Search Results (29)

The multilayers of Ta/Pd/[CoFeB (0.3 nm)/Pd]×5/Pd films were fabricated by ultra-high-vacuum (UHV) magnetron sputtering and subsequently annealed at temperatures (T_A) ranging from 100 °C to 400 °C. The magnetic measurements were performed with the applied field oriented parallel and perpendicular to the film plane to evaluate the out-of-plane magnetic anisotropy (PMA). A maximum effective PMA energy density (K_eff) of ≈7.82 × 10⁵ erg/cc and a small out-of-plane saturation magnetisation (M_s⊥) were achieved at the optimal T_A. The evolution of PMA is associated with interfacial atomic migration and oxidation processes, as confirmed by X-ray photoelectron spectroscopy (XPS). Annealing at 300 °C initiates the formation of TaB and TaOB interfacial phases, whereas annealing at 400 °C promotes the enhanced growth of Ta₂O₅ and TaB, along with additional TaOB formation owing to increased oxygen migration. These thermally stable Ta–boride phases lead to pronounced modifications in the magnetic properties. Consequently, oxygen migration and interfacial reactions at elevated temperatures primarily alter the chemical states of the B 1s, Pd 3d, and Ta 4f orbitals, thereby influencing the PMA. The field-dependent electrical resistance (MR) study demonstrates that annealing at 100–400 °C optimises the anisotropic effect in the [CoFeB/Pd]×5-based multilayers. However, higher temperatures can trigger atomic intermixing, which degrades PMA strength and the resistance response. Moreover, the samples were further characterised by their structural, anomalous Hall effect (AHE) and magnetoresonance (MRO) properties. Overall, controlled T_A-driven oxygen diffusion and interfacial oxidation enable effective tuning of the PMA, MR, and MRO properties of ultrathin [CoFeB/Pd]×5 multilayers, highlighting their strong potential for spin–orbit torque (SOT), Dzyaloshinskii–Moriya interaction (DMI), and magnetic skyrmion-based spintronic devices. Full article

Ultra-high-field 7 T time-of-flight MR angiography (TOF-MRA) provides detailed visualization of intracranial vasculature, but quantitative analysis is sensitive to intensity inhomogeneity and non-standardized post-processing. We present TOFR-VET (Time-of-Flight Radiomics and Vessel Enhancement Toolkit), a unified MATLAB workflow that integrates vessel enhancement, objective image quality evaluation (PSNR, SSIM, entropy, contrast improvement index (CII), and brightness preservation factor (BPF)), and radiomic feature extraction within a single as a proposed methodological framework for consistent analysis. Using 7 T TOF-MRA datasets (n = 120 subjects), we comparatively evaluated histogram-based and adaptive enhancement approaches and quantified their impact on image quality behavior and radiomic feature sensitivity. Adaptive Gamma Correction with Weighting Distribution (AGCWD), as one of the methods tested, resulted in higher fidelity-to-baseline metrics than standard histogram equalization (HE), demonstrated by improved PSNR metrics (23.54 dB versus 15.82 dB; increase of 7.72 dB) along with observed complementary trends in SSIM and BPF. Brightness-preserving methods maintained BPF values close to unity. Because enhancement methods intentionally reshape intensity distributions, PSNR/SSIM are interpreted here as structural deviation indicators relative to the original image rather than absolute measures of diagnostic quality. Quantitative analysis of 120 subjects using one-way ANOVA revealed that while Laplacian of Gaussian (LoG) filtering provides the highest contrast improvement for visual vessel continuity (CII = 1.65 ± 0.22, p < 0.001), Adaptive Gamma Correction (AGCWD) is superior for radiomic pipelines, maintaining an Intraclass Correlation Coefficient (ICC) of 0.94. These findings provide a specific decision-making framework for standardizing 7T TOF-MRA preprocessing based on the desired diagnostic or quantitative objective. Full article

