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Endocrines
Special Issues
Recent Advances in Type 1 Diabetes
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Recent Advances in Type 1 Diabetes

A special issue of Endocrines (ISSN 2673-396X). This special issue belongs to the section "Obesity, Diabetes Mellitus and Metabolic Syndrome".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 1894

Special Issue Editors

Dr. Marina Basina

E-Mail Website
Guest Editor
Clinical Professor, Medicine-Endocrinology, Gerontology, & Metabolism, Stanford University Medical Center, Stanford, CA 94305, USA
Interests: type 1 diabetes; diabetes technology; diabetes in pregnancy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Daniela Foti

E-Mail Website
Guest Editor
Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
Interests: pathophysiology of diabetes; traditional and novel laboratory biomarkers in diabetes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue of Endocrines focused on "Recent Advances in Type 1 Diabetes."

The prevalence of Type 1 Diabetes (T1D) is increasing worldwide, and it is crucial to shed light on the significant strides made in the diagnosis and management of this condition.

Since the discovery of insulin over a century ago, there have been remarkable advancements in multiple areas of T1D research and treatment. These include the following:

  1. Early Identification of High-Risk Individuals: Research has led to the discovery of biomarkers for early identification of individuals at high risk of developing T1D during pre-clinical stages. This early detection is pivotal in implementing recently approved strategies to delay progression to the clinical stages of the disease.
  2. Prolonging the Honeymoon Phase: ongoing studies aim to extend the honeymoon phase, when the body still produces some insulin, thus improving patient outcomes and quality of life.
  3. Diabetes Technology: Technological advancements have revolutionized diabetes management. Automated insulin delivery systems, continuous glucose monitoring (CGM), and other innovative devices have become standard care, significantly improving glycemic control and reducing the burden of diabetes management.
  4. Adjunct Therapies to Insulin: the introduction of adjunct therapies, alongside insulin, has enhanced the management of T1D, offering better glucose control and reducing complications.
  5. Behavioral Research and Quality of Life: Significant attention is being paid to the psychological and behavioral aspects of diabetes. Research in this area aims to reduce the burden of diabetes and improve the overall quality of life for individuals with T1D.

Despite these advancements, there remain gaps in our understanding and management of T1D. This Special Issue aims to raise awareness about T1D, disseminate information on recent advancements, and identify future directions for research and development.

We invite researchers and clinicians to submit their original research articles, reviews, and case studies that address these topics. Your contributions will be invaluable in shaping the future of T1D management and improving the lives of those affected by this condition.

Dr. Marina Basina
Prof. Dr. Daniela Foti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Endocrines is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • type 1 diabetes risk
  • diabetes technology
  • continuous glucose monitoring
  • insulin
  • quality of life with type 1 diabetes

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

14 pages, 1224 KiB  
Article
Glomerular Hyperfiltration in Children and Adolescents with Type 1 Diabetes Mellitus: A Cross-Sectional Observational Study
by Luiza Santos de Argollo Haber, Lucas Fornari Laurindo, Rafael Fagundes de Melo, Dennis Penna Carneiro, Piero Biteli, Henrique Villa Chagas, Luciano Junqueira Mellem, Jesselina Francisco dos Santos Haber, Lance Alan Sloan, Kátia Portero Sloan, Sandra Maria Barbalho and Eduardo Federighi Baisi Chagas
Endocrines 2025, 6(3), 35; https://doi.org/10.3390/endocrines6030035 - 10 Jul 2025
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Abstract
Background/Objectives: This study investigated the relationship between glycemic control and increased glomerular filtration rate (eGFR), as assessed by serum creatinine and the CKiD equation in children and adolescents with T1DM. Methods: This cross-sectional observational study involved 80 T1DM patients (4–19 years) attending the [...] Read more.
Background/Objectives: This study investigated the relationship between glycemic control and increased glomerular filtration rate (eGFR), as assessed by serum creatinine and the CKiD equation in children and adolescents with T1DM. Methods: This cross-sectional observational study involved 80 T1DM patients (4–19 years) attending the Interdisciplinary Center for Diabetes. Biochemical, anthropometric, and skeletal muscle mass parameters were evaluated. The GFR was estimated using the CKiD equation expressed in mL/min/1.73 m2. Results: Our results showed that nearly 19.0% of the included patients presented increased values for eGFR, and most had poor glycemic control. Patients with HbA1c levels above 8% presented eGRF > 130. There was a positive correlation between hyperglycemia, elevated HbA1c, and fat percentage with higher eGRF values. In addition, the reduction in lean mass and skeletal muscle mass was related to elevated eGRF. Conclusions: Our study indicates that children and adolescents with T1DM who have elevated HbA1c, lower lean mass, and less than five years of diagnosis of diabetes are more likely to present higher eGRF values. Full article
(This article belongs to the Special Issue Recent Advances in Type 1 Diabetes)
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20 pages, 2760 KiB  
Article
Comprehensive Insights into Anxiety, Depression, and Glycemic Control in Adolescents with Type 1 Diabetes and Their Parents: A First Look in Latvia and Implications for Multidisciplinary Care
by Evija Silina, Maksims Zolovs, Iveta Dzivite-Krisane, Inta Zile and Maris Taube
Endocrines 2025, 6(2), 17; https://doi.org/10.3390/endocrines6020017 - 7 Apr 2025
Viewed by 987
Abstract
Background/Objectives: Chronic somatic diseases are significant risk factors for the development of mental disorders. Type 1 diabetes mellitus (T1D) is the most common chronic endocrine pathology in children. Treatment requires nutrition management, physical activity, lifelong insulin therapy, and proper self-monitoring of blood glucose. [...] Read more.
Background/Objectives: Chronic somatic diseases are significant risk factors for the development of mental disorders. Type 1 diabetes mellitus (T1D) is the most common chronic endocrine pathology in children. Treatment requires nutrition management, physical activity, lifelong insulin therapy, and proper self-monitoring of blood glucose. It is complicated and therefore may result in a variety of psychosocial problems for children, adolescents, and their families. Considering the rapidly growing incidence of type 1 diabetes in the pediatric population of Latvia, it is important to detect and prevent the risks of anxiety and depression in families with children suffering from type 1 diabetes. Methods: This was a quantitative interdisciplinary cross-sectional study to determine the prevalence of anxiety and depression in adolescents with T1D and their parents. Two tools were used to detect the presence of symptoms of anxiety and depression: the Generalized Anxiety Disorder Scale-7 (GAD-7) and the Patient Health Questionnaire 9 (PHQ-9) scale. Results: A total of 812 respondents were eligible for screening. Anxiety and depression symptoms were seen significantly more frequently in the study group than in the control group. The study found negative effects of anxiety and depression on the compensation of diabetes. Conclusions: Adolescents with type 1 diabetes and their parents are more predisposed to anxiety and depression symptoms than somatic healthy children and their parents, thus worsening disease control and prognosis. Full article
(This article belongs to the Special Issue Recent Advances in Type 1 Diabetes)
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