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24 pages, 337 KiB  
Article
State-by-State Review: The Spread of Law Enforcement Accountability Policies
by Hossein Zare, Danielle R. Gilmore, Khushbu Balsara, Celina Renee Pargas, Rebecca Valek, Andrea N. Ponce, Niloufar Masoudi, Michelle Spencer, Tatiana Y. Warren and Cassandra Crifasi
Soc. Sci. 2025, 14(8), 483; https://doi.org/10.3390/socsci14080483 - 5 Aug 2025
Abstract
Purpose: Following George Floyd’s death, the push for law enforcement accountability policies has intensified. Despite robust legislative action, challenges in enacting and implementing meaningful reforms persist. This study analyzes police accountability policies (PAP) in the U.S. from 2020 to 2022, identifying barriers and [...] Read more.
Purpose: Following George Floyd’s death, the push for law enforcement accountability policies has intensified. Despite robust legislative action, challenges in enacting and implementing meaningful reforms persist. This study analyzes police accountability policies (PAP) in the U.S. from 2020 to 2022, identifying barriers and facilitators through expert perspectives in enforcement oversight, policy advocacy, and community engagement. Methods: The study used a dual approach: analyzing 226 police accountability bills from all 50 U.S. states, D.C., and Puerto Rico via the National Conference of State Legislatures database, and categorizing them into six key areas such as training, technology use, and certification. Additionally, a survey was conducted among experts to identify the challenges and drivers in passing police accountability legislation. Findings: A legislative analysis showed that although 48 states passed police accountability laws, California, New Jersey, Oklahoma, and Colorado have made significant strides by passing multiple pieces of legislation aimed at enhancing law enforcement accountability and ensuring better policing practices. The most common policies focused on training and technology, enacted by 16 and 12 states, respectively. However, crucial certification and decertification policies were adopted in just 13 states, highlighting the inconsistent implementation of measures critical for police accountability and transparency. The survey identified several barriers to passing PAP, including inadequate support from local governments (72.7%). Structural exclusion of poor and minority communities from policing resources was also a significant barrier (54.5%). Facilitators included community support (81.8%) and a cultural shift in policing towards viewing officers as “guardians” rather than “warriors” (63.6%). Conclusions: While some progress has been made in passing PAP, considerable gaps remain, particularly in enforcement and comprehensive reform. Resistance from law enforcement institutions, lack of community support, and structural inequalities continue to impede the adoption of effective PAP. Full article
22 pages, 1254 KiB  
Systematic Review
How Do the Psychological Functions of Eating Disorder Behaviours Compare with Self-Harm? A Systematic Qualitative Evidence Synthesis
by Faye Ambler, Andrew J. Hill, Thomas A. Willis, Benjