Search Results (755)

Pt/TiO₂ and Pt-Eu₂O₃/TiO₂ catalysts were prepared via the impregnation method for catalytic oxidation of CO. The Pt-2Eu₂O₃/TiO₂ catalyst exhibited better CO oxidation activity as well as greater SO₂ resistance than the Pt/TiO₂ catalyst. For the inlet gas consisting of 0.8% CO, 5% O₂, and balanced N₂, the lowest complete conversion temperatures (T₁₀₀) of CO were 120 °C and 140 °C for the Pt-2Eu₂O₃/TiO₂ and Pt/TiO₂ catalysts, respectively. During the 72 h SO₂-resistance test at 200 °C under an inlet gas composition of 0.8% CO, 5% O₂, 15% H₂O, 50 ppm SO₂, and balanced N₂, the CO conversion on the Pt-2Eu₂O₃/TiO₂ catalyst remained >99%, while that on the Pt/TiO₂ catalyst gradually decreased to 77.8%. Pre-loading 2 wt% Eu₂O₃ on TiO₂ enhanced the dispersion of Pt, increased the proportion of Pt⁰, and facilitated the adsorption and dissociation of H₂O, all of which promoted CO oxidation. SO₂ preferentially occupied the Eu₂O₃ sites by forming stable sulfates on the Pt-2Eu₂O₃/TiO₂ catalyst, which protected the Pt active sites from poisoning. The OH* species produced from the dissociation of H₂O played a significant role in promoting CO oxidation through the formation of COOH* as the key reaction intermediate. The developed Pt-2Eu₂O₃/TiO₂ catalyst has great application potential in terms of the removal of CO from industrial flue gases. Full article

This study reviews existing research on the effects of the interaction between in-plane (IP) and out-of-plane (OOP) behaviors on the seismic response of non-framed unreinforced masonry (URM) structures. During earthquakes, masonry buildings exhibit complex behaviors. First, walls may experience simultaneous IP and OOP actions, or pre-existing IP and OOP damage, deformation, or loads that can alter their unidirectional IP or OOP seismic response. Second, the IP and OOP action of one wall can affect the behavior of its intersecting walls. However, the effects of these behaviors, referred to as “direct IP-OOP interactions” and “Flange effects”, respectively, are often disregarded in design and assessment provisions. To address this gap, this study explores findings from experimental and numerical research conducted at the wall level currently available in the literature, identifying the nature of these interaction effects and the key parameters that affect their extent. The available body of work includes only a few experimental studies on interaction effects, whereas numerical investigations are more extensive. However, most numerical studies focus on how OOP pre-damage/deformation influences the IP behaviors (OOP/IP interactions) and the role of flanges in IP response (F/IP interactions), leaving significant gaps in understanding the effects of IP pre-damage/deformation on the OOP response (IP/OOP interactions) and the OOP response in the presence of flanges (F/OOP interactions). Among the parameters studied, boundary conditions, wall height-to-length aspect ratio, and vertical overburden are found to have the most significant influence on interaction effects because of their relevance for the IP and OOP failure mechanisms. Other parameters, such as the restriction of top uplift, the presence of openings, or changes in slenderness ratio, are not comprehensively studied, and the available data are insufficient for definitive conclusions. Methodologies available in the literature for extrapolating the findings observed at the wall level to building-level analyses are reviewed. The current predictive equations primarily address the effects of OOP pre-load and Flange effects on IP response. Furthermore, only a few macro-element models are proposed for cost-effective, large-scale building simulations. To bridge these gaps, future research must expand experimental investigations, develop more comprehensive design and assessment equations, and refine numerical modeling techniques for building-level applications. Full article

Collaborative unmanned aerial vehicle (UAV) swarm operations using the open-source PX4–ROS2 system have been extensively studied for reconnaissance and autonomous missions. PX4–ROS2 utilizes data distribution service (DDS) middleware to ensure network flexibility and support scalable operations. DDS enables decentralized information exchange through its discovery protocol. However, in dense swarm environments, the default initialization process of this protocol generates considerable communication overhead, which hinders reliable peer detection among UAVs. This study introduces an optimized DDS discovery scheme incorporating two key strategies: a preloading method that embeds known participant data before deployment, and a dynamic network awareness approach that regulates discovery behavior based on real-time connectivity. Integrated into PX4–ROS2, the proposed scheme was assessed through both simulations and real-world testing. Results demonstrate that the optimized discovery process reduced peak packet traffic by over 90% during the initial exchange phase, thereby facilitating more stable and scalable swarm operations in wireless environments. Full article

