Search Results (1,377)

Liver fibrosis, the progressive accumulation of scar tissue resulting from chronic liver disease, is increasingly recognized as a multi-system condition, the effects of which extend beyond the liver, affecting brain health. Dementia, characterized by progressively impaired cognition sufficient to impede daily functioning, is a major global health issue with incompletely defined risk factors and pathogenic precursors. To examine the relationship between liver fibrosis and cognitive outcomes, we conducted a comprehensive PubMed literature search, and human studies published in English were included. Evidence is synthesized on the pathophysiology and clinical significance of liver fibrosis, types of dementia, and studies supporting the association between liver fibrosis and cognitive impairment. Meta-analytic data indicate that liver fibrosis is associated with an approximately 30% increased risk of incident dementia (pooled hazard ratio ~1.3), with progressively higher risks across more advanced fibrosis stages. Putative pathomechanisms, potentially modulated by age and sex, include chronic systemic and neuro-inflammation, insulin resistance, vascular dysfunction, and a perturbed intestinal microbiota–liver–brain axis. Non-invasive liver fibrosis diagnostics, advanced neuroimaging, and biomarkers represent key tools for assessing risk. In conclusion, liver fibrosis is a systemic condition that can affect brain health. Early detection, thorough risk assessment and interventions, such as lifestyle changes, metabolic therapies, and antifibrotic treatments, may help protect neural function. Key research gaps are identified, with suggestions for improving understanding of liver fibrosis’s connection to dementia or cognitive impairment. Full article

Background: Endolichenic fungi represent an emerging source of bioactive secondary metabolites; however, the genomic basis of their chemical diversity remains largely poorly characterized. Specifically, the metabolic capabilities of Cladosporium limoniforme have not been explored at the genomic level. Objectives: This study aimed to characterize the biosynthetic potential of C. limoniforme by presenting its first whole-genome sequence and conducting a comparative analysis of its biosynthetic gene clusters (BGCs), with a specific focus on the evolutionary conservation of the DHN-melanin pathway. Methods: Genome mining was performed using antiSMASH and fungiSMASH tools. Comparative genomics involved heatmap-based distribution analysis across the Cladosporium genus, synteny profiling using Clinker to assess gene order conservation, and Maximum Likelihood phylogenetic analysis of the polyketide synthase (T1PKS) domain. Results: We identified 26 putative BGCs, revealing a largely untapped metabolic repertoire. Comparative analysis demonstrated a high degree of conservation for the metachelin C (siderophore) and 1,3,6,8-tetrahydroxynaphthalene (T4HN) clusters across the genus. Notably, synteny and phylogenetic analyses showed that while C. limoniforme retains a conserved, ancestral T1PKS core essential for stress survival, it exhibits a significant reduction in accessory genes compared to plant-pathogenic congeners. Conclusions: These findings support a “metabolic streamlining” hypothesis driven by the endolichenic lifestyle, where the fungus retains essential protective machinery while shedding costly accessory genes unnecessary in the buffered lichen niche. This study establishes C. limoniforme as a valuable genomic resource for future biotechnological research. Full article

Blue economy aims to bring prosperity to coastal communities whilst also protecting natural ocean resources for future generations. But how can this vision be put into practice, especially in communities in which dependence on natural resources is high, and food and livelihood security are key concerns? This paper examines two cases of community-led nature-based enterprise in Kenya in a search for solutions to this challenge: fisheries reform through market access and gear sustainability; mangrove forest conservation and community development using carbon credit revenues. I use a ‘diverse economies framework’ for the first time in blue economy contexts to delve into the heterogeneous relations at work and in search of insights that can be applied in multiple contexts. Analysed through key informant interviews and field observation, the cases reveal a complex assemblage of institutions, knowledges, technologies, and practices within which enterprises operate. Whilst the enterprises featured are still relatively new and developing, they suggest a direction of travel for a community-led sustainable blue economy that both supports and benefits from nature recovery. The insights gained from this diverse economies analysis lead us to appreciate a sustainable blue economy as a rediscovered and reinvigorated relationship of reciprocity between society and nature—one that nurtures place-based nature-based livelihoods and nature recovery together, and which embodies a set of values and ethics shared by government, communities, and business. Full article

