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28 pages, 15295 KiB  
Article
Innovation in the Use of Recycled and Heat-Treated Glass in Various Applications: Mechanical and Chemical Properties
by Cristian Epure, Corneliu Munteanu, Bogdan Istrate, Maria Harja, Fabian Cezar Lupu and Dorin Luca
Coatings 2025, 15(6), 651; https://doi.org/10.3390/coatings15060651 - 28 May 2025
Viewed by 482
Abstract
By decreasing manufacturing costs for different civic purposes, glass recycling is an economically significant technology that also helps conserve natural resources and mitigates environmental problems. Throughout the recycling process, this study used recycled domestic glass in compliance with European guidelines for recycling of [...] Read more.
By decreasing manufacturing costs for different civic purposes, glass recycling is an economically significant technology that also helps conserve natural resources and mitigates environmental problems. Throughout the recycling process, this study used recycled domestic glass in compliance with European guidelines for recycling of household garbage. The purpose of this research is to examine the chemical and mechanical properties of recycled and crushed glass with particle sizes varying from 0.1 mm to 2 mm as a function of various treatment temperatures. This might pave the way for novel building materials, artwork, and interior design components, among other potential uses. “Silica glass”, the most common and ancient kind of glass, which includes SiOk, NakO, CaO, and small amounts of other elements, was utilized in the investigation. Several materials can be successfully modified or altered using step heat treatment. The mechanical and chemical properties of recycled and shattered glass were assessed using microhardness, compressive, and chemical testing. These samples were then compared to mosaics from Murano, Italy, and Dynasty Smalti, China. The recycled and heat-treated glass produced microhardness values of 550.6 HV and 555.0 HV, respectively, when tested with forces of 0.981 N and 2.942 N. These values were higher than those of Murano (Italy) and were comparable to those of Dynasty Smalti mosaic (China). Furthermore, compression testing demonstrated that tempered and heat-tempered glass, which might include up to 5 g of TiO2, could endure compressive strains of up to 16 MPa. This is in sharp contrast to Dynasty Smalti, which could only withstand tensions of 6–8 MPa, and Murano, which could only withstand stresses of 3–4 MPa. Tests conducted chemically over a seven-day period using KOH at 30 g/L and 100 g/L, along with HCl at 3% and 18%, showed that the samples did not alter in any way; their surface, color, and weight were untouched. Crushing and heating recycled glass makes it a viable alternative to using new glass in civil engineering projects. This helps make material reuse more efficient, which in turn helps the environment. Sturdy and resilient in a variety of contexts, the material shares mechanical and chemical properties with standard mosaics. Full article
(This article belongs to the Special Issue Ceramic and Glass Material Coatings)
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14 pages, 12688 KiB  
Article
Numerical Investigation of Disturbance Characteristics of Surrounding Rock in Ultra-Close Coal Seams Mining Based on Particle Flow
by Jiahui Xu, Bowen Tian, Guichen Li, Changlun Sun and Haoyu Rong
Appl. Sci. 2025, 15(6), 3063; https://doi.org/10.3390/app15063063 - 12 Mar 2025
Cited by 1 | Viewed by 538
Abstract
To reveal the influence of ultra-close coal seams mining on surrounding rock disturbance, PFC2D is introduced to establish a simplified particle flow model of strata in the deeply buried mine, the damage and stress evolution characteristics of the surrounding rock were studied [...] Read more.
