Search Results (191)

Background: Pain is a complex phenomenon characterized by unpleasant experiences with profound heterogeneity influenced by biological, psychological, and social factors. According to the National Health Interview Survey, 50.2 million U.S. adults (20.5%) experience pain on most days, with the annual cost of prescription medication for pain reaching approximately USD 17.8 billion. Theranostic pain nanomedicine therefore emerges as an attractive analgesic strategy with the potential for increased efficacy, reduced side-effects, and treatment personalization. Theranostic nanomedicine combines drug delivery and diagnostic features, allowing for real-time monitoring of analgesic efficacy in vivo using molecular imaging. However, clinical translation of these nanomedicines are challenging due to complex manufacturing methodologies, lack of standardized quality control, and potentially high costs. Quality by Design (QbD) can navigate these challenges and lead to the development of an optimal pain nanomedicine. Our lab previously reported a macrophage-targeted perfluorocarbon nanoemulsion (PFC NE) that demonstrated analgesic efficacy across multiple rodent pain models in both sexes. Here, we report PFC-free, biphasic nanoemulsions formulated with a biocompatible and non-immunogenic plant-based coconut oil loaded with a COX-2 inhibitor and a clinical-grade, indocyanine green (ICG) near-infrared fluorescent (NIRF) dye for parenteral theranostic analgesic nanomedicine. Methods: Critical process parameters and material attributes were identified through the FMECA (Failure, Modes, Effects, and Criticality Analysis) method and optimized using a 3 × 2 full-factorial design of experiments. We investigated the impact of the oil-to-surfactant ratio (w/w) with three different surfactant systems on the colloidal properties of NE. Small-scale (100 mL) batches were manufactured using sonication and microfluidization, and the final formulation was scaled up to 500 mL with microfluidization. The colloidal stability of NE was assessed using dynamic light scattering (DLS) and drug quantification was conducted through reverse-phase HPLC. An in vitro drug release study was conducted using the dialysis bag method, accompanied by HPLC quantification. The formulation was further evaluated for cell viability, cellular uptake, and COX-2 inhibition in the RAW 264.7 macrophage cell line. Results: Nanoemulsion droplet size increased with a higher oil-to-surfactant ratio (w/w) but was no significant impact by the type of surfactant system used. Thermal cycling and serum stability studies confirmed NE colloidal stability upon exposure to high and low temperatures and biological fluids. We also demonstrated the necessity of a solubilizer for long-term fluorescence stability of ICG. The nanoemulsion showed no cellular toxicity and effectively inhibited PGE2 in activated macrophages. Conclusions: To our knowledge, this is the first instance of a celecoxib-loaded theranostic platform developed using a plant-derived hydrocarbon oil, applying the QbD approach that demonstrated COX-2 inhibition. Full article

The exponential increase in electronic waste (e-waste) from end-of-life electrical and electronic equipment presents a growing environmental challenge. E-waste contains high concentrations of rare earth elements (REEs), which are classified as critical raw materials (CRMs). Their removal and recovery from contaminated systems not only mitigate pollution but also support resource sustainability within a circular economy framework. The present study proposed the use of hazelnut shells as a biosorbent to reduce water contamination and recover REEs. The sorption capabilities of this lignocellulosic material were assessed and optimized using the response surface methodology (RSM) combined with a Box–Behnken Design (three factors, three levels). Factors such as pH (4 to 8), salinity (0 to 30), and biosorbent dose (0.25 to 0.75 g/L) were evaluated in a complex mixture containing 9 REEs (Y, La, Ce, Pr, Nd, Eu, Gd, Tb and Dy; equimolar concentration of 1 µmol/L). Salinity was found to be the factor with greater significance for REEs sorption efficiency, followed by water pH and biosorbent dose. At a pH of 7, salinity of 0, biosorbent dose of 0.75 g/L, and a contact time of 48 h, optimal conditions were observed, achieving removals of 100% for Gd and Eu and between 81 and 99% for other REEs. Optimized conditions were also predicted to maximize the REEs concentration in the biosorbent, which allowed us to obtain values (total REEs content of 2.69 mg/g) higher than those in some ores. These results underscore the high potential of this agricultural waste with no relevant commercial value to improve water quality while providing an alternative source of elements of interest for reuse (circular economy). Full article

