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Search Results (1,045)

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Keywords = pressure-state-response

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18 pages, 3741 KiB  
Article
The Mechanical Behavior of a Shield Tunnel Reinforced with Steel Plates Under Complex Strata
by Yang Yu, Yazhen Sun and Jinchang Wang
Buildings 2025, 15(15), 2722; https://doi.org/10.3390/buildings15152722 (registering DOI) - 1 Aug 2025
Abstract
The stability of shield tunnel segmental linings is highly sensitive to the lateral pressure coefficient, especially under weak, heterogeneous, and variable geological conditions. However, the mechanical behavior of steel plate-reinforced linings under such conditions remains insufficiently characterized. This study aims to investigate the [...] Read more.
The stability of shield tunnel segmental linings is highly sensitive to the lateral pressure coefficient, especially under weak, heterogeneous, and variable geological conditions. However, the mechanical behavior of steel plate-reinforced linings under such conditions remains insufficiently characterized. This study aims to investigate the effects of varying lateral pressures on the structural performance of reinforced tunnel linings. To achieve this, a custom-designed full-circumference loading and unloading self-balancing apparatus was developed for scaled-model testing of shield tunnels. The experimental methodology allowed for precise control of loading paths, enabling the simulation of realistic ground stress states and the assessment of internal force distribution, joint response, and load transfer mechanisms during the elastic stage of the structure. Results reveal that increased lateral pressure enhances the stiffness and bearing capacity of the reinforced lining. The presence and orientation of segment joints, as well as the bonding performance between epoxy resin and expansion bolts at the reinforcement interface, significantly influence stress redistribution in steel plate-reinforced zones. These findings not only deepen the understanding of tunnel behavior in complex geological environments but also offer practical guidance for optimizing reinforcement design and improving the durability and safety of shield tunnels. Full article
(This article belongs to the Section Building Structures)
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45 pages, 10039 KiB  
Article
Design of an Interactive System by Combining Affective Computing Technology with Music for Stress Relief
by Chao-Ming Wang and Ching-Hsuan Lin
Electronics 2025, 14(15), 3087; https://doi.org/10.3390/electronics14153087 (registering DOI) - 1 Aug 2025
Abstract
In response to the stress commonly experienced by young people in high-pressure daily environments, a music-based stress-relief interactive system was developed by integrating music-assisted care with emotion-sensing technology. The design principles of the system were established through a literature review on stress, music [...] Read more.
In response to the stress commonly experienced by young people in high-pressure daily environments, a music-based stress-relief interactive system was developed by integrating music-assisted care with emotion-sensing technology. The design principles of the system were established through a literature review on stress, music listening, emotion detection, and interactive devices. A prototype was created accordingly and refined through interviews with four experts and eleven users participating in a preliminary experiment. The system is grounded in a four-stage guided imagery and music framework, along with a static activity model focused on relaxation-based stress management. Emotion detection was achieved using a wearable EEG device (NeuroSky’s MindWave Mobile device) and a two-dimensional emotion model, and the emotional states were translated into visual representations using seasonal and weather metaphors. A formal experiment involving 52 users was conducted. The system was evaluated, and its effectiveness confirmed, through user interviews and questionnaire surveys, with statistical analysis conducted using SPSS 26 and AMOS 23. The findings reveal that: (1) integrating emotion sensing with music listening creates a novel and engaging interactive experience; (2) emotional states can be effectively visualized using nature-inspired metaphors, enhancing user immersion and understanding; and (3) the combination of music listening, guided imagery, and real-time emotional feedback successfully promotes emotional relaxation and increases self-awareness. Full article
(This article belongs to the Special Issue New Trends in Human-Computer Interactions for Smart Devices)
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23 pages, 4708 KiB  
Article
Mechanical Characteristics and Precision Analysis of Inflatable Deployable Parabolic Membrane Antenna Structures
by Yu Hu, Huichao Ji and Wujun Chen
Aerospace 2025, 12(8), 677; https://doi.org/10.3390/aerospace12080677 - 29 Jul 2025
Viewed by 135
Abstract
As accuracy of the reflector surface of a space parabolic deployable antenna is an important factor to determine its electrical characteristics (transmission gain and side lobes), mechanical characteristics of parabolic antennas under various internal pressures should be studied. The objective of this paper [...] Read more.
As accuracy of the reflector surface of a space parabolic deployable antenna is an important factor to determine its electrical characteristics (transmission gain and side lobes), mechanical characteristics of parabolic antennas under various internal pressures should be studied. The objective of this paper is to explore the force analysis of parabolic antennas by theoretical method and to estimate the effect of different air pressures on the surface precision of parabolic antennas via experiments in horizontal and vertical directions, and then a numerical analysis of the vibration characteristics of the parabolic antenna is proposed to explore the transient response of parabolic antennas. It is found that the ratio of tension reduces as depth of the parabolic membrane increases and can infinitely converge to 1/2. For precision analysis, it is concluded that precision of the parabolic membrane surface in a vertical state is higher than that in a horizontal state. Full article
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18 pages, 9954 KiB  
Article
Adaptive Continuous Non-Singular Terminal Sliding Mode Control for High-Pressure Common Rail Systems: Design and Experimental Validation
by Jie Zhang, Yinhui Yu, Sumin Wu, Wenjiang Zhu and Wenqian Liu
Processes 2025, 13(8), 2410; https://doi.org/10.3390/pr13082410 - 29 Jul 2025
Viewed by 156
Abstract
The High-Pressure Common Rail System (HPCRS) is designed based on fundamental hydrodynamic principles, after which this paper formally defines the key control challenges. The proposed continuous sliding mode control strategy is developed based on a non-singular terminal sliding mode framework, integrated with an [...] Read more.
The High-Pressure Common Rail System (HPCRS) is designed based on fundamental hydrodynamic principles, after which this paper formally defines the key control challenges. The proposed continuous sliding mode control strategy is developed based on a non-singular terminal sliding mode framework, integrated with an improved power reaching law. This design effectively eliminates chattering and achieves fast dynamic response with enhanced tracking precision. Subsequently, a bidirectional adaptive mechanism is integrated into the proposed control scheme to eliminate the necessity for a priori knowledge of unknown disturbances within the HPCRS. This mechanism enables real-time evaluation of the system’s state relative to a predefined detection region. To validate the effectiveness of the proposed strategy, experimental studies are conducted under three distinct operating conditions. The experimental results indicate that, compared with conventional rail pressure controllers, the proposed method achieves superior tracking accuracy, faster dynamic response, and improved disturbance rejection. Full article
(This article belongs to the Special Issue Design and Analysis of Adaptive Identification and Control)
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20 pages, 2215 KiB  
Article
Acquired Radioresistance Through Adaptive Evolution with Gamma Radiation as Selection Pressure: Increased Expression and Induction of Anti-Stress Genes
by Takeshi Saito and Hiroaki Terato
Int. J. Mol. Sci. 2025, 26(15), 7275; https://doi.org/10.3390/ijms26157275 - 28 Jul 2025
Viewed by 126
Abstract
Elucidating the mechanisms of radioresistance in highly radiotolerant organisms can provide valuable insights into the adaptation and evolution of organisms. However, research has been limited on many naturally occurring radioresistant organisms due to a lack of information regarding their genetic and biochemical characteristics [...] Read more.