To reveal the influence of ultra-close coal seams mining on surrounding rock disturbance, PFC2D is introduced to establish a simplified particle flow model of strata in the deeply buried mine, the damage and stress evolution characteristics of the surrounding rock were studied based on double coal seam mining. The results show that after the model excavation, the fracture length of the rock strata reached an accuracy of 97% compared with the theoretical calculation results, showing a good match with the theoretical calculations and the initial stress level obtained by the subsequent model monitoring is consistent with the measured value. The primary and secondary key layers are broken as a result of mining the higher coal seam, the siltstone interlayer is unaffected while the bottom coal seam is partially harmed, and there is noticeable extrusion damage between the rocks. Meanwhile, the damage to the rocks inside the gob is only becoming worse as a result of mining the lower coal seam. While the surrounding rock of the upper coal seam mining exhibits clear stress redistribution features in three zones, the lower coal seam mining creates a local and multi-point high-stress distribution. The siltstone interlayer’s stress variation is essentially identical to that of the surrounding rock. The extrusion state among rocks is related to the porosity of the shattered surrounding rock area. The siltstone interlayer is pressured during the upper coal seam mining, but it maintains its integrity, only collapsing during the lower coal seam mining. Though the siltstone interlayer can retain the necessary integrity of support before the lower coal seam mining, its internal stress is unstable which should be paid attention to when designing the support scheme during the mining period. Full article
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19 pages, 16156 KiB  
Article
Exploring the Regimes of Particle Behavior upon Impact via the Discrete Element Method
by Chanh Nguyen, Jennifer Curtis and Kambiz Salari
Pharmaceutics 2024, 16(6), 727; https://doi.org/10.3390/pharmaceutics16060727 - 28 May 2024
Viewed by 1491
Abstract
Discrete element method simulations are conducted to probe the various regimes of post-impact behavior of particles with solid surfaces. The impacting particles are described as spherical agglomerates consisting of smaller constituent (or primary) particles held together via surface adhesion. Under the influence of [...] Read more.
Discrete element method simulations are conducted to probe the various regimes of post-impact behavior of particles with solid surfaces. The impacting particles are described as spherical agglomerates consisting of smaller constituent (or primary) particles held together via surface adhesion. Under the influence of a wide range of impact velocities and particle surface energies, five distinct behavioral regimes—rebounding, vibration, fragmentation, pancaking, and shattering—are identified, and force transmission patterns are linked to post-impact behavior. In the rebounding regime, the coefficient of restitution decreases linearly as impact velocity increases and the particle agglomerate experiences compaction. In the fragmentation regime, rebound velocity generally decreases with increasing fragment size. The rebound velocity of fragments decreases with time except for the smallest fragments, which can increase in velocity due to collisions with other fragments of high velocity. Particle breakage in the pancaking regime does not follow common mechanistic models of breakage. Full article
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12 pages, 7564 KiB  
Article
The Design and Preparation of Permittivity-Adjustable FeNi@SrFe-MOF Composite Powders
by Zhifen Yuan, Donghan Jiang, Lei Chen and Zhenghou Zhu
Coatings 2024, 14(1), 112; https://doi.org/10.3390/coatings14010112 - 15 Jan 2024
Cited by 1 | Viewed by 1401
Abstract
When the thickness of the wave-absorbing material is low, there exists the problem of the narrow wave-absorbing frequency band, making it difficult to regulate the position of the wave-absorbing peak. In this study, FeNi@SrFe-MOF composite powders were synthesized using a hydrothermal method and [...] Read more.
