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Keywords = water loading

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23 pages, 3759 KB  
Article
Taguchi-Based Experimental Optimization of PET and Bottom Ash Cement Composites for Sustainable Cities
by Arzu Cakmak, Hacer Mutlu Danaci, Salih Taner Yildirim and İsmail Veli Sezgin
Sustainability 2025, 17(20), 9206; https://doi.org/10.3390/su17209206 (registering DOI) - 17 Oct 2025
Abstract
Waste valorization in construction materials offers a promising pathway to reducing environmental burdens while promoting circular resource strategies in the built environment. This study develops a novel composite mortar formulated with sustainable materials and alternative aggregates, namely polyethylene terephthalate (PET) particles recovered from [...] Read more.
Waste valorization in construction materials offers a promising pathway to reducing environmental burdens while promoting circular resource strategies in the built environment. This study develops a novel composite mortar formulated with sustainable materials and alternative aggregates, namely polyethylene terephthalate (PET) particles recovered from post-consumer plastic waste and bottom ash from thermal power generation. Natural pumice was incorporated to improve the lightness and the thermal insulation, with cement serving as the binder. The mix design was systematically optimized using the Taguchi method to enhance performance while minimizing carbon emissions. The resulting mortar, produced at both laboratory and small-scale commercial levels, demonstrated favorable technical properties: dry density of 1.3 g/cm3, compressive strength of 5.96 MPa, thermal conductivity of 0.27 W/(m*K), and water absorption of 16.1%. After exposure to 600 °C, it retained 60.6% of its strength and exhibited only a 10.1% mass loss. These findings suggest its suitability for non-load-bearing urban components where sustainability, thermal resistance, and durability are essential. The study contributes to global sustainability goals, particularly Sustainable Development Goal (SDG) 11, 12, and 13, by illustrating how waste valorization can foster resilient construction while reducing the environmental footprint of cities. Full article
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18 pages, 3076 KB  
Article
Study on Mooring Design and Hydrodynamic Performance of Floating Offshore Wind Turbines with CFRP Mooring Lines
by Yaqiang Yang, Riwei Xi, Mingxin Li, Jianzhe Shi, Yongzheng Li, Xin Wang, Wentao Shang and Hongming Li
Buildings 2025, 15(20), 3734; https://doi.org/10.3390/buildings15203734 - 16 Oct 2025
Abstract
To address the issues of traditional mooring lines, such as high self-weight, low strength, and poor durability, Carbon-Fiber-Reinforced Polymer (CFRP) was investigated as a material for mooring lines of offshore floating wind turbines, aiming to achieve high performance, lightweight design, and long service [...] Read more.
To address the issues of traditional mooring lines, such as high self-weight, low strength, and poor durability, Carbon-Fiber-Reinforced Polymer (CFRP) was investigated as a material for mooring lines of offshore floating wind turbines, aiming to achieve high performance, lightweight design, and long service life for mooring systems. Based on a “chain–cable–chain” configuration, a CFRP mooring line design is proposed in this study. Taking a 5 MW offshore floating wind turbine as the research object, the dynamic performance of offshore floating wind turbines with steel chains, steel cables, polyester ropes, and CFRP mooring lines under combined wind, wave, and current loads was compared and analyzed to demonstrate the feasibility of applying CFRP mooring lines by combining the potential flow theory and the rigid–flexible coupling multi-body model. The research results indicate that, compared to traditional mooring systems such as steel chains, steel cables, and polyester ropes, (1) under static water, the CFRP mooring system exhibits a larger static water free decay response and longer free decay duration; (2) under operating sea conditions, the motion response and mooring tension of the offshore floating wind turbine with CFRP mooring lines are smaller than those with steel cables and steel chains but greater than those with polyester ropes; and (3) under extreme sea conditions, the motion responses of the offshore floating wind turbine with CFRP mooring lines are smaller than those with steel wire ropes and steel chains but close to the displacement responses of the polyester rope system, while the increase in mooring tension is relatively moderate and the safety factor is the highest. Full article
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24 pages, 7688 KB  
Article
Localized Swelling-Induced Instability of Tunnel-Surrounding Rock: Experimental and FLAC3D Simulation Study
by Jubao Yang, Yang Chen, Pengfei Li, Chongbang Xu and Mingju Zhang
Appl. Sci. 2025, 15(20), 11101; https://doi.org/10.3390/app152011101 - 16 Oct 2025
Abstract
Addressing the core issue of rock mass failure and deformation induced by local water-induced uneven expansion in expansive soft rock tunnels, this study systematically analyzes the stress–displacement response of the rock mass under various working conditions. This analysis integrates physical model testing with [...] Read more.
