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Search Results (239)

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22 pages, 5533 KB  
Review
The Fusion Mechanism and Prospective Application of Physics-Informed Machine Learning in Bridge Lifecycle Health Monitoring
by Jiaren Sun, Jiangjiang He, Guangbing Zhou, Jun Yang, Xiaoli Sun and Shuai Teng
Infrastructures 2026, 11(1), 16; https://doi.org/10.3390/infrastructures11010016 - 8 Jan 2026
Abstract
Bridge health monitoring is crucial for ensuring the safety and durability of infrastructure. In traditional methods, physics-based models have high interpretability but are difficult to handle complex nonlinear problems, while purely data-driven machine learning methods are limited by data scarcity and physical inconsistency. [...] Read more.
Bridge health monitoring is crucial for ensuring the safety and durability of infrastructure. In traditional methods, physics-based models have high interpretability but are difficult to handle complex nonlinear problems, while purely data-driven machine learning methods are limited by data scarcity and physical inconsistency. Physics-informed machine learning, as an emerging “gray box” paradigm, effectively integrates the advantages of both by embedding physical laws (such as control equations) into machine learning models in the form of constraints, priors, or residuals. This article systematically elaborates on the core fusion mechanism of physics-informed machine learning (PIML) in bridge engineering, innovative applications throughout the entire lifecycle of design, construction, operation, and maintenance, as well as its unique data augmentation strategy. Research has shown that PIML can significantly improve the accuracy and robustness of damage identification, load inversion, and performance prediction, and is the core engine for constructing dynamic and predictive digital twin systems. Despite facing challenges in complex physical modeling, loss function balancing, and engineering interpretability, PIML represents a fundamental shift in bridge health monitoring towards intelligent and predictive maintenance by combining advanced strategies such as active learning and meta learning with IoT technology. Full article
(This article belongs to the Special Issue Sustainable Bridge Engineering)
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32 pages, 3734 KB  
Article
A Hierarchical Framework Leveraging IIoT Networks, IoT Hub, and Device Twins for Intelligent Industrial Automation
by Cornelia Ionela Bădoi, Bilge Kartal Çetin, Kamil Çetin, Çağdaş Karataş, Mehmet Erdal Özbek and Savaş Şahin
Appl. Sci. 2026, 16(2), 645; https://doi.org/10.3390/app16020645 - 8 Jan 2026
Abstract
Industrial Internet of Things (IIoT) networks, Microsoft Azure Internet of Things (IoT) Hub, and device twins (DvT) are increasingly recognized as core enablers of adaptive, data-driven manufacturing. This paper proposes a hierarchical IIoT framework that integrates industrial IoT networking, DvT for asset-level virtualisation, [...] Read more.
Industrial Internet of Things (IIoT) networks, Microsoft Azure Internet of Things (IoT) Hub, and device twins (DvT) are increasingly recognized as core enablers of adaptive, data-driven manufacturing. This paper proposes a hierarchical IIoT framework that integrates industrial IoT networking, DvT for asset-level virtualisation, system-level digital twins (DT) for cell orchestration, and cloud-native services to support the digital transformation of brownfield, programmable logic controller (PLC)-centric modular automation (MA) environments. Traditional PLC/supervisory control and data acquisition (SCADA) paradigms struggle to meet interoperability, observability, and adaptability requirements at scale, motivating architectures in which DvT and IoT Hub underpin real-time orchestration, virtualisation, and predictive-maintenance workflows. Building on and extending a previously introduced conceptual model, the present work instantiates a multilayered, end-to-end design that combines a federated Message Queuing Telemetry Transport (MQTT) mesh on the on-premises side, a ZigBee-based backup mesh, and a secure bridge to Azure IoT Hub, together with a systematic DvT modelling and orchestration strategy. The methodology is supported by a structured analysis of relevant IIoT and DvT design choices and