Topic Editors

Department of Biological and Environmental Sciences and Technologies, Campus Ecotekne, University of Salento, Via Monteroni, 73100 Lecce, Italy
Prof. Dr. Filomena Corbo
Department of Pharmacy-Pharmaceutical Sciences, Università degli studi Aldo Moro, Bari, Italy

Natural Bioactive Compounds as a Promising Approach to Mitigating Oxidative Stress

Abstract submission deadline
31 October 2025
Manuscript submission deadline
31 December 2025
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1585

Topic Information

Dear Colleagues,

Oxidative stress is a pathological condition that arises due to an imbalance between oxidants and antioxidant defense systems in the body. It is implicated in the pathogenesis of several chronic diseases, including diabetes, cancer, and neurodegenerative disorders.

Natural bioactive compounds, such as polyphenols, flavonoids, and terpenoids, offer a promising approach to mitigating oxidative stress. These compounds are found in various sources, including fruits, vegetables, and medicinal plants, and have demonstrated potent antioxidant properties capable of preventing oxidative damage to cells. Additionally, they exhibit beneficial effects, including anti-inflammatory, antibacterial, anticancer, and immune-modulating properties.

Despite their robust pharmacodynamic effects, these compounds often exhibit poor pharmacokinetics. In response, nanotechnological approaches have been leveraged to enhance the characteristics of these compounds, addressing issues such as solubility, bioavailability, and stability. This improvement aims to enhance the therapeutic efficacy of natural bioactive compounds, making them more suitable for pharmaceutical applications.

Within this topic, we welcome contributions related to natural bioactive compounds and the exploitation of their antioxidant effects in fighting oxidative stress. We encourage the exploration of green extraction methods for natural sources, the structural characterization of complex biomolecules, and investigations into their interactions with cellular receptors and enzymes. Additionally, contributions discussing the potential application of novel nanotechnologies to enhance the physicochemical characteristics of these compounds are also appreciated. 

Prof. Dr. Andrea Ragusa
Prof. Dr. Filomena Corbo
Topic Editors

Keywords

  • antioxidants
  • secondary metabolites
  • polyphenols
  • phytochemicals
  • oxidative stress
  • reactive oxygen species (ROS)
  • NADES
  • molecular modeling
  • inflammation
  • neuroprotection
  • cancer
  • dietary supplements

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Antioxidants
antioxidants
6.0 10.6 2012 13.9 Days CHF 2900 Submit
Chemistry
chemistry
2.4 3.2 2019 19.1 Days CHF 1800 Submit
International Journal of Molecular Sciences
ijms
4.9 8.1 2000 16.3 Days CHF 2900 Submit
Molecules
molecules
4.2 7.4 1996 14.6 Days CHF 2700 Submit
Pharmaceutics
pharmaceutics
4.9 7.9 2009 14.2 Days CHF 2900 Submit

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Published Papers (2 papers)

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18 pages, 9614 KiB  
Article
Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress
by Sepideh Zununi Vahed, Marisol Zuluaga Tamayo, Violeta Rodriguez-Ruiz, Olivier Thibaudeau, Sobhan Aboulhassanzadeh, Jalal Abdolalizadeh, Anne Meddahi-Pellé, Virginie Gueguen, Abolfazl Barzegari and Graciela Pavon-Djavid
Pharmaceutics 2024, 16(7), 840; https://doi.org/10.3390/pharmaceutics16070840 - 21 Jun 2024
Viewed by 183
Abstract
It was previously reported that crocin, a water-soluble carotenoid isolated from the Crocus sativus L. (saffron), has protective effects on cardiac cells and may neutralize and even prevent the formation of excess number of free radicals; however, functional mechanisms of crocin activity have [...] Read more.
It was previously reported that crocin, a water-soluble carotenoid isolated from the Crocus sativus L. (saffron), has protective effects on cardiac cells and may neutralize and even prevent the formation of excess number of free radicals; however, functional mechanisms of crocin activity have been poorly understood. In the present research, we aimed to study the functional mechanism of crocin in the heart exposed to oxidative stress. Accordingly, oxidative stress was modeled in vitro on human umbilical vein endothelial cells (HUVECs) and in vivo in mice using cellular stressors. The beneficial effects of crocin were investigated at cellular and molecular levels in HUVECs and mice hearts. Results indicated that oral administration of crocin could have protective effects on HUVECs. In addition, it protects cardiac cells and significantly inhibits inflammation via modulating molecular signaling pathways TLR4/PTEN/AKT/mTOR/NF-κB and microRNA (miR-21). Here we show that crocin not only acts as a direct free radical scavenger but also modifies the gene expression profiles of HUVECs and protects mice hearts with anti-inflammatory action under oxidative stress. Full article
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18 pages, 9765 KiB  
Article
Stress Granule Core Protein-Derived Peptides Inhibit Assembly of Stress Granules and Improve Sorafenib Sensitivity in Cancer Cells
by Juan Li, Yaobin Zhang, Jinxuan Gu, Yulin Zhou, Jie Liu, Haiyan Cui, Tiejun Zhao and Zhigang Jin
Molecules 2024, 29(9), 2134; https://doi.org/10.3390/molecules29092134 - 4 May 2024
Viewed by 888
Abstract
Upon a variety of environmental stresses, eukaryotic cells usually recruit translational stalled mRNAs and RNA-binding proteins to form cytoplasmic condensates known as stress granules (SGs), which minimize stress-induced damage and promote stress adaptation and cell survival. SGs are hijacked by cancer cells to [...] Read more.
Upon a variety of environmental stresses, eukaryotic cells usually recruit translational stalled mRNAs and RNA-binding proteins to form cytoplasmic condensates known as stress granules (SGs), which minimize stress-induced damage and promote stress adaptation and cell survival. SGs are hijacked by cancer cells to promote cell survival and are consequently involved in the development of anticancer drug resistance. However, the design and application of chemical compounds targeting SGs to improve anticancer drug efficacy have rarely been studied. Here, we developed two types of SG inhibitory peptides (SIPs) derived from SG core proteins Caprin1 and USP10 and fused with cell-penetrating peptides to generate TAT-SIP-C1/2 and SIP-U1-Antp, respectively. We obtained 11 SG-inducing anticancer compounds from cell-based screens and explored the potential application of SIPs in overcoming resistance to the SG-inducing anticancer drug sorafenib. We found that SIPs increased the sensitivity of HeLa cells to sorafenib via the disruption of SGs. Therefore, anticancer drugs which are competent to induce SGs could be combined with SIPs to sensitize cancer cells, which might provide a novel therapeutic strategy to alleviate anticancer drug resistance. Full article
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