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Article

7 Citations

2,988 Views

10 Pages

Perturbations in the Heme and Siroheme Biosynthesis Pathways Causing Accumulation of Fluorescent Free Base Porphyrins and Auxotrophy in Ogataea Yeasts

Azamat V. Karginov,
Alexander I. Alexandrov,
Vitaly V. Kushnirov and
Michael O. Agaphonov

J. Fungi2021, 7(10), 884;https://doi.org/10.3390/jof7100884

19 October 2021

The biosynthesis of cyclic tetrapyrrol chromophores such as heme, siroheme, and chlorophyll involves the formation of fluorescent porphyrin precursors or compounds, which become fluorescent after oxidation. To identify Ogataea polymorpha mutations af...

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Article

5 Citations

3,074 Views

21 Pages

Biosynthesis of Tetrapyrrole Cofactors by Bacterial Community Inhabiting Porphyrine-Containing Shale Rock (Fore-Sudetic Monocline)

Robert Stasiuk,
Tomasz Krucoń and
Renata Matlakowska

Molecules2021, 26(21), 6746;https://doi.org/10.3390/molecules26216746

8 November 2021

This study describes for the first time the comprehensive characterization of tetrapyrrole cofactor biosynthetic pathways developed for bacterial community (BC) inhabiting shale rock. Based on the genomic and proteomic metadata, we have detailed the...

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Article

9 Citations

2,971 Views

13 Pages

Implication of a Key Region of Six Bacillus cereus Genes Involved in Siroheme Synthesis, Nitrite Reductase Production and Iron Cluster Repair in the Bacterial Response to Nitric Oxide Stress

Constance Porrini,
Cyprien Guérin,
Seav-Ly Tran,
Rozenn Dervyn,
Pierre Nicolas and
Nalini Ramarao

Int. J. Mol. Sci.2021, 22(10), 5079;https://doi.org/10.3390/ijms22105079

11 May 2021

Bacterial response to nitric oxide (NO) is of major importance for bacterial survival. NO stress is a main actor of the eukaryotic immune response and several pathogenic bacteria have developed means for detoxification and repair of the damages cause...

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Article

2 Citations

2,112 Views

15 Pages

The Radical SAM Heme Synthase AhbD from Methanosarcina barkeri Contains Two Auxiliary [4Fe-4S] Clusters

Isabelle Fix,
Lorenz Heidinger,
Thorsten Friedrich and
Gunhild Layer

Biomolecules2023, 13(8), 1268;https://doi.org/10.3390/biom13081268

18 August 2023

In archaea and sulfate-reducing bacteria, heme is synthesized via the siroheme-dependent pathway. The last step of this route is catalyzed by the Radical SAM enzyme AhbD and consists of the conversion of iron-coproporphyrin III into heme. AhbD belong...

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