Background/Objectives: Cardiac magnetic resonance (CMR) imaging at 7 Tesla provides a substantially higher intrinsic signal-to-noise ratio compared with conventional 1.5 T and 3 T systems, potentially enabling higher spatial resolution, improved tissue contrast, and advanced metabolic imaging. However, clinical translation remains limited by technical challenges associated with ultra-high-field operation. This systematic review aimed to synthesize current human in vivo evidence on the feasibility, applications, and methodological limitations of 7-T cardiovascular MRI. Methods: A PRISMA-guided systematic search of PubMed, Cochrane Library, Web of Science, and Scopus was conducted from database inception through January 2025. Studies reporting human in vivo cardiovascular MRI at 7 Tesla were included. Data regarding study design, sample characteristics, imaging applications, feasibility, quantitative findings, and reported limitations were extracted and qualitatively synthesized. Results: Sixty-five studies met inclusion criteria, predominantly small prospective cohorts (mean sample size = 13), largely involving healthy volunteers. Across diverse applications—including coronary MR angiography, cine imaging, valvular assessment, vascular imaging, flow quantification, myocardial tissue characterization, and multinuclear (³¹P, ²³Na, ³⁹K) imaging—7-T CMR was consistently feasible and capable of producing high-quality images. Quantitative ventricular and vascular measurements were generally concordant with lower field strengths. Incremental benefits were most apparent in high-resolution structural imaging and metabolic applications, whereas routine functional and flow assessments showed limited additional advantages. No serious adverse events were reported. Conclusions: Human cardiovascular MRI at 7 Tesla represents a technically feasible research and early translational platform with selective advantages over established field strengths. Further advances in radiofrequency technology, protocol harmonization, and larger disease-focused studies are required to clarify its potential clinical role. Full article

Localized ¹H magnetic resonance spectroscopy (MRS) is a powerful tool in pre-clinical and clinical neurological research, offering non-invasive insight into neurochemical composition in localized brain regions. Zebrafish (Danio rerio) are increasingly being utilized as models in neurological disorder research, providing valuable insights into disease mechanisms. However, the small size of the zebrafish brain and limited MRS sensitivity at low magnetic fields hinder comprehensive neurochemical analysis of localized brain regions. Here, we investigate the potential of ultra-high-field (UHF) MR systems, particularly 28.2 T, for this purpose. This present study pioneers the application of localized ¹H spectroscopy in zebrafish brain at 28.2 T. Point resolved spectroscopy (PRESS) sequence parameters were optimized to reduce the impact of chemical shift displacement error and to enable molecular level information from distinct brain regions. Optimized parameters included gradient strength, excitation frequency, echo time, and voxel volume specifically targeting the 0–4.5 ppm chemical shift regions. Exceptionally high-resolution cerebral metabolite spectra were successfully acquired from localized regions of the zebrafish brain in voxels as small as 125 nL, allowing for the identification and quantification of major brain metabolites with remarkable spectral clarity, including lactate, myo-inositol, creatine, alanine, glutamate, glutamine, choline (phosphocholine + glycerol-phospho-choline), taurine, aspartate, N-acetylaspartyl-glutamate (NAAG), N-acetylaspartate (NAA), and γ-aminobutyric acid (GABA). The unprecedented spatial resolution achieved in a small model organism enabled detailed comparisons of the neurochemical composition across distinct zebrafish brain regions, including the forebrain, midbrain, and hindbrain. This level of precision opens exciting new opportunities to investigate how specific diseases in zebrafish models influence the neurochemical composition of specific brain areas. Full article

The literature reports highlight the transmission field (B₁⁺) uniformity and efficiency constraints of cardiac magnetic resonance imaging (MRI) at ultrahigh magnetic fields (UHF). This simulation study proposes a 3D Metamaterial (MM) to address these challenges. The study proposes a 3D MM consisting of unit cells (UC) with split ring resonator (SRR) layers immersed in dielectric material glycerol. Implementing the proposed MM design aims to reduce the effective thickness and weight of the dielectric material while shaping B₁⁺ and improving the penetration depth. The latter is dictated by the chosen array size, where small local UC arrays can focus B₁⁺ and larger UC arrays can increase the field of view, at the cost of a lower penetration depth. Designing RF antennas that can effectively transmit at 21.0 T while maintaining patient safety and comfort is challenging. Using Self-Grounded Bow-Tie (SGBT) antennas in conjunction with the proposed MM demonstrated enhanced B₁⁺ efficiency and uniformity across the human heart without signal voids. The study employed dynamic parallel transmission with tailored kT points to homogenize the 3D flip angle over the whole heart. This proof-of-concept study provides the technical foundation for human cardiac MRI at 21.0 T. Such numerical simulations are mandatory precursors for the realization of whole-body human UHF MR instruments. Full article