When the thickness of the wave-absorbing material is low, there exists the problem of the narrow wave-absorbing frequency band, making it difficult to regulate the position of the wave-absorbing peak. In this study, FeNi@SrFe-MOF composite powders were synthesized using a hydrothermal method and a liquid-phase reduction method. The composite powder was spherical, with a particle size of about 50 μm–60 μm; the core layers of the powders were porous SrFe-MOF powders with permanent magnetization, and the outer layers were FeNi alloy nano-powder coatings with a particle size of 100 nm–120 nm, which took into account both the soft magnetization and the permanent magnetization properties of the composite powders. Additionally, a directional magnetic field was applied to the powder coating. By regulating the intensity and direction of the magnetic field, the electromagnetic parameters of the composite powder coating underwent sensitive changes, allowing for the precise regulation of the electromagnetic wave absorption performance of the composite powders. With the increase in magnetic field intensity, the ε′ value decreased significantly. The ε′ values were 8.56–7.35 for H453mT and 6.73–6.12 for H472mT. When no magnetic field was applied, the Snoke limit frequency of the μ′ value was 6.0 GHz. When the magnetic field intensity increased, the Snoke limit frequency of the μ′ value increased from 6.0 GHz, without the magnetic field, to 8.3 GHz; the Snoke limit of the composite powders was shattered. After the H453mT magnetic field regulation treatment, the powder coating exhibited good impedance matching characteristics with air. When the magnetic field intensity was 453mT and the thickness of the composite powders coating was 3.5 mm, the composite powders coating showed the strongest absorption peak when the R-value was −59 dB at 7.8 GHz, and the effective absorption bandwidth reached 3.2 GHz, exhibiting superb absorbent qualities. The wave absorption property of the coating can be sensitively changed by the magnetic field regulation treatment at the condition without changing the powder structure or coating structure, which provides a new strategy for the regulation of the wave absorption property and has broad application prospects. Full article
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34 pages, 10165 KiB  
Article
A Numerical Simulation Study of Secondary Ice Productions in a Squall Line Case
by Jie Gao, Xuqing Han, Yichen Chen, Shuangxu Li and Huiwen Xue
Atmosphere 2023, 14(12), 1752; https://doi.org/10.3390/atmos14121752 - 28 Nov 2023
Cited by 2 | Viewed by 1455
Abstract
Secondary ice productions (SIPs) can produce ice crystals with a number concentration much higher than that of ice nucleating particles in mixed-phase clouds and therefore influence cloud glaciation and precipitation. For midlatitude continental mesoscale convective systems (MCSs), how SIPs affect the microphysical properties [...] Read more.
Secondary ice productions (SIPs) can produce ice crystals with a number concentration much higher than that of ice nucleating particles in mixed-phase clouds and therefore influence cloud glaciation and precipitation. For midlatitude continental mesoscale convective systems (MCSs), how SIPs affect the microphysical properties and precipitation is still not clear. There are few studies of SIPs in midlatitude continental MCSs. This study investigates the roles of three SIPs (rime splintering, freezing drop shattering, and ice-ice collisional breakup) on a squall line case in North China on 18 August 2020 using the WRF model with a modified Morrison double-moment bulk microphysical scheme. Including SIPs, especially ice-ice collisional breakup, in the model simulations markedly improves the simulated convective area and convective precipitation rate of the squall line, while slightly improving the area and precipitation of the stratiform region. Within the mixed-phase layer in both the convective and stratiform regions of the squall line, ice-ice collisional breakup is the dominant process to generate ice crystals. In contrast, rime splintering generates an order of magnitude fewer ice crystals than ice-ice collisional breakup, while freezing drop shattering plays a negligible role due to the lack of large drops. Ice multiplication through ice-ice collisional breakup and rime splintering produces numerous snowflakes and graupel. This leads to enhanced depositional growth and weaker riming, which in turn weakens rime splintering. It is recommended to add SIP parameterization to the model. Full article
(This article belongs to the Section Atmospheric Techniques, Instruments, and Modeling)
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12 pages, 4139 KiB  
Article
Estimation of Compressive Resistance of Briquettes Obtained from Groundnut Shells with Different Machine Learning Algorithms
by Abdulkadir Kocer, Onder Kabas and Bianca Stefania Zabava
Appl. Sci. 2023, 13(17), 9826; https://doi.org/10.3390/app13179826 - 30 Aug 2023
Cited by 3 | Viewed by 1783
Abstract
Briquetting is considered one of the pre-treatment methods available to produce raw materials of uniform size and moisture content that are easy to process, transport, and store. The quality of briquettes in terms of density and strength depends on the physical and chemical [...] Read more.
