Hypoxia-Driven Redox Signaling: From Molecular Mechanisms to Therapeutic Opportunities
A Special Issue of Antioxidants (ISSN 2076-3921) belonging to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 154
Editor
Interests: hypoxia; animal ecophysiology; antioxidant; biochemical adaptation; comparative physiology; diapause; estivation; free radical; glutathione; oxidative stress; reactive oxygen species; redox biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxygen deprivation is a defining feature of numerous physiological and pathological states, from tumor microenvironments and ischemia–reperfusion injury to high-altitude adaptation and diving physiology. Central to how cells sense and respond to hypoxia is a tightly interconnected network of redox signaling pathways: shifts in mitochondrial ROS production, activation of transcriptional programs, thiol-based redox switches, and metabolic rewiring. Understanding how these mechanisms are coordinated—and how they can fail or be exploited therapeutically—remains a central challenge in redox biology.
This Special Issue invites original research and review articles addressing the molecular mechanisms linking hypoxia and redox signaling across model systems, from cell culture and animal models to clinical studies. We welcome contributions on topics including, but not limited to, the following: redox-sensitive transcription factors’ crosstalk and regulation; mitochondrial ROS and NADPH redox balance under low oxygen; oxidative and nitrosative stress in ischemic and reperfusion injury; redox-dependent adaptations in hypoxia-tolerant organisms; metabolic reprogramming and signaling; and emerging therapeutic strategies targeting redox pathways in hypoxia-related disease, including cancer, cardiovascular, and neurodegenerative conditions.
By bringing together mechanistic, translational, and comparative perspectives, this Issue aims to advance our understanding of hypoxia–redox biology and identify new avenues for therapeutic intervention.
We look forward to your contributions.
Dr. Daniel Carneiro Moreira
Guest Editor
Manuscript Submission Information
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Keywords
- hypoxia
- redox
- ROS signaling
- oxidative stress
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