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Pathogens
Volume 10
Issue 6
10.3390/pathogens10060754
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Communication

Rapid Inactivation of SARS-CoV-2 Variants by Continuous and Intermittent Irradiation with a Deep-Ultraviolet Light-Emitting Diode (DUV-LED) Device

by
Hiroko Inagaki
1,
Akatsuki Saito
2,3,4,
Chiho Kaneko
4,
Hironobu Sugiyama
1,5,
Tamaki Okabayashi
2,3,4 and
Shouichi Fujimoto
6,*
1
M&N Collaboration Research Laboratory, Department of Medical Environment Innovation, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan
2
Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan
3
Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki 889-2192, Japan
4
Center for Animal Disease Control, University of Miyazaki, Miyazaki 889-2192, Japan
5
Nikkiso Co., Ltd., Tokyo 150-6022, Japan
6
Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Nicola Coppola
Pathogens 2021, 10(6), 754; https://doi.org/10.3390/pathogens10060754
Received: 9 May 2021 / Revised: 8 June 2021 / Accepted: 11 June 2021 / Published: 15 June 2021
(This article belongs to the Collection Feature Papers in Viral Pathogens)
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Abstract

More than 1 year has passed since social activities have been restricted due to the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More recently, novel SARS-CoV-2 variants have been spreading around the world, and there is growing concern that they may have higher transmissibility and that the protective efficacy of vaccines may be weaker against them. Immediate measures are needed to reduce human exposure to the virus. In this study, the antiviral efficacy of deep-ultraviolet light-emitting diode (DUV-LED) irradiation (280 ± 5 nm, 3.75 mW/cm2) against three SARS-CoV-2 variants was evaluated. For the B.1.1.7, B.1.351, and P.1 variant strains, irradiation of the virus stocks for 1 s resulted in infectious titer reduction rates of 96.3%, 94.6%, and 91.9%, respectively, and with irradiation for 5 s, the rates increased to 99.9%, 99.9%, and 99.8%, respectively. We also tested the effect of pulsed DUV-LED irradiation (7.5 mW/cm2, duty rate: 50%, frequency: 1 kHz) under the same output conditions as for continuous irradiation and found that the antiviral efficacy of pulsed and continuous irradiation was the same. These findings suggest that by further developing and optimizing the DUV-LED device to increase its output, it may be possible to instantly inactivate SARS-CoV-2 with DUV-LED irradiation. View Full-Text
Keywords: SARS-CoV-2; variants; UV-LED; viral inactivation; COVID-19 SARS-CoV-2; variants; UV-LED; viral inactivation; COVID-19
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MDPI and ACS Style

Inagaki, H.; Saito, A.; Kaneko, C.; Sugiyama, H.; Okabayashi, T.; Fujimoto, S. Rapid Inactivation of SARS-CoV-2 Variants by Continuous and Intermittent Irradiation with a Deep-Ultraviolet Light-Emitting Diode (DUV-LED) Device. Pathogens 2021, 10, 754. https://doi.org/10.3390/pathogens10060754

AMA Style

Inagaki H, Saito A, Kaneko C, Sugiyama H, Okabayashi T, Fujimoto S. Rapid Inactivation of SARS-CoV-2 Variants by Continuous and Intermittent Irradiation with a Deep-Ultraviolet Light-Emitting Diode (DUV-LED) Device. Pathogens. 2021; 10(6):754. https://doi.org/10.3390/pathogens10060754

Chicago/Turabian Style

Inagaki, Hiroko, Akatsuki Saito, Chiho Kaneko, Hironobu Sugiyama, Tamaki Okabayashi, and Shouichi Fujimoto. 2021. "Rapid Inactivation of SARS-CoV-2 Variants by Continuous and Intermittent Irradiation with a Deep-Ultraviolet Light-Emitting Diode (DUV-LED) Device" Pathogens 10, no. 6: 754. https://doi.org/10.3390/pathogens10060754

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