The increasing demand for critical raw materials, such as antimony—a semimetal with strategic relevance in fire-retardant applications, electronic components, and national security—has made the identification of European sources essential for the European Union’s strategic autonomy. Remote sensing offers a valuable tool for detecting alteration minerals associated with subsurface gold and antimony deposits that reach the surface. However, the coarse spatial resolution of the most freely available satellite data remains a limiting factor. The PlanetScope satellite constellation presents a promising low-cost alternative for the academic community, providing 3 m spatial resolution and eight spectral bands. In this study, we evaluated PlanetScope’s capacity to detect Fe³⁺-bearing iron oxides—key indicators of hydrothermal alteration—by applying targeted band ratios (BRs) in northern Portugal. A comparative analysis was conducted to validate its performance using established BRs from Sentinel-2, ASTER, and Landsat 9. The results were assessed through relative comparison methods, enabling both quantitative and qualitative evaluation of the spectral similarity among sensors. Spatial patterns were analyzed, and points of interest were identified and subsequently validated through fieldwork. Our findings demonstrate that PlanetScope is a viable option for mineral exploration applications, capable of detecting iron oxide anomalies associated with alteration zones while offering finer spatial detail than most freely accessible satellites. Full article

Against the backdrop of China’s “dual-carbon” initiative, this study innovatively applies a process-based life cycle assessment (PLCA) methodology, meticulously tracking energy and carbon flows across material production, transportation, and maintenance processes. By comparing six asphalt pavement maintenance technologies in Xinjiang, the research reveals that milling and resurfacing (MR) exhibits the highest energy consumption 250,809 MJ/10³ m²) and carbon emissions (15,095.67 kg CO₂/10³ m²), while preventive techniques like hot asphalt grouting reduce emissions by up to 87%. The PLCA approach uncovers a critical insight: 40–60% of total emissions originate from the raw material production phase, with cement and asphalt identified as primary contributors. This granular analysis, unique in regional road maintenance research, challenges traditional assumptions and emphasizes the necessity of upstream intervention. By contrasting reactive and preventive strategies, the study validates that early-stage maintenance aligns seamlessly with circular economy principles. Tailored to a local arid climate and vast transportation network, the study concludes that prioritizing preventive maintenance, adopting low-carbon materials, and optimizing logistics can significantly decarbonize road infrastructure. These region-specific strategies, underpinned by the novel application of PLCA, not only provide actionable guidance for local policymakers but also offer a replicable framework for sustainable road development worldwide, bridging the gap between scientific research and practical decarbonization efforts. Full article

Several attempts have been made to replace the critical raw material platinum (Pt) with other metals, mainly focusing on its functional performance, while safety and sustainability criteria are often overlooked. Here, the substitution of Pt by nickel-based coatings is addressed for water electrolysis applications. Risk assessment and life cycle assessment are iteratively performed at the laboratory scale and after upscaling metal coating protocols. The challenges for the transition towards an integrated safe and sustainable by design (SSbD) approach are identified, and strategies are proposed to resolve them. Valuable insights emerge from the individual assessments (e.g., hotspots, trade-offs, and recommendations for sustainability and safety), as well as regarding the transition towards an integrated SSbD (e.g., dealing with data gaps and uncertainties). Full article

Electric passenger vehicles are set to dominate the European car market, driven by EU climate policies and the 2035 ban on internal combustion engine production. This study assesses the sustainability of this transition, focusing on global warming potential and Critical Raw Material (CRM) extraction throughout its life cycle. The intensive use of CRMs raises environmental, economic, social, and geopolitical concerns. These materials are scarce and are concentrated in a few politically sensitive regions, leaving the EU highly dependent on external suppliers. The extraction, transport, and refining of CRMs and battery production are high-emission processes that contribute to climate change and pose risks to ecosystems and human health. A Life Cycle Assessment (LCA) was conducted, using OpenLCA software and the Ecoinvent 3.10 database, comparing a Peugeot 308 in its diesel and electric versions. This study adopts a cradle-to-grave approach, analyzing three phases: production, utilization, and end-of-life treatment. Key indicators included Global Warming Potential (GWP100) and Abiotic Resource Depletion Potential (ADP) to assess CO₂ emissions and mineral resource consumption. Technological advancements could mitigate mineral depletion concerns. Li-ion battery recycling is still underdeveloped, but has high recovery potential, with the sector expected to expand significantly. Moreover, repurposing used Li-ion batteries for stationary energy storage in renewable energy systems can extend their lifespan by over a decade, decreasing the demand for new batteries. Such innovations underscore the potential for a more sustainable electric vehicle industry. Full article