In vivo phosphorus-31 (³¹P) magnetic resonance spectroscopy (MRS) imaging (MRSI) is an important non-invasive imaging tool for studying cerebral energy metabolism, intracellular nicotinamide adenine dinucleotide (NAD) and redox ratio, and mitochondrial function. However, it is challenging to achieve high signal-to-noise ratio (SNR) ³¹P MRS/MRSI results owing to low phosphorus metabolites concentration and low phosphorous gyromagnetic ratio ($\gamma$). Many works have demonstrated that ultrahigh field (UHF) could significantly improve the ³¹P-MRS SNR. However, there is a lack of studies of the ³¹P MRSI SNR in the 10.5 Tesla (T) human scanner. In this study, we designed and constructed a novel ³¹P-¹H dual-frequency loop-dipole probe that can operate at both 7T and 10.5T for a quantitative comparison of ³¹P MRSI SNR between the two magnetic fields, taking into account the RF coil B₁ fields (RF coil receive and transmit fields) and relaxation times. We found that the SNR of the ³¹P MRS signal is 1.5 times higher at 10.5T as compared to 7T, and the power dependence of SNR on magnetic field strength (B₀) is 1.9. Full article

Perfusion measures of the total vasculature are commonly derived with gradient-echo (GE) dynamic susceptibility contrast (DSC) MR images, which are acquired during the early passes of a contrast agent. Alternatively, spin-echo (SE) DSC can be used to achieve specific sensitivity to the capillary signal. For an improved contrast-to-noise ratio, ultra-high-field MRI makes this technique more appealing to study cerebral microvascular physiology. Therefore, this study assessed the applicability of SE-DSC MRI at 7 T. Forty-one elderly adults underwent 7 T MRI using a multi-slice SE-EPI DSC sequence. The cerebral blood volume (CBV) and cerebral blood flow (CBF) were determined in the cortical grey matter (CGM) and white matter (WM) and compared to values from the literature. The relation of CBV and CBF with age and sex was investigated. Higher CBV and CBF values were found in CGM compared to WM, whereby the CGM-to-WM ratios depended on the amount of largest vessels excluded from the analysis. CBF was negatively associated with age in the CGM, while no significant association was found with CBV. Both CBV and CBF were higher in women compared to men in both CGM and WM. The current study verifies the possibility of quantifying cerebral microvascular perfusion with SE-DSC MRI at 7 T. Full article

This study presents the feasibility of a dual-mode high-pass birdcage RF coil to acquire MR images at both ¹H and ²³Na frequencies at ultra-high-field MR scanner, 7 T. A dual-mode circuit (DMC) in the dual-mode birdcage (DMBC) RF coil operates at two frequencies, addressing the limitations of sensitivity reduction and isolation between two frequencies as in traditional dual-tuned RF coil. Finite-difference time-domain (FDTD) based electromagnetic (EM) simulations were performed to verify the RF coil at each frequency on the three-dimensional human head model. The DMBC RF coil resonated at proton (¹H) and sodium (²³Na) frequencies, and also single-tuned high-pass birdcage RF coils were constructed for both ¹H and ²³Na frequencies. The bench test performance of the RF coils was evaluated using network analysis parameters, including the measurement of scattering parameters (S-parameters) and quality factors (Q-factors). Q-factor of the DMBC coil at ¹H port was 10.2% lower than that of ¹H single-tuned birdcage (STBC) coil, with a modest SNR reduction of 6.5%. Similarly, the Q-factor for the DMBC coil at ²³Na port was 12.3% less than that of ²³Na STBC coil, and the SNR showed a minimal reduction of 5.4%. Utilizing the DMBC coil, promising ¹H and ²³Na MR images were acquired compared to those by using STBC coils. In conclusion, deploying a DMBC ¹H/²³Na coil has been demonstrated to overcome traditional constraints associated with dual-tuned RF coils, achieving this with only nominal signal attenuation across both nuclei operational frequencies. Full article