Addressing the core issue of rock mass failure and deformation induced by local water-induced uneven expansion in expansive soft rock tunnels, this study systematically analyzes the stress–displacement response of the rock mass under various working conditions. This analysis integrates physical model testing with FLAC3D 6.0 numerical simulation and covers four typical expansion zone configurations (vault, spandrel, haunch, invert) as well as multiple stages of stress loading. Leveraging the mathematical analogy between heat conduction and fluid seepage and combining it with a thermo-hydraulic coupling approach, the FLAC3D temperature field module precisely simulates the moisture-induced stress field. This overcomes the limitations of traditional tools for direct moisture field simulation and enables quantitative assessment of how localized expansion impacts tunnel lining failure. The study reveals that horizontal expansion zones significantly increase the risk of shear failure in tunnel structures. Expansion zones at the tunnel crown and base (invert) pose critical challenges to overall safety and exhibit a pronounced nonlinear relationship between stress loading and displacement. This research deepens the theoretical understanding of the interaction between localized non-uniform expansion and the surrounding rock mass and provides crucial technical guidance for optimizing tunnel support systems and improving disaster monitoring and prevention measures. Full article
(This article belongs to the Special Issue New Challenges in Urban Underground Engineering)
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24 pages, 8369 KB  
Article
Development of Efficient In-Situ Cleaning Methods for Stained Textile Relics
by Yuhui Wei, Jinxia Guo, Zhaowei Su, Kui Yu, Xue Ling, Zhenlin Zhang, Kaixuan Liu and Wei Pan
Gels 2025, 11(10), 830; https://doi.org/10.3390/gels11100830 (registering DOI) - 16 Oct 2025
Abstract
To address limitations such as cleaning difficulties or secondary contamination/damage of cultural relics caused by the uncontrollable diffusion of water/cleaning agent/dirty liquids during the cleaning process in traditional cleaning methods, this study, using cotton textiles as an example, systematically investigated the cleaning efficacy [...] Read more.
To address limitations such as cleaning difficulties or secondary contamination/damage of cultural relics caused by the uncontrollable diffusion of water/cleaning agent/dirty liquids during the cleaning process in traditional cleaning methods, this study, using cotton textiles as an example, systematically investigated the cleaning efficacy of four in situ methods (blank gel, cleaning gel, ultrasonic emulsification, and gel + ultrasonic emulsification synergistic cleaning) on eight types of stains, including sand, clay, rust, blood, ink, oil, and mixed solid/liquid stains. Building upon this, this study proposed an efficient, targeted, in situ, and controllable cleaning strategy tailored for fragile, stained textile relics. Results demonstrated that, regardless of the stain type, the synergistic cleaning method of G+U (gel poultice + ultrasonic emulsification) consistently outperformed the cleaning methods of blank gel poultice, cleaning gel poultice, and ultrasonic emulsification. Furthermore, the gel loaded with cleaning agents was always more effective than the blank gel (unloaded cleaning agents). The poultice methods of blank gel and cleaning gel were better suited for solid stains, while the ultrasonic emulsification cleaning method was more effective for liquid stains. Meanwhile, it was also found that the optimal cleaning method proposed in this study (the G+U synergistic cleaning method) was a cleaning method that restricted the cleaning agent within the gel network/emulsion system, and utilized the porous network physical structure of gel, the chemical action of emulsion’s wetting/dissolving dirt, and the cavitation synergistic effect of ultrasound to achieve the targeted removal of contaminants from relics’ surfaces. Crucially, the cleaning process of G+U also had the characteristics of controlling the cleaning area at the designated position and effectively regulating the diffusion rate of the cleaning solution within the treatment zone, as well as the reaction intensity. Therefore, the proposed optimal (the synergistic cleaning method of G+U) cleaning method conforms to the significant implementation of the “minimal intervention and maximal preservation” principle in modern cultural heritage conservation. Consequently, the synergistic cleaning method of G+U holds promise for practical application in artifact cleaning work. Full article
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19 pages, 1230 KB  
Article
Monitoring of Nutrient Removal in Swine Effluents Using Sequential Reactors with Oxygen Control
by Sedolfo Carrasquero-Ferrer, Gabriel Vaca-Suárez, Grace Viteri-Guzmán and Gilberto Colina-Andrade
Oxygen 2025, 5(4), 21; https://doi.org/10.3390/oxygen5040021 - 16 Oct 2025
Abstract
Swine effluents require effective treatment due to their high pollutant load, particularly nitrogen and phosphorus, which can cause eutrophication of water bodies. This study focused on monitoring nutrient removal in a sequential biological reactor through online measurements of parameters such as dissolved oxygen [...] Read more.
Swine effluents require effective treatment due to their high pollutant load, particularly nitrogen and phosphorus, which can cause eutrophication of water bodies. This study focused on monitoring nutrient removal in a sequential biological reactor through online measurements of parameters such as dissolved oxygen (DO), pH, oxidation-reduction potential (ORP), and total alkalinity during the treatment of effluents from a pig slaughterhouse. A laboratory-scale reactor was used, operated with timer switches in an anaerobic–aerobic–anoxic sequence, a sludge retention time (SRT) of 25 days, and an operational cycle time of 16 h. The reactor demonstrated notable efficiency in contaminant removal, with an average organic matter removal of 87.1% measured as chemical oxygen demand (COD) and 95.5% as biochemical oxygen demand (BOD). Regarding nitrogen and phosphorus removal, a 69.4% reduction in total nitrogen (TN) and a 53.2% reduction in total phosphorus (TP) were observed. The pH, ORP, and DO profiles showed a clear correlation with the nutrient removal processes, allowing optimization of the phase durations in the reactor to enhance treatment efficiency. Full article
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21 pages, 12126 KB  
Article
Optimization of Synergistic Water Resources, Water Environment, and Water Ecology Remediation and Restoration Project: Application in the Jinshan Lake Basin
by Wenyang Jiang, Xin Liu, Yue Wang, Yue Zhang, Xinxin Chen, Yuxing Sun, Jun Chen and Wanshun Zhang
Water 2025, 17(20), 2986; https://doi.org/10.3390/w17202986 - 16 Oct 2025
Abstract
The concept of synergistic water resources, water environment, water ecology remediation, and restoration (3WRR) is essential for addressing the interlinked challenges of water scarcity, pollution, and ecological degradation. An intelligent platform of remediation and restoration project optimization was developed, integrating multi-source data fusion, [...] Read more.
