Search Results (15,761)

Background: Bioactive composite resins combine the esthetic and mechanical properties of resin composites with therapeutic functions such as ion release, remineralization, and caries inhibition. While in vitro studies suggest promising bioactivity, their clinical performance in permanent teeth remains uncertain. Objective: This systematic review and meta-analysis critically appraised randomized controlled trials and prospective clinical studies to determine whether bioactive composites offer superior clinical performance compared to conventional resin composites and glass ionomer-based materials. Methods: Electronic databases (PubMed/MEDLINE, Scopus, Web of Science, Google Scholar) were searched for eligible studies (2018–2025). Clinical outcomes assessed restoration survival, marginal integrity, secondary caries, postoperative sensitivity, and esthetic outcomes (color match). Data were pooled using a random-effects model, and risk of bias was assessed with Cochrane criteria. Results: Twenty-two trials met the inclusion criteria. No significant differences were found between bioactive and control restorations for survival/retention (RD = 0.01; 95% CI, –0.01 to 0.03), marginal adaptation (RD = 0.02; 95% CI, –0.02 to 0.06), secondary caries (RD = 0.01; 95% CI, –0.01 to 0.03), or postoperative sensitivity (RD = 0.01; 95% CI, –0.02 to 0.04), with negligible heterogeneity (I² = 0–4%). For color match, glass ionomer restorations showed significantly poorer outcomes (RD = –0.23; 95% CI, –0.31 to –0.14; p < 0.00001; I² = 98%), while conventional resin composites had a slight but significant advantage over bioactive composites (RD = 0.07; 95% CI, 0.02 to 0.12; p = 0.003; I² = 76%). Most studies presented moderate risk of bias and short-term follow-up (<36 months). Conclusions: Current evidence indicates that bioactive composites perform comparably, but not superior, to conventional restoratives in permanent teeth. The discrepancy between laboratory bioactivity and clinical effectiveness highlights the need for long-term, well-designed clinical trials with standardized outcome reporting. Full article

To evaluate the application potential of bamboo in cold regions, this study systematically compared the differences in the effects of freeze–thaw cycles on the longitudinal compressive properties of moso bamboo (Phyllostachys edulis) and Chinese fir (Cunninghamia lanceolata). By subjecting the materials to 0, 5, and 10 standard freeze–thaw cycles, the evolution patterns were analyzed from three aspects: mechanical properties, failure modes, and apparent color. The results show that bamboo exhibits significantly superior freeze–thaw resistance: after 10 cycles, bamboo retained 95.4% of its compressive strength (decreasing from 50.2 MPa to 47.9 MPa), whereas the strength of Chinese fir decreased by 14.2% (from 46.7 MPa to 40.0 MPa). The elastic modulus of bamboo remained stable, while that of Chinese fir decreased by 30.86%. Load–displacement curves revealed that bamboo displayed a ductile plateau after failure, whereas Chinese fir exhibited a linear drop-off. Analysis of failure modes further highlighted the intrinsic differences between the materials: bamboo primarily underwent progressive buckling of fiber bundles, forming typical accordion-like folds; Chinese fir mainly showed brittle failures such as end crushing and longitudinal splitting. Color characterization indicated that the lightness index L of the bamboo outer skin (bamboo green) decreased by 26.1%, while the chromaticity indices a (red) and b* (yellow) increased significantly, showing the most notable changes; the color of Chinese fir and the bamboo inner skin (bamboo yellow) remained relatively stable. This study demonstrates that natural bamboo outperforms Chinese fir in terms of frost resistance, toughness, and strength retention in the short term. The findings provide important experimental evidence and design references for promoting the application of bamboo in engineering projects in cold regions. Full article

