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Search Results (1,509)

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Keywords = sheet conductivity

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16 pages, 4733 KiB  
Article
Vibratory Pile Driving in High Viscous Soil Layers: Numerical Analysis of Penetration Resistance and Prebored Hole of CEL Method
by Caihui Li, Changkai Qiu, Xuejin Liu, Junhao Wang and Xiaofei Jing
Buildings 2025, 15(15), 2729; https://doi.org/10.3390/buildings15152729 (registering DOI) - 2 Aug 2025
Abstract
High-viscosity stratified strata, characterized by complex geotechnical properties such as strong cohesion, low permeability, and pronounced layered structures, exhibit significant lateral friction resistance and high-end resistance during steel sheet pile installation. These factors substantially increase construction difficulty and may even cause structural damage. [...] Read more.
High-viscosity stratified strata, characterized by complex geotechnical properties such as strong cohesion, low permeability, and pronounced layered structures, exhibit significant lateral friction resistance and high-end resistance during steel sheet pile installation. These factors substantially increase construction difficulty and may even cause structural damage. This study addresses two critical mechanical challenges during vibratory pile driving in Fujian Province’s hydraulic engineering project: prolonged high-frequency driving durations, and severe U-shaped steel sheet pile head damage in high-viscosity stratified soils. Employing the Coupled Eulerian–Lagrangian (CEL) numerical method, a systematic investigation was conducted into the penetration resistance, stress distribution, and damage patterns during vibratory pile driving under varying conditions of cohesive soil layer thickness, predrilled hole spacing, and aperture dimensions. The correlation between pile stress and penetration depth was established, with the influence mechanisms of key factors on driving-induced damage in high-viscosity stratified strata under multi-factor coupling effects elucidated. Finally, the feasibility of predrilling techniques for resistance reduction was explored. This study applies the damage prediction model based on the CEL method to U-shaped sheet piles in high-viscosity stratified formations, solving the problem of mesh distortion in traditional finite element methods. The findings provide scientific guidance for steel sheet pile construction in high-viscosity stratified formations, offering significant implications for enhancing construction efficiency, ensuring operational safety, and reducing costs in such challenging geological conditions. Full article
(This article belongs to the Section Building Structures)
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29 pages, 5040 KiB  
Article
The Investigation of a Biocide-Free Antifouling Coating on Naval Steels Under Both Simulated and Actual Seawater Conditions
by Polyxeni Vourna, Pinelopi P. Falara and Nikolaos D. Papadopoulos
Processes 2025, 13(8), 2448; https://doi.org/10.3390/pr13082448 (registering DOI) - 1 Aug 2025
Abstract
This study developed a water-soluble antifouling coating to protect ship hulls against corrosion and fouling without the usage of a primer. The coating retains its adhesion to the steel substrate and reduces corrosion rates compared to those for uncoated specimens. The coating’s protective [...] Read more.
This study developed a water-soluble antifouling coating to protect ship hulls against corrosion and fouling without the usage of a primer. The coating retains its adhesion to the steel substrate and reduces corrosion rates compared to those for uncoated specimens. The coating’s protective properties rely on the interaction of conductive polyaniline (PAni) nanorods, magnetite (Fe3O4) nanoparticles, and graphene oxide (GO) sheets modified with titanium dioxide (TiO2) nanoparticles. The PAni/Fe3O4 nanocomposite improves the antifouling layer’s out-of-plane conductivity, whereas GO increases its in-plane conductivity. The anisotropy in the conductivity distribution reduces the electrostatic attraction and limits primary bacterial and pathogen adsorption. TiO2 augments the conductivity of the PAni nanorods, enabling visible light to generate H2O2. The latter decomposes into H2O and O2, rendering the coating environmentally benign. The coating acts as an effective barrier with limited permeability to the steel surface, demonstrating outstanding durability for naval steel over extended periods. Full article
(This article belongs to the Special Issue Metal Material, Coating and Electrochemistry Technology)
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12 pages, 3313 KiB  
Article
Graphene-Based Grid Patterns Fabricated via Direct Ink Writing for Flexible Transparent Electrodes
by Yongcheng Zheng, Hai Zi, Shuqi Wang, Shengming Yin and Xu Shen
Appl. Sci. 2025, 15(15), 8553; https://doi.org/10.3390/app15158553 (registering DOI) - 1 Aug 2025
Abstract
Graphene is considered one of the most promising flexible transparent electrode materials as it has high charge carrier mobility, high electrical conductivity, low optical absorption, excellent mechanical strength, and good bendability. However, graphene-based flexible transparent electrodes face a critical challenge in balancing electrical [...] Read more.