The concept of synergistic water resources, water environment, water ecology remediation, and restoration (3WRR) is essential for addressing the interlinked challenges of water scarcity, pollution, and ecological degradation. An intelligent platform of remediation and restoration project optimization was developed, integrating multi-source data fusion, a coupled air–land–water model, and dynamic decision optimization to support 3WRR in river basins. Applied to the Jinshan Lake Basin (JLB) in China’s Greater Bay Area, the platform assessed 894 scenarios encompassing diverse remediation and restoration plans, including point/non-point source reduction, sediment dredging, recycled water reuse, ecological water replenishment, and sluice gate control, accounting for inter-annual meteorological variability. The results reveal that source control alone (95% reduction in point and non-point loads) leads to limited improvement, achieving less than 2% compliance with Class IV water quality standards in tributaries. Integrated engineering–ecological interventions, combining sediment dredging with high-flow replenishment from the Xizhijiang River (26.1 m3/s), increases compliance days of Class IV water quality standards by 10–51 days. Concerning the lake plans, including sluice regulation and large-volume water exchange, the lake area met the Class IV standard for COD, NH3-N, and TP by over 90%. The platform’s multi-objective optimization framework highlights that coordinated, multi-scale interventions substantially outperform isolated strategies in both effectiveness and sustainability. These findings provide a replicable and data-driven paradigm for 3WRR implementation in complex river–lake systems. The platform’s application and promotion in other watersheds worldwide will serve to enable the low-cost and high-efficiency management of watershed water environments. Full article
(This article belongs to the Section Water Resources Management, Policy and Governance)
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17 pages, 1955 KB  
Article
Structural Analysis of Oil-Spill Boom Grounding at Low Tide
by Frédéric Muttin
J. Mar. Sci. Eng. 2025, 13(10), 1984; https://doi.org/10.3390/jmse13101984 - 16 Oct 2025
Abstract
Oil-spill booms in shallow waters and high tidal amplitudes could ground on the seabed and retain high amounts of seawater. The object of this study is to estimate the mooring force at both boom section ends and the occurrence of submarining observed along [...] Read more.
Oil-spill booms in shallow waters and high tidal amplitudes could ground on the seabed and retain high amounts of seawater. The object of this study is to estimate the mooring force at both boom section ends and the occurrence of submarining observed along the crest line. We use a Lagrangian linear elastic membrane theory incorporating the non-linear Green strain tensor and a non-updated hydrostatic or hydrodynamic load. We describe a numerical method using geometrically non-linear finite elements and 2D vertical hydrostatic pressure estimation. The calculated results indicate the role of hydrostatic pressure caused by the water height difference—several centimeters at the mid-section—and the influence of the elasticity module. We consolidate the mooring force results by supposing 2D horizontal hydrodynamic pressure. We associate the current velocity that produces the same mooring force with that generated by the hydrostatic load. The associated Froude number is close to 0.8. Full article
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18 pages, 3499 KB  
Article
Minute Rebond: A Simple Method for Making Lab-Scale Rebonded Foam and Its Application as a Novel Soilless Growing Media
by Michael S. Harris, Harry Charles Wright, Tom Lilly, Nathan Seithel, Chris Hayes, Julie Walker, Jacob Nickles, Duncan Drummond Cameron and Anthony John Ryan
Polymers 2025, 17(20), 2770; https://doi.org/10.3390/polym17202770 - 16 Oct 2025
Abstract
Polyurethane foams (PUFs) utilised in the comfort industry generate substantial trim waste volumes requiring end-of-life management. Rebonding, one form of mechanical recycling, is a technique involving the mechanical breakdown and subsequent adhesion of PUF using polyurethane prepolymers yielding a recycled material. However, the [...] Read more.