Elucidating the mechanisms of radioresistance in highly radiotolerant organisms can provide valuable insights into the adaptation and evolution of organisms. However, research has been limited on many naturally occurring radioresistant organisms due to a lack of information regarding their genetic and biochemical characteristics and the difficulty of handling them experimentally. To address this, we conducted an experiment on adaptive evolution using gamma radiation as the selection pressure to generate evolved Escherichia coli with gamma radiation resistance approximately one order of magnitude greater than that of wild-type E. coli. Gene expressions in all wild-type and evolved radioresistant E. coli in the presence or absence of gamma irradiation were analyzed and compared using RNA sequencing. Under steady-state conditions, the genes involved in survival, cell recovery, DNA repair, and response following stress exposure were upregulated in evolved E. coli compared with those in wild-type E. coli. Furthermore, the evolved E. coli induced these genes more efficiently following gamma irradiation and greater DNA repair activity than that in the wild-type E. coli. Our results indicate that an increased steady-state expression of various anti-stress genes, including DNA repair-related genes, and their highly efficient induction under irradiation are responsible for the remarkable radioresistance of evolved E. coli. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
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24 pages, 569 KiB  
Systematic Review
Artificial Intelligence Approach for Waste-Printed Circuit Board Recycling: A Systematic Review
by Muhammad Mohsin, Stefano Rovetta, Francesco Masulli and Alberto Cabri
Computers 2025, 14(8), 304; https://doi.org/10.3390/computers14080304 - 27 Jul 2025
Viewed by 238
Abstract
The rapid advancement of technology has led to a substantial increase in Waste Electrical and Electronic Equipment (WEEE), which poses significant environmental threats and increases pressure on the planet’s limited natural resources. In response, Artificial Intelligence (AI) has emerged as a key enabler [...] Read more.
The rapid advancement of technology has led to a substantial increase in Waste Electrical and Electronic Equipment (WEEE), which poses significant environmental threats and increases pressure on the planet’s limited natural resources. In response, Artificial Intelligence (AI) has emerged as a key enabler of the Circular Economy (CE), particularly in improving the speed and precision of waste sorting through machine learning and computer vision techniques. Despite this progress, to our knowledge, no comprehensive, systematic review has focused specifically on the role of AI in disassembling and recycling Waste-Printed Circuit Boards (WPCBs). This paper addresses this gap by systematically reviewing recent advancements in AI-driven disassembly and sorting approaches with a focus on machine learning and vision-based methodologies. The review is structured around three areas: (1) the availability and use of datasets for AI-based WPCB recycling; (2) state-of-the-art techniques for selective disassembly and component recognition to enable fast WPCB recycling; and (3) key challenges and possible solutions aimed at enhancing the recovery of critical raw materials (CRMs) from WPCBs. Full article
(This article belongs to the Special Issue Advanced Image Processing and Computer Vision (2nd Edition))
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20 pages, 1480 KiB  
Review
Molecular Pathways Potentially Involved in Hallucinatory Experiences During Sleep Paralysis: The Emerging Role of β-Arrestin-2
by Lena M. Rudy and Michał M. Godlewski
Int. J. Mol. Sci. 2025, 26(15), 7233; https://doi.org/10.3390/ijms26157233 - 26 Jul 2025
Viewed by 354
Abstract
Sleep paralysis (SP), an REM parasomnia, can be characterized as one of the symptoms of narcolepsy. The SP phenomenon involves regaining meta-consciousness by the dreamer during REM, when the physiological atonia of skeletal muscles is accompanied by visual and auditory hallucinations that are [...] Read more.