Briquetting is considered one of the pre-treatment methods available to produce raw materials of uniform size and moisture content that are easy to process, transport, and store. The quality of briquettes in terms of density and strength depends on the physical and chemical properties of the raw material and the briquetting conditions. However, determining briquette quality is difficult, very costly, and requires long laboratory studies. In this paper, an easy, inexpensive, and fast methodology based on machine learning for the determination of quality parameters of briquette samples is presented. Compressive resistance, one of the most important briquette quality parameters, was estimated by machine learning methods, considering particle size, material moisture, applied pressure value, briquette density, shatter index, and tumbler index. Extra Trees, Random Forest, and Light Gradient Boosting regression models were used. The best estimate is seen in the Extra Trees regression model. The R2 and MAPE values are 0.76 and 0.0799, respectively. Full article
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14 pages, 4844 KiB  
Article
Construction of an Accurate Wheat-Grain Model Based on X-ray Tomography and Bonding Parameters by Discrete Element
by Ying Zhou, Wenyu Shang, Yanbo Hui, Chuang Shi, Ju Gao, Yongzhen Zhang, Juanjuan Liu, Dongdong Cheng and Kang Zhu
Appl. Sci. 2023, 13(16), 9265; https://doi.org/10.3390/app13169265 - 15 Aug 2023
Cited by 4 | Viewed by 1557
Abstract
There will be great damage in the process of harvesting, transporting, and storing after grain matures. The injury rate is as high as 8% to 12%. After damage, the germination rate of the grain becomes lower, the quality decreases, and it is easily [...] Read more.
There will be great damage in the process of harvesting, transporting, and storing after grain matures. The injury rate is as high as 8% to 12%. After damage, the germination rate of the grain becomes lower, the quality decreases, and it is easily infected with pests and molds. This study of the grain-crushing characteristics is of great significance to ensure grain quality, and an accurate crushing model is a prerequisite for effectively simulating crushing characteristics. This paper studies the shattering characteristics of wheat grains. Two-dimensional slices of wheat grain were obtained using X-ray tomography technology. Then, an accurate three-dimensional outer contour model of the wheat particle was constructed using image filtering and segmentation algorithms. The particle filling process was conducted using EDEM 2018 software to establish a wheat particle simulation model based on the Hertz–Mindlin with a Bonding contact model. Using the DOE experimental design method, single-factor experiments, Plackett–Burman experiments, steepest-climb experiments, and Box–Behnken were designed to study the fragmentation characteristics of wheat particles combined with parameter calibration and physical experiments. The test results show that the normal stiffness per unit area is 7.392 × 1010 N/m3, critical normal stress is 5.293 × 106 Pa, critical tangential stress is 5.001 × 106 Pa, and the relative error about 3%, which verifies the reliability of the simulation parameters in the discrete-element crushing model of wheat grain. This study focuses on two essential aspects: 1. establishing an accurate wheat-grain contour model; and 2. calibrating the bonding parameters of the discrete-element simulation model of wheat grain. The wheat grain discrete-element crushing model and the calibration of its bonding parameters are constructed to provide a foundation for the study of wheat-grain crushing characteristics. It is of great significance to study the situation of wheat grains and where cracks are produced. In this paper, an accurate model of the wheat-grain contour is established, and the bonding parameters of the discrete-element simulation model of the wheat grain are calibrated. The calibration of the model of the discrete elements of wheat-grain fragmentation and its bonding parameters will provide a basis for studying the crushing characteristics of wheat grain. Understanding the condition of wheat grains and the causes of cracks carries significant academic significance. Full article
(This article belongs to the Section Agricultural Science and Technology)
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27 pages, 3506 KiB  
Review
A Review of Biomaterials and Associated Performance Metrics Analysis in Pre-Clinical Finite Element Model and in Implementation Stages for Total Hip Implant System
by Md Mohiuddin Soliman, Muhammad E. H. Chowdhury, Mohammad Tariqul Islam, Farayi Musharavati, Mohammad Nabil, Muhammad Hafizh, Amith Khandakar, Sakib Mahmud, Erfan Zal Nezhad, Md Nazmul Islam Shuzan and Farhan Fuad Abir
Polymers 2022, 14(20), 4308; https://doi.org/10.3390/polym14204308 - 13 Oct 2022
Cited by 26 | Viewed by 9008
Abstract
Total hip replacement (THR) is a common orthopedic surgery technique that helps thousands of individuals to live normal lives each year. A hip replacement replaces the shattered cartilage and bone with an implant. Most hip implants fail after 10–15 years. The material selection [...] Read more.
