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Article

10 Citations

3,238 Views

8 Pages

Non-Pungent n-3 Polyunsaturated Fatty Acid (PUFA)-Derived Capsaicin Analogues as Potential Functional Ingredients with Antioxidant and Carbohydrate-Hydrolysing Enzyme Inhibitory Activities

Mariarosaria Leporini,
Monica Rosa Loizzo,
Rosa Tundis,
Chiara La Torre,
Alessia Fazio and
Pierluigi Plastina

Antioxidants2019, 8(6), 162;https://doi.org/10.3390/antiox8060162

5 June 2019

N-Eicosapentaenoyl vanillylamine (EPVA) and N-docosahexaenoyl vanillylamine (DHVA), derived from n-3 polyunsaturated eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), respectively, were studied for their potential antioxidant and carbohydra...

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Article

20 Citations

6,407 Views

14 Pages

Capsaicin Analogues Derived from n-3 Polyunsaturated Fatty Acids (PUFAs) Reduce Inflammatory Activity of Macrophages and Stimulate Insulin Secretion by β-Cells In Vitro

Erika Cione,
Pierluigi Plastina,
Attilio Pingitore,
Mariarita Perri,
Maria Cristina Caroleo,
Alessia Fazio,
Renger Witkamp and
Jocelijn Meijerink

Nutrients2019, 11(4), 915;https://doi.org/10.3390/nu11040915

24 April 2019

In this study, two capsaicin analogues, N-eicosapentaenoyl vanillylamine (EPVA) and N-docosahexaenoyl vanillylamine (DHVA), were enzymatically synthesized from their corresponding n-3 long chain polyunsaturated fatty acids eicosapentaenoic acid (EPA)...

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Article

1,117 Views

12 Pages

Small Structural Changes in Chili-Derived Capsaicin Resulting in Nonivamide Analogs of Significantly Improved Cytotoxicity and Good Tumor/Non-Tumor Cell Selectivity

Niels V. Heise,
René Csuk and
Thomas Mueller

Molecules2025, 30(17), 3488;https://doi.org/10.3390/molecules30173488

25 August 2025

Capsaicin, the major pungent alkaloid in Capsicum species, has been reported to exhibit cytotoxic activity through various mechanisms. In this study, capsaicin and 37 structurally related vanillylamide and ester analogs were synthesized and evaluated...

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Article

8 Citations

4,486 Views

19 Pages

Identification of Interleukin-8-Reducing Lead Compounds Based on SAR Studies on Dihydrochalcone-Related Compounds in Human Gingival Fibroblasts (HGF-1 cells) In Vitro

Katharina Schueller,
Joachim Hans,
Stefanie Pfeiffer,
Jessica Walker,
Jakob P. Ley and
Veronika Somoza

Molecules2020, 25(6), 1382;https://doi.org/10.3390/molecules25061382

18 March 2020

Background: In order to identify potential activities against periodontal diseases, eighteen dihydrochalcones and structurally related compounds were tested in an established biological in vitro cell model of periodontal inflammation using human ging...

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