Sleep paralysis (SP), an REM parasomnia, can be characterized as one of the symptoms of narcolepsy. The SP phenomenon involves regaining meta-consciousness by the dreamer during REM, when the physiological atonia of skeletal muscles is accompanied by visual and auditory hallucinations that are perceived as vivid and distressing nightmares. Sensory impressions include personification of an unknown presence, strong chest pressure sensation, and intense fear resulting from subjective interaction with the unfolding nightmare. While the mechanism underlying skeletal muscle atonia is known, the physiology of hallucinations remains unclear. Their complex etiology involves interactions among various membrane receptor systems and neurotransmitters, which leads to altered neuronal functionality and disruptions in sensory perception. According to current knowledge, serotonergic activation of 5-hydroxytryptamine-receptor-2A (5-HT2A)-associated pathways plays a critical role in promoting hallucinogenesis during SP. Furthermore, they share similarities with psychedelic-substance-induced ones (i.e., LSD, psilocybin, and 2,5-dimethoxy-4-iodoamphetamine). These compounds also target the 5-HT2A receptor; however, their molecular mechanism varies from serotonin-induced ones. The current review discusses the intracellular signaling pathways responsible for promoting hallucinations in SP, highlighting the critical role of β-arrestin-2. We propose that the β-arrestin-2 signaling pathway does not directly induce hallucinations but creates a state of network susceptibility that facilitates their abrupt emergence in sensory areas. Understanding the molecular basis of serotonergic hallucinations and gaining better insight into 5-HT2A-receptor-dependent pathways may prove crucial in the treatment of multifactorial neuropsychiatric disorders associated with the dysfunctional activity of serotonin receptors. Full article
(This article belongs to the Section Molecular Neurobiology)
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26 pages, 2227 KiB  
Article
Beyond the Hype: Stakeholder Perceptions of Nanotechnology and Genetic Engineering for Sustainable Food Production
by Madison D. Horgan, Christopher L. Cummings, Jennifer Kuzma, Michael Dahlstrom, Ilaria Cimadori, Maude Cuchiara, Colin Larter, Nick Loschin and Khara D. Grieger
Sustainability 2025, 17(15), 6795; https://doi.org/10.3390/su17156795 - 25 Jul 2025
Viewed by 421
Abstract
Ensuring sustainable food systems is an urgent global priority as populations grow and environmental pressures mount. Technological innovations such as genetic engineering (GE) and nanotechnology (nano) have been promoted as promising pathways for achieving greater sustainability in agriculture and food production. Yet, the [...] Read more.
Ensuring sustainable food systems is an urgent global priority as populations grow and environmental pressures mount. Technological innovations such as genetic engineering (GE) and nanotechnology (nano) have been promoted as promising pathways for achieving greater sustainability in agriculture and food production. Yet, the sustainability of these technologies is not defined by technical performance alone; it hinges on how they are perceived by key stakeholders and how well they align with broader societal values. This study addresses the critical question of how expert stakeholders evaluate the sustainability of GE and nano-based food and agriculture (agrifood) products. Using a multi-method online platform, we engaged 42 experts across academia, government, industry, and NGOs in the United States to assess six real-world case studies—three using GE and three using nano—across ten different dimensions of sustainability. We show that nano-based products were consistently rated more favorably than their GE counterparts in terms of environmental, economic, and social sustainability, as well as across ethical and societal dimensions. Like prior studies, our results reveal that stakeholders see meaningful distinctions between nanotechnology and biotechnology, likely due to underlying value-based concerns about animal welfare, perceived naturalness, or corporate control of agrifood systems. The fruit coating and flu vaccine—both nano-enabled—received the most positive ratings, while GE mustard greens and salmon were the most polarizing. These results underscore the importance of incorporating stakeholder perspectives in technology assessment and innovation governance. These results also suggest that responsible innovation efforts in agrifood systems should prioritize communication, addressing meaningful societal needs, and the contextual understanding of societal values to build trust and legitimacy. Full article
(This article belongs to the Special Issue Food Science and Engineering for Sustainability)
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53 pages, 1950 KiB  
Article
Redefining Energy Management for Carbon-Neutral Supply Chains in Energy-Intensive Industries: An EU Perspective
by Tadeusz Skoczkowski, Sławomir Bielecki, Marcin Wołowicz and Arkadiusz Węglarz
Energies 2025, 18(15), 3932; https://doi.org/10.3390/en18153932 - 23 Jul 2025
Viewed by 277
Abstract
Energy-intensive industries (EIIs) face mounting pressure to reduce greenhouse gas emissions while maintaining international competitiveness—a balance that is central to achieving the EU’s 2030 and 2050 climate objectives. In this context, energy management (EM) emerges as a strategic instrument to decouple industrial growth [...] Read more.