Background/Objectives: NANOBODY^® molecules (VHHs) are attractive vectors for radiopharmaceuticals due to their small size and high target affinity, but rapid clearance and pronounced kidney retention limit their therapeutic applicability. Binding to serum albumin is a widely used strategy to prolong circulation, yet the respective contributions of albumin-binding affinity and molecular format remain insufficiently defined. This study aimed to systematically evaluate how affinity and valency modulate VHH pharmacokinetics. Methods: Four monovalent albumin-binding VHHs spanning nanomolar to micromolar affinities and two bivalent constructs were engineered, generated by fusing an albumin-binding VHH to an irrelevant non-binding VHH. All constructs incorporated a site-specific cysteine for DFO* conjugation, enabling uniform zirconium-89 labeling with high radiochemical purity. Pharmacokinetics were assessed in healthy mice using serial blood sampling and positron emission tomography. Blood and kidney exposure were quantified by non-compartmental analysis. Results: All albumin-binding constructs showed increased systemic exposure and reduced kidney uptake relative to a non-binding control. Nanomolar-affinity binders reached maximal exposure, and further affinity increases (K_D < ~100 nM) did not improve pharmacokinetics, suggesting a threshold. The micromolar binder showed intermediate exposure but still reduced renal retention compared with control. Valency effects were affinity-dependent. They were negligible at high affinity but pronounced at low affinity, where bivalency reduced systemic exposure and increased kidney uptake toward control levels. Conclusions: Albumin binding enables tuning of VHH pharmacokinetics in an affinity-dependent manner. Above an apparent affinity threshold, pharmacokinetics become format independent, whereas below this threshold, molecular format substantially influences systemic and renal disposition. Full article

This study investigated the technological, nutritional, and sensory effects of incorporating soybean flour and radish leaves into steamed manti, with emphasis on moisture-loss kinetics, protein denaturation, true retention (TR), and relative nutrient density (RND). Four formulations were examined: potato control (PC), potato + soy (PS), greens control (GC), and greens + soy (GS). Steaming induced compositional increases in dry matter, ash, protein, and fat due to moisture reduction rather than absolute changes in solids. Greens-based formulations exhibited significantly lower moisture-loss and protein-denaturation rate constants, indicating stronger hydration stability and structural resistance during thermal processing. These kinetic advantages translated into higher TR values for protein and fat in GC and GS compared with potato-based samples. Soy flour substantially increased protein and lipid content and improved dough cohesiveness but did not influence thermal behavior or moisture-loss kinetics within the same matrix. When nutrient delivery was normalized to energy content, soy- and greens-enriched manti showed the highest RND values, reflecting a favorable combination of nutrient retention and lower caloric density. Sensory evaluation confirmed that soy enhanced textural attributes, while radish leaves contributed desirable juiciness and aroma. Overall, the combined use of radish leaves and soybean flour offers a sustainable approach to producing nutrient-dense, sensory-acceptable traditional foods while supporting the valorisation of leafy by-products. Full article

The oily wastewater produced by transformer oil leakage contains pollutants such as mineral oil, metal particles, aged oil and additives, which can disrupt the dissolved oxygen balance in water bodies, pollute soil and endanger human health through the food chain, causing serious environmental pollution. Effective oil–water separation technology is the key to ecological protection and resource recovery. This paper reviews the principles, influencing factors and research progress of traditional (gravity sedimentation, air flotation, adsorption, demulsification) and new (nanocomposite adsorption, metal–organic skeleton materials, superhydrophobic/superlipophilic modified films) transformer oil–water separation technologies. Traditional technologies are mostly applicable to large-particle-free oil and are difficult to adapt to complex matrix wastewater. However, the new technology has significant advantages in separation efficiency (up to over 99.5%), selectivity and cycling stability (with a performance retention rate of over 85% after 20–60 cycles), breaking through the bottlenecks of traditional methods. In the future, it is necessary to develop low-cost and efficient separation technologies, promote the research and development of intelligent responsive materials, upgrade low-carbon preparation processes and their engineering applications, support environmental protection treatment in the power industry and encourage the coupling of material innovation and processes. Full article

