Search Results (38)

Climate change is projected to increase the intensity and frequency of natural hazards such as heat waves, extreme rainfall, heavy snowfall, typhoons, droughts, floods, and cold waves, potentially impacting the operational safety of critical infrastructure, including nuclear power plants (NPPs). Although quantitative indicators exist to screen-out natural hazards at NPPs, comprehensive methodologies for assessing climate-related hazards remain underdeveloped. Furthermore, given the variability and uncertainty of climate change, it is realistically and resource-wise difficult to evaluate all potential risks quantitatively. Using a structured expert elicitation approach, this study systematically identifies and prioritizes climate-related natural hazards for Korean NPPs. An iterative Delphi survey involving 42 experts with extensive experience in nuclear safety and systems was conducted and also evaluated using the best–worst scaling (BWS) method for cross-validation to enhance the robustness of the Delphi priorities. Both methodologies identified extreme rainfall, typhoons, marine organisms, forest fires, and lightning as the top five hazards. The findings provide critical insights for climate resilience planning, inform vulnerability assessments, and support regulatory policy development to mitigate climate-induced risks to Korean nuclear power plants. Full article

Mycotoxins are toxic secondary metabolites produced by various fungal species, posing significant food safety concerns due to their health impacts and economic burden. Accurate structural elucidation and quantitative analysis are essential for effective risk assessment and regulatory control. This review highlights recent advances in the application of nuclear magnetic resonance (NMR) spectroscopy for the structural and quantitative analysis of major mycotoxins, including aflatoxins, ochratoxins, fumonisins, trichothecenes, and zearalenone. One- and two-dimensional NMR techniques enable precise molecular characterization, positional isomer identification, including modified forms such as masked or conjugated mycotoxins, and toxicity-related molecular interaction investigation. NMR spectroscopy offers superior structural resolution, high reproducibility, and nondestructive analysis, making it invaluable in mycotoxin research. Quantitative NMR spectroscopy has emerged as a robust and accurate method for determining the absolute concentration and purity of mycotoxins, without requiring analyte-specific reference standards, an advantage particularly important for modified toxins lacking commercially available standards. The integration of NMR-based approaches strengthens analytical reliability, supports reference material development, and contributes to enhanced food safety assessment. This review also discusses ongoing analytical challenges and future directions, including the application of artificial intelligence to improve the automation and interpretation of NMR data in mycotoxin research. Full article

The purpose of this paper is to review and compare the criteria of seismic design ground motions and approaches in seismic hazard analysis set forth by various agencies and organizations. A total of 13 agencies and organizations were reviewed including three for non-dam structures. It was found the both the deterministic and probabilistic seismic hazard analysis approaches have been used. Many have combined the two approaches to complement each other. High-consequence dams are designed for a long ground motion return period of approximately 10,000 years, which lies between the design return periods of bridges and nuclear power plants. In contrast to other agencies and organizations, U.S. Bureau of Reclamation dams are not subjected to specific design return periods; they are designed based on risk-informed decisions, which consider the failure probability in relation to the public protection guideline values. In addition, criteria from the Reclamation Design Standards are to be followed in any dam modifications. Based on the findings of this paper, it was deemed that the current Reclamation dam safety decisions and practices are in general agreement with other dam agencies and organizations that also adopt the risk-informed decision process. Full article

Uranium–niobium (U-Nb) alloys, used in a variety of industrial and energy applications that require high density, ductility, and good corrosion resistance, comprise a highly complex, multiphasic system with a phase diagram well established through decades of extensive experimental and theoretical research. They are also one of the best candidates for a metallic fuel alloy with high-temperature strength sufficient to support the core, acceptable nuclear properties, good fabricability, and compatibility with usable coolant media. The key factor determining the performance and safety of a metallic fuel such as U-Nb is its operational limits in the application environment, which are closely related to material’s structure and thermodynamic stability. They are in turn closely related to the ambient (zero-pressure) melting point $\left(T_m\right);$ thus, $T_m$ is an important engineering parameter. However, the current knowledge of $T_m$ of the U-Nb system is limited, as the only experimental study of its Nb-rich portion dates back to 1958. In addition, it has not yet been adequately modeled based on general thermodynamics principles or using an equation-of-state approach. In this study, we present a theoretical model for the melting curve (liquidus) of a mixture, and apply it to U-Nb, which is considered as a mixture of pure U and pure Nb. The model uses the known melting curves of pure constituents as an input and predicts the melting curve of their mixture. It has only one free parameter, which must be determined independently. The ambient liquidus of U-Nb predicted by the model appears to be in good agreement with the available experimental data. We calculate the melting curve (the pressure dependence of $T_m$) of pure U using ab initio quantum molecular dynamics (QMD), the knowledge of which is required for obtaining the model parameters for U. We also generalize the new model to nonzero pressure and consider the melting curve of U-6 wt.% Nb (U-6Nb) alloy as an example. The melting curve of U-6Nb alloy predicted by the model appears to be in good agreement with the ab initio melting curve obtained from our QMD simulations. We suggest that the U-18Nb alloy can be considered as a proxy for protactinium (Pa) and demonstrate that the melting curves of U-18Nb and Pa are in good agreement with each other. Full article