Energy-intensive industries (EIIs) face mounting pressure to reduce greenhouse gas emissions while maintaining international competitiveness—a balance that is central to achieving the EU’s 2030 and 2050 climate objectives. In this context, energy management (EM) emerges as a strategic instrument to decouple industrial growth from fossil energy consumption. This study proposes a redefinition of EM to support carbon-neutral supply chains within the European Union’s EIIs, addressing critical limitations of conventional EM frameworks under increasingly stringent carbon regulations. Using a modified systematic literature review based on PRISMA methodology, complemented by expert insights from EU Member States, this research identifies structural gaps in current EM practices and highlights opportunities for integrating sustainable innovations across the whole industrial value chain. The proposed EM concept is validated through an analysis of 24 EM definitions, over 170 scientific publications, and over 80 EU legal and strategic documents. The framework incorporates advanced digital technologies—including artificial intelligence (AI), the Internet of Things (IoT), and big data analytics—to enable real-time optimisation, predictive control, and greater system adaptability. Going beyond traditional energy efficiency, the redefined EM encompasses the entire energy lifecycle, including use, transformation, storage, and generation. It also incorporates social dimensions, such as corporate social responsibility (CSR) and stakeholder engagement, to cultivate a culture of environmental stewardship within EIIs. This holistic approach provides a strategic management tool for optimising energy use, reducing emissions, and strengthening resilience to regulatory, environmental, and market pressures, thereby promoting more sustainable, inclusive, and transparent supply chain operations. Full article
(This article belongs to the Section B: Energy and Environment)
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30 pages, 10277 KiB  
Article
A Finite Element Formulation for True Coupled Modal Analysis and Nonlinear Seismic Modeling of Dam–Reservoir–Foundation Systems: Application to an Arch Dam and Validation
by André Alegre, Sérgio Oliveira, Jorge Proença, Paulo Mendes and Ezequiel Carvalho
Infrastructures 2025, 10(8), 193; https://doi.org/10.3390/infrastructures10080193 - 22 Jul 2025
Viewed by 162
Abstract
This paper presents a formulation for the dynamic analysis of dam–reservoir–foundation systems, employing a coupled finite element model that integrates displacements and reservoir pressures. An innovative coupled approach, without separating the solid and fluid equations, is proposed to directly solve the single non-symmetrical [...] Read more.
This paper presents a formulation for the dynamic analysis of dam–reservoir–foundation systems, employing a coupled finite element model that integrates displacements and reservoir pressures. An innovative coupled approach, without separating the solid and fluid equations, is proposed to directly solve the single non-symmetrical governing equation for the whole system with non-proportional damping. For the modal analysis, a state–space method is adopted to solve the coupled eigenproblem, and complex eigenvalues and eigenvectors are computed, corresponding to non-stationary vibration modes. For the seismic analysis, a time-stepping method is applied to the coupled dynamic equation, and the stress–transfer method is introduced to simulate the nonlinear behavior, innovatively combining a constitutive joint model and a concrete damage model with softening and two independent scalar damage variables (tension and compression). This formulation is implemented in the computer program DamDySSA5.0, developed by the authors. To validate the formulation, this paper provides the experimental and numerical results in the case of the Cahora Bassa dam, instrumented in 2010 with a continuous vibration monitoring system designed by the authors. The good comparison achieved between the monitoring data and the dam–reservoir–foundation model shows that the formulation is suitable for simulating the modal response (natural frequencies and mode shapes) for different reservoir water levels and the seismic response under low-intensity earthquakes, using accelerograms measured at the dam base as input. Additionally, the dam’s nonlinear seismic response is simulated under an artificial accelerogram of increasing intensity, showing the structural effects due to vertical joint movements (release of arch tensions near the crest) and the concrete damage evolution. Full article
(This article belongs to the Special Issue Advances in Dam Engineering of the 21st Century)
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23 pages, 5120 KiB  
Article
Diagnosis of Performance and Obstacles of Integrated Management of Three-Water in Chaohu Lake Basin
by Jiangtao Kong, Yongchao Liu, Jialin Li and Hongbo Gong
Water 2025, 17(14), 2135; https://doi.org/10.3390/w17142135 - 17 Jul 2025
Viewed by 217
Abstract
The integration of water resources, water environment, and water ecology (hereinafter “three-water”) is essential not only for addressing the current water crisis but also for achieving sustainable development. Chaohu Lake is an important water resource and ecological barrier in the middle and lower [...] Read more.