The climate in extremely cold regions is becoming increasingly unstable, resulting in more frequent freeze-thaw cycles. These cycles significantly degrade the mechanical properties of soft soil foundations, reducing their bearing capacity and ultimately compromising the safety and lifespan of construction and infrastructure. To mitigate these effects, soil stabilization technology is commonly employed to reinforce soft soil in cold regions. However, evaluating the durability of stabilized soft soil, particularly its resistance to freezing in extremely cold environments, remains a critical challenge. This study investigates the use of industrial waste raw materials, such as slag and fly ash (FA), in combination with a solid alkali activator (NaOH), to develop one-part alkali-activated cementitious materials (ACMs) for soft soil stabilization. The effects of different raw material ratios, freeze-thaw temperatures, and the number of freeze-thaw cycles on the freezing resistance of one-part alkali-activated slag/FA (OP-ASF) stabilized soft soil were examined. Mass loss, unconfined compressive strength (UCS), and pH value were conducted to assess soil deterioration and structural integrity under freeze-thaw conditions. Additionally, microstructure analysis was conducted using scanning electron microscopy with energy dispersive X-ray spectrometry (SEM-EDS) and X-ray diffraction (XRD) to analyze hydration product formation and internal structure characteristics. Image-pro plus (IPP) was also employed for structure looseness evolution, providing deeper insights into the freezing resistance mechanisms of OP-ASF stabilized soft soil. The results indicated that as the freezing temperature decreases and the number of freeze-thaw cycles increases, both mass loss and UCS loss become more pronounced. When the ratio of slag to fly ash was optimized at 80:20, OP-ASF stabilized soft soil exhibited the highest freezing resistance, characterized by the lowest mass loss and UCS loss, along with the highest UCS and pH value. Furthermore, structure looseness remained at its lowest across all freeze-thaw temperatures and cycles, highlighting the beneficial role of slag and FA in OP-ASF. These findings contribute to the advancement of sustainable and durable construction materials by demonstrating the potential of one-part alkali-activated slag/fly ash for stabilizing soft soils in seasonally frozen regions. Full article

Mobile phone waste management is a growing environmental challenge, with improper disposal contributing to resource depletion, pollution and missed opportunities for material recovery. This study presents the findings of a dual-purpose survey (11,163 respondents) conducted in a wide academic context in Italy, aimed at both assessing mobile phones disposal behaviors and knowledge and raising awareness through structured educational prompts about sustainable e-waste management. The results reveal significant behavioral patterns and knowledge gaps across demographic groups. While most respondents (90.6%) own one phone, males tend to have more than females. Phones are replaced every 3–5 years by 48.8% of users and every 1–3 years by 36.7%, with students tending to replace them earlier. Only 20.2% replace their phone when irreparable while 46% replace them due to high repair costs. A large majority (92.3%) store old devices at home, forming an estimated urban mine of 29,799 unused phones. The awareness of hazardous components is higher than that of critical raw materials, with males more informed than females and students in scientific fields displaying greater awareness than those in humanities and health disciplines. The awareness of official take-back programs is particularly low, especially among younger generations. Notably, 90% reported increased awareness from the educational survey and 93.1% expressed willingness to use an on-campus e-waste collection system. These results highlight the role of universities as catalysts for sustainable behavior, supporting the design of targeted educational strategies and policy actions in line with circular economy principles and Sustainable Development Goal 12 “Responsible consumption and production”. Full article

In recent years, the research and development of sustainable materials have seen a growing interest. The driving force behind this is environmental policies that aim towards a transition to a circular economy. There are numerous investigations into the potential use of waste and/or by-products in building materials and components. Using such materials, called “secondary raw materials”, is to be favored due to their low environmental impact. Although research is numerous, most studies are limited to a purely performance assessment. There are still a few studies that also address environmental (or sometimes economic) aspects. Lacking such considerations, is it possible to say that the industrial product of research is truly sustainable? Is it enough to use secondary raw materials to define a product with a low environmental impact? By critically reviewing publications on this topic, this paper aims to highlight possible new developments for future research. Including environmental assessments among the criteria for evaluating the impact of research would provide a vision that is not limited only to the performance profile but can capture aspects that are currently underestimated. Overcoming this limitation would make it possible to obtain products capable of responding to the demands of sustainability regulations, avoiding the strategy of greenwashing. Full article