Graphene is considered one of the most promising flexible transparent electrode materials as it has high charge carrier mobility, high electrical conductivity, low optical absorption, excellent mechanical strength, and good bendability. However, graphene-based flexible transparent electrodes face a critical challenge in balancing electrical conductivity and optical transmittance. Here, we present a green and scalable direct ink writing (DIW) strategy to fabricate graphene grid patterns by optimizing ink formulation with sodium dodecyl sulfate (SDS) and ethanol. SDS eliminates the coffee ring effect via Marangoni flow, while ethanol enhances graphene flake alignment during hot-pressing, achieving a high conductivity of 5.22 × 105 S m−1. The grid-patterned graphene-based flexible transparent electrodes exhibit a low sheet resistance of 21.3 Ω/sq with 68.5% transmittance as well as a high stability in high-temperature and corrosive environments, surpassing most metal/graphene composites. This method avoids toxic solvents and high-temperature treatments, demonstrating excellent stability in harsh environments. Full article
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20 pages, 4765 KiB  
Article
Ultrasonic EDM for External Cylindrical Surface Machining with Graphite Electrodes: Horn Design and Hybrid NSGA-II–AHP Optimization of MRR and Ra
by Van-Thanh Dinh, Thu-Quy Le, Duc-Binh Vu, Ngoc-Pi Vu and Tat-Loi Mai
Machines 2025, 13(8), 675; https://doi.org/10.3390/machines13080675 (registering DOI) - 1 Aug 2025
Abstract
This study presents the first investigation into the application of ultrasonic vibration-assisted electrical discharge machining (UV-EDM) using graphite electrodes for external cylindrical surface machining—an essential surface in the production of tablet punches and sheet metal-forming dies. A custom ultrasonic horn was designed and [...] Read more.
This study presents the first investigation into the application of ultrasonic vibration-assisted electrical discharge machining (UV-EDM) using graphite electrodes for external cylindrical surface machining—an essential surface in the production of tablet punches and sheet metal-forming dies. A custom ultrasonic horn was designed and fabricated using 90CrSi material to operate effectively at a resonant frequency of 20 kHz, ensuring stable vibration transmission throughout the machining process. A Box–Behnken experimental design was employed to explore the effects of five process parameters—vibration amplitude (A), pulse-on time (Ton), pulse-off time (Toff), discharge current (Ip), and servo voltage (SV)—on two key performance indicators: material removal rate (MRR) and surface roughness (Ra). The optimization process was conducted in two stages: single-objective analysis to maximize MRR while ensuring Ra < 4 µm, followed by a hybrid multi-objective approach combining NSGA-II and the Analytic Hierarchy Process (AHP). The optimal solution achieved a high MRR of 9.28 g/h while maintaining Ra below the critical surface finish threshold, thus meeting the practical requirements for punch surface quality. The findings confirm the effectiveness of the proposed horn design and hybrid optimization strategy, offering a new direction for enhancing productivity and surface integrity in cylindrical EDM applications using graphite electrodes. Full article
(This article belongs to the Section Advanced Manufacturing)
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18 pages, 7903 KiB  
Article
Study on the Mechanical Response of FSP-IV Steel Sheet Pile Cofferdam and the Collaborative Mechanism of Sediment Control Technology in the Nenjiang Water Intake Project
by Ziguang Zhang, Liang Wu, Rui Luo, Lin Wei and Feifei Chen
Buildings 2025, 15(15), 2610; https://doi.org/10.3390/buildings15152610 - 23 Jul 2025
Viewed by 267
Abstract
In response to the dual challenges of the mechanical behavior of steel sheet pile cofferdam and sediment control in urban water intake projects, a multi-method integrated study was conducted based on the Nenjiang Project. The results show that the peak stress of FSP-IV [...] Read more.