The integration of water resources, water environment, and water ecology (hereinafter “three-water”) is essential not only for addressing the current water crisis but also for achieving sustainable development. Chaohu Lake is an important water resource and ecological barrier in the middle and lower reaches of the Yangtze River, undertaking such functions as agricultural irrigation, urban water supply, and flood control and storage. Studying the performance of “three-water” in the Chaohu Lake Basin will help to understand the pollution mechanism and governance dilemma in the lake basin. It also provides practical experience and policy references for the ecological protection and high-quality development of the Yangtze River Basin. We used the DPSIR-TOPSIS model to analyze the performance of the river–lake system in the Chaohu Lake Basin and employed an obstacle model to identify factors influencing “three-water.” The results indicated that overall governance and performance of the “three-water” in the Chaohu Lake Basin exhibited an upward trend from 2011 to 2022. Specifically, the obstacle degree of driving force decreased by 19.6%, suggesting that economic development enhanced governance efforts. Conversely, the obstacle degree of pressure increased by 34.4%, indicating continued environmental stress. The obstacle degree of state fluctuated, showing a decrease of 13.2% followed by an increase of 3.8%, demonstrating variability in the effectiveness of water resource, environmental, and ecological management. Additionally, the obstacle degree of impact declined by 12.8%, implying the reduced efficacy of governmental measures in later stages. Response barriers decreased by 5.8%. Variations in the obstacle degree of response reflected differences in response capacities. Spatially, counties and districts at the origins of major rivers and their lake outlets showed lower performance levels in “three-water” management compared to other regions in the basin. Notably, Wuwei City and Feidong County exhibited better governance performance, while Feixi County and Chaohu City showed lower performance levels. Despite significant progress in water resource management, environmental improvement, and ecological restoration, further policy support and targeted countermeasures remain necessary. Counties and districts should pursue coordinated development, leverage the radiative influence of high-performing areas, deepen regional collaboration, and optimize, governance strategies to promote sustainable development. Full article
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27 pages, 5072 KiB  
Article
Study on the Mechanical Properties of Optimal Water-Containing Basalt Fiber-Reinforced Concrete Under Triaxial Stress Conditions
by Kaide Liu, Songxin Zhao, Yaru Guo, Wenping Yue, Chaowei Sun, Yu Xia, Qiyu Wang and Xinping Wang
Materials 2025, 18(14), 3358; https://doi.org/10.3390/ma18143358 - 17 Jul 2025
Viewed by 190
Abstract
In response to the high-performance requirements of concrete materials under complex triaxial stress states and water-containing environments in marine engineering, this study focuses on water-containing basalt fiber-reinforced concrete (BFRC). Uniaxial compression and splitting tensile tests were conducted on specimens with different fiber contents [...] Read more.
