Natural Bioactive Compounds as a Promising Approach to Mitigating Oxidative Stress—Second Edition

Topic Information

Dear Colleagues,

Following the success of the first edition of this Topic (https://www.mdpi.com/topics/79AKQ1L484), which highlighted the crucial role of natural bioactive compounds in mitigating oxidative stress-mediated pathologies, we are pleased to announce this second edition.

Oxidative stress remains a central driver in the pathogenesis of chronic conditions, including metabolic syndrome, oncological diseases, and neurodegenerative disorders. While the first edition established the potent antioxidant, anti-inflammatory, and immunomodulatory profiles of polyphenols, flavonoids, and terpenoids, the transition from in vitro efficacy to clinical application continues to face significant hurdles.

In this second edition, we aim to build upon previous findings by further exploring the synergy between natural products, nutraceuticals, pharmaceutical chemistry, and nanotechnology. A primary focus remains the extraction of bioactive natural products, the characterization of their physicochemical behaviour and therapeutic potential, and the mitigation of their inherent pharmacokinetic limitations, such as poor aqueous solubility, low bioavailability, and metabolic instability, through advanced nanocarrier systems and novel targeted drug delivery platforms.

We welcome original research and review articles focusing on the following:

• Green Extraction and Isolation: Sustainable methodologies for recovering high-purity bioactive scaffolds.
• Structural Characterization: Advanced analytical techniques to elucidate complex natural architectures.
• Molecular Pharmacology: Mechanistic studies on ligand–receptor interactions and the modulation of signaling pathways (e.g., Nrf2/ARE, NF-κB).
• Nanomedicine and Formulation Science: Utilization of lipid-based, polymeric, or inorganic nanoparticles to enhance the biopharmaceutical profile and therapeutic index of antioxidant compounds.

By integrating these multidisciplinary approaches, this edition seeks to bridge the gap between traditional natural product chemistry and modern pharmaceutical technology.

Prof. Dr. Andrea Ragusa
Prof. Dr. Michele Maffia
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antioxidants antioxidants	6.6	12.4	2012	18.7 Days	CHF 2900	Submit
Biomolecules biomolecules	4.8	9.2	2011	17.9 Days	CHF 2700	Submit
Chemistry chemistry	2.4	3.9	2019	15 Days	CHF 1800	Submit
International Journal of Molecular Sciences ijms	4.9	9.0	2000	17.8 Days	CHF 2900	Submit
Molecules molecules	4.6	8.6	1996	15.1 Days	CHF 2700	Submit
Oxygen oxygen	-	8.4	2021	26.7 Days	CHF 1200	Submit
Pharmaceutics pharmaceutics	5.5	10.0	2009	15.7 Days	CHF 2900	Submit
Separations separations	2.7	4.5	2014	16 Days	CHF 2600	Submit

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Open AccessArticle

Modulating Blood-Brain Barrier Metabolites of Broiler Chickens Through Dietary Flaxseed Oil

by Safiu A. Suberu, Paul C. Omaliko, Deji A. Ekunseitan, Nathanael I. Lichti, Bruce R. Cooper and Yewande O. Fasina

Biomolecules 2026, 16(5), 661; https://doi.org/10.3390/biom16050661 - 29 Apr 2026

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Abstract

Dietary polyunsaturated fatty acids (PUFAs) are vital for brain health and cognitive function. The dorsal raphe nucleus (DRN) regulates mood via serotonin, while the hypothalamus (HYP) controls energy homeostasis. Flaxseed oil (FLAX) is rich in omega-3 PUFAs like α-linolenic acid (ALA), and has [...] Read more.

Dietary polyunsaturated fatty acids (PUFAs) are vital for brain health and cognitive function. The dorsal raphe nucleus (DRN) regulates mood via serotonin, while the hypothalamus (HYP) controls energy homeostasis. Flaxseed oil (FLAX) is rich in omega-3 PUFAs like α-linolenic acid (ALA), and has been reported to influence serotonergic signaling in mammals, but data in poultry are scarce. This study investigated the effects of FLAX on metabolites crossing the blood-brain barrier (BBB) to serotonergic brain regions and on growth performance in broiler chickens. Day-old chicks (n = 160) were assigned to two diets (5 replicates/treatment): control (CON; poultry fat-based diet) or FLAX (3% inclusion level). Growth performance was recorded, and DRN, HYP, and plasma were analyzed using HPLC-MS metabolomics. Serotonin and its metabolite 5-HIAA were quantified using LC-MS/MS. FLAX-fed birds had higher body weight gain (p < 0.0055) and better feed conversion ratio (p < 0.0049) than CON. Metabolomics identified 2271 features, of which 650 were annotated as metabolites. Of 35 differentially abundant plasma metabolites, eight were also differentially abundant in brain tissues. In the DRN, tryptophan (serotonin precursor) and corydaline (neuroprotective) were upregulated. Serotonin levels were significantly higher in both the DRN and HYP of FLAX-fed birds compared to CON. This suggest that dietary flaxseed oil may modulate stress responses, behavior, and welfare in broilers. In the HYP, dethiobiotin (energy), galanthamine (neuroprotective), and gambogic acid (antioxidative) were upregulated, while xanthoxyletin (anti-inflammatory) was downregulated. In conclusion, flaxseed oil improved growth and elevated serotonin in the DRN and HYP via enhanced tryptophan availability, suggesting potential benefits for stress resilience and welfare. Full article

(This article belongs to the Topic Natural Bioactive Compounds as a Promising Approach to Mitigating Oxidative Stress—Second Edition)

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