Phytotechnologies offer sustainable solutions for remediating mine residues by combining site rehabilitation with the potential recovery of secondary and critical raw materials (SRMs and CRMs, respectively), contributing to resource efficiency strategies. This study explored the direct propagation of Atriplex halimus unrooted cuttings into metal-contaminated mine tailings, assessing survival, biomass production, and trace metal accumulation. Treatments were carried out on mine tailings, with and without the addition of organic and inorganic amendments, and on commercial soil as a control. After an 8-week preliminary trial, Atriplex halimus demonstrated moderate survival and growth without phytotoxic symptoms, despite elevated trace metal concentrations. Significant accumulation of zinc, lead, and cadmium as model contaminants in the biomass of Atriplex halimus (up to 495.4, 31.9, and 1.2 mg kg⁻¹, respectively), as well as magnesium and manganese as model CRMs (2081 and 87.8 mg kg⁻¹, respectively) was observed in aerial tissues, comparable with traditional, though more labor-intensive propagation methods. Plants’ ability to accumulate metals was high in the presence of amendments added to promote biomass growth. These results highlight the significance of direct propagation by unrooted cuttings as a promising, low-cost strategy to initiate site restoration in metal-contaminated areas and warrant further investigation under field conditions and over longer durations. Full article

CoCrMo alloys are interesting materials for implantable devices due to their favorable mechanical properties, high wear resistance, and good biocompatibility with the human body. Recent studies have demonstrated the possibility to further increase their wear resistance with an innovative approach consisting of nitriding treatments by the High-Power Impulse Magnetron Sputtering (HiPIMS) technique. Given the novelty of this treatment, it is relevant to develop a preliminary sustainability analysis of the processes to highlight the total environmental impact and to evaluate possible strategies to decrease it. Here, a Life Cycle Assessment (LCA) of HiPIMS nitriding treatments of CoCrMo alloys using a tantalum or molybdenum target is presented. The main impact driver in all impact categories was the electrical consumption of the vacuum apparatus and cooling system of HiPIMS instrumentation with a 45–47% and 37–39% contribution for Ta-based, and 39–40% and 41–42% for Mo-based treatments, respectively. Climate Change was found to be the most impacted category, followed by Resource Use both for Mo and Ta nitriding targets. Therefore, some perspectives to enhance the environmental sustainability of the synthesis process have been considered by means of a sensitivity analysis. Moreover, a Critical Raw Material (CRM) assessment is discussed, providing a complete sustainability evaluation of the proposed HiPIMS treatments. Full article

Objective: The rapid growth of electric vehicle (EV) adoption has led to an unprecedented increase in lithium-ion battery (LIB) demand and end-of-life waste, underscoring the urgent need for effective recycling strategies. This review evaluates current progress in EV battery recycling and explores future prospects. Design: Review based on PRISMA 2020. Data sources: Scientific publications indexed in major databases such as Scopus, Web of Science, and ScienceDirect were searched for relevant studies published between 2020 and 15 April 2025. Inclusion criteria: Studies were included if they were published in English between 2020 and 15 April 2025, and focused on the recycling of electric vehicle batteries. Eligible studies specifically addressed (i) recycling methods, technologies, and material recovery processes for EV batteries; (ii) the impact of recycled battery systems on power generation processes and grid stability; and (iii) assessments of materials used in battery manufacturing, including efficiency and recyclability. Review articles and meta-analyses were excluded to ensure the inclusion of only original research data. Data extraction: Data were independently screened and extracted by two researchers and analyzed for recovery rates, environmental impact, and system-level energy contributions. One researcher independently screened all articles and extracted relevant data. A second researcher validated the accuracy of extracted data. The data were then organized and analyzed based on reported quantitative and qualitative indicators related to recycling methods, material recovery rates, environmental impact, and system-level energy benefits. Results: A total of 23 studies were included. Significant progress has been made in hydrometallurgical and direct recycling processes, with recovery rates of critical metals (Li, Co, Ni) improving. Second-life battery applications also show promise for grid stabilization and renewable energy storage. Furthermore, recycled batteries show potential in stabilizing power grids through second-life applications in BESS. Conclusion: EV battery recycling is a vital strategy for addressing raw material scarcity, minimizing environmental harm, and supporting energy resilience. However, challenges persist in policy harmonization, technology scaling, and economic viability. Future progress will depend on integrated efforts across sectors and regions to build a circular battery economy. Full article

