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Article

7 Citations

2,644 Views

18 Pages

Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity

Shihab Kochumon,
Hossein Arefanian,
Sardar Sindhu,
Reeby Thomas,
Texy Jacob,
Amnah Al-Sayyar,
Steve Shenouda,
Fatema Al-Rashed,
Heikki A. Koistinen and
Rasheed Ahmad
+ 2 authors

Cells2022, 11(24), 4007;https://doi.org/10.3390/cells11244007

11 December 2022

Steroid receptor RNA activator gene (SRA1) emerges as a player in pathophysiological responses of adipose tissue (AT) in metabolic disorders such as obesity and type 2 diabetes (T2D). We previously showed association of the AT SRA1 expression with in...

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Article

11 Citations

3,960 Views

15 Pages

Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation

Shihab Kochumon,
Hossein Arefanian,
Sardar Sindhu,
Steve Shenouda,
Reeby Thomas,
Fahd Al-Mulla,
Jaakko Tuomilehto and
Rasheed Ahmad

Cells2021, 10(10), 2602;https://doi.org/10.3390/cells10102602

30 September 2021

Steroid receptor RNA activator 1 (SRA1) is involved in pathophysiological responses of adipose tissue (AT) in obesity. In vitro and animal studies have elucidated its role in meta-inflammation. Since SRA1 AT expression in obesity/type 2 diabetes (T2D...

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Article

17 Citations

3,601 Views

18 Pages

Long, Noncoding RNA SRA Induces Apoptosis of β-Cells by Promoting the IRAK1/LDHA/Lactate Pathway

Yu-Nan Huang,
Shang-Lun Chiang,
Yu-Jung Lin,
Su-Ching Liu,
Yen-Hsien Li,
Yu-Chen Liao,
Maw-Rong Lee,
Pen-Hua Su,
Fuu-Jen Tsai and
Chung-Hsing Wang
+ 1 author

Int. J. Mol. Sci.2021, 22(4), 1720;https://doi.org/10.3390/ijms22041720

9 February 2021

Long non-coding RNA steroid receptor RNA activators (LncRNA SRAs) are implicated in the β-cell destruction of Type 1 diabetes mellitus (T1D), but functional association remains poorly understood. Here, we aimed to verify the role of LncRNA SRA regula...

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Feature Paper
Review

153 Citations

12,577 Views

34 Pages

Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication

Carolyn M. Klinge

Non-Coding RNA2018, 4(4), 40;https://doi.org/10.3390/ncrna4040040

12 December 2018

Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes, including levels and activity of estrogen receptor α (ER&alpha...

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Review

46 Citations

6,429 Views

26 Pages

Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance

Vianet Argelia Tello-Flores,
Fredy Omar Beltrán-Anaya,
Marco Antonio Ramírez-Vargas,
Brenda Ely Esteban-Casales,
Napoleón Navarro-Tito,
Luz del Carmen Alarcón-Romero,
Carlos Aldair Luciano-Villa,
Mónica Ramírez,
Óscar del Moral-Hernández and
Eugenia Flores-Alfaro

Int. J. Mol. Sci.2021, 22(14), 7256;https://doi.org/10.3390/ijms22147256

6 July 2021

Long non-coding RNAs (lncRNAs) are single-stranded RNA biomolecules with a length of >200 nt, and they are currently considered to be master regulators of many pathological processes. Recent publications have shown that lncRNAs play important role...

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