In response to the dual challenges of the mechanical behavior of steel sheet pile cofferdam and sediment control in urban water intake projects, a multi-method integrated study was conducted based on the Nenjiang Project. The results show that the peak stress of FSP-IV steel sheet piles (64.3 MPa) is located at a depth of 5.5–8.0 m in the center of the foundation pit, and that the maximum horizontal displacement (6.96 mm) occurs at the middle of the side span of the F pile. The internal support stress increases with depth, reaching 87.2 MPa at the bottom, with significant stress concentration at the connection of the surrounding girder. The lack of support or excessively large spacing leads to insufficient stiffness at the side span (5.3 mm displacement at the F point) and right-angle area (B/H point). The simultaneously developed sediment control integrated system, through double-line water intake, layered placement of the geotextile filter, and the collaborative construction of the water intake hole–filter layer system, achieves a 75% reduction in sediment content and a decrease in standard deviation. This approach ensures stable water quality and continuous water supply, ultimately forming a systematic solution for water intake in high-sediment rivers. Full article
(This article belongs to the Section Building Structures)
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29 pages, 1609 KiB  
Review
Recent Advances in Silver Nanowire-Based Transparent Conductive Films: From Synthesis to Applications
by Ji Li, Jun Luo and Yang Liu
Coatings 2025, 15(7), 858; https://doi.org/10.3390/coatings15070858 - 21 Jul 2025
Viewed by 535
Abstract
Silver nanowire (AgNW)-based transparent conductive films are essential for flexible electronics due to their superior optoelectronic properties and mechanical flexibility. This review examines the characteristics and fabrication methods of AgNW thin films in detail. Among various fabrication techniques, the AgNW thin film produced [...] Read more.
Silver nanowire (AgNW)-based transparent conductive films are essential for flexible electronics due to their superior optoelectronic properties and mechanical flexibility. This review examines the characteristics and fabrication methods of AgNW thin films in detail. Among various fabrication techniques, the AgNW thin film produced by silk-screen printing exhibits the highest quality factor of 568.47, achieving 95.3% visible light transmittance of 95.3% and 13.6 Ω/sq sheet resistance. Ensuring the stability of AgNW films requires the deposition of protective layers through physical or chemical approaches. This review also systematically evaluates the different methods for preparing these protective layers, including their respective advantages and limitations. Furthermore, the review proposes strategies to enhance the conductivity, transparency, and flexibility of AgNW films. Finally, it discusses potential future applications and challenges, offering valuable insights for the development of next-generation flexible transparent electrodes. Full article
(This article belongs to the Special Issue Advanced Thin Films Technologies for Optics, Electronics, and Sensing)
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15 pages, 7744 KiB  
Article
FEM Analysis of Superplastic-Forming Process to Manufacture a Hemispherical Shell
by Gillo Giuliano and Wilma Polini
Appl. Sci. 2025, 15(14), 8080; https://doi.org/10.3390/app15148080 - 21 Jul 2025
Viewed by 192
Abstract
Superplastic materials are characterised by extreme lightness and remarkable ductility. Instead of a punch, a gas is used to push the sheet into the die cavity, and it is precisely regulated to control the material’s strain rate. Forming a superplastic material while maintaining [...] Read more.
Superplastic materials are characterised by extreme lightness and remarkable ductility. Instead of a punch, a gas is used to push the sheet into the die cavity, and it is precisely regulated to control the material’s strain rate. Forming a superplastic material while maintaining a high strain rate sensitivity index requires the forming gas to follow a precise pressure–time loading curve. This can be excellently predicted with the aid of the finite element method (FEM). Therefore, for the superplastic material to exhibit its best formability throughout the entire process, it is necessary to control the strain rate step by step to keep the maximum strain rate within the material’s optimal superplastic range. In this work, the results of a superplastic-forming process used to create a hemispherical shell are presented. This was carried out using both a circular blank of uniform thickness and a blank with a conical cross-section. The analysis was performed using finite element modelling. Specifically, the results obtained using 3D analysis were compared with those obtained using axisymmetric analysis for conditions of axial symmetry. Using the conical cross-section blank helped achieve a more uniform thickness distribution in the produced hemispherical shell. The success of the numerical activity was validated through results from appropriate experimental work conducted on the magnesium alloy AZ31. The results show that, by employing a blank characterised by a conical section profile, the thickness distribution appears more uniform than that of a constant-thickness blank. Full article
(This article belongs to the Section Mechanical Engineering)
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16 pages, 2312 KiB  
Article
A Multi-Response Investigation of Abrasive Waterjet Machining Parameters on the Surface Integrity of Twinning-Induced Plasticity (TWIP) Steel
by Onur Cavusoglu
Materials 2025, 18(14), 3404; https://doi.org/10.3390/ma18143404 - 21 Jul 2025
Viewed by 295
Abstract
Twinning-induced plasticity (TWIP) steels represent a significant development in automotive steel production, characterized by advanced strength and ductility properties. The present study empirically investigated the effects of process parameters on the cutting process and surface quality of TWIP980 steel sheet by abrasive water [...] Read more.