Total hip replacement (THR) is a common orthopedic surgery technique that helps thousands of individuals to live normal lives each year. A hip replacement replaces the shattered cartilage and bone with an implant. Most hip implants fail after 10–15 years. The material selection for the total hip implant systems is a major research field since it affects the mechanical and clinical performance of it. Stress shielding due to excessive contact stress, implant dislocation due to a large deformation, aseptic implant loosening due to the particle propagation of wear debris, decreased bone remodeling density due to the stress shielding, and adverse tissue responses due to material wear debris all contribute to the failure of hip implants. Recent research shows that pre-clinical computational finite element analysis (FEA) can be used to estimate four mechanical performance parameters of hip implants which are connected with distinct biomaterials: von Mises stress and deformation, micromotion, wear estimates, and implant fatigue. In vitro, in vivo, and clinical stages are utilized to determine the hip implant biocompatibility and the unfavorable local tissue reactions to different biomaterials during the implementation phase. This research summarizes and analyses the performance of the different biomaterials that are employed in total hip implant systems in the pre-clinical stage using FEA, as well as their performances in in vitro, in vivo, and in clinical studies, which will help researchers in gaining a better understanding of the prospects and challenges in this field. Full article
(This article belongs to the Special Issue Machine Learning Applications in Polymeric Biomaterials)
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14 pages, 10834 KiB  
Article
An Online Detection Method for Coal Dry Screening Based on Image Processing and Fractal Analysis
by Deyi He and Chusheng Liu
Appl. Sci. 2022, 12(13), 6463; https://doi.org/10.3390/app12136463 - 25 Jun 2022
Cited by 4 | Viewed by 1868
Abstract
In coal dry screening, online detection for screening efficiency is a significant challenge. Notwithstanding, the method of image processing is strenuous to implement in this field due to the complex surface texture of shattered coal. This method identifies the fractal phenomenon before and [...] Read more.
In coal dry screening, online detection for screening efficiency is a significant challenge. Notwithstanding, the method of image processing is strenuous to implement in this field due to the complex surface texture of shattered coal. This method identifies the fractal phenomenon before and after coal screening is discovered for the indirect detection of screening efficiency. For better fractal dimension distribution, an image denoising and filter method for wiping off the coal image surface texture is applied. Additionally, an enhanced Kirsch edge-detection algorithm is employed to obtain coal particle edges. Furthermore, the relation between fractal dimension and screening efficiency is presented by using the box-counting method. In this research, we skilfully transform the tough problem of image detection for particle size distribution into the calculation of the fractal dimension of the coal-edge image, and closely associate the fractal dimension with screening efficiency. With this method, it will be easier to predict the screening efficiency in real-time. Full article
(This article belongs to the Section Applied Industrial Technologies)
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28 pages, 8305 KiB  
Article
The Impacts of Single-Scattering and Microphysical Properties of Ice Particles Smaller Than 100 µm on the Bulk Radiative Properties of Tropical Cirrus
by Seonghyeon Jang, Jeonggyu Kim, Greg M. McFarquhar, Sungmin Park, Suji Han, Seoung Soo Lee, Chang Hoon Jung, Heejung Jung, Ki-Ho Chang, Woonseon Jung and Junshik Um
Remote Sens. 2022, 14(13), 3002; https://doi.org/10.3390/rs14133002 - 23 Jun 2022
Cited by 1 | Viewed by 2254
Abstract
There are large uncertainties in the single-scattering (i.e., morphologies) and microphysical (i.e., concentrations) properties of ice particles whose size are less than ~100 µm. Insufficient resolutions of the most advanced cloud probes (e.g., cloud particle imager) cannot resolve the micrometer-scale morphologies of small [...] Read more.