by a concrete implementation in a nine-cell MA laboratory featuring a robotic arm predictive-maintenance scenario. The resulting framework sustains closed-loop monitoring, anomaly detection, and control under realistic workloads, while providing explicit envelopes for telemetry volume, buffering depth, and latency budgets in edge-cloud integration. Overall, the proposed architecture offers a transferable blueprint for evolving PLC-centric automation toward more adaptive, secure, and scalable IIoT systems and establishes a foundation for future extensions toward full DvT ecosystems, tighter artificial intelligence/machine learning (AI/ML) integration, and fifth/sixth generation (5G/6G) and time-sensitive networking (TSN) support in industrial networks. Full article
(This article belongs to the Special Issue Novel Technologies of Smart Manufacturing)
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21 pages, 2996 KB  
Article
Sustainable Energy Transitions in Smart Campuses: An AI-Driven Framework Integrating Microgrid Optimization, Disaster Resilience, and Educational Empowerment for Sustainable Development
by Zhanyi Li, Zhanhong Liu, Chengping Zhou, Qing Su and Guobo Xie
Sustainability 2026, 18(2), 627; https://doi.org/10.3390/su18020627 - 7 Jan 2026
Abstract
Amid global sustainability transitions, campus energy systems confront growing pressure to balance operational efficiency, resilience to extreme weather events, and sustainable development education. This study proposes an artificial intelligence-driven framework for smart campus microgrids that synergistically advances environmental sustainability and disaster resilience, while [...] Read more.
Amid global sustainability transitions, campus energy systems confront growing pressure to balance operational efficiency, resilience to extreme weather events, and sustainable development education. This study proposes an artificial intelligence-driven framework for smart campus microgrids that synergistically advances environmental sustainability and disaster resilience, while deepening students’ understanding of sustainable development. The framework integrates an enhanced multi-scale gated temporal attention network (MS-GTAN+) to realize end-to-end meteorological hazard-state recognition for adaptive dispatch mode selection. Compared with Transformer and Informer baselines, MS-GTAN+ reduces prediction RMSE by approximately 48.5% for wind speed and 46.0% for precipitation while maintaining a single-sample inference time of only 1.82 ms. For daily operations, a multi-intelligence co-optimization algorithm dynamically balances economic efficiency with carbon reduction objectives. During disaster scenarios, an improved PageRank algorithm incorporating functional necessity and temporal sensitivity enables precise identification of critical loads and adaptive power redistribution, achieving an average critical-load assurance rate of approximately 75%, nearly doubling the performance of the traditional topology-based method. Furthermore, the framework bridges the divide between theoretical knowledge and educational practice via an educational digital twin platform. Simulation results demonstrate that the framework substantially improves carbon footprint reduction, resilience to power disruptions, and student sustainability competency development. By unifying technical innovation with pedagogical advancement, this study offers a holistic model for educational institutions seeking to advance sustainability transitions while preparing the next generation of sustainability leaders. Full article
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20 pages, 5947 KB  
Article
A Knowledge Graph-Guided and Multimodal Data Fusion-Driven Rapid Modeling Method for Digital Twin Scenes: A Case Study of Bridge Tower Construction
by Yongtao Zhang, Yongwei Wang, Zhihao Guo, Jun Zhu, Fanxu Huang, Hao Zhu, Yuan Chen and Yajian Kang
ISPRS Int. J. Geo-Inf. 2026, 15(1), 27; https://doi.org/10.3390/ijgi15010027 - 6 Jan 2026
Viewed by 28
Abstract
Establishing digital twin scenes facilitates the understanding of geospatial phenomena, representing a significant research focus for GIS scientists and engineers. However, current research on digital twin scenes modeling relies on manual intervention or the overlay of static models, resulting in low modeling efficiency [...] Read more.