Twinning-induced plasticity (TWIP) steels represent a significant development in automotive steel production, characterized by advanced strength and ductility properties. The present study empirically investigated the effects of process parameters on the cutting process and surface quality of TWIP980 steel sheet by abrasive water jet (AWJ) cutting. The cutting experiments were conducted on 1.4 mm thick sheet metal using four different traverse speeds (50, 100, 200, and 400 mm/min) and four different water jet pressures (1500, 2000, 2500, and 3000 bar). Two different abrasive flow rates (300 and 600 g/min) were also utilized. The cut surfaces were characterized in three dimensions with an optical profilometer. The parameters of surface roughness, kerf width, taper angle, and material removal rate (MRR) were determined. Furthermore, microhardness measurements were conducted on the cut surfaces. The optimal surface quality and geometrical accuracy were achieved by applying a combination of parameters, including 3000 bar of pressure, a traverse rate of 400 mm/min, and an abrasive flow rate of 600 g/min. Concurrently, an effective cutting performance with increased MRR and reduced taper angles was achieved under these conditions. The observed increase in microhardness with increasing pressure is attributable to a hardening effect resulting from local plastic deformation. Full article
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16 pages, 4562 KiB  
Article
Preparation and Properties of Flexible Multilayered Transparent Conductive Films on Substrate with High Surface Roughness
by Mengfan Li, Kai Tao, Jinghan Lu, Shenyue Xu, Yuanyuan Sun, Yaman Chen and Zhiyong Liu
Materials 2025, 18(14), 3389; https://doi.org/10.3390/ma18143389 - 19 Jul 2025
Viewed by 305
Abstract
The flexible transparent conductive films (TCFs) of a ZnS/Cu/Ag/TiO2 multilayered structure were deposited on a flexible PET substrate with high surface roughness using magnetic sputtering, and the effects of structural characteristics on the performance of the films were analyzed. The TCFs with [...] Read more.
The flexible transparent conductive films (TCFs) of a ZnS/Cu/Ag/TiO2 multilayered structure were deposited on a flexible PET substrate with high surface roughness using magnetic sputtering, and the effects of structural characteristics on the performance of the films were analyzed. The TCFs with TiO2/Cu/Ag/TiO2 and ZnS/Cu/Ag/ZnS symmetric structures were also prepared for comparison. The TCF samples were deposited using ZnS, TiO2, Cu and Ag targets, and they were analyzed using scanning electronic microscopy, atomic force microscopy, grazing incidence X-ray diffraction, spectrophotometry and a four-probe tester. The TCFs exhibit generally uniform surface morphology, excellent light transmittance and electrical conductivity with optimized structure. The optimal values are 84.40%, 5.52 Ω/sq and 33.19 × 10−3 Ω−1 for the transmittance, sheet resistance and figure of merit, respectively, in the visible spectrum. The satisfactory properties of the asymmetric multilayered TCF deposited on a rough-surface substrate should be mainly attributed to the optimized structure parameters and reasonable interfacial compatibilities. Full article
(This article belongs to the Section Thin Films and Interfaces)
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22 pages, 4829 KiB  
Article
Development of a Flexible and Conductive Heating Membrane via BSA-Assisted Electroless Plating on Electrospun PVDF-HFP Nanofibers
by Mun Jeong Choi, Dae Hyeob Yoon, Yoo Sei Park, Hyoryung Nam and Geon Hwee Kim
Appl. Sci. 2025, 15(14), 8023; https://doi.org/10.3390/app15148023 - 18 Jul 2025
Viewed by 263
Abstract
Planar heaters are designed to deliver uniform heat across broad surfaces and serve as critical components in applications requiring energy efficiency, safety, and mechanical flexibility, such as wearable electronics and smart textiles. However, conventional metal-based heaters are limited by poor adaptability to curved [...] Read more.