The deterioration of concrete hydraulic structures caused by chemical factors, seepage, and environmental stress necessitates advanced protective coatings that enhance durability, flexibility, and environmental sustainability. Conventional protective systems often exhibit limited durability under combined hydraulic, thermal, and chemical stress. In this study, a novel polyfluorosilicone-based coating system is presented, which integrates a deep-penetrating nano-primer for substrate reinforcement, a crack-bridging polymer intermediate layer for impermeability, and a polyfluorosilicone topcoat providing UV and weather resistance. The multilayer architecture addresses the inherent trade-offs between adhesion, flexibility, and durability observed in conventional waterproofing systems. Informed by a mechanistic study of interfacial adhesion and failure modes, the coating exhibits outstanding high mechanical and performance characteristics, including a mean pull-off bond strength of 4.56 ± 0.14 MPa for the fully cured triple-layer coating system, with cohesive failure occurring within the concrete substrate, signifying a bond stronger than the material it protects. The system withstood 2.2 MPa water pressure and 200 freeze–thaw cycles with 87.2% modulus retention, demonstrating stable mechanical and environmental durability. The coating demonstrated excellent resilience, showing no evidence of degradation after 1000 h of UV aging, 200 freeze–thaw cycles, and exposure to alkaline solutions. This water-based formulation meets green-material standards, with low volatile organic compound (VOC) levels and minimal harmful chemicals. The results validate that a multi-scale, layered design strategy effectively decouples and addresses the distinct failure mechanisms in hydraulic environments, providing a robust and sustainable solution. Full article

Froth flotation is a widely used method for the selective separation of particulates from aqueous dispersions or slurries. This technology is based on the attachment of sufficiently hydrophobic particles to the air–water interface of gas bubbles. However, when the target particles are strongly hydrophilic, the requirement of hydrophobicity limits the effectiveness of conventional froth flotation. A prominent example is the deinking step in paper recycling, where modern hydrophilic inkjet inks are difficult to remove by flotation. In this study, we evaluated oil-coated bubble flotation as an alternative to conventional air flotation for removing inkjet ink from pulped newsprint. We examined the effects of oil type, salt type and concentration, and pH on deinking efficiency. Compared with traditional air flotation, oil-coated bubble flotation produced substantial improvements in standard performance metrics, including ISO brightness, effective residual ink concentration (ERIC), and the fiber retention of recycled paper pads. Full article

Autoimmune flares are often accompanied by abrupt surges of circulating plasmablasts—short-lived, high-output antibody-secreting cells generated through extrafollicular B-cell activation in response to microbial cues. Three categories of microbial input appear to repeatedly trigger these “plasmablast storms”: latent herpesvirus reactivations (Epstein–Barr virus, cytomegalovirus, human herpesvirus-6, varicella–zoster virus), acute respiratory or gastrointestinal infections including SARS-CoV-2, and chronic oral or gut dysbiosis. Although biologically distinct, these stimuli converge on innate sensing pathways driven by pathogen-associated molecular patterns such as unmethylated CpG DNA, single-stranded RNA, lipopolysaccharide, and bacterial lipoglycans. Through Toll-like receptors and type I interferon signalling, microbial signatures accelerate class switching, amplify inflammatory cytokine milieus, and lower B-cell activation thresholds, enabling rapid plasmablast mobilisation. Dysbiosis further maintains B cells in a hyper-responsive state by disrupting mucosal homeostasis and altering microbial metabolite profiles, thereby reducing the stimulus required to trigger plasmablast bursts. Once generated, these waves of oligoclonal plasmablasts home to inflamed tissues, where chemokine and adhesion landscapes shape their retention during flares. Emerging evidence suggests that such episodic plasmablast expansions promote autoantibody diversification, somatic hypermutation, and epitope spreading, progressively eroding tolerance. This review synthesizes these insights into a unified model in which infections and dysbiosis promote microbe-licensed plasmablast storms that influence the tempo and severity of autoimmune disease. Full article