Establishing digital twin scenes facilitates the understanding of geospatial phenomena, representing a significant research focus for GIS scientists and engineers. However, current research on digital twin scenes modeling relies on manual intervention or the overlay of static models, resulting in low modeling efficiency and poor standardization. To address these challenges, this paper proposes a knowledge graph-guided and multimodal data fusion-driven rapid modeling method for digital twin scenes, using bridge tower construction as an illustrative example. We first constructed a knowledge graph linking the three domains of “event-object-data” in bridge tower construction. Guided by this graph, we designed a knowledge graph-guided multimodal data association and fusion algorithm. Then a rapid modeling method for bridge tower construction scenes based on dynamic data was established. Finally, a prototype system was developed, and a case study area was selected for analysis. Experimental results show that the knowledge graph we built clearly captures all elements and their relationships in bridge tower construction scenes. Our method enables precise fusion of 5 types of multimodal data: BIM, DEM, images, videos, and point clouds. It improves spatial registration accuracy by 21.83%, increases temporal fusion efficiency by 65.6%, and reduces feature fusion error rates by 70.9%. Local updates of the 3D geographic scene take less than 30 ms, supporting millisecond-level digital twin modeling. This provides a practical reference for building geographic digital twin scenes. Full article
(This article belongs to the Special Issue Knowledge-Guided Map Representation and Understanding)
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19 pages, 2688 KB  
Article
Framework for the Development of a Process Digital Twin in Shipbuilding: A Case Study in a Robotized Minor Pre-Assembly Workstation
by Ángel Sánchez-Fernández, Elena-Denisa Vlad-Voinea, Javier Pernas-Álvarez, Diego Crespo-Pereira, Belén Sañudo-Costoya and Adolfo Lamas-Rodríguez
J. Mar. Sci. Eng. 2026, 14(1), 106; https://doi.org/10.3390/jmse14010106 - 5 Jan 2026
Viewed by 213
Abstract
This article proposes a framework for the development of process digital twins (DTs) in the shipbuilding sector, based on the ISO 23247 standard and structured around the achievement of three levels of digital maturity. The framework is demonstrated through a real pilot cell [...] Read more.
This article proposes a framework for the development of process digital twins (DTs) in the shipbuilding sector, based on the ISO 23247 standard and structured around the achievement of three levels of digital maturity. The framework is demonstrated through a real pilot cell developed at the Innovation and Robotics Center of NAVANTIA—Ferrol shipyard, incorporating various cutting-edge technologies such as robotics, artificial intelligence, automated welding, computer vision, visual inspection, and autonomous vehicles for the manufacturing of minor pre-assembly components. Additionally, the study highlights the crucial role of discrete event simulation (DES) in adapting traditional methodologies to meet the requirements of Process digital twins. By addressing these challenges, the research contributes to bridging the gap in the current state of the art regarding the development and implementation of Process digital twins in the naval sector. Full article
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27 pages, 29558 KB  
Article
A Bigraph-Based Digital Twin for Multi-UAV Landing Management
by Tianxiong Zhang, Dominik Grzelak, Martin Lindner, Hartmut Fricke and Uwe Aßmann
Drones 2026, 10(1), 12; https://doi.org/10.3390/drones10010012 - 26 Dec 2025
Viewed by 209
Abstract
Applications of Innovative Air Mobility (IAM) place high demands on the safe coordination of multiple UAVs and UAV-tailored takeoff and landing pads to mitigate unforeseen adverse effects. However, existing modeling approaches for multi-UAV flight operation often provide neither formal correctness guarantees nor effective [...] Read more.