Planar heaters are designed to deliver uniform heat across broad surfaces and serve as critical components in applications requiring energy efficiency, safety, and mechanical flexibility, such as wearable electronics and smart textiles. However, conventional metal-based heaters are limited by poor adaptability to curved or complex surfaces, low mechanical compliance, and susceptibility to oxidation-induced degradation. To overcome these challenges, we applied a protein-assisted electroless copper (Cu) plating strategy to electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) nanofiber substrates to fabricate flexible, conductive planar heating membranes. For interfacial functionalization, a protein-based engineering approach using bovine serum albumin (BSA) was employed to facilitate palladium ion coordination and seed formation. The resulting membrane exhibited a dense, continuous Cu coating, low sheet resistance, excellent durability under mechanical deformation, and stable heating performance at low voltages. These results demonstrate that the BSA-assisted strategy can be effectively extended to complex three-dimensional fibrous membranes, supporting its scalability and practical potential for next-generation conformal and wearable planar heaters. Full article
(This article belongs to the Section Applied Thermal Engineering)
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15 pages, 4358 KiB  
Article
Nickel-Rich Cathodes for Solid-State Lithium Batteries: Comparative Study Between PVA and PIB Binders
by José M. Pinheiro, Beatriz Moura Gomes, Manuela C. Baptista and M. Helena Braga
Molecules 2025, 30(14), 2974; https://doi.org/10.3390/molecules30142974 - 15 Jul 2025
Viewed by 358
Abstract
The growing demand for high-energy, safe, and sustainable lithium-ion batteries has increased interest in nickel-rich cathode materials and solid-state electrolytes. This study presents a scalable wet-processing method for fabricating composite cathodes for all-solid-state batteries. The cathodes studied herein are high-nickel LiNi0.90Mn [...] Read more.
The growing demand for high-energy, safe, and sustainable lithium-ion batteries has increased interest in nickel-rich cathode materials and solid-state electrolytes. This study presents a scalable wet-processing method for fabricating composite cathodes for all-solid-state batteries. The cathodes studied herein are high-nickel LiNi0.90Mn0.05Co0.05O2, NMC955, the sulfide-based electrolyte Li6PS5Cl, and alternative binders—polyvinyl alcohol (PVA) and polyisobutylene (PIB)—dispersed in toluene, a non-polar solvent compatible with the electrolyte. After fabrication, the cathodes were characterized using SEM/EDX, sheet resistance, and Hall effect measurements. Electrochemical tests were additionally performed in all-solid-state battery half-cells comprising the synthesized cathodes, lithium metal anodes, and Li6PS5Cl as the separator and electrolyte. The results show that both PIB and PVA formulations yielded conductive cathodes with stable microstructures and uniform particle distribution. Electrochemical characterization exposed that the PVA-based cathode outperformed the PIB-based counterpart, achieving the theoretical capacity of 192 mAh·g−1 even at 1C, whereas the PIB cathode reached a maximum capacity of 145 mAh.g−1 at C/40. Post-mortem analysis confirmed the structural integrity of the cathodes. These findings demonstrate the viability of NMC955 as a high-capacity cathode material compatible with solid-state systems. Full article
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18 pages, 8645 KiB  
Article
CIC-Rearranged Sarcoma: A Clinical and Pathological Study of a Peculiar Entity
by Ward Maaita, Nabil Hasasna, Sameer Yaser, Yacob Saleh, Ramiz Abu-Hijlih, Wafa Asha, Hadeel Halalsheh, Samer Abdel Al, Maysa Al-Hussaini and Omar Jaber
Diagnostics 2025, 15(14), 1758; https://doi.org/10.3390/diagnostics15141758 - 11 Jul 2025
Viewed by 460
Abstract
Background: CIC-rearranged sarcoma is a rare and aggressive type of undifferentiated round cell tumor characterized by CIC gene fusion, most commonly CIC::DUX4. This study presents a series of eleven cases, highlighting their clinicopathological features. Methods: Pathology records (2019 to 2024) [...] Read more.