In response to the high-performance requirements of concrete materials under complex triaxial stress states and water-containing environments in marine engineering, this study focuses on water-containing basalt fiber-reinforced concrete (BFRC). Uniaxial compression and splitting tensile tests were conducted on specimens with different fiber contents (0.0%, 0.05%, 0.10%, 0.15%, and 0.20%) to determine the optimal fiber content of 0.1%. The compressive strength of the concrete with this fiber content increased by 13.5% compared to the control group without fiber, reaching 36.90 MPa, while the tensile strength increased by 15.9%, reaching 2.33 MPa. Subsequently, NMR and SEM techniques were employed to analyze the internal pore structure and micro-morphology of BFRC. It was found that an appropriate amount of basalt fiber (content of 0.1%) can optimize the pore structure and form a reticular three-dimensional structure. The pore grading was also improved, with the total porosity decreasing from 7.48% to 7.43%, the proportion of harmless pores increasing from 4.03% to 4.87%, and the proportion of harmful pores decreasing from 1.67% to 1.42%, thereby significantly enhancing the strength of the concrete. Further triaxial compression tests were conducted to investigate the mechanical properties of BFRC under different confining pressures (0, 3, and 6 MPa) and water contents (0%, 1%, 2%, and 4.16%). The results showed that the stress–strain curves primarily underwent four stages: initial crack compaction, elastic deformation, yielding, and failure. In terms of mechanical properties, when the confining pressure increased from 0 MPa to 6 MPa, taking dry sandstone as an example, the peak stress increased by 54.0%, the elastic modulus increased by 15.7%, the peak strain increased by 37.0%, and the peak volumetric strain increased by 80.0%. In contrast, when the water content increased from 0% to 4.16%, taking a confining pressure of 0 MPa as an example, the peak stress decreased by 27.4%, the elastic modulus decreased by 43.2%, the peak strain decreased by 59.3%, and the peak volumetric strain decreased by 106.7%. Regarding failure characteristics, the failure mode shifted from longitudinal splitting under no confining pressure to diagonal shear under confining pressure. Moreover, as the confining pressure increased, the degree of failure became more severe, with more extensive cracks. However, when the water content increased, the failure degree was relatively mild, but it gradually worsened with further increases in water content. Based on the CDP model, a numerical model for simulating the triaxial compression behavior of BFRC was developed. The simulation results exhibited strong consistency with the experimental data, thereby validating the accuracy and applicability of the model. Full article
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12 pages, 1042 KiB  
Article
Steady-State PERG Adaptation Reveals Temporal Abnormalities of Retinal Ganglion Cells in Treated Ocular Hypertension and Glaucoma
by Tommaso Salgarello, Andrea Giudiceandrea, Grazia Maria Cozzupoli, Martina Cocuzza, Romolo Fedeli, Donato Errico, Antonello Fadda, Filippo Amore, Marco Sulfaro, Epifanio Giudiceandrea, Matteo Salgarello, Stanislao Rizzo and Benedetto Falsini
Diagnostics 2025, 15(14), 1797; https://doi.org/10.3390/diagnostics15141797 - 16 Jul 2025
Viewed by 255
Abstract
Background/Objectives: This study investigates adaptive changes in long-lasting pattern electroretinogram (PERG) responses in ocular hypertension (OHT) and open-angle glaucoma (OAG) patients, and in healthy subjects. Methods: Sixty consecutive individuals were recruited, including 20 OHT, 20 OAG, and 20 normal subjects. All participants underwent [...] Read more.
Background/Objectives: This study investigates adaptive changes in long-lasting pattern electroretinogram (PERG) responses in ocular hypertension (OHT) and open-angle glaucoma (OAG) patients, and in healthy subjects. Methods: Sixty consecutive individuals were recruited, including 20 OHT, 20 OAG, and 20 normal subjects. All participants underwent comprehensive ophthalmologic examination, 30–2 perimetry, and retinal nerve fiber layer imaging. Steady-state (7.5 Hz) PERGs were recorded over approximately 2 min, in response to 90% contrast alternating gratings within a large field size. The recordings were acquired into a sequence of 10 averages (packets), lasting 10 s each, following a standardized adaptation paradigm (Next Generation PERG, PERGx). Key outcome measures included PERGx parameters reflecting response amplitude and phase changes over time. Results: The PERGx grand average scalar amplitude, a surrogate of ordinary PERG, was significantly reduced in both OHT and OAG groups compared to normal subjects (p < 0.01). In contrast, minimal adaptation changes were noted in PERGx amplitude among all groups. The PERGx phase exhibited a progressive decline over time, with consistent delays of approximately 20 degrees across all groups. Angular dispersion of the PERGx phase increased significantly in OHT patients compared to normal subjects (p < 0.05). An inverse relationship was observed between PERGx angular dispersion and treated intraocular pressure, specifically in OHT patients. Conclusions: The findings suggest that both OHT and OAG eyes may exhibit temporal abnormalities in PERG adaptation, potentially indicating early dysfunction in retinal ganglion cell activity. Translational Relevance: PERGx phase changes may have significant implications for glaucoma early detection and management. Full article
(This article belongs to the Special Issue Innovative Diagnostic Approaches in Retinal Diseases)
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21 pages, 5154 KiB  
Article
Mechanical Response Analysis of Ultra-Thin Asphalt Wearing Course Pavement Under Non-Uniform Loading Pressure
by Wei Zhou, Yingying Dou, Chupeng Chen, Yi Yang, Xinquan Xu, Lintao Li, Jiangyin Xiao and Feng Chen
Materials 2025, 18(14), 3335; https://doi.org/10.3390/ma18143335 - 16 Jul 2025
Viewed by 277
Abstract
Traditional ultra-thin asphalt wearing course designs often oversimplify wheel loads as uniform pressures, neglecting critical non-uniform effects. This study establishes a 3D finite element model incorporating realistic non-uniform tire loading to reveal its mechanistic influence on pavement responses. Results demonstrate that non-uniform loading [...] Read more.