Applications of Innovative Air Mobility (IAM) place high demands on the safe coordination of multiple UAVs and UAV-tailored takeoff and landing pads to mitigate unforeseen adverse effects. However, existing modeling approaches for multi-UAV flight operation often provide neither formal correctness guarantees nor effective mechanisms for maintaining cyber–physical consistency. To address these limitations, this paper proposes a bigraph-based digital twin framework that unifies modeling, execution, and synchronization for the management of landing operations involving multiple UAVs. Leveraging Bigraphical Reactive Systems (BRS), the framework employs a bigrid-based spatial model to formally represent UAV–pad occupancy constraints and to enforce one-to-one pad assignments via reaction rules, supporting formal proofs of safety properties. The model is linked to physical execution through modular APIs and a state-machine-based control service, enabling runtime cyber–physical synchronization. The formal specification is verified through model checking, which exhaustively explores the solution space (i.e., UAV behaviors in abstracted environments) to identify bigraph-algebraic solutions that guarantee conflict-free landings across different pad configurations. The framework is instantiated on the Crazyflie platform, demonstrating its ability to bridge formal modeling and physical execution while maintaining safety, scalability, and robustness in operational scenarios involving multiple UAVs. Full article
(This article belongs to the Special Issue Urban Air Mobility Solutions: UAVs for Smarter Cities)
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31 pages, 2296 KB  
Review
AI-Driven Digital Twins for Manufacturing: A Review Across Hierarchical Manufacturing System Levels
by Phat Nguyen, Minjung Kim, Elaina Nichols and Hwan-Sik Yoon
Sensors 2026, 26(1), 124; https://doi.org/10.3390/s26010124 - 24 Dec 2025
Viewed by 727
Abstract
Digital Twins (DTs) integrated with Artificial Intelligence (AI) are emerging as transformative tools in smart manufacturing. By bridging the physical and virtual domains, DTs enable real-time monitoring, predictive analytics, and autonomous decision-making. Originally conceived as advanced simulation models, DTs have evolved significantly with [...] Read more.
Digital Twins (DTs) integrated with Artificial Intelligence (AI) are emerging as transformative tools in smart manufacturing. By bridging the physical and virtual domains, DTs enable real-time monitoring, predictive analytics, and autonomous decision-making. Originally conceived as advanced simulation models, DTs have evolved significantly with the incorporation of AI, which enhances their ability to acquire process knowledge, optimize scheduling, and autonomously control system variables. This evolution transforms DTs from passive representations into prescriptive, self-optimizing systems. AI-driven DTs support a wide range of applications, including predictive maintenance, process optimization, quality control, and dynamic scheduling, using techniques such as deep reinforcement learning and convolutional neural networks. These capabilities have been successfully deployed across industrial domains such as CNC machining, robotics, and industrial printing, yielding substantial improvements in efficiency, reliability, and responsiveness. Despite these advancements, the full realization of intelligent DTs relies heavily on the availability of high-fidelity, real-time data and a seamless alignment between physical systems and their digital counterparts. This literature survey provides a state-of-the-art review of AI-driven DTs in manufacturing, highlighting their key applications, challenges, and emerging research directions that will shape the future of intelligent and adaptive manufacturing systems. To present a structured perspective on the evolution and scalability of AI-driven DTs, the application case studies are organized according to four integration levels—machine, cell, shop floor, and enterprise—highlighting how these technologies scale from individual assets to fully interconnected manufacturing ecosystems. Full article
(This article belongs to the Section Industrial Sensors)
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29 pages, 3290 KB  
Article
A Digital Twin-Enhanced KJ-Kano Framework for User-Centric Conceptual Design of Underwater Rescue Robots
by Xiaojing Niu, Jingying Ye and Liling Chen
Appl. Sci. 2026, 16(1), 135; https://doi.org/10.3390/app16010135 - 22 Dec 2025
Viewed by 284
Abstract
To address the increasing complexity and diversity of user requirements in underwater rescue equipment, this study proposes a Digital Twin (DT)-enhanced KJ-Kano conceptual design framework. It systematically closes the feedback loop between requirement prioritization and experiential validation. Unlike traditional approaches, this framework orchestrates [...] Read more.
To address the increasing complexity and diversity of user requirements in underwater rescue equipment, this study proposes a Digital Twin (DT)-enhanced KJ-Kano conceptual design framework. It systematically closes the feedback loop between requirement prioritization and experiential validation. Unlike traditional approaches, this framework orchestrates KJ clustering, Kano analysis, and mission-aware DT simulation in a domain-adapted, iterative workflow, enabling dynamic validation of user needs under high-risk, simulated rescue scenarios. Functional expectations and preferences were clustered and prioritized, then instantiated in a modular DT prototype for navigation, manipulation, and perception tasks. To evaluate design effectiveness, 55 participants operated the robot DT model and its control interfaces in virtual rescue missions. User satisfaction across functionality, interactivity, intelligence, and appearance was assessed with a five-point Likert scale, and the results showed high reliability (Cronbach’s α = 0.86) and positive evaluations (overall mean = 3.83). Intelligent experience scored highest (3.95), while ease of operation was lowest (3.60), suggesting potential for interface optimization. The framework effectively transforms heterogeneous, context-specific user requirements into validated design solutions, offering a replicable, data-driven methodology for early-stage conceptual design of underwater rescue robots and other safety-critical human–machine systems, bridging the gap between generic design methods and high-risk domain application. Full article
(This article belongs to the Special Issue Modeling, Guidance and Control of Marine Robotics, 2nd Edition)
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29 pages, 6826 KB  
Article
MetaD-DT: A Reference Architecture Enabling Digital Twin Development for Complex Engineering Equipment
by Hanyu Gao, Feng Wang, Taoping Zhao and Yi Gu
Electronics 2026, 15(1), 38; https://doi.org/10.3390/electronics15010038 - 22 Dec 2025
Viewed by 369
Abstract
Digital twin technology is emerging as a critical enabler for the lifecycle management of complex engineering equipment, yet its implementation faces significant hurdles. Generic, one-size-fits-all digital twin platforms often fail to address the unique characteristics of this domain—such as tightly coupled multi-physics, high-fidelity [...] Read more.
Digital twin technology is emerging as a critical enabler for the lifecycle management of complex engineering equipment, yet its implementation faces significant hurdles. Generic, one-size-fits-all digital twin platforms often fail to address the unique characteristics of this domain—such as tightly coupled multi-physics, high-fidelity modeling requirements, and the need for real-time model execution under harsh operating conditions. This creates a critical need for a structured, reusable blueprint. However, a dedicated reference architecture that systematically guides the development of such specialized digital twins is notably absent. To bridge this gap, this paper proposes MetaD-DT, a reference architecture designed to enable and streamline the development of digital twins specifically for complex engineering equipment. We detail its comprehensive four-layer architecture, core functional modules, and streamlined graphical development workflow. The MetaD-DT’s efficacy and practical value are validated through two distinct industrial case studies: a health management system for diesel engine Diesel Particulate Filter (DPF) and an intelligent control optimization system for Indirect Air-Cooled (IAC) towers. These applications validate the framework’s ability to support the creation of robust digital twins that can effectively handle complex industrial dynamics and improve O&M (Operation And Maintenance) efficiency. This work provides a systematic architectural blueprint for the future development of specialized and efficient digital twins in the engineering equipment domain. Full article
(This article belongs to the Special Issue Digital Twinning: Trends Challenging the Future)
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25 pages, 3111 KB  
Review
From Local to Global Perspective in AI-Based Digital Twins in Healthcare
by Maciej Piechowiak, Aleksander Goch, Ewelina Panas, Jolanta Masiak, Dariusz Mikołajewski, Izabela Rojek and Emilia Mikołajewska
Appl. Sci. 2026, 16(1), 83; https://doi.org/10.3390/app16010083 - 21 Dec 2025
Viewed by 406
Abstract
Digital twins (DTs) powered by artificial intelligence (AI) are becoming important transformational tools in healthcare, enabling real-time simulation and personalized decision support at the patient level. The aim of this review is to critically examine the evolution, current applications, and future potential of [...] Read more.
