

Dear Colleagues,

Suicide is a serious public health problem. Every 40 seconds, a person dies by suicide; over 800,000 people die by suicide every year. Up to 73% of global suicides occur in low- and middle-income countries; however, the highest age-standardized suicide rate is within high-income countries. Suicide is the third leading cause of death among 15 to 29-year-olds. For each suicide committed, there are more than 20 nonfatal suicide attempts. A previous suicide attempt is a significant risk factor for suicide in the general population. Furthermore, men have higher suicide mortality rates than women. The reasons for suicide are multi-factorial, influenced by social, cultural, biological, psychological, and environmental factors. Most suicides are related to mental disorders, particularly depression, substance use disorders, and psychosis. However, many suicides occurs impulsively in moments of crisis. Suicide incidents are also high among vulnerable groups who experience discrimination. In the pathophysiology of suicidal behavior, hyperactivity of the hypothalamic–pituitary–adrenal axis and dysfunction of the serotonergic and noradrenergic systems have been postulated. Structural and functional alterations in particular brain areas (e.g., the frontal lobe) with regard to suicidal behavior have been found in neuroimaging studies. Numerous studies on biomarkers for suicidal ideation and attempts have been performed in the last few years.

This Topic is focused on the prediction of suicidal behaviour, with an emphasis on clinical and biological markers. Articles on neurobiology, neuroimaging, genetics, as well as the prevention of suicide are also encouraged. This Topic will accept original articles, literature reviews, and meta-analyses.

Dr. Maria Skibińska
Prof. Dr. Monika Wiłkość-Dębczyńska
Dr. Przemyslaw Zakowicz
Topic Editors

Keywords

  • suicide
  • suicide attempt
  • suicide risk
  • suicide prevention
  • biomarkers

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Brain Sciences
brainsci
2.8 5.6 2011 17.6 Days CHF 2200
Neurology International
neurolint
3.0 4.8 2009 21.5 Days CHF 1800
NeuroSci
neurosci
2.0 - 2020 23.3 Days CHF 1200

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Published Papers (1 paper)

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Systematic Review
5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes
by Carmen Rodriguez-Cerdeira
NeuroSci 2026, 7(1), 20; https://doi.org/10.3390/neurosci7010020 - 2 Feb 2026
Viewed by 2260
Abstract
5a-reductase (5a-R) isozymes are essential for androgen metabolism and neurosteroid biosynthesis, linking endocrinology and neuropsychiatry. This systematic review, conducted in accordance with PRISMA 2020 guidelines, aimed to synthesize current evidence on the tissue distribution of SRD5A1, SRD5A2, and SRD5A3 and their implications in [...] Read more.
5a-reductase (5a-R) isozymes are essential for androgen metabolism and neurosteroid biosynthesis, linking endocrinology and neuropsychiatry. This systematic review, conducted in accordance with PRISMA 2020 guidelines, aimed to synthesize current evidence on the tissue distribution of SRD5A1, SRD5A2, and SRD5A3 and their implications in mental health. A systematic search of the PubMed, Scopus, and Web of Science databases up to February 2025 identified 257 articles, of which 83 met the inclusion criteria. SRD5A1 is broadly expressed in the liver, skin, and central nervous system, contributing to allopregnanolone synthesis; SRD5A2 is mainly restricted to androgen-dependent tissues, playing a key role in prostate development and alopecia; and SRD5A3 is associated with glycosylation processes and oncogenesis. Converging evidence suggests that impaired neurosteroidogenesis due to 5α-R inhibition may underlie vulnerability to anxiety, depression, and suicidality. While earlier epidemiological findings were heterogeneous, recent pharmacovigilance data have strengthened the evidence supporting this association. Pharmacovigilance and clinical reports show that a subset of patients treated with finasteride or dutasteride may experience persistent psychiatric and sexual adverse effects, known as post-finasteride syndrome. The current findings underscore the need for careful patient counseling, systematic monitoring, and further translational studies integrating genetics, neuroendocrine markers, and standardized psychiatric outcomes to identify individuals at risk and advance personalized medicine in this field. Full article
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