This entry explores the implications of generative AI for the underlying foundational premises of copyright law and the potential threat it poses to human creativity. It identifies the gaps and inconsistencies in legal frameworks as regards authorship, training-data use, moral rights, and human originality in the context of AI systems that are capable of imitating human expression at both syntactic and semantic levels. The entry includes: (i) a comparative analysis of the legal frameworks of the United Kingdom, United States, and Germany, using the Berne Convention as a harmonising baseline, (ii) a systematic synthesis of the relevant academic literature, and (iii) insights gained from semi-structured interviews with legal scholars, AI developers, industry stakeholders, and creators. Evidence suggests that existing laws are ill-equipped for semantic and stylistic reproduction; there is no agreement on authorship, no clear licensing model for training data, and inadequate protection for the moral identity of creators—especially posthumously, where explicit protections for likeness, voice, and style are fragmented. The entry puts forward a draft global framework to restore legal certainty and cultural value, incorporating a semantics-aware definition of the term “work”, and encompassing licensing and remuneration of training data, enhanced moral and posthumous rights, as well as enforceable transparency. At the same time, parallel personality-based safeguards, including rights of publicity, image, or likeness, although present in all three jurisdictions studied, are not subject to the same copyright and thus do not offer any coherent or adequate protection against semantic or stylistic imitation, which once again highlights the need for a more unified and robust copyright strategy. Full article

The global literature underscores a set of human wellbeing challenges and opportunities for forestland exploitation, albeit the lack of region-specific evidence. This concerns the Congo Basin, the second-largest forest ecosystem in the world. This study uses the case of the Campo Ma’an Landscape to: (i) analyze the challenges linked to the exploitation of forestland resources, and (ii) explore forest resource exploitation opportunities in the landscape. The study employed a random sample of 200 natural resource-dependent households drawn from four study zones—Niete, Campo, Ma’an and Akom II. This was complemented by focus group discussions (n = 4), key informant (n = 6) and expert (n = 6) interviews. The descriptive and inferential analyses led to the following results: First, economic, technical, socio-cultural and institutional challenges affect the sustainable exploitation of forestland resources in the Campo Ma’an Landscape. The economic challenges of forest (B = −0.389, p = 0.01) and land resource exploitation (B = −0.423, p = 0.006) significantly affect sustainable exploitation compared to other challenges, leading to biodiversity loss and deforestation. These constitute a threat to planetary health systems. Almost all households rely on forestland resources for their livelihoods and development, with opportunities for land resource exploitation outweighing those in forest resource exploitation. Protected area management and agriculture are affected owing to competing interests among farmers, conservationists and other land users. Thus, short-term economic gains are prioritized over long-term sustainability, putting the resource landscape at risk of degradation and future uncertainties. Integrated stakeholder engagement, capacity building, and policy revision could enhance the planetary health approach by linking the social, economic and environmental dimensions of forestland resource management. Full article

The ethical and legal governance of Animal-Assisted Interventions (AAIs) remains conceptually and normatively fragmented. Although animals engaged in therapeutic, educational, and assistive activities make valuable contributions to human well-being, they continue to be defined by law as property or welfare objects, despite their meaningful yet limited forms of relational participation within structured human-controlled environments. This perspective obscures their context-dependent responsiveness and their institutional embeddedness. The present paper addresses this gap by adopting a normative and interdisciplinary approach grounded in relational legal theory and vulnerability scholarship. The concept is developed by drawing on Jennifer Nedelsky’s notion of relational autonomy and Martha Fineman’s theory of universal vulnerability. This results in the conceptualisation of AAI animals as correlated subjects: beings whose ethical and legal significance derives from the relationships and institutional contexts that shape their participation. The analysis identifies weaknesses in current medico-legal practices that frame veterinary certification and welfare assessment as static technical acts, ignoring their relational and systemic dimensions. The paper puts forward a relational ethical–legal framework for Animal-Assisted Interventions, centred on relational vulnerability, context-sensitive oversight and continuous institutional accountability. A number of practical recommendations are put forward, including the introduction of renewable ethical licences, inter-institutional monitoring and the establishment of multidisciplinary oversight mechanisms. By redefining animals’ normative status through relational ethics, in alignment with the interconnected human, animal, and environmental dimensions emphasized by the One Welfare principles, the study advances a shift from welfare-based protection toward a model of justice grounded in interspecies interdependence and institutional responsiveness. Full article

Calcium magnesium phosphate cements (CMPCs) were obtained starting from dolomite (alone or mixed with fly ash) thermally treated at two different temperatures. Dolomite calcination at 750 °C for 3 h determined the formation of a mixture of MgO and CaCO₃. The mixing of dolomite with fly ash and the increase in the calcination temperature at 1200 °C determined the formation of new compounds (calcium aluminum silicate and calcium magnesium silicates), which are present along with MgO and small amounts of CaO in the thermally treated material. These two precursors were mixed with KH₂PO₄ solution and borax (as a retardant admixture) to obtain the CMPCs. The setting time and compressive strengths of these CMPCs were assessed and the XRD analyses provided insights into their mineralogical composition after hardening and thermal treatment. The cements, as so or mixed with perlite, were applied on steel plates, to assess their behavior when put in direct contact with a flame. The compatibility of these materials with the steel substrate was evaluated by scanning electron microscopy (SEM). The direct contact with the flame up to 60 min provided information regarding the CMPCs’ ability to prevent the rapid increase in the substrate (steel plate) temperature. The findings indicate that CMPC pastes and composites containing perlite can offer a degree of protection for steel structures in the event of a fire. Full article

The Health Data Space (HDS) is a promising platform for the secure health data sharing among entities including patients and healthcare providers. However, health data is highly sensitive and critical for diagnosis, and unauthorized access or destruction by malicious users can lead to serious privacy leaks or medical negligence. Thus, robust access control, privacy preservation, and data integrity are essential for HDS. Although Ciphertext-Policy Attribute-Based Encryption (CP-ABE) supports secure sharing, it has limitations when directly applied to HDS. Many current schemes cannot simultaneously handle data integrity violations, trace and revoke malicious users, and protect against privacy leaks from plaintext access policies, with key escrow being another major risk. To overcome these issues, we put forward a Traceable and Revocable Privacy-Preserving Data Sharing (TRPPDS) scheme. Our solution uses a novel distributed CP-ABE with a large universe alongside data auditing to provide fine-grained, key-escrow-resistant access control over unbounded attributes and guarantee data integrity. It also features tracing-then-revocation and full policy hiding to thwart malicious users and protect policy privacy. Formal security analysis is presented for our proposal, with thorough performance assessment also demonstrates its feasibility in HDS. Full article

Two endogenous peptides, β-alanyl-L-histidine, named carnosine (Car), and glycyl-L-histidyl-L-lysine (GHK), derived from the matricellular protein Secreted Protein Acidic and Rich in Cysteine (SPARC), share many beneficial functions. The hydrolytic enzyme carnosinase for Car and the low stability for GHK can put into question their antioxidant, antiaggregating, and anti-inflammatory properties. The glycoconjugates of Car with a di- (trehalose, Tre) or polysaccharide (hyaluronan, HA) inhibit carnosinase, while the synthesis of HAGHK derivatives increases the tripeptide stability and protects/delays the biopolymer degradation. A synergic effect between the two components of the glycoconjugates is evident in their consequently preserved protective features. TreCar, HACar, and HAGHK maintain the copper-binding ability of the peptides alone, and the saccharides potentiate the Cu,Zn-superoxide dismutase-like ability of the copper(II) complexes with the glycoconjugates. These peptide derivatives behave as copper ionophores, utilizing Cu²⁺ present in the culture medium; also, an increase in the metal intracellular level occurs with a consequent stimulation of the copper-driven signaling pathways that produce the expression/release of trophic (Brain-Derived Neurotrophic Factor, BDNF, and Bone Morphogenetic Protein 2, BMP-2) and angiogenic (Vascular Endothelial Growth Factor, VEGF) proteins. Copper chaperons for SOD1, CCS, and Antioxidant 1 (Atox-1) are the copper chaperones that act as transcription factors. Full article

As smart education evolves, there is an increasing need for the cloud-centric management and sharing of student exercise physiological data gathered through wearable devices in the physical education domain. However, challenges arise in achieving authentication for data sources, ensuring the security of sensitive data, and implementing efficient dynamic access control. Traditional cryptographic schemes face limitations in resisting quantum attacks, authenticating data sources, protecting identity privacy, handling dynamic permission changes, and computational efficiency. To tackle these challenges, we put forward a lattice-based Online/Offline Identity-Based Matchmaking Proxy Re-Encryption (OO-IB-MPRE) scheme. The scheme offers post-quantum security assurances grounded in lattice cryptography (under the LWE/ISIS assumptions); incorporates Identity-Based matchmaking encryption (IB-ME) to realize bidirectional identity matching, which not only enables identity authentication for data sources but also safeguards the sender’s identity privacy from exposure to other entities; leverages Proxy Re-Encryption (PRE) to support dynamic management of access control; and combines online/offline encryption to adapt to resource constrained sensors. The security of the OO-IB-MPRE scheme is verified under standard lattice assumptions to meet the security requirements of semi-selective privacy and authenticity. Performance analysis and experimental validation demonstrate that in comparison to existing lattice-based PRE schemes, the devised scheme shows notable advantages in both space and computational overhead. Therefore, the proposed OO-IB-MPRE offers a secure, efficient, and scalable solution for the sensitive health data in smart physical education. Full article

Carbonic anhydrase 3 (CA3) exhibits low enzymatic activity compared to other CA isoforms but contains two surface-exposed cysteine residues that undergo glutathionylation under oxidative stress. Highly expressed in muscle tissue, CA3 has been implicated in cellular protection, particularly through interactions with Bcl2-Associated Athanogene 3 (BAG3), modulating autophagy, while CA3 overexpression decreased hypoxia-induced apoptosis in cardiomyocytes. In this study, we investigated the impact of CA3 overexpression on cellular pathways in HEK293T, MDA-MB-231, and SVCT cells using RNA sequencing and proteomics. Gene Set Enrichment Analysis (GSEA) in HEK293T cells revealed the down-regulation of pathways related to protein synthesis, RNA processing, Roundabout signalling, selenocysteine-metabolism, and suppression of neurodegenerative disease-associated pathways. Human breast epithelial cell lines under normoxia and hypoxia showed down-regulation of similar pathways, although notably, hypoxic conditions also suppressed interferon α/β signalling. Proteomic analysis in HEK293T cells using HaloTag pull-down experiments identified putative novel CA3 binding partners, including heat shock 70 kDa proteins 1 and 8, and ribosomal protein S2 (RPS2). RANBP2 protein was consistently up-regulated after CA3 overexpression, irrespective of the presence of CA3 surface-exposed cysteines and HaloTag orientation. These findings suggest that CA3 modulates key cellular processes beyond its enzymatic role, contributing to stress resilience through pathway-level regulation and protein interactions, potentially impacting autophagy and neurodegenerative disease. Full article

Face recognition systems are widely used for biometric authentication but face two major problems. First, processing high-resolution images and large databases requires extensive computational time. Second, emerging quantum computers threaten to break the encryption methods that protect stored facial templates. Quantum computers will soon be able to decrypt current security systems, putting biometric data at permanent risk since facial features cannot be changed like passwords. This paper presents a solution that uses quantum computing to speed up face recognition while adding quantum-resistant security. It applies quantum principal component analysis (QPCA) and the SWAP test to reduce the computational complexity and implement lattice-based cryptography, which quantum computers cannot break. Experimental evaluation demonstrates a significant overall speedup with improved accuracy. The proposed framework achieves a significant improvement in performance, provides 125-bit security against quantum attacks and compresses the data storage requirements significantly. These results demonstrate that quantum-enhanced face recognition can solve both the speed and security challenges facing current biometric systems, making it practical for real-world deployment as quantum technology advances. Full article

In the context of new-type urbanization and high-quality development, this study aims to construct a multi-objective synergistic land-use mechanism to tackle the “growth-equity-ecology” trilemma in the Chengdu–Chongqing Urban Agglomeration (CCUA). By building an economic–social–ecological benefit evaluation index system and applying TOPSIS with entropy weighting, the coupling coordination degree (CCD) model, and the spatial Durbin model (SDM), we systematically explore the spatiotemporal patterns of land-use benefit synergies and their driving mechanisms. The results reveal the following: (1) From 2015 to 2023, CCUA’s land-use CCD generally improved but showed marked core–periphery polarization. Chongqing’s economic agglomeration worsened regional gaps, while Sichuan’s intra-regional policies boosted internal balance; cross-jurisdictional collaboration eased border disparities but failed to stop overall polarization. (2) Spatial clustering identified hotspots in Chongqing’s main urban and suburban areas and cold spots in eastern Sichuan, reflecting the coexistence of factor agglomeration and cross-border policy synergy. (3) Road network expansion directly hindered CCD, and neighboring ecological protection triggered resource-competition spillovers, emphasizing the key role of cross-regional governance in balancing the “ecology-development” trade-off. This study puts forward spatially differentiated strategies and cross-jurisdictional coordination mechanisms to optimize land-use structures and advance sustainable development in urban agglomerations. Full article

Mesoporous silica nanoparticles (MSNs) are among the most adaptable nanocarriers in modern pharmaceutics, characterized by a high surface area, tunable pore size, controllable morphology, and excellent biocompatibility. These qualities enable effective encapsulation, protection, and the delivery of drugs in a specific area and, therefore, MSNs are powerful platforms for the targeted and controlled delivery of drugs and theragnostic agents. Over the past ten years and within the 2021–2025 period, the advancement of MSN design has led to the creation of hybrid nanostructures into polymers, lipids, metals, and biomolecules that have yielded multifunctional carriers with enhanced stability, responsiveness, and biological activities. The current review provides a review of the synthesis methods, surface functionalization techniques, and physicochemical characterization techniques that define the next-generation MSN-based delivery systems. The particular focus is put on stimuli-responsive systems, such as redox, pH, enzyme-activated, and light-activated systems, that enable delivering drugs in a controlled and localized manner. We further provide a summary of the biomedical use of MSNs and their hybrids such as in cancer chemotherapy, gene and nucleic acid delivery, antimicrobial and vaccine delivery, and central nervous system targeting, supported by recent in vivo and in vitro studies. Important evaluations of biocompatibility, immunogenicity, degradation, and biodistribution in vivo are also provided with a focus on safety in addition to the regulatory impediments to clinical translation. The review concludes by saying that there are still limitations such as large-scale reproducibility, long-term toxicity, and standardization by the regulators, and that directions are being taken in the future in the fields of smart programmable nanocarriers, green synthesis, and sustainable manufacture. Overall, mesoporous silica and hybrid nanoparticles represent a breakthrough technology in the nanomedicine sector with potentials that are unrivaled in relation to targeted, controlled, and personalized therapeutic interventions. Full article

Enterococcus alishanensis JNUCC 77 (=BLH10) was isolated from the flowers of Zinnia elegans collected at Ilchul Land, Jeju Island, Republic of Korea. Whole-genome sequencing was conducted to clarify its taxonomic position, genomic composition, and adaptive metabolic potential. The assembled genome comprised five contigs totaling 3.86 Mb, with a G + C content of 35.6% and 100% completeness. Genome-based phylogenomic analyses using the Type Strain Genome Server (TYGS) and digital DNA–DNA hybridization (dDDH) confirmed that strain JNUCC 77 belongs to E. alishanensis. Functional annotation revealed enrichment of genes related to transcriptional regulation, carbohydrate metabolism, replication, and DNA repair, suggesting a lifestyle adapted to oxidative and UV-exposed floral habitats rather than pathogenic competitiveness. Genome mining with antiSMASH identified two putative biosynthetic regions associated with terpenoid and isoprenoid metabolism, which are commonly linked to redox regulation and cellular protection. These genomic features indicate that E. alishanensis JNUCC 77 has evolved a metal-assisted, redox-regulated survival strategy suitable for floral microenvironments. Given its origin from vibrant flowers and its genomic potential for redox-protective metabolism, this strain represents an attractive microbial resource for future development of nature-inspired postbiotic and cosmeceutical ingredients that align with the clean and eco-friendly image of flower-derived biotechnologies. Full article