Digital twins (DTs) powered by artificial intelligence (AI) are becoming important transformational tools in healthcare, enabling real-time simulation and personalized decision support at the patient level. The aim of this review is to critically examine the evolution, current applications, and future potential of AI-based DTs in healthcare, with a particular focus on their role in enabling real-time simulation and personalized patient-level decision support. Specifically, the review aims to provide a comprehensive overview of how AI-based DTs are being developed and implemented in various clinical domains, identifying existing scientific and technical gaps and highlighting methodological, regulatory, and ethical issues. Taking a “local to global” perspective, the review aims to explore how individual patient-level models can be scaled and integrated to inform population health strategies, global data networks, and collaborative research ecosystems. This will provide a structured foundation for future research, clinical applications, and policy development in this rapidly evolving field. Locally, DTs allow medical professionals to model individual patient physiology, predict disease progression, and optimize treatment strategies. Hospitals are implementing AI-based DT platforms to simulate workflows, efficiently allocate resources, and improve patient safety. Generative AI further enhances these applications by creating synthetic patient data for training, filling gaps in incomplete records, and enabling privacy-respecting research. On a broader scale, regional health systems can use connected DTs to model population health trends and predict responses to public health interventions. On a national scale, governments and policymakers can use these insights for strategic planning, resource allocation, and increasing resilience to health crises. Internationally and globally, AI-based DTs can integrate diverse datasets across borders to support research collaboration and improve early pandemic detection. Generative AI contributes to global efforts by harmonizing heterogeneous data, creating standardized virtual patient cohorts, and supporting cross-cultural medical education. Combining local precision with global insights highlights DTs’ role as a bridge between personalized and global health. Despite the efforts of medical and technical specialists, ethical, regulatory, and data governance challenges remain crucial to ensuring responsible and equitable implementation worldwide. In conclusion, AI-based DTs represent a transformative paradigm, combining individual patient care with systemic and global health management. These perspectives highlight the potential of AI-based DTs to bridge precision medicine and public health, provided ethical, regulatory, and governance challenges are addressed responsibly. Full article
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36 pages, 2717 KB  
Review
Fire Resistance of Steel-Reinforced Concrete Columns: A Review of Ordinary Concrete to Ultra-High Performance Concrete
by Chang Liu, Xiaochen Wu and Jinsheng Du
Buildings 2026, 16(1), 24; https://doi.org/10.3390/buildings16010024 - 20 Dec 2025
Viewed by 244
Abstract
This review surveys the recent literature on the fire resistance of reinforced concrete (RC) columns based on a bibliometric analysis of publications to reveal research trends and focus areas. The collected studies are synthesized from the perspectives of materials, structural behaviors, parameter influences, [...] Read more.
This review surveys the recent literature on the fire resistance of reinforced concrete (RC) columns based on a bibliometric analysis of publications to reveal research trends and focus areas. The collected studies are synthesized from the perspectives of materials, structural behaviors, parameter influences, and predictive modeling. From the material aspect, the review summarizes the degradation mechanisms of conventional concrete at elevated temperatures and highlights the improved performance of ultra-high-performance concrete (UHPC) and reactive powder concrete (RPC), where dense microstructures and fiber bridging effectively suppress spalling and help maintain residual capacity. In terms of structural behavior, experimental and numerical studies on RC columns under fire are reviewed to clarify the deformation, failure modes, and effects of axial load ratio, slenderness, cover thickness, reinforcement ratio, boundary restraint, and load eccentricity on fire endurance. Parametric analyses addressing the influence of these factors, as well as the heating–cooling history, on overall stability and post-fire performance is discussed. Recent advances in thermomechanical finite element analysis and the integration of data-driven approaches such as machine learning have been summarized for evaluating and predicting fire performance. Future directions are outlined, emphasizing the need for standardized parameters for fiber-reinforced systems, a combination of multi-scale numerical and machine-learning models, and further exploration of multi-hazard coupling, durability, and digital-twin-based monitoring to support next-generation performance-based fire design. Full article
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21 pages, 1794 KB  
Article
A Model-Based Systems Engineering Framework for Reassessing Structural Capacity Integrating Health Monitoring Data
by Sharmistha Chowdhury, Stephan Husung and Matthias Kraus
Systems 2026, 14(1), 2; https://doi.org/10.3390/systems14010002 - 19 Dec 2025
Viewed by 467
Abstract
The reassessment of structural capacity is critical to maintain the safety, serviceability, and sustainability of ageing civil engineering infrastructure. Structural Health Monitoring (SHM) allows in situ measurements to be incorporated into structural models, updating the performance and reliability estimation based on available information. [...] Read more.