This study assesses how different anode materials influence neutron production rates (NPRs) in multi-state fusion (MSF) reactors, with a particular focus on the effects of deuterium (D) pre-loading on the anode surface. Three types of mesh anodes were assessed: stainless steel (SS), zirconium (Zr), and D pre-loaded zirconium (ZrD). MSF operates using two electrodes to confine ions to various fusion reactions, including D-D and D-T. The reactor features a negatively biased central cathode and a grounded anode within a vacuum vessel. Neutrons and protons are produced through the application of high voltage (tens of kV) and current (tens of mA) on the system to spark the plasma and start the fusion. Assessments at voltages up to 50 kV and currents up to 30 mA showed that Zr mesh anodes produced higher NPRs than SS ones, reaching 1.912 at 30 kV. This increased performance is attributed to surface fusion processes occurring in the anode. These processes were further modified by the deuterium pre-loading in the ZrD anode, as compared to SS and Zr with 1.832 at 30 kV. The findings suggest that material properties and deuterium pre-loading play significant roles in optimizing the efficiency of MSF reactors and the NPR. Future research may explore the long-term stability and durability of these anode materials under continuous operation conditions to fully harness their potential in fusion energy applications. Full article

Background: Low-glycemic index (GI) carbohydrates like isomaltulose (ISO) are known to enhance incretin release and to improve postprandial glucose control at the following meal (an effect known as second meal effect, or SME), which is particularly beneficial for individuals with metabolic syndrome (MetS). This study aimed to assess the most effective preprandial interval of ISO- or saccharose (SUC) snacks (1 h vs. 3 h preload) to enhance prandial incretin responses to a subsequent meal. Methods: In a randomized crossover design, 15 participants with MetS completed four experimental conditions on four non-consecutive days, combining two preload types (ISO or SUC) and two preload timings (Intervention A: 3 h preload; Intervention B: 1 h preload). Specifically, the four conditions were (1) ISO + Intervention A, (2) SUC + Intervention A, (3) ISO + Intervention B, and (4) SUC + Intervention B. The order of conditions was randomized and separated by a 3–7-day washout period to minimize carryover effects. On each study day, participants consumed two mixed meal tests (MMT-1 and MMT-2) with a standardized preload (50 g ISO or SUC) administered either 3 h or 1 h prior to MMT-2. Blood samples were collected over 9 h at 15 predefined time points for analysis of glucose, insulin, C-peptide, and incretin hormones (GLP-1, GIP, and PYY). Results: The unique digestion profile of ISO resulted in a blunted glucose ascent rate (ΔG/Δt: 0.28 vs. 0.53 mmol/L/min for SUC, p < 0.01), paralleled by synonyms PYY elevation over 540 min monitoring, compared with SUC. ISO also led to higher and more sustained GLP-1 and PYY levels, while SUC induced a stronger GIP response. Notably, the timing of ISO consumption significantly influenced PYY secretion, with the 3 h preload showing enhanced PYY responses and a more favorable SME compared to the 1 h preload. Conclusions: ISO, particularly when consumed 3 h before a meal (vs. 1 h), offers significant advantages over SUC by elevating PYY levels, blunting the glucose ascent rate, and sustaining GLP-1 release. This synergy enhances the second meal effect, suggesting ISO’s potential for managing postprandial glycemic excursions in MetS. Full article