Precise morphology engineering is essential for enhancing the charge-storage capabilities of cobalt molybdate (CoMoO₄). In this study, cobalt molybdate (CoMoO₄, abbreviated as CoMo), cobalt molybdate–cetyltrimethylammonium bromide (CoMo-CTAB), and cobalt molybdate–cetyltrimethylammonium bromide/polyethylene glycol (CoMo-CTAB/PEG) electrodes were synthesized through a cationic–nonionic surfactant-assisted hydrothermal route. he introduction of CTAB promoted the formation of well-defined nanoflake structures, whereas the synergistic CTAB/PEG system produced a highly porous and interconnected nanosheet architecture, enabling enhanced electrolyte diffusion and redox accessibility. As a result, the CoMo-CTAB/PEG electrode delivered a high areal capacitance of 10.321 F cm⁻² at 10 mA cm⁻², markedly outperforming CoMo-CTAB and pristine CoMo electrodes. It also exhibited good rate capability, maintaining 63.64% of its capacitance at 50 mA cm⁻². Long-term cycling tests revealed excellent durability, with over 83% capacitance retention after 12,000 cycles and high coulombic efficiency, indicating highly reversible Faradaic behavior. Moreover, an asymmetric pouch-type supercapacitor device (APSD) assembled using the optimized electrode demonstrated robust cycling stability. These findings underscore surfactant-directed morphology modulation as an effective and scalable strategy for developing high-performance CoMoO₄-based supercapacitor electrodes. Full article

The mental distress experienced by ethnic minority students studying at predominantly White institutions is well documented. These institutions and their spaces can be hostile environments for ethnic minority students and staff, leading to low retention, engagement and poor mental health. Often posited through a deficit lens, we challenge models that situate the experiences of what we call the resilient minority (ReM)—racialised ethnic groups—into categories to be fixed. By deploying qualitative research into Black and White university student experiences of racial inclusion, we explore alternative views to building stronger, more resilient communities. By further theorising interracial anxiety (the increased levels of anxiety felt by White people when interacting with ReM or experienced by ReM in predominantly White contexts), we highlight how decolonisation, built on representation and recognition, not only generates important discussions about interracial anxiety but also creates opportunities for change. We evidence how the representation of ReM groups through a Black feminist and decolonial critique in predominantly White contexts can reduce anxiety, promote wellbeing and potentially foster interracial inclusivity in higher education. Full article

Offshore unconsolidated sandstone reservoirs suffer from severe sand production, which impairs wellbore stability and productivity. This study evaluates gravel packing in light-oil unconsolidated sandstone reservoirs in the Weizhou field. This paper conducts visual sand-control experiments to compare screens and gravel packs, and to quantify the effects of gravel size, packing thickness, packing density, and clay content on sand-retention behavior. On this basis, a coupled CFD–DEM model was developed to simulate sand transport and plugging within the gravel pack. Results show that gravel packing rapidly forms a stable bridging structure, reaching stabilized production 38.1% earlier than the screen and reducing sand production by 74.4%, while maintaining a stable pressure difference and limiting fine-sand breakthrough. Low-viscosity oil enhances sand carrying, increasing the stabilized pressure difference by 12% relative to water. For the low-clay fine reservoir, gravel sizes of 3–6 times the median sand size, packing thickness ≥ 25 mm, and packing density of 90–95% provide a balance between permeability and sand control. Numerical simulations identify a four-stage plugging process—initiation, surface accumulation, deep filling, and equilibrium—offering pore-scale support for the experimental observations. This study offers technical and theoretical guidance for the optimization of gravel-pack sand control in offshore light-oil unconsolidated sandstone reservoirs. Full article

This study examines the psychological mechanisms underlying service stickiness during the mature phase of the AI subscription economy, with particular attention to the paradox of subscription fatigue. To enhance conceptual clarity, AI-driven stimuli—specifically Algorithmic Curation and Technological Fluidity—are defined as perceived attributes at the individual level. Employing the Stimulus–Organism–Response (S-O-R) framework, the research explores how these perceived stimuli influence consumers’ internal states (Cognitive Efficiency and Serendipity) and subsequent behavioral responses (Service Stickiness). Empirical analysis using partial least squares structural equation modeling (PLS-SEM) on data from U.S. subscription service users yields several theoretical insights. Cognitive Efficiency is identified as the primary driver of stickiness, indicating that, in the context of subscription fatigue, the utilitarian benefit of reduced cognitive effort surpasses hedonic enjoyment. Additionally, the study identifies a “Frictionless Trap,” in which excessive Technological Fluidity negatively affects Serendipity (β = −0.195), suggesting that an entirely seamless experience may create a filter bubble that limits unexpected discovery. As a result, Serendipity does not significantly affect stickiness in the aggregate model. However, post hoc analysis demonstrates that Serendipity remains significant for high-income users, while Cognitive Efficiency is most influential in high-frequency utilitarian contexts, such as food services. These findings indicate that sustainable retention depends on reducing cognitive load while intentionally introducing friction to preserve opportunities for discovery. Full article