There are large uncertainties in the single-scattering (i.e., morphologies) and microphysical (i.e., concentrations) properties of ice particles whose size are less than ~100 µm. Insufficient resolutions of the most advanced cloud probes (e.g., cloud particle imager) cannot resolve the micrometer-scale morphologies of small ice particles. Further, the shattering of large ice particles on probes’ inlets or tips causes uncertainties in the measurement of the concentrations of small ice particles. These uncertainties have large impacts on the single-scattering and microphysical properties of small ice particles that are utilized to quantify the bulk radiative properties of cirrus. In this study, the impacts of uncertainties in the morphologies and concentrations of small ice particles on the bulk radiative properties of tropical cirrus were calculated using measurements acquired during the Tropical Warm Pool-International Cloud Experiment. Five different models (i.e., budding Buckyball, Chebyshev particle, droxtal, Gaussian random sphere, and sphere) that represent the shapes of small ice particles were used to calculate the single-scattering properties. The bulk radiative properties, average phase-function (P11¯), and average asymmetry parameter (g¯) were computed by combining the measured size/habit distributions and the calculated single-scattering properties of ice particles. The impacts of the selection of varying morphologies of small particles on the bulk radiative properties were quantified. For these calculations, the possible range of the concentrations of small ice particles which depend on the degree of shattered large particles were also used. The impacts of varying the single-scattering properties of small ice particles on the bulk radiative properties were the largest in the upper parts of cirrus (T < −60 °C), while they were the smallest in the lower parts of cirrus (−45 < T < −30 °C). The impacts of uncertainties in the concentrations of small ice particles on the bulk radiative properties were largest in the lower parts of cirrus (−45 < T < −30 °C), whereas they were smallest in the upper parts of cirrus (T < −60 °C). The effect of shattering was maximum in the lower parts of cirrus, whilst it was minimum in the upper parts of cirrus. The combined impacts of uncertainties in the single-scattering (i.e., morphologies) and microphysical (i.e., concentrations) properties of small ice particles revealed variations of up to 11.2% (127.1%; 67.3%) of the integrated intensity in the forward (sideward; backward) angles in P11¯ and a corresponding change in g¯ by up to 12.61%. Full article
(This article belongs to the Special Issue Scattering by Ice Crystals in the Earth's Atmosphere)
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17 pages, 32328 KiB  
Article
Towards Transient Electronics through Heat Triggered Shattering of Off-the-Shelf Electronic Chips
by Shashank Pandey and Carlos Mastrangelo
Micromachines 2022, 13(2), 242; https://doi.org/10.3390/mi13020242 - 31 Jan 2022
Cited by 5 | Viewed by 2447
Abstract
With most of the critical data being stored in silicon (Si) based electronic devices, there is a need to develop such devices with a transient nature. Here, we have focused on developing a programmable and controllable heat triggered shattering transience mechanism for any [...] Read more.
With most of the critical data being stored in silicon (Si) based electronic devices, there is a need to develop such devices with a transient nature. Here, we have focused on developing a programmable and controllable heat triggered shattering transience mechanism for any off-the-shelf (OTS) Si microchip as a means to develop transient electronics which can then be safely and rapidly disabled on trigger when desired. This transience mechanism is based on irreversible and spontaneous propagation of cracks that are patterned on the back of the OTS chip in the form of grooves and then filled with thermally expandable (TE) material. Two types of TE materials were used in this study, commercially available microsphere particles and a developed elastomeric material. These materials expand >100 times their original volume on the application of heat which applies wedging stress of the groove boundaries and induces crack propagation resulting in the complete shattering of the OTS Si chip into tiny silicon pieces. Transience was controlled by temperature and can be triggered at ~160–190 °C. We also demonstrated the programmability of critical parameters such as transience time (0.35–12 s) and transience efficiency (5–60%) without the knowledge of material properties by modeling the swelling behavior using linear viscoelastic models. Full article
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13 pages, 2813 KiB  
Article
Differences in the Ice Particle Shattering Impact on the CIP Measurements in the Stratiform Cloud Region and the Embedded Convection Region
by Minsong Huang
Water 2021, 13(17), 2322; https://doi.org/10.3390/w13172322 - 25 Aug 2021
Cited by 2 | Viewed by 2320
Abstract
Stratiform clouds with embedded convective cells is an important precipitation system. Precise knowledge of the cloud’s microphysical structure can be useful for the development of a numerical weather prediction model and precipitation enhancement. Airborne measurement is one of the important ways for determining [...] Read more.