Achieving accurate fit in implant-supported prostheses is critical for avoiding mechanical complications; however, the influence of digital manufacturing techniques and abutment designs on misfit and preload remains unclear. This study evaluated the impact of different manufacturing techniques (CAD-cast and 3D printing) and abutment connection types (engaging [E], non-engaging [NE]) on the misfit and preload of implant-supported cantilevered fixed dental prostheses (ICFDPs). Misfit was measured at six points using scanning electron microscopy, and preload was assessed via eight strain gauges placed buccally and lingually on four implants. Frameworks were torqued to 35 Ncm, retorqued after 10 min, and subjected to 200,000 cycles of loading. Mean preload values ranged from 173.4 ± 79.5 Ncm (PF) to 330 ± 253.2 Ncm (3DP). Preload trends varied depending on the abutment type and manufacturing technique, with the 3DP group showing higher preload in engaging (E) abutments, whereas the CAD-cast group showed the opposite pattern. Although preload values varied numerically, these differences were not statistically significant (p = 0.5). In terms of misfit, significant differences were observed between groups (p < 0.05), except between CAD-cast E (86.4 ± 17.8 μm) and 3DP E (84.1 ± 19.2 μm). Additionally, E and NE abutments showed significant differences in misfit within both CAD-cast and 3DP groups. Overall, 3DP frameworks showed superior fit over CAD-cast. These findings suggest that 3DP may offer improved clinical outcomes in terms of implant–abutment fit. Full article

The intranasal delivery of exogenous mitochondria is a potential therapy for Parkinson’s disease (PD). The regulatory mechanisms and effectiveness in genetic models remains uncertain, as well as the impact of modulating the mitochondrial permeability transition pore (mPTP) in grafts. Utilizing UQCRC1 (p.Tyr314Ser) knock-in mice, and a cellular model, this study validated the transplantation of mitochondria with or without cyclosporin A (CsA) preloading as a method to treat mitochondrial dysfunction and improve disease progression through intranasal delivery. Liver-derived mitochondria were labeled with bromodeoxyuridine (BrdU), incubated with CsA to inhibit mPTP opening, and were administered weekly via the nasal route to 6-month-old mice for six months. Both treatment groups showed significant locomotor improvements in open-field tests. PET imaging showed increased striatal tracer uptake, indicating enhanced dopamine synthesis capacity. The immunohistochemical analysis revealed increased neuron survival in the dentate gyrus, a higher number of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra (SN) and striatum (ST), and a thicker granule cell layer. In SN neurons, the function of mitochondrial complex III was reinstated. Additionally, the CsA-accumulated mitochondria reduced more proinflammatory cytokine levels, yet their therapeutic effectiveness was similar to that of unmodified mitochondria. External mitochondria were detected in multiple brain areas through BrdU tracking, showing a 3.6-fold increase in the ST compared to the SN. In the ST, about 47% of TH-positive neurons incorporated exogenous mitochondria compared to 8% in the SN. Notably, GFAP-labeled striatal astrocytes (ASTs) also displayed external mitochondria, while MBP-labeled striatal oligodendrocytes (OLs) did not. On the other hand, fewer ASTs and increased OLs were noted, along with lower S100β levels, indicating reduced reactive gliosis and a more supportive environment for OLs. Intranasally, mitochondrial transplantation showed neuroprotective effects in genetic PD, validating a noninvasive therapeutic approach. This supports mitochondrial recovery and is linked to anti-inflammatory responses and glial modulation. Full article

As a critical precision transmission element in numerical control (NC) machines, the linear rolling guide (LRG) suffers from surface wear degradation, which significantly impairs machining accuracy and operational reliability. Despite its importance, effective identification methods for LRG degradation remain limited. In this study, a hybrid approach combining multi-scale fuzzy entropy (MFE) with a gray wolf-optimized random forest (GWO-RF) algorithm was proposed to identify the surface wear state of the LRG. Preload degradation and vibration signals were collected at three surface wear stages throughout the LGR’s service life. The vibration signals were decomposed and reconstructed using complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN), followed by multi-scale fuzzy entropy analysis of the reconstructed signals. After dimensionality reduction via kernel principal component analysis (KPCA), the processed features were fed into the GWO-RF model for classification. Experimental results demonstrated a recognition accuracy of 97.9%. Full article

The scaphoid is the most commonly fractured carpal bone. Headless compression screws became the gold standard for fixation, but the ideal screw diameter remains debated. This study investigates the relative benefit of using a larger screw diameter to improve stability in typical scaphoid fractures. It also examines the effects of preload and screw length on mechanical behaviour. A finite element (FE) model of a mid-waist scaphoid fracture was created. Screws from Medartis (1.7 mm, 2.2 mm, and 3.0 mm diameter; 23 mm length) were placed along the longitudinal axis. Boundary and loading conditions matched prior studies. Interfragmentary displacement (IFD) and von Mises stress were compared across screw sizes. The effects of screw length and preload were also evaluated. Maximum in-plane IFD was 2.08 mm (1.7 mm screw), 0.53 mm (2.2 mm), and 0.27 mm (3.0 mm). The 1.7 mm screw exceeded the scaphoid’s average ultimate stress (60.51 MPa). Increasing preload reduced IFD, especially above 60 N. Screws longer than 1.5 times the mid-waist diameter offered no added benefit. Larger screws provide better biomechanical fracture stability. However, the gain from 2.2 mm to 3.0 mm is minor, while 1.7 mm screws lack sufficient strength. The 2.2 mm screw offers a good balance of stability and bone preservation, making it the preferred choice. Full article

The integrity of bolted components primarily relies on the quality of interfacial contact, which is achieved by maintaining prescribed bolt torque levels. However, challenges arise from corrosion-induced bolt head damage, potentially compromising the bolt preload, and quantifying such effects remains unanswered. Many studies often compare bolt corrosion’s effects to bolt loosening as both affect the interfacial contact stresses to some extent. This technical study aimed to investigate whether a correlation exists between the impact of bolt head damage and the different levels of bolt torque. Guided wave ultrasonic testing (UT) was implemented for this investigation. Laboratory experiments were conducted to monitor the transmission of ultrasonic signals across the bolted interface first during the bolt-tightening process. Once the highest bolt torque was achieved, the process was repeated for a simplified corrosion scenario, simulated by artificially damaging the bolt head in a controlled manner. The analysis focused on studying the transmission of signal energy for both scenarios. The findings revealed different trends for the signal energy transmission during bolt tightening, which are subjective to the inspection frequency. On the contrary, even at an advanced level of bolt head damage corresponding to 16% mass loss, no clear or monotonic trend was observed in the total transmitted energy. While the total energy remained relatively stable across all inspection frequencies, distinct waveform changes, such as energy redistribution and the emergence of additional wave packets, were observed. The findings emphasize the need for more advanced waveform-based analysis techniques to detect and interpret subtle changes caused by bolt degradation. Full article

Hypertensive left ventricular hypertrophy (LVH) is an ominous cardiovascular sequel to chronic hypertension, marked by structural and functional alterations in the heart. Identified as a significant risk factor for adverse cardiovascular outcomes, LVH is typically detected through echocardiography and is characterized by pathological thickening of the left ventricular wall. This hypertrophy results from chronic pressure overload (increased afterload), leading to concentric remodelling, or from increased diastolic filling (preload), contributing to eccentric changes. Apoptosis, a regulated process of cell death, plays a critical role in the pathogenesis of LVH by contributing to cardiomyocyte loss and subsequent cardiac dysfunction. Given the substantial clinical implications of LVH for cardiovascular health, this review critically examines the role of cardiomyocyte apoptosis in its disease progression, evaluates the impact of pharmacological interventions, and highlights the necessity of a comprehensive, multifaceted treatment approach for the prevention and management of hypertensive LVH. Finally, we address the health disparities associated with LVH, with particular attention to the disproportionate burden faced by African Americans and other Black communities, as this remains a key priority in advancing equity in cardiovascular care. Full article

In this study, a novel shape memory alloy actuated bearing active preload system (SMA-BAPS) was proposed and experimentally demonstrated. SMA actuators placed in a single or antagonistic configuration were employed to drive the screw pair and thus fulfill one-way or bidirectional preload adjustment. Moreover, the self-locking screw pair was used to maintain the bearing preload without external energy input. To determine the parameters of screw pair and SMA actuators, a detailed design process was conducted based on analytical models of the proposed system. Finally, a screw pair with a lead of 3 mm and SMA actuators with a diameter of 0.5 mm and a length of 130 mm were adopted. Prototype tests were conducted to validate and evaluate the performance of the preload adjustment with the SMA-BAPS. The resistive torque and the natural frequency of spindles were recorded to represent the preload level of the bearing. Through the performance tests, the SMA-BAPS induced a maximum 47% variation in the resistive torque and a 20% variation in the spindle’s natural frequency. The response time of the SMA-BAPS was less than 5 s when the heating current of 5 A was applied on the SMA actuator. This design highlighted the compact size, quick response, as well as the bidirectional preload adjustment, representing its potential use in aerospace mechanisms and advanced motors. Full article