Background: CIC-rearranged sarcoma is a rare and aggressive type of undifferentiated round cell tumor characterized by CIC gene fusion, most commonly CIC::DUX4. This study presents a series of eleven cases, highlighting their clinicopathological features. Methods: Pathology records (2019 to 2024) were searched using “sarcoma with CIC”, identifying eleven cases, of which seven referred cases were initially misdiagnosed. Pathological and clinical analysis was conducted. Treatment was dictated upon multidisciplinary panel discussion based on tumor stage. Follow-up data (1–25 months) was available for all patients. Results: The cohort included six males and five females, with a median age of 43 years (range;14–53), with nine in soft tissue and two in bone. Tumor size ranged from 3.5 cm to 20.0 cm (mean: 9.8 cm). Most cases showed sheets of undifferentiated round- to oval-shaped cells. Two cases showed an Ewing-like pattern, and one case showed spindle cells in a fibrotic stroma transitioning to epithelioid cells. Necrosis was present in nine cases, and mitotic count ranged from 2 to 38/ 10HPFs (mean = 14.2). CD99 was positive in (10/11) cases and WT-1 in (6/9). NKX2.2, S100, and MDM2 were positive in rare cases. CIC::DUX4 fusion was detected in four cases. FISH for CIC gene rearrangement was positive in seven cases, two of them confirmed by methylation analysis. Metastasis at diagnosis was common (n = 8), primarily in the lungs, with later metastasis to the brain and bone. At time of final analysis, eight patients died within a median of 10 months (range: 1–19 months), while three were alive, two with stable disease (for a period of 6 and 25 months) and one with progression after 10 months. Significant correlation was seen between overall survival and the presence of metastasis at diagnosis (p value = 0.03). Conclusions: CIC-rearranged sarcomas are rare, high-grade tumors with predilection for soft tissue. Misdiagnosis is frequent, necessitating molecular confirmation. These tumors are treatment-resistant, often present with lung metastasis, and carry a poor prognosis, especially with initial metastasis. Full article
(This article belongs to the Section Pathology and Molecular Diagnostics)
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21 pages, 3209 KiB  
Article
Towards Sustainable Health and Safety in Mining: Evaluating the Psychophysical Impact of VR-Based Training
by Aldona Urbanek, Kinga Stecuła, Krzysztof Kaźmierczak, Szymon Łagosz, Wojtek Kwoczak and Artur Dyczko
Sustainability 2025, 17(13), 6205; https://doi.org/10.3390/su17136205 - 7 Jul 2025
Viewed by 486
Abstract
Mining involves daily descents underground and enduring dangerous and difficult conditions. Hence, it is very important to use solutions that will reduce the risk in miners’ work and ensure the greater safety and comfort of work in accordance with the goals of sustainable [...] Read more.
Mining involves daily descents underground and enduring dangerous and difficult conditions. Hence, it is very important to use solutions that will reduce the risk in miners’ work and ensure the greater safety and comfort of work in accordance with the goals of sustainable development. One way is training using virtual reality. Virtual reality provides greater safety (safe training conditions, the possibility of making a mistake without health consequences, practicing emergency scenarios, etc.) and aligns with the Sustainable Development Goals—particularly SDG 3 (health), SDG 8 (decent work), SDG 9 (innovation), and SDG 12 (sustainable production). However, it is also a technology that has its weaknesses (occurrence of contraindications, side effects, etc.). Therefore, the use of VR-based training should be examined in terms of the well-being and health of training employees. Due to this, this article examines the occurrence of psychophysical complaints during VR training; the tolerance and adequacy of the duration of a 50 min training session in VR was assessed; and the average time needed to adapt to the virtual environment was determined. The VR training was developed as a result of a research project conducted by JSW Nowe Projekty S.A. (ul. Ignacego Paderewskiego 41, 40-282 Katowice, Poland), Główny Instytut Górnictwa—Państwowy Instytut Badawczy (plac Gwarków 1, 40-160 Katowice, Poland), JSW Szkolenie i Górnictwo Sp. z o.o. at Jastrzębska Spółka Węglowa Capital Group (ul. Górnicza 1, 44-335 Jastrzębie-Zdrój, Poland) on the development and implementation of innovative training using VR for miners. The solution was developed in the context of mining’s striving for sustainable development in the area of improving working conditions and human safety. The first method used in the study is a survey completed by participants of training courses using virtual reality. The second method is the analysis of trainer observation sheets, which contain observations from training courses. The results revealed that for over 70% of respondents, the need to carry out activities in VR was not associated with fatigue. No average score for psychophysical symptoms assessed by respondents on a scale of 1 to 6 (including disorientation, blurred vision, dizziness, confusion, etc.) exceeded 1.4. The vast majority (85.5%) did not take off the goggles before the end of the training—the training lasted 50 min. This research contributes to the discussion on sustainable industrial transformation by demonstrating that VR training not only improves worker safety and preparedness but also supports development goals through human-centered innovation in the mining sector. Full article
(This article belongs to the Section Sustainable Management)
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19 pages, 19033 KiB  
Article
Disclosing Pathogenic Variant Effects on the Structural Dynamics of the VAPB MSP Domain Causing Familial ALS
by Md Abul Bashar, Nayan Dash, Sarmistha Mitra and Raju Dash
Int. J. Mol. Sci. 2025, 26(13), 6489; https://doi.org/10.3390/ijms26136489 - 5 Jul 2025
Viewed by 474
Abstract
Vesicle-associated membrane protein (VAMP)-associated protein B (VAPB) serves as a tethering factor that interacts with various proteins and recruits these proteins to the ER surface, exerting multiple functions, such as organelle membrane tethering, lipid transfer between organelles, regulation of calcium homeostasis, autophagy, and [...] Read more.
