Tumor Microenvironment in Cancer Progression and Therapy Resistance
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 263
Special Issue Editors
Interests: tumor microenvironment; cancer stem cell; treatment resistance; liquid biopsy
Interests: precision oncology; drug resistance; thoracic cancer
Special Issue Information
Dear Colleagues,
This Special Issue of Cancers focuses on the dynamic interplay between tumor metabolism and the immune microenvironment, a critical axis influencing cancer progression and therapy resistance. Tumors exploit metabolic reprogramming to not only sustain their own proliferation but also to suppress anti-tumor immunity, fostering an immunosuppressive niche. This Special Issue will explore mechanisms by which oncogenic signaling and nutrient competition shape immune cell function and exhaustion, highlighting emerging insights into metabolic checkpoints. We welcome original research and reviews addressing how targeting metabolic pathways—e.g., involving glucose, amino acids, or lipids—can reprogram the tumor microenvironment to enhance immunotherapeutic efficacy. Submissions may cover preclinical models, clinical correlates, and novel therapeutic strategies aimed at overcoming metabolic immunosuppression.
Prof. Dr. Hongxia Wang
Dr. Zhihuang Hu
Dr. Zhonghua Tao
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer metabolism
- tumor immune microenvironment
- metabolic reprogramming
- immunometabolism
- metabolic checkpoints
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