In modern multi-core processors, memory request latency critically constrains overall performance. Prefetching, a promising technique, mitigates memory access latency by pre-loading data into faster cache structures. However, existing core-side prefetchers lack visibility to the DRAM state and may issue suboptimal requests, while conventional memory-side prefetchers often default to simple next-line policies that miss complex access patterns. We propose a comprehensive memory-side prefetch optimization scheme, which includes a prefetcher that utilizes advanced prefetching algorithms and an optimization module. Our prefetcher is capable of detecting more complex memory access patterns, thereby improving both prefetch accuracy and coverage. Additionally, considering the characteristics of DRAM memory access, the optimization module minimizes the negative impact of prefetch requests on DRAM by enhancing coordination with memory operations. Additionally, our prefetcher works in synergy with core-side prefetchers to deliver superior overall performance. Simulation results using Gem5 and SPEC CPU2017 workloads show that our approach delivers an average performance improvement of 10.5% and reduces memory access latency by 61%. Our prefetcher also operates in conjunction with core-side prefetchers to form a multi-level prefetching hierarchy, enabling further performance gains through coordinated and complementary prefetching strategies. Full article

Accurate settlement prediction for high-speed railway (HSR) soft foundations remains challenging due to the irregular and dynamic nature of real-world monitoring data, often represented as non-equidistant and non-stationary time series (NENSTS). Existing empirical models lack clear applicability criteria under such conditions, resulting in subjective model selection. This study introduces a Monte Carlo-based evaluation framework that integrates data-driven simulation with geotechnical principles, embedding the concept of symmetry across both modeling and assessment stages. Equivalent permeability coefficients (EPCs) are used to normalize soil consolidation behavior, enabling the generation of a large, statistically robust dataset. Four empirical settlement prediction models—Hyperbolic, Exponential, Asaoka, and Hoshino—are systematically analyzed for sensitivity to temporal features and resistance to stochastic noise. A symmetry-aware comprehensive evaluation index (CEI), constructed via a robust entropy weight method (REWM), balances multiple performance metrics to ensure objective comparison. Results reveal that while settlement behavior evolves asymmetrically with respect to EPCs over time, a symmetrical structure emerges in model suitability across distinct EPC intervals: the Asaoka method performs best under low-permeability conditions (EPC ≤ 0.03 m/d), Hoshino excels in intermediate ranges (0.03 < EPC ≤ 0.7 m/d), and the Exponential model dominates in highly permeable soils (EPC > 0.7 m/d). This framework not only quantifies model robustness under complex data conditions but also formalizes the notion of symmetrical applicability, offering a structured path toward intelligent, adaptive settlement prediction in HSR subgrade engineering. Full article

Duplex ball bearings are common components in space satellite mechanisms, and their behaviour impacts the overall performance and reliability of these systems. During rocket launches, these bearings suffer high vibrational loads, making their dynamic response essential for their survival. To predict the dynamic behaviour under vibration, simulations and experimental tests are performed. However, published models for space applications fail to capture the variations observed in test responses. This study presents a multi-degree-of-freedom nonlinear multibody model of a hard-preloaded duplex space ball bearing, particularized for this work to the case in which the outer ring is attached to a shaker and the inner ring to a test dummy mass. The model incorporates the Hunt and Crossley contact damping formulation and employs quaternions to accurately represent rotational dynamics. The simulated model response is validated against previously published axial test data, and its response under step, sine, and random excitations is analysed both in the case of radial and axial excitation. The results reveal key insights into frequency evolution, stress distribution, gapping phenomena, and response amplification, providing a deeper understanding of the dynamic performance of space-grade ball bearings. Full article