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation and progressive joint destruction. Recent data underscore oxidative stress as a primary factor in the pathophysiology of rheumatoid arthritis, intensifying inflammatory processes and tissue damage via the overproduction of reactive oxygen species (ROS) and compromised antioxidant defenses. Current therapies, including disease-modifying antirheumatic drugs (DMARDs), primarily target immune dysregulation but fail to address oxidative stress, necessitating novel adjunctive treatment strategies. This review explores the potential of antioxidant-based therapies as complementary approaches to RA management. Natural compounds such as curcumin, resveratrol, sulforaphane, and propolis exhibit strong anti-inflammatory and antioxidative properties by modulating redox-sensitive pathways, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase (HO-1). N-acetylcysteine (NAC) replenishes intracellular glutathione, enhancing cellular resilience against oxidative stress. Additionally, molecular hydrogen (H₂) selectively neutralizes harmful ROS, reducing oxidative damage and inflammation. The role of vitamin supplementation (D, B12, C, and K) in regulating immune responses and protecting joint structures is also discussed. This review aims to evaluate the efficacy and potential clinical applications of antioxidant therapies in RA, emphasizing their role in mitigating oxidative damage and improving treatment outcomes. While preliminary findings are promising, further clinical trials are needed to establish standardized dosing, long-term safety, and their integration into current RA treatment protocols. Full article

This study presents a method to add a crack analysis algorithm to the Acoustic Leak Monitoring System (ALMS) to detect and evaluate the crack growth process in the primary system piping of nuclear power plants. To achieve this, a fracture test was conducted by applying stepwise loading to welded specimens that simulate the cold leg section, and acoustic emission (AE) signals were measured in relation to the increase in strain using an AE testing system. The experimental results indicated that the stability and instability of cracks could be assessed through the Kaiser effect and the Felicity effect when detecting crack growth using AE signals. Additionally, by utilizing both root mean square (RMS) and amplitude parameters simultaneously to calculate the b-value, it was confirmed that the RMS-based b-value minimizes the effects of AE signal attenuation and allows for a more stable assessment of crack progression. This demonstrates that the RMS, which reflects signal energy, is effective for real-time monitoring of the crack growth state. Finally, the results of this study suggest the potential for real-time crack monitoring using AE data in piping systems of critical structures, such as nuclear power plants; by adding a simple AE analysis method to the ALMS system, a practical approach has been derived that enhances the safety of the structure and allows for quantitative assessment of crack progression. Future research is expected to further refine the AE parameters and algorithms, leading to the advancement of safety monitoring systems in various industrial settings. Full article

Dezocine, which is well-known as an analgesic, had about 45% share of the Chinese opioid analgesic market. Since drug products containing impurities could bring serious health consequences, it was important to control the generation of impurities and degradation products in the dezocine product. In this study, two kinds of photodegradation products (i.e., degradation product 1 and degradation product 2) in the dezocine injection were isolated using high-performance liquid chromatography. The possible structures of the photodegradation products were identified using both high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy. In addition, the possible generation mechanism showed that degradation product 1 was the oxidation product of dezocine, and degradation product 2 was the coupled dimer of dezocine. Finally, we found that the degradation rate of dezocine increased with the increase in light intensity. Moreover, the degradation of dezocine easily occurred under ultraviolet light in comparison with visible light. A deeper insight into the generation of the photodegradation products in the dezocine injection would directly contribute to the safety of drug therapy based on the dezocine injection by minimizing the degradant/impurity-related adverse effects of drug preparations. Full article