The reassessment of structural capacity is critical to maintain the safety, serviceability, and sustainability of ageing civil engineering infrastructure. Structural Health Monitoring (SHM) allows in situ measurements to be incorporated into structural models, updating the performance and reliability estimation based on available information. Digital Twins can be used to capture the behaviour of the system in the real world as live data and make use of rich sensorial data flow from the structural system. However, the growing complexity of multi-domain models, as well as decision-making and stakeholder interactions, makes it necessary to implement a structured modelling framework. This paper proposes a Model-Based Systems Engineering (MBSE) framework that incorporates an MBSE layer to coordinate model dependencies, correlate important parameters, and enforce traceability between measurement data, probabilistic assessment, and decision-making. Illustrated with a prototype application to an idealised case study of a bridge, this paper describes how using MBSE as a scalable, adaptive, and comprehensive framework can help enable data-driven structural reassessment. The work illustrates that MBSE can be used in civil engineering processes across multi-disciplinary departments to benefit the system lifecycle over time and identifies areas of further research required before the approach can be adopted for large-scale, real-world infrastructure. Full article
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34 pages, 6958 KB  
Review
A Novel Integrative Framework for Depression: Combining Network Pharmacology, Artificial Intelligence, and Multi-Omics with a Focus on the Microbiota–Gut–Brain Axis
by Lele Zhang, Kai Chen, Shun Li, Shengjie Liu and Zhenjie Wang
Curr. Issues Mol. Biol. 2025, 47(12), 1061; https://doi.org/10.3390/cimb47121061 - 18 Dec 2025
Viewed by 530
Abstract
Major Depressive Disorder (MDD) poses a significant global health burden, characterized by a complex and heterogeneous pathophysiology insufficiently targeted by conventional single-treatment approaches. This review presents an integrative framework incorporating network pharmacology, artificial intelligence (AI), and multi-omics technologies to advance a systems-level understanding [...] Read more.
Major Depressive Disorder (MDD) poses a significant global health burden, characterized by a complex and heterogeneous pathophysiology insufficiently targeted by conventional single-treatment approaches. This review presents an integrative framework incorporating network pharmacology, artificial intelligence (AI), and multi-omics technologies to advance a systems-level understanding and management of MDD. Its central contribution lies in moving beyond reductionist methods by embracing a holistic perspective that accounts for dynamic interactions within biological networks. The primary objective is to demonstrate how AI-powered integration of multi-omics data—spanning genomics, proteomics, and metabolomics—can enable the construction of predictive network models. These models are designed to uncover fundamental disease mechanisms, identify clinically relevant biotypes, and reveal novel therapeutic targets tailored to specific pathological contexts. Methodologically, the review examines the microbiota–gut–brain (MGB) axis as an illustrative case study, detailing its pathogenic roles through neuroimmune alterations, metabolic dysfunction, and disrupted neuro-plasticity. Furthermore, we propose a translational roadmap that includes AI-assisted biomarker discovery, computational drug repurposing, and patient-specific “digital twin” models to advance precision psychiatry. Our analysis confirms that this integrated framework offers a coherent route toward mechanism-based personalized therapies and helps bridge the gap between computational biology and clinical practice. Nevertheless, important challenges remain, particularly pertaining to data heterogeneity, model interpretability, and clinical implementation. In conclusion, we stress that future success will require integrating prospective longitudinal multi-omics cohorts, high-resolution digital phenotyping, and ethically aligned, explainable AI (XAI) systems. These concerted efforts are essential to realize the full potential of precision psychiatry for MDD. Full article
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67 pages, 2221 KB  
Systematic Review
Artificial Intelligence of Things for Next-Generation Predictive Maintenance
by Taimia Bitam, Aya Yahiaoui, Djallel Eddine Boubiche, Rafael Martínez-Peláez, Homero Toral-Cruz and Pablo Velarde-Alvarado
Sensors 2025, 25(24), 7636; https://doi.org/10.3390/s25247636 - 16 Dec 2025
Viewed by 1212
Abstract
Industry 5.0 introduces a shift toward human-centric, sustainable, and resilient industrial ecosystems, emphasizing intelligent automation, collaboration, and adaptive operations. Predictive Maintenance (PdM) plays a critical role in this transition, addressing the limitations of traditional maintenance approaches in increasingly complex and data-driven environments. The [...] Read more.
