Quinoline and Quinazoline Derivatives: A Valuable Prospect for Drug Discovery
A Special Issue of Molecules (ISSN 1420-3049) belonging to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 314
Editor
Special Issue Information
Dear Colleagues,
The importance of nitrogen rings in medicinal chemistry has been undeniable for several years. Following the identification of numerous bioactive molecules containing quinoline/isoquinoline (benzopyridine) in natural sources, the biological activities of similar molecules have frequently been investigated on this basis. Currently, clinically used quinoline-containing drugs generally exhibit antiprotozoal, antineoplastic, and antibacterial activity, while isoquinoline-containing drugs are seen to exhibit vasodilator, analgesic, and antihypertensive activity. Regarding quinazolines (benzopyrimidines), in addition to being found in the structure of sedative–hypnotic and antihypertensive drugs, their anticancer activity is particularly prominent, and together with quinolines, they are considered to form the group of protein kinase inhibitor anticancer drugs known as "…tinibs".
Quinoline/isoquinoline and quinazoline derivatives are mimics of molecules that are the building blocks of many bioactive molecules found in nature and organisms, and the newly obtained derivatives demonstrate high efficacy across a wide biological activity profile. These privileged scaffolds are considered pharmacophores due to their ability to bind to enzymes and receptors, their wide variety of biological activities depending on the substituents they contain, their purine similarity, and their metabolic stability. Research is underway to obtain novel, effective, and non-toxic derivatives of these ring systems, which are known to primarily possess chemotherapeutic activity. Tyrosine kinase inhibition is a key molecular target used particularly in the treatment of cancer, autoimmune diseases, and inflammation, and the discovery of new drugs from derivatives holds great promise, especially for the treatment of cancer, a challenging disease.
This Special Issue invites researchers to submit original research articles and reviews on the synthesis and/or isolation of organic/inorganic quinoline/isoquinoline and quinazoline derivatives, evaluating their various biological activities, mechanisms of action, structure–activity relationships, and computational studies.
I look forward to receiving your contributions.
Prof. Dr. Leyla Yurttas
Guest Editor
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Keywords
- quinoline
- isoquinoline
- quinolone
- quinazoline
- quinazolinone
- biological evaluation
- chemotherapeutic molecules
- anticancer activity
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