Stratiform clouds with embedded convective cells is an important precipitation system. Precise knowledge of the cloud’s microphysical structure can be useful for the development of a numerical weather prediction model and precipitation enhancement. Airborne measurement is one of the important ways for determining the microphysical structure of clouds. However, cloud particle shattering during measurement poses a serious problem to the measured microphysical characterization of clouds. In order to study the different influences of the shattered ice particles on the standard cloud imaging probe (CIP) measurement in the stratiform cloud region and the convective cloud region, a time-variant threshold method to identify the shattered fragments is presented. After application of this algorithm, the shattered fragments were recognized and their impacts on the particle size distribution (PSD), particle number concentration and ice water content measurement were analyzed. It was found that the shattering effect on the PSD decreases with the increasing size of less than 400 μm, fluctuates between 400 μm and 1000 μm and slightly increases with the increasing size of larger than 1000 μm on average in a stratiform region and a convective region. However, the average ratio of PSD uncorrected to that corrected for shattering events using the presented algorithm in convective clouds is larger than that in the stratiform regions in the whole size, and nearly twice that in the size of less than 1000 μm. The measured number concentration can be overestimated by up to a factor of 3.9 on average in a stratiform region, while in a convective region, it is 7.7, nearly twice that of a stratiform region. The ice water content in a stratiform region can be overestimated by 29.5% on average, but by 60.7% in a convective region. These findings can be helpful for the cloud physics community to use the airborne CIP measurement data for numerical weather and climate models. Full article
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17 pages, 1566 KiB  
Review
Effect of COVID-19 on Lungs: Focusing on Prospective Malignant Phenotypes
by Pritam Sadhukhan, M. Talha Ugurlu and Mohammad O. Hoque
Cancers 2020, 12(12), 3822; https://doi.org/10.3390/cancers12123822 - 18 Dec 2020
Cited by 36 | Viewed by 10223
Abstract
Currently, the healthcare management systems are shattered throughout the world, even in the developed nations due to the COVID-19 viral outbreak. A substantial number of patients infected with SARS-CoV2 develop acute respiratory distress syndrome (ARDS) and need advanced healthcare facilities, including invasive mechanical [...] Read more.
Currently, the healthcare management systems are shattered throughout the world, even in the developed nations due to the COVID-19 viral outbreak. A substantial number of patients infected with SARS-CoV2 develop acute respiratory distress syndrome (ARDS) and need advanced healthcare facilities, including invasive mechanical ventilation. Intracellular infiltration of the SARS-CoV2 virus particles into the epithelial cells in lungs are facilitated by the spike glycoprotein (S Protein) on the outer side of the virus envelope, a membrane protein ACE2 (angiotensin-converting enzyme 2) and two proteases (TMPRSS2 and Furin) in the host cell. This virus has unprecedented effects on the immune system and induces a sudden upregulation of the levels of different pro-inflammatory cytokines. This can be a cause for the onset of pulmonary fibrosis in the lungs. Existence of a high concentration of inflammatory cytokines and viral load can also lead to numerous pathophysiological conditions. Although it is well established that cancer patients are among the high-risk population due to COVID-19-associated mortality, it is still unknown whether survivors of COVID-19-infected subjects are at high-risk population for developing cancer and whether any biologic and clinical features exist in post-COVID-19 individuals that might be related to carcinogenesis. Full article
(This article belongs to the Collection The Impact of COVID-19 Infection in Cancer)
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19 pages, 3310 KiB  
Article
Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering—A Critical Risk for Chromothripsis
by Antonio Pantelias, Demetre Zafiropoulos, Roberto Cherubini, Lucia Sarchiapone, Viviana De Nadal, Gabriel E. Pantelias, Alexandros G. Georgakilas and Georgia I. Terzoudi
Cancers 2020, 12(9), 2336; https://doi.org/10.3390/cancers12092336 - 19 Aug 2020
Cited by 9 | Viewed by 4943
Abstract
For precision cancer radiotherapy, high linear energy transfer (LET) particle irradiation offers a substantial advantage over photon-based irradiation. In contrast to the sparse deposition of low-density energy by χ- or γ-rays, particle irradiation causes focal DNA damage through high-density energy deposition along the [...] Read more.