Over 50% of nuclear power plants (NPPs) worldwide have operated for over three decades, leading to a surge in decommissioning projects. This study addresses the gap in current guidelines by analyzing risks in nuclear decommissioning. Using the fuzzy-AHP technique, tasks within dismantling radioactive concrete structures are prioritized. Findings reveal structural and human-related risks across five main cutting tasks. Collision emerges as a significant concern, particularly during wire saw installation and concrete block hoisting hole creation. Subcategory risk priorities highlight variations in risk across tasks, with jamming, falling, and falling objects identified as top concerns during wire saw transportation. This study emphasizes the importance of comprehensive risk assessment in enhancing safety during decommissioning. It underscores the need to consider both physical risks and risks to personnel throughout the process. By prioritizing safety, stakeholders can ensure worker safety and operational efficiency while minimizing hazards. This research contributes to standardized safety protocols for nuclear decommissioning worldwide, aligning with sustainable energy practices. The outcomes offer practical insights for safety manual development and decision-making processes. This study represents progress in ensuring safety during nuclear decommissioning, paving the way for further refinement of safety protocols and guidelines tailored to decommissioning sites. Full article

Glycidyl azide polymer (GAP)-based polyurethane is an ideal elastomeric matrix for high-energy, low-smoke, and insensitive solid propellants. As the skeleton structure of GAP propellants, changes in the structure and properties of GAP elastomers during aging lead to the deterioration of propellant performance (especially in relation to mechanical properties), which causes safety risks. A high-temperature-accelerated aging experiment (70 °C) on a GAP elastomer was conducted. The evolution of the microstructure of the GAP elastomer system was analyzed by Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy (NMR), and variations in the macroscopic properties were analyzed by the hardness test and the uniaxial tensile test. The experimental results showed that thermal aging of the GAP elastomer is a coupled process of multiple chemical reactions. The azide groups, urethane groups, and ether bonds were the weak links in the network structure, breaking during the aging process, and the crosslinking density rose and then decreased. Macroscopic properties also showed segmented changes. The aging process was divided into three stages: post-curing (stage one); when the crosslinked network began to break (stage two), and when the crosslinked network was destroyed (stage three). Changes in the microstructure and macroscopic properties were consistent. This work is of great significance for exploring the aging mechanism of GAP propellants and extending their storage life. Full article

Hypertrophic cardiomyopathy (HCM) is characterized by abnormal growth of the myocardium with myofilament disarray and myocardial hyper-contractility, leading to left ventricular hypertrophy and fibrosis. Where culprit genes are identified, they typically relate to cardiomyocyte sarcomere structure and function. Multi-modality imaging plays a crucial role in the diagnosis, monitoring, and risk stratification of HCM, as well as in screening those at risk. Following the recent publication of the first European Society of Cardiology (ESC) cardiomyopathy guidelines, we build on previous reviews and explore the roles of electrocardiography, echocardiography, cardiac magnetic resonance (CMR), cardiac computed tomography (CT), and nuclear imaging. We examine each modality’s strengths along with their limitations in turn, and discuss how they can be used in isolation, or in combination, to facilitate a personalized approach to patient care, as well as providing key information and robust safety and efficacy evidence within new areas of research. Full article

Nuclear safety-related structures are crucial for ensuring the safety of nuclear facilities and preventing the leakage of radioactive materials, with the primary structural component being low-rise reinforced concrete (LRC) walls. These walls are required to carry combined in-plane axial and horizontal loads, making the accurate prediction of their lateral load-carrying capacity particularly important. In this study, six LRC walls with aspect ratios between 0.33 and 1 were tested and a model for the prediction of the lateral load-carrying capacity of LRC walls was established based on the observed failure mode and plastic limit theory. The parameter in the model was calibrated using the obtained results in this test along with a database containing 131 walls in the literature. Compared to the equations in the American standard ACI 349 and the French standard RCC-CW, the proposed equation is most suitable for assessing the lateral load-carrying capacity of LRC walls in nuclear safety-related structures. The calculated values of the proposed equation exhibit a ratio closest to 1 when compared to experimental values and possess the minimum degree of variation. The computational results reveal that the proposed equations in this study exhibit superior precision and stability. Full article

Conditioning of radioactive waste generated from the operation of medical institutions, nuclear cycle facilities, and nuclear facilities is important for the safety of the environment. One of the most hazardous radionuclides is radioactive cesium. There is a need for more effective solutions to contain radionuclides, especially cesium (Cs+). Geopolymers are promising inorganic materials that can provide a large active surface area with adjustable porosity and binding capacity. The existence of nanosized zeolite-like structures in aluminosilicate gels was shown earlier. These structures are candidates for immobilizing radioactive cesium (Cs⁺). However, the mechanisms of their interactions with the aluminosilicate framework related to radionuclide immobilization have not been well studied. In this work, the influence of alkaline cations (Na⁺ or K⁺) and the aluminosilicate framework structure on the binding capacity and mechanism of interaction of geopolymers with Cs⁺ is explored in the example of a sodalite framework. The local structure of the water molecules and alkaline ions in the equilibrium state and its behavior when the Si/Al ratio was changed were studied by DFT. Full article