The Sanandaj–Sirjan Zone and Zagros Fold–Thrust Belt in Iran host numerous Mediterranean-type karst bauxite deposits; however, their formation mechanisms and critical raw material potential remain ambiguous. This study combines mineralogical and geochemical analyses to explore (1) the formation of authigenic minerals, (2) the role of microbial organic processes in Fe cycling, and (3) the assessment of their critical raw materials potential. Mineralogical analyses of the Late Cretaceous Daresard and Middle–Late Permian Yakshawa bauxites reveal distinct horizons reflecting their genetic conditions: Yakshawa exhibits a vertical weathering sequence (clay-rich base → ferruginous oolites → nodular massive bauxite → bleached cap), while Daresard shows karst-controlled profiles (breccia → oolitic-pisolitic ore → deferrified boehmite). Authigenic illite forms via isochemical reactions involving kaolinite and K-feldspar dissolution. Scanning electron microscopy evidence demonstrates illite replacing kaolinite with burial depth enhancing crystallinity. Diaspore forms through both gibbsite transformation and direct precipitation from aluminum-rich solutions under surface conditions in reducing microbial karst environments, typically associated with pyrite, anatase, and fluorocarbonates under neutral–weakly alkaline conditions. Redox-controlled Fe-Al fractionation governs bauxite horizon development: (1) microbial sulfate reduction facilitates Fe³⁺ → Fe²⁺ reduction under anoxic conditions, forming Fe-rich horizons, while (2) oxidative weathering (↑Eh, ↓moisture) promotes Al-hydroxide/clay enrichment in upper profiles, evidenced by progressive total organic carbon depletion (0.57 → 0.08%). This biotic–abiotic coupling ultimately generates stratified, high-grade bauxite. Finally, both the Yakshawa and Daresard karst bauxite ores are enriched in critical raw materials. It is worth noting that the overall enrichment appears to be mostly driven by the processes that led to the formation of the ores and not by the chemical features of the parent rocks. Divergent bauxitization pathways and early diagenetic processes—controlled by paleoclimatic fluctuations, redox shifts, and organic matter decay—govern critical raw material distributions, unlike typical Mediterranean-type deposits where parent rock composition dominates critical raw material partitioning. Full article

For the European Union in the field of raw material policy, it is primarily important to ensure reliable, seamless, and unrestricted access to raw materials in all EU countries. An important aspect in assessing the European Union’s raw material policy is a detailed analysis of selected significant raw materials. This paper focuses on raw material policy within the European Union (EU). Specifically, it examines five types of raw materials: critical raw materials, metal ores, non-metallic minerals, fossil energy materials, and biomass. The research is oriented to analyzing the materials from the perspectives of consumption, mining, export, and import. The objective is to assess the European Union’s (EU) raw material policy by employing specific tools and statistical methodologies to analyze individual data. We aimed to assess the European Union (EU) raw material policy using selected statistical methods such as regression and correlation analysis, multivariate analysis, and pairwise correlation to reveal and describe the relationships between variables. Based on the examination of import and export data, it is evident that imports are on the rise while exports are declining. This trend underscores the EU’s continued reliance on raw materials sourced from other global regions. The results show that domestic production and consumption are sufficient; on the other hand, the EU remains dependent on imports of critical raw materials. The results are useful for the development of future EU raw material policy. Full article

The global shift toward green technologies presents a dual challenge: surging demand for clean technology products and an increasing reliance on critical raw materials (CRMs). While the existing literature has largely concentrated on economic, geopolitical, or general governance perspectives, scant attention has been devoted to the legal, institutional, and justice dimensions of mineral resource governance. This article addresses this gap by examining the European Union’s evolving policy framework—particularly the Critical Raw Materials (CRM) Act—and its implications for Romania’s national regulatory landscape. Employing a mixed-method approach that combines a systematic literature review and a SWOT analysis, this study assesses Romania’s capacity to align its mineral governance with the EU’s objectives for supply security, environmental sustainability, and strategic autonomy. Its findings underscore the urgent need for Romania to streamline its regulatory frameworks, enhance institutional coherence, clarify property rights, and reform licensing and fiscal regimes to attract investment and ensure legal predictability. Advancing green mining technologies, recycling initiatives, and sustainability-focused innovations is also vital for aligning national practices with the EU’s environmental and economic goals. By foregrounding issues of transparency, good governance, and procedural justice, this article offers new insights into how national and supranational governance structures intersect in the context of the green transition. This study provides valuable recommendations for policymakers, industry actors, and scholars seeking to strengthen Romania’s position within the EU’s broader resource security and sustainable development strategies. Full article