Polyurethane foams (PUFs) utilised in the comfort industry generate substantial trim waste volumes requiring end-of-life management. Rebonding, one form of mechanical recycling, is a technique involving the mechanical breakdown and subsequent adhesion of PUF using polyurethane prepolymers yielding a recycled material. However, the limited investigation into the properties of rebond PUF constrains its potential for novel alternative uses, such as soilless plant-growing media. A laboratory-scale rebond production method has been developed, and a series of rebond PUFs produced to evaluate the influence of crumb size, density, prepolymer chemistry, and prepolymer loading on the properties of the rebond PUFs and their suitability as growing media. The results indicated that higher quality rebonds were obtained with larger crumb sizes (mixed or >7 mm), moderate amounts of prepolymer (4.5 to 7.5% by mass), and higher densities. Increasing density directly influenced plant growth-related properties, including reducing airflow, increasing water uptake through wicking, and increasing water retention through drainage alongside larger crumb sizes [>7 mm]. To demonstrate the method’s utility for rapid screening, a plant growth trial was conducted using density as the key variable. Eruca sativa plants grown in low-density rebonds exhibited comparable growth (leaf length, leaf width, and shoot fresh weight) to mineral wool, whereas medium- and high-density rebonds showed reduced growth. This study validates a lab-scale technique that enables the rapid optimisation of rebond PUFs for novel applications like soilless growing media. Full article
(This article belongs to the Section Circular and Green Sustainable Polymer Science)
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33 pages, 891 KB  
Review
The Role of Probiotics in Enhancing Animal Health: Mechanisms, Benefits, and Applications in Livestock and Companion Animals
by Sorin Marian Mârza, Camelia Munteanu, Ionel Papuc, Lăcătuş Radu and Robert Cristian Purdoiu
Animals 2025, 15(20), 2986; https://doi.org/10.3390/ani15202986 - 15 Oct 2025
Abstract
This review examines the diverse ways in which probiotics, defined as live microorganisms that provide health benefits to the host when administered in adequate amounts, contribute to animal health and welfare across both livestock and companion species. By modulating gut microbiota, enhancing immune [...] Read more.
This review examines the diverse ways in which probiotics, defined as live microorganisms that provide health benefits to the host when administered in adequate amounts, contribute to animal health and welfare across both livestock and companion species. By modulating gut microbiota, enhancing immune responses, and suppressing harmful pathogens, probiotics represent an effective strategy for disease prevention and performance improvement without reliance on antibiotics. In livestock production, these beneficial microbes have been shown to optimize feed utilization, support growth, and reduce methane emissions, thereby contributing to more sustainable farming practices. Their role extends beyond productivity, as probiotics also help mitigate antimicrobial resistance (AMR) by offering natural alternatives to conventional treatments. In aquaculture, they further promote environmental sustainability by improving water quality and reducing pathogen loads. For companion animals such as dogs and cats, probiotics are increasingly recognized for their ability to support gastrointestinal balance, alleviate stress through gut–brain axis interactions, and aid in the management of common conditions including diarrhea, food sensitivities, and allergies. The integration of probiotics into veterinary practice thus reflects a growing emphasis on holistic and preventive approaches to animal health. Despite these advances, several challenges remain, including variability in strain-specific efficacy, regulatory limitations, and cost-effectiveness in large-scale applications. Emerging research into precision probiotics, host–microbiome interactions, and innovative delivery methods offers promising avenues to overcome these barriers. As such, probiotics can be regarded not only as functional supplements but also as transformative tools that intersect animal health, productivity, and sustainability. Full article
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21 pages, 5863 KB  
Article
Performance Evaluation of Diverse Filter Media Combinations Under Different Pollution and Hydraulic Loads in Constructed Wetlands
by Huaiwei Chen, Huaqi Yao, Jialei Yuan, Han Ke, Xuanqi Zhang and Anfeng Hu
Water 2025, 17(20), 2969; https://doi.org/10.3390/w17202969 - 15 Oct 2025
Abstract
During rapid social and economic growth, large amounts of organic matter, nitrogen, and phosphorus are released into the environment with wastewater, and constructed wetlands (CWs) play a key role in water pollution prevention and control. This study employed six test columns to evaluate [...] Read more.