Vesicle-associated membrane protein (VAMP)-associated protein B (VAPB) serves as a tethering factor that interacts with various proteins and recruits these proteins to the ER surface, exerting multiple functions, such as organelle membrane tethering, lipid transfer between organelles, regulation of calcium homeostasis, autophagy, and the unfolded protein response (UPR). Its interaction is often mediated by its MSP (major sperm) domain, which binds with FFAT (two phenylalanines in an acidic tract)-motif-containing proteins. However, pathogenic variations, such as P56S, P56H, and T46I, in the VAPB MSP domain lead to the familial form of amyotrophic lateral sclerosis (ALS8). Still, the underlying pathophysiology of ALS8 due to pathogenic variations in the VAPB MSP domain remains elusive. In this study, we conducted molecular dynamics (MD) simulations to understand the pathogenic-variant-derived changes in the structural dynamics of the VAPB MSP domain. We found that pathogenic variants altered the fluctuations and conformational dynamics of the VAPB protein. Analyzing the organizations of the secondary structure revealed that pathogenic variants changed the composition of secondary structure elements, especially increasing the proportion of α-helix while reducing β-sheet formation, which might affect the organelle tethering and other functions of VAPB, as well as VAPB homodimer and heterodimer formation. Taken together, these findings can be further investigated through in vivo and/or in vitro studies to not only clarify the pathophysiology of ALS8 resulting from VAPB MSP domain pathogenic variants but also develop novel therapeutics for the disease that restore the native structural organizations as well as fluctuations and motions. Full article
(This article belongs to the Special Issue Research on Molecular Dynamics: 2nd Edition)
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13 pages, 3092 KiB  
Article
Carbon Dioxide Gas Sensor Based on Terahertz Metasurface with Asymmetric Cross-Shaped Holes Empowered by Quasi-Bound States in the Continuum
by Kai He and Tian Ma
Sensors 2025, 25(13), 4178; https://doi.org/10.3390/s25134178 - 4 Jul 2025
Viewed by 348
Abstract
In this paper, a novel type of polarization-insensitive terahertz metal metasurface with cross-shaped holes is presented, which is designed based on the theory of bound states in continuous media. The fundamental unit of the metasurface comprises a metal tungsten sheet with a cross-shaped [...] Read more.
In this paper, a novel type of polarization-insensitive terahertz metal metasurface with cross-shaped holes is presented, which is designed based on the theory of bound states in continuous media. The fundamental unit of the metasurface comprises a metal tungsten sheet with a cross-shaped hole structure. A thorough analysis of the optical properties and the quasi-BIC response is conducted using the finite element method. Utilizing the symmetry-breaking theory, the symmetry of the metal metasurface is broken, allowing the excitation of double quasi-BIC resonance modes with a high quality factor and high sensitivity to be achieved. Analysis of the multipole power distribution diagram and the spatial distribution of the electric field at the two quasi-BIC resonances verifies that the two quasi-BIC resonances of the metasurface are excited by electric dipoles and electric quadrupoles, respectively. Further simulation analysis demonstrates that the refractive index sensitivities of the two quasi-BIC modes of the metasurface reach 404.5 GHz/RIU and 578.6 GHz/RIU, respectively. Finally, the functional material PHMB is introduced into the metasurface to achieve highly sensitive sensing and detection of CO2 gas concentrations. The proposed metallic metasurface structure exhibits significant advantages, including high sensitivity, ease of preparation, and a high Q-value, which renders it highly promising for a broad range of applications in the domains of terahertz biosensing and highly sensitive gas sensing. Full article
(This article belongs to the Special Issue The Advanced Flexible Electronic Devices: 2nd Edition)
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