Industry 5.0 introduces a shift toward human-centric, sustainable, and resilient industrial ecosystems, emphasizing intelligent automation, collaboration, and adaptive operations. Predictive Maintenance (PdM) plays a critical role in this transition, addressing the limitations of traditional maintenance approaches in increasingly complex and data-driven environments. The convergence of Artificial Intelligence and the Industrial Internet of Things, referred to as the Artificial Intelligence of Things (AIoT), enables real-time sensing, learning, and decision-making for advanced fault detection, Remaining Useful Life estimation, and prescriptive maintenance actions. This study provides a systematic and structured review of AIoT-enabled PdM aligned with Industry 5.0 objectives. It presents a unified taxonomy integrating AI models, Industrial Internet of Things (IIoT) infrastructures, and AIoT architectures; reviews AI-driven techniques, sector-specific implementations in manufacturing, transportation, and energy; and analyzes emerging paradigms such as Edge–Cloud collaboration, federated learning, self-supervised learning, and digital twins for autonomous and privacy-preserving maintenance. Furthermore, this paper synthesizes strengths, limitations, and cross-industry challenges, and outlines future research directions centered on explainability, data quality and heterogeneity, resource-constrained intelligence, cybersecurity, and human–AI collaboration. By bridging technological advancements with Industry 5.0 principles, this review contributes a comprehensive foundation for the development of scalable, trustworthy, and next-generation AIoT-based predictive maintenance systems. Full article
(This article belongs to the Section Internet of Things)
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37 pages, 3631 KB  
Article
Research on Unified Information Modeling and Cross-Protocol Real-Time Interaction Mechanisms for Multi-Energy Supply Systems in Green Buildings
by Xue Li, Haotian Ge and Bining Huang
Sustainability 2025, 17(24), 11230; https://doi.org/10.3390/su172411230 - 15 Dec 2025
Viewed by 252
Abstract
Green buildings increasingly couple electrical, thermal, and hydrogen subsystems, yet these assets are typically monitored and controlled through separate standards and protocols. The resulting heterogeneous information models and communication stacks hinder millisecond-level coordination, plug-and-play integration, and resilient operation. To address this gap, we [...] Read more.
Green buildings increasingly couple electrical, thermal, and hydrogen subsystems, yet these assets are typically monitored and controlled through separate standards and protocols. The resulting heterogeneous information models and communication stacks hinder millisecond-level coordination, plug-and-play integration, and resilient operation. To address this gap, we develop a unified information model and a cross-protocol real-time interaction mechanism based on extensions of IEC 61850. At the modeling level, we introduce new logical nodes and standardized data objects that describe electrical, thermal, and hydrogen devices in a single semantic space, supported by a global unit system and knowledge-graph-based semantic checking. At the communication level, we introduce a semantic gateway with adaptive mapping bridges IEC 61850 and legacy building protocols, while fast event messaging and 5G-enabled edge computing support deterministic low-latency control. The approach is validated on a digital-twin platform that couples an RTDS-based multi-energy system with a 5G test network. Experiments show device plug-and-play within 0.8 s, cross-protocol response-time differences below 50 ms, GOOSE latency under 5 ms, and critical-data success rates above 90% at a bit-error rate of 10−3. Under grid-fault scenarios, the proposed framework reduces voltage recovery time by about 60% and frequency deviation by about 70%, leading to more than 80% improvement in a composite resilience index compared with a conventional non-unified architecture. These results indicate that the framework provides a practical basis for interoperable, low-carbon, and resilient energy management in green buildings. Full article
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