During rapid social and economic growth, large amounts of organic matter, nitrogen, and phosphorus are released into the environment with wastewater, and constructed wetlands (CWs) play a key role in water pollution prevention and control. This study employed six test columns to evaluate the pollutant removal performance of various filter media combinations in CWs when treating synthetic sewage under different pollution and hydraulic loads. The results showed that all columns containing bio-ceramsite exhibited superior pollutant removal performance, especially for organics and phosphorus. A synergistic effect was observed between bio-ceramsite and volcanic rock in enhancing pollutant removal, with average removal rates of 88.02%, 69.69%, 62.96%, and 88.22% for COD, NH4+, TN, and TP, respectively, under the nine experimental conditions. Scanning Electron Microscopy (SEM), BET surface area testing, and microbial community structure analysis were conducted to investigate the reasons for the differences in pollutant removal efficiency among the columns. The results showed that bio-ceramsite exhibits a highly microporous structure and a large surface area of 1.3816 m2/g, which provides abundant adsorption sites for microorganisms and pollutant molecules. The microbial community structure on bio-ceramsite remained highly consistent across all column tests, with dominant microbial species playing a key role in enhancing pollutant removal efficiency. The conclusions of this study indicate the potential application of some filter media combinations in CW design for environmental conservation. Full article
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19 pages, 2442 KB  
Article
Spatiotemporal Evolution and Integrated Risk Assessment of Potentially Toxic Element Pollution in Coastal Waters: A Case Study of Bohai Bay Cases in China
by Limei Qu, Jianbiao Peng, Pifu Cong and Yanan Huang
Toxics 2025, 13(10), 880; https://doi.org/10.3390/toxics13100880 - 15 Oct 2025
Abstract
Under the increasing pressures of land-based pollution and intensive coastal development, marine ecosystems are facing unprecedented challenges, highlighting the urgent need for enhanced protection and management of marine environmental quality. This study examines the spatiotemporal distribution and pollution risks of seven potentially toxic [...] Read more.
Under the increasing pressures of land-based pollution and intensive coastal development, marine ecosystems are facing unprecedented challenges, highlighting the urgent need for enhanced protection and management of marine environmental quality. This study examines the spatiotemporal distribution and pollution risks of seven potentially toxic elements (Hg, Cd, Pb, Cr, As, Zn, and Cu) in the coastal waters of Bohai Bay, China, based on monitoring data collected from 2020 to 2023. Results show a significant decline in annual average concentrations of Pb (from 3.23 ± 1.11 μg/L to 0.10 ± 0.06 μg/L) and Hg (from 0.05 ± 0.02 μg/L to 0.01 ± 0.00 μg/L), reflecting effective pollution control measures. In contrast, Cu concentrations nearly doubled, rising from 0.90 ± 0.50 μg/L in 2020 to 1.98 ± 0.42 μg/L in 2023, while Zn exhibited a “V”-shaped fluctuation over the study period. Spatially, Zn, Pb, and Hg displayed pronounced clustering patterns, with coefficients of variation (CV) of 1.04, 1.49, and 1.17, respectively. The Pollution Load Index (PLI) decreased from 1.82 in 2020 to 0.94 in 2023, indicating an overall improvement in ecological quality. However, the Risk Index (RI) reached a maximum of 672.5 at Site 11 in 2020, with Hg and Cd contributing 49.6% and 22.7% to the total risk, respectively. Health risk assessment revealed non-carcinogenic risks (Hi) below the safety threshold (Hi < 1) across all sites. In contrast, carcinogenic risks (CR) ranged from 5.7 × 10−4 to 9.1 × 10−4, approaching the acceptable upper limit of 10−3, primarily due to dermal exposure to Hg and the high toxicity of Cd. Principal Component Analysis (PCA) suggested familiar sources for Hg, Pb, and Zn, whereas As appeared to originate from distinct pathways. Overall, this study establishes an integrated “pollution–ecological–health” assessment framework, offering scientific support for targeted pollution prevention and zonal management strategies in coastal environments. Full article
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15 pages, 1863 KB  
Article
Energy Dissipation and Damage Evolution of Water-Saturated Skarn Under Impact Loading
by Ximing Jian, Pinzhe Zhao, Xianglong Li, Jianguo Wang, Yaohong Li and Yang Yang
Appl. Sci. 2025, 15(20), 11040; https://doi.org/10.3390/app152011040 - 15 Oct 2025
Viewed by 68
Abstract
Understanding the combined effects of water and dynamic disturbance on rock behavior is essential for deep underground engineering, where groundwater and blasting often coexist. Existing studies have mainly emphasized static weakening by water or the strength characteristics under impact, while the energy evolution [...] Read more.