For precision cancer radiotherapy, high linear energy transfer (LET) particle irradiation offers a substantial advantage over photon-based irradiation. In contrast to the sparse deposition of low-density energy by χ- or γ-rays, particle irradiation causes focal DNA damage through high-density energy deposition along the particle tracks. This is characterized by the formation of multiple damage sites, comprising localized clustered patterns of DNA single- and double-strand breaks as well as base damage. These clustered DNA lesions are key determinants of the enhanced relative biological effectiveness (RBE) of energetic nuclei. However, the search for a fingerprint of particle exposure remains open, while the mechanisms underlying the induction of chromothripsis-like chromosomal rearrangements by high-LET radiation (resembling chromothripsis in tumors) await to be elucidated. In this work, we investigate the transformation of clustered DNA lesions into chromosome fragmentation, as indicated by the induction and post-irradiation repair of chromosomal damage under the dynamics of premature chromosome condensation in G0 human lymphocytes. Specifically, this study provides, for the first time, experimental evidence that particle irradiation induces localized shattering of targeted chromosome domains. Yields of chromosome fragments and shattered domains are compared with those generated by γ-rays; and the RBE values obtained are up to 28.6 for α-particles (92 keV/μm), 10.5 for C-ions (295 keV/μm), and 4.9 for protons (28.5 keV/μm). Furthermore, we test the hypothesis that particle radiation-induced persistent clustered DNA lesions and chromatin decompaction at damage sites evolve into localized chromosome shattering by subsequent chromatin condensation in a single catastrophic event—posing a critical risk for random rejoining, chromothripsis, and carcinogenesis. Consistent with this hypothesis, our results highlight the potential use of shattered chromosome domains as a fingerprint of high-LET exposure, while conforming to the new model we propose for the mechanistic origin of chromothripsis-like rearrangements. Full article
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16 pages, 61439 KiB  
Article
Microscopic Characterization of the Brazilian Giant Samba Virus
by Jason R. Schrad, Eric J. Young, Jônatas S. Abrahão, Juliana R. Cortines and Kristin N. Parent
Viruses 2017, 9(2), 30; https://doi.org/10.3390/v9020030 - 14 Feb 2017
Cited by 14 | Viewed by 13431
Abstract
Prior to the discovery of the mimivirus in 2003, viruses were thought to be physically small and genetically simple. Mimivirus, with its ~750-nm particle size and its ~1.2-Mbp genome, shattered these notions and changed what it meant to be a virus. Since this [...] Read more.
Prior to the discovery of the mimivirus in 2003, viruses were thought to be physically small and genetically simple. Mimivirus, with its ~750-nm particle size and its ~1.2-Mbp genome, shattered these notions and changed what it meant to be a virus. Since this discovery, the isolation and characterization of giant viruses has exploded. One of the more recently discovered giant viruses, Samba virus, is a Mimivirus that was isolated from the Rio Negro in the Brazilian Amazon. Initial characterization of Samba has revealed some structural information, although the preparation techniques used are prone to the generation of structural artifacts. To generate more native-like structural information for Samba, we analyzed the virus through cryo-electron microscopy, cryo-electron tomography, scanning electron microscopy, and fluorescence microscopy. These microscopy techniques demonstrated that Samba particles have a capsid diameter of ~527 nm and a fiber length of ~155 nm, making Samba the largest Mimivirus yet characterized. We also compared Samba to a fiberless mimivirus variant. Samba particles, unlike those of mimivirus, do not appear to be rigid, and quasi-icosahedral, although the two viruses share many common features, including a multi-layered capsid and an asymmetric nucleocapsid, which may be common amongst the Mimiviruses. Full article
(This article belongs to the Special Issue Viruses of Protozoa)
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