Precise and accurate atomic mass data provide crucial information for applications in a wide range of fields in physics and beyond, including astrophysics, nuclear structure, particle and neutrino physics, fundamental symmetries, chemistry, and metrology. The most precise atomic mass measurements are performed on charged particles confined in a Penning trap. Here, we describe the development, status, and outlook of CHIP-TRAP: the Central Michigan University high-precision Penning trap. CHIP-TRAP aims to perform ultra-high precision (∼1 part in 10${}^{11}$ fractional precision) mass measurements on stable and long-lived isotopes produced with external ion sources and transported to the Penning traps. Along the way, ions of a particular $m/q$ are selected with a multi-reflection time-of-flight mass separator (MR-TOF-MS), with further filtering performed in a cylindrical capture trap before the ions are transported to a pair of hyperbolic measurement traps. In this paper, we report on the design and status of CHIP-TRAP and present results from the commissioning of the ion sources, MR-TOF-MS, and capture trap. We also provide an outlook on the continued development and commissioning of CHIP-TRAP. Full article

Background and Purpose: Magnetic resonance spectroscopy (MRS)—a method of analysing metabolites in vivo—has been utilized in several studies of brain glioma biomarkers at lower field strengths. At ultra-high field strengths, MRS provides an improved signal-to-noise-ratio and spectral resolution, but 7T studies on patients with gliomas are sparse. The purpose of this exploratory study was to evaluate the potential clinical implication of the use of single-voxel MRS at 7T to assess metabolic information on lesions in a pilot cohort of patients with grade II and III gliomas. Methods: We scanned seven patients and seven healthy controls using the semi-localization by adiabatic-selective refocusing sequence on a Philips Achieva 7T system with a standard dual-transmit head coil. The metabolic ratios were calculated relative to water and total creatine. Additionally, 2-hydroxyglutarate (2-HG) MRS was carried out in four of the patients, and the 2-HG concentration was calculated relative to water. Results: When comparing the tumour data to control regions in both patients and healthy controls, we found that the choline/creatine and myo-inositol/creatine ratios were significantly increased and that the N-acetylaspartate/creatine and the neurotransmitter glutamate/creatine ratios were significantly decreased. The N-acetylaspartate/water and glutamate/water ratios were also significantly decreased. The lactate/water and lactate/creatine ratios showed increases, although not significant. The GABA/water ratio was significantly decreased, but the GABA/creatine ratio was not. MRS spectra showed the presence of 2-HG in three of the four patients studied. Three of the patients, including the MRS 2-HG-negative patient, were operated on, and all of them had the IDH mutation. Conclusion: Our findings were consistent with the existing literature on 3T and 7T MRS. Full article

The brain is a highly energetic organ. Although the brain can consume metabolic substrates, such as lactate, glycogen, and ketone bodies, the energy metabolism in a healthy adult brain mainly relies on glucose provided via blood. The cerebral metabolism of glucose produces energy and a wide variety of intermediate metabolites. Since cerebral metabolic alterations have been repeatedly implicated in several brain disorders, understanding changes in metabolite levels and corresponding cell-specific neurotransmitter fluxes through different substrate utilization may highlight the underlying mechanisms that can be exploited to diagnose or treat various brain disorders. Magnetic resonance spectroscopy (MRS) is a noninvasive tool to measure tissue metabolism in vivo. ¹H-MRS is widely applied in research at clinical field strengths (≤3T) to measure mostly high abundant metabolites. In addition, X-nuclei MRS including, ¹³C, ²H, ¹⁷O, and ³¹P, are also very promising. Exploiting the higher sensitivity at ultra-high-field (>4T; UHF) strengths enables obtaining unique insights into different aspects of the substrate metabolism towards measuring cell-specific metabolic fluxes in vivo. This review provides an overview about the potential role of multinuclear MRS (¹H, ¹³C, ²H, ¹⁷O, and ³¹P) at UHF to assess the cerebral metabolism and the metabolic insights obtained by applying these techniques in both healthy and diseased states. Full article