Understanding the combined effects of water and dynamic disturbance on rock behavior is essential for deep underground engineering, where groundwater and blasting often coexist. Existing studies have mainly emphasized static weakening by water or the strength characteristics under impact, while the energy evolution process remains insufficiently addressed. To fill this gap, uniaxial impact compression tests were conducted on dry and water-saturated skarn specimens using a separated Split Hopkinson Pressure Bar system. The relationship between peak stress and impact pressure was analyzed, and the total input energy, releasable elastic strain energy, and dissipated energy were quantified to examine their evolution with strain. The results indicate that water saturation significantly reduces dynamic strength and modifies the damage process. During the compaction and elastic stages, dissipated energy is low but slightly higher in water-saturated specimens due to microcrack initiation. In the plastic stage, dry specimens exhibit faster energy dissipation, while water-saturated specimens show reduced capacity for crack propagation dissipation. Damage–strain curves follow an S-shaped pattern, with water-saturated specimens presenting higher damage growth rates in the plastic stage. These findings clarify the energy-based damage mechanisms of skarn under impact loading and provide theoretical support for evaluating stability in water-rich underground environments. Full article
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22 pages, 4274 KB  
Article
Enhanced Bioavailability and Stability of Curcumin in Cosmeceuticals: Exploiting Droplet Microfluidics for Nanoemulsion Development
by Nikolaos D. Bikiaris, Afroditi Kapourani, Ioannis Pantazos and Panagiotis Barmpalexis
Cosmetics 2025, 12(5), 226; https://doi.org/10.3390/cosmetics12050226 - 15 Oct 2025
Viewed by 131
Abstract
Curcumin (Cur), a natural polyphenolic compound with potent antioxidant and anti-inflammatory properties, faces significant challenges in cosmeceutical applications due to its poor aqueous solubility and low bioavailability. Nanotechnology offers a promising approach to overcome these limitations and enhance the functionality of cosmetic formulations. [...] Read more.
Curcumin (Cur), a natural polyphenolic compound with potent antioxidant and anti-inflammatory properties, faces significant challenges in cosmeceutical applications due to its poor aqueous solubility and low bioavailability. Nanotechnology offers a promising approach to overcome these limitations and enhance the functionality of cosmetic formulations. In this work, Cur-loaded nanoemulsions (NEs) were developed using a droplet microfluidics technique to enhance Cur’s stability, bioavailability, and permeability for advanced cosmeceuticals. Various oils were screened for Cur solubility, with coconut oil demonstrating the highest capacity. Optimal oil-to-water flow ratios were determined to produce monodisperse NEs with controlled droplet sizes. Characterization via dynamic light scattering (DLS) revealed stable NEs with Z-potential values exceeding −30 mV at both room temperature and +4 °C for up to 21 days, indicating strong colloidal stability. Antioxidant activity was evaluated through DPPH assays, while in vitro permeability studies of the drug-loaded NEs after incorporation into suitable hydrogels, using Strat-M® membranes mimicking human skin, demonstrated significantly enhanced penetration of the encapsulated Cur. In sum, this work highlights the potential of droplet microfluidics as a scalable and precise method for producing high-performance Cur NEs tailored for cosmeceutical applications. Full article
(This article belongs to the Section Cosmetic Formulations)
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24 pages, 3671 KB  
Review
Composite Hydrogels with Embedded Electrospun Fibers as Drug Delivery Systems
by Paul Codrin Fuioaga, Delia Mihaela Rata, Tabinda Riaz, Guadalupe Rivero, Gustavo A. Abraham and Leonard Ionut Atanase
Gels 2025, 11(10), 826; https://doi.org/10.3390/gels11100826 - 14 Oct 2025
Viewed by 100
Abstract
Hydrogel/electrospun polymer nanofiber composites (HENC) integrate the advantages of both components. Hydrogels provide high water content, biocompatibility, and tunable drug release, while electrospun nanofibers offer a high surface area, loading capacity, customizable morphology, and opportunities for functionalization. Nanofibers can also be incorporated into [...] Read more.
