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6 Results Found

  • Article
  • Open Access
7 Citations
5,510 Views
20 Pages

A Model for the Production of Regulatory Grade Viral Hemorrhagic Fever Exposure Stocks: From Field Surveillance to Advanced Characterization of SFTSV

  • Unai Perez-Sautu,
  • Se Hun Gu,
  • Katie Caviness,
  • Dong Hyun Song,
  • Yu-Jin Kim,
  • Nicholas Di Paola,
  • Daesang Lee,
  • Terry A. Klein,
  • Joseph A. Chitty and
  • Seong Tae Jeong
  • + 19 authors

29 August 2020

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging human pathogen, endemic in areas of China, Japan, and the Korea (KOR). It is primarily transmitted through infected ticks and can cause a severe hemorrhagic fever disease with c...

  • Article
  • Open Access
20 Citations
5,002 Views
14 Pages

Kikwit Ebola Virus Disease Progression in the Rhesus Monkey Animal Model

  • Richard S. Bennett,
  • James Logue,
  • David X. Liu,
  • Rebecca J. Reeder,
  • Krisztina B. Janosko,
  • Donna L. Perry,
  • Timothy K. Cooper,
  • Russell Byrum,
  • Danny Ragland and
  • Lisa E. Hensley
  • + 11 authors

14 July 2020

Ongoing Ebola virus disease outbreaks in the Democratic Republic of the Congo follow the largest recorded outbreak in Western Africa (2013–2016). To combat outbreaks, testing of medical countermeasures (therapeutics or vaccines) requires a well...

  • Article
  • Open Access
21 Citations
8,083 Views
18 Pages

Development and Characterization of a Sin Nombre Virus Transmission Model in Peromyscus maniculatus

  • Bryce M. Warner,
  • Derek R. Stein,
  • Bryan D. Griffin,
  • Kevin Tierney,
  • Anders Leung,
  • Angela Sloan,
  • Darwyn Kobasa,
  • Guillaume Poliquin,
  • Gary P. Kobinger and
  • David Safronetz

21 February 2019

In North America, Sin Nombre virus (SNV) is the main cause of hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease with a fatality rate of 35–40%. SNV is a zoonotic pathogen carried by deer mice (Peromyscus maniculatus), and...

  • Communication
  • Open Access
23 Citations
6,173 Views
8 Pages

Rapid Inactivation of SARS-CoV-2 Variants by Continuous and Intermittent Irradiation with a Deep-Ultraviolet Light-Emitting Diode (DUV-LED) Device

  • Hiroko Inagaki,
  • Akatsuki Saito,
  • Chiho Kaneko,
  • Hironobu Sugiyama,
  • Tamaki Okabayashi and
  • Shouichi Fujimoto

More than 1 year has passed since social activities have been restricted due to the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More recently, novel SARS-CoV-2 variants have been spreading around the world, and there is gr...

  • Article
  • Open Access
3 Citations
2,507 Views
16 Pages

5 July 2022

Salmonid species demonstrate varied susceptibility to the viral pathogen infectious hematopoietic necrosis virus (IHNV). In California conservation hatcheries, juvenile Chinook salmon (Oncorhynchus tshawytscha) have experienced disease outbreaks due...

  • Article
  • Open Access
3 Citations
2,968 Views
16 Pages

AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery

  • Darrick L. Yu,
  • Laura P. van Lieshout,
  • Brenna A. Y. Stevens,
  • Kelsie J. (Jagt) Near,
  • Jenny K. Stodola,
  • Kevin J. Stinson,
  • Durda Slavic and
  • Sarah K. Wootton

29 December 2023

Adeno-associated virus (AAV) vectors are among the most widely used delivery vehicles for in vivo gene therapy as they mediate robust and sustained transgene expression with limited toxicity. However, a significant impediment to the broad clinical su...