This study screens the permeability of volatile organic compounds (VOCs) through edible films made of candelilla wax and guar gum, offering new insights into their role as aroma and moisture barriers. Four formulations (0.2–0.4% wax, 0.4–0.8% gum, and 0.2–0.3% glycerol) were tested using a fractional factorial design. VOC fluxes (one ester, two aldehydes, two terpenes, and one lactone) were monitored via headspace solid-phase microextraction coupled to gas chromatography–mass spectrometry (HS-SPME/GC-MS) in a diffusion cell and modeled kinetically. Wax-rich matrices compacted the network, reducing initial VOC transmission by up to 60%, while glycerol fine-tuned micromobility and selectivity. The formulation containing 0.4% wax, 0.8% gum, and 0.2% glycerol minimized time-dependent flux acceleration and reduced the cumulative permeability of both polar (hexanal) and non-polar (limonene) markers by 80%. Aroma loss decreased across all blends, correlating with improved water vapor control. These results establish quantitative criteria for developing sustainable edible coatings that balance aroma retention, water-barrier performance, and mechanical flexibility. Full article

This study evaluated the efficiency and potential risks associated with three clinical tools for removing cement-retained implant-supported prostheses: Magnetic Mallet, sliding hammer, and Coronaflex. The tests consisted of: cementation of three-unit bridge models onto titanium abutments with different geometries using Zinc Oxide non-eugenol or Zinc Phosphate cement. Seven different geometries of three-unit bridges were tested; therefore, a total of 7 bridges × 2 luting agents × 3 tools were combined in a full factorial analysis. Five test replicates were performed for each combination, resulting in a total of 5 × 7 × 2 × 3 = 210 retrieval tests. The 70 tests regarding the Coronaflex were taken from a previously conducted experiment on the topic, using the same dental bridge models and the same experimental conditions. Efficiency was assessed by the percentage of successful removals and the maximum force recorded with a piezoelectric load cell. For temporary cementations, the sliding hammer achieved the highest retrieval rate, while the Magnetic Mallet demonstrated comparable efficiency with lower forces. Coronaflex showed lower success rates and higher forces than Magnetic Mallet. For permanent cementations, most bridges were not removable, and attempts with the sliding hammer occasionally resulted in abutment screw damage. Within the limitations of this study, the Magnetic Mallet appears to be an effective option for removing bridges cemented with temporary cement, potentially in combination with a sliding hammer for highly retentive geometries. Zinc phosphate cement should be avoided when retrievability is desired, except for abutments with very low retention capability. Full article

Grounding Systems (GS) play a critical role in electrical safety, lightning protection, and the reliable operation of power and renewable energy infrastructures, particularly in high-resistivity soils. In this context, Ground Enhancement Materials (GEM) are widely used to reduce soil resistivity and improve grounding performance. This systematic review analyzes and synthesizes recent advances (2018–2025) in GEM applied to GS, with emphasis on their electrical performance, durability, and environmental sustainability. The review covers conventional GEM, industrial waste-derived materials, and hybrid formulations, evaluating their effectiveness under different soil types and moisture conditions. Comparative analysis of the literature indicates that GEM derived from industrial byproducts and hybrid composites often exhibit superior long-term resistivity reduction due to enhanced moisture retention and material-soil interactions, especially in clay-rich and heterogeneous soils. Sustainability considerations such as environmental impact, material availability, and long-term stability are increasingly influencing GEM selection and design. Overall, this review provides a structured framework for understanding the factors governing GEM performance while highlighting current trends, challenges, and future research directions in the development of sustainable grounding solutions. Full article