Hydrogel/electrospun polymer nanofiber composites (HENC) integrate the advantages of both components. Hydrogels provide high water content, biocompatibility, and tunable drug release, while electrospun nanofibers offer a high surface area, loading capacity, customizable morphology, and opportunities for functionalization. Nanofibers can also be incorporated into hydrogels as 3D-printable inks. Together, these features create biomimetic composites that modulate drug release and mimic native tissues. This article reviews electrospinning fundamentals, limitations, preparation methods for HENC, and their applications in drug delivery, as well as future perspectives for developing advanced functional materials with improved therapeutic efficacy, controlled release kinetics, and broad biomedical adaptability. Full article
(This article belongs to the Special Issue Designing Hydrogels for Sustained Delivery of Therapeutic Agents)
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17 pages, 4844 KB  
Article
Hypericin-Mediated Photodynamic Inactivation Against the Plant Pathogen Clavibacter michiganensis: Preventative Seed Decontamination Enhanced by Potassium Iodide
by Linda Jernej, Sonja Gschwendtner, Andreas Kubin, Lionel Wightman and Kristjan Plaetzer
Microorganisms 2025, 13(10), 2360; https://doi.org/10.3390/microorganisms13102360 - 14 Oct 2025
Viewed by 157
Abstract
Clavibacter michiganensis causes significant crop losses in tomatoes, and the disease may be transferred by plant seeds. This study evaluates the efficacy of Photodynamic Inactivation (PDI) with a water-soluble hypericin derivative, developed as a complex with polyvinylpyrrolidone (high hypericin-loaded PVP, HHL-PVP), as a [...] Read more.
Clavibacter michiganensis causes significant crop losses in tomatoes, and the disease may be transferred by plant seeds. This study evaluates the efficacy of Photodynamic Inactivation (PDI) with a water-soluble hypericin derivative, developed as a complex with polyvinylpyrrolidone (high hypericin-loaded PVP, HHL-PVP), as a decontamination strategy for tomato seeds. HHL-PVP was chosen for its overall stability, as the complex remains stable in solution for over 950 days, maintains its absorption capacity after illumination with 200 J·cm−2, and produces reactive oxygen species (ROS) even at concentrations as low as 1 µM. PDI against C. michiganensis with 5 μM HHL-PVP, 10 min drug to light interval (DLI), and illumination with red light (600–700 nm, 100 J·cm−2) exceeded the antimicrobial effect of a 99.9% reduction in liquid culture. Increasing the DLI to 24 h did not alter the photokilling effect. A 14 h light/10 h dark cycle in white light (118 J·cm−2) with 0.3 µM HHL-PVP inhibited the growth of C. michiganensis by more than 6 log10 steps, indicating that HHL-PVP has a stable and long-lasting photokilling effect. The combination of HHL-PVP with potassium iodide (KI, 100 mM) completely eradicated C. michiganensis in liquid culture with red and white light, indicating KI’s role in enhancing phototoxicity. Tomato seed photodynamic decontamination using 1.0 µM HHL-PVP activated by 200 J·cm−2 white light inactivated >5 log10 of C. michiganensis, without diminishing sprouting. An addition of 100 mM KI increased the percentage of sprouted seedlings and inactivated 100% of bacteria. These results demonstrate that HHL-PVP-mediated PDI combined with KI could be highly effective as a preventative strategy in tomato protection against C. michiganensis. Full article
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