Allergies related to kiwi consumption have become a growing health concern, with their prevalence on the rise. Many of these allergic reactions are attributed to cross-reactivity, particularly with the major allergen found in birch pollen. This cross-reactivity is associated with proteins belonging to the pathogenesis-related class 10 (PR-10) protein family. In our study, we determined the three-dimensional structures of the two PR-10 proteins in gold and green kiwi fruits, Act c 8 and Act d 8, using nuclear magnetic resonance (NMR) spectroscopy. The structures of both kiwi proteins closely resemble the major birch pollen allergen, Bet v 1, providing a molecular explanation for the observed immunological cross-reactivity between kiwi and birch pollen. Compared to Act d 11, however, a kiwi allergen that shares the same architecture as PR-10 proteins, structural differences are apparent. Moreover, despite both Act c 8 and Act d 8 containing multiple cysteine residues, no disulfide bridges are present within their structures. Instead, all the cysteines are accessible on the protein’s surface and exposed to the surrounding solvent, where they are available for reactions with components of the natural food matrix. This structural characteristic sets Act c 8 and Act d 8 apart from other kiwi proteins with a high cysteine content. Furthermore, we demonstrate that pyrogallol, the most abundant phenolic compound found in kiwi, binds into the internal cavities of these two proteins, albeit with low affinity. Our research offers a foundation for further studies aimed at understanding allergic reactions associated with this fruit and exploring how interactions with the natural food matrix might be employed to enhance food safety. Full article

The radiation effect of materials is very important and directly related to the safety and reliability of nuclear reactors. Polymer materials, one of the indispensable materials in nuclear power equipment, must withstand the ordeal of high-energy ionizing rays. In this work, through screening different γ-ray dose irradiation conditions, we systematically and comprehensively study the changes in the structure and properties of nitrile butadiene rubber (NBR) before and after γ-ray static irradiation at a high dose rate, and master the rule and mechanism of the γ-ray static irradiation effect of these polymer materials. The mapping relationship between the macroscopic properties, microstructure, and irradiation dose of NBR is accurately characterized. With an increase in total irradiation dose, the C=C double bond reaction occurs, and the C≡N bond, C=C, and C=O participate in the hyper crosslinking reaction. The glass transition temperature (T_g) increases with the cumulative irradiation amount. With the increased total irradiation amount, the degree of rubber cross-linking increases, causing an increased crystallinity and decomposition temperature. A growing amount of gamma irradiation causes the mechanical properties of the rubber to degrade simultaneously, increasing the shore hardness while decreasing the tensile strength and ultimate elongation at break. When the cumulative amount reaches 1 MGy, the ultimate elongation at break decreases significantly. A cumulative dose of radiation resistance of 4 MGy can be achieved by the samples. This work can provide theoretical and experimental support for the long-term stability of nitrile butadiene rubber and its derivatives in nuclear radiation fields and space radiation conditions. Full article

In order to compare and analyze the seismic response characteristics of a safety-related nuclear structure on a non-rock site in the condition of raft and pile group foundations under unidirectional and multidirectional seismic motion input, a large-scale shaking table test of the soil-nuclear structure system was carried out in this paper. In the test, the soil was uniform silted clay, and the shear wave velocity was 213 m/s. Considering the similarity of the superstructure natural frenquency, the actual nuclear power structure was simplified to a three-story frame shear wall structure model. The annular laminated shear model box was used to take the boundary effect of soil into consideration; the seismic motions = were input in only one horizontal direction or three directions at the same time for the shaking table test, and the results were analyzed. The results of the test show that the acceleration response of the safety-related nuclear plant is affected by the directions of input seismic motion and the forms of the foundation. When the seismic motion is input simultaneously in three directions, the acceleration responses of the horizontal motion and vertical rocking of the safety-related plant are larger than those of the single-direction input. The acceleration response of the horizontal motion and vertical rocking of the safety-related structure with the pile group foundation is smaller than that with the raft foundation. The values of most frequency bands in the horizontal acceleration Fourier amplitude spectrum at the top of the pile-foundation structure are smaller than that at the top of the raft-foundation structure, while the displacement is basically the same as that of the raft-foundation structure. This is related to the relation between the frequency component of input seismic motion and the natural frequency of the structure system. Therefore, it is more reasonable to use three-dimensional seismic input in the seismic response analysis of nuclear power plants. The seismic performance of nuclear power plants can be enhanced by using pile group foundations. Full article