Combining magnetic nanoparticles (MNPs) with high-voltage processes to produce ultra-thin magnetic nanofibers (MNFs) fosters the development of next-generation technologies. In this study, polycarbonate urethane nanofibers incorporating magnetic particles were produced via the electrospinning technique. Two distinct types of magnetic payload were used: (a) iron oxide nanoparticles (IONPs) with an average size and polydispersity index of 7.2 nm and 3.3%, respectively; (b) nickel particles (NiPs) exhibiting a bimodal size distribution with average sizes of 129 nanometers and 600 nanometers, respectively, and corresponding polydispersity indexes of 27.8% and 3.9%. Due to varying particle sizes, significant differences were observed in their aggregation and distribution within the nanofibers. Further, the magnetic response of the IONP and/or NiP-loaded fiber mats was consistent with their morphology and polydispersity index. In the case of IONPs, the remanence ratio (M_r/M_s) and the coercive field (H_c) were found to be zero, which agrees with their superparamagnetic behavior when the average size is smaller than 20–30 nm. However, the NiPs show M_r/M_s = 22% with a coercive field of 0.2kOe as expected for particles in a single or pseudo-single domain state interacting with each other via dipolar interaction. We conclude that magnetic properties can be modulated by controlling the average size and polydispersity index of the magnetic particles embedded in fiber mats to design magneto-active systems suitable for different applications (i.e., wound healing and drug delivery). Full article

For precise delineation of glioma extent, amino acid PET is superior to conventional MR imaging. Since metabolic MR sequences such as chemical exchange saturation transfer (CEST) imaging and MR spectroscopy (MRS) were developed, we aimed to evaluate the diagnostic accuracy of combined CEST and MRS to predict glioma infiltration. Eighteen glioma patients of different tumor grades were enrolled in this study; ¹⁸F-fluoroethyltyrosine (FET)-PET, amide proton transfer CEST at 7 Tesla(T), MRS and conventional MR at 3T were conducted preoperatively. Multi modalities and their association were evaluated using Pearson correlation analysis patient-wise and voxel-wise. Both CEST (R = 0.736, p < 0.001) and MRS (R = 0.495, p = 0.037) correlated with FET-PET, while the correlation between CEST and MRS was weaker. In subgroup analysis, APT values were significantly higher in high grade glioma (3.923 ± 1.239) and IDH wildtype group (3.932 ± 1.264) than low grade glioma (3.317 ± 0.868, p < 0.001) or IDH mutant group (3.358 ± 0.847, p < 0.001). Using high FET uptake as the standard, the CEST/MRS combination (AUC, 95% CI: 0.910, 0.907–0.913) predicted tumor infiltration better than CEST (0.812, 0.808–0.815) or MRS (0.888, 0.885–0.891) alone, consistent with contrast-enhancing and T2-hyperintense areas. Probability maps of tumor presence constructed from the CEST/MRS combination were preliminarily verified by multi-region biopsies. The combination of 7T CEST/MRS might serve as a promising non-radioactive alternative to delineate glioma infiltration, thus reshaping the guidance for tumor resection and irradiation. Full article

For ultra-high field and frequency (UHF) magnetic resonance imaging (MRI), the associated short wavelengths in biological tissues leads to penetration and homogeneity issues at 10.5 tesla (T) and require antenna transmit arrays for efficiently generated 447 MHz B₁⁺ fields (defined as the transmit radiofrequency (RF) magnetic field generated by RF coils). Previously, we evaluated a 16-channel combined loop + dipole antenna (LD) 10.5 T head array. While the LD array configuration did not achieve the desired B₁⁺ efficiency, it showed an improvement of the specific absorption rate (SAR) efficiency compared to the separate 8-channel loop and separate 8-channel dipole antenna arrays at 10.5 T. Here we compare a 16-channel dipole antenna array with a 16-channel LD array of the same dimensions to evaluate B₁⁺ efficiency, 10 g SAR, and SAR efficiency. The 16-channel dipole antenna array achieved a 24% increase in B₁⁺ efficiency in the electromagnetic simulation and MR experiment compared to the LD array, as measured in the central region of a phantom. Based on the simulation results with a human model, we estimate that a 16-channel dipole antenna array for human brain imaging can increase B₁⁺ efficiency by 15% with similar SAR efficiency compared to a 16-channel LD head array. Full article

The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers. Full article