Traditional ultra-thin asphalt wearing course designs often oversimplify wheel loads as uniform pressures, neglecting critical non-uniform effects. This study establishes a 3D finite element model incorporating realistic non-uniform tire loading to reveal its mechanistic influence on pavement responses. Results demonstrate that non-uniform loading significantly alters stress states in ultra-thin layers, substantially elevating critical stresses compared to uniform assumptions. A novel Non-uniform Load Influence Factor (NLIF) accounting for thickness effects is developed to quantify these deviations. The analysis provides a foundation for revising material strength specifications and fatigue design criteria, contributing to improved performance and durability of ultra-thin pavement systems. Full article
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21 pages, 10296 KiB  
Article
Spatiotemporal Mechanical Effects of Framework–Slope Systems Under Frost Heave Conditions
by Wendong Li, Xiaoqiang Hou, Jixian Ren and Chaoyang Wu
Appl. Sci. 2025, 15(14), 7877; https://doi.org/10.3390/app15147877 - 15 Jul 2025
Viewed by 261
Abstract
To investigate the slope instability caused by differential frost heaving mechanisms from the slope crest to the toe during frost heave processes, this study takes a typical silty clay slope in Xinjiang, China, as the research object. Through indoor triaxial consolidated undrained shear [...] Read more.
To investigate the slope instability caused by differential frost heaving mechanisms from the slope crest to the toe during frost heave processes, this study takes a typical silty clay slope in Xinjiang, China, as the research object. Through indoor triaxial consolidated undrained shear tests, eight sets of natural and frost-heaved specimens were prepared under confining pressure conditions ranging from 100 to 400 kPa. The geotechnical parameters of the soil in both natural and frost-heaved states were obtained, and a spatiotemporal thermo-hydro-mechanical coupled numerical model was established to reveal the dynamic evolution law of anchor rod axial forces and the frost heave response mechanism between the frame and slope soil. The analytical results indicate that (1) the frost heave process is influenced by slope boundaries, resulting in distinct spatial variations in the temperature field response across the slope surface—namely pronounced responses at the crest and toe but a weaker response in the mid-slope. (2) Under the coupled drive of the water potential gradient and gravitational potential gradient, the ice content in the toe area increases significantly, and the horizontal frost heave force exhibits exponential growth, reaching its peak value of 92 kPa at the toe in February. (3) During soil freezing, the reverse stress field generated by soil arching shows consistent temporal variation trends with the temperature field. Along the height of the soil arch, the intensity of the reverse frost heave force field displays a nonlinear distribution characteristic of initial strengthening followed by attenuation. (4) By analyzing the changes in anchor rod axial forces during frost heaving, it was found that axial forces during the frost heave period are approximately 1.3 times those under natural conditions, confirming the frost heave period as the most critical condition for frame anchor design. Furthermore, through comparative analysis with 12 months of on-site anchor rod axial force monitoring data, the reliability and accuracy of the numerical simulation model were validated. These research outcomes provide a theoretical basis for the design of frame anchor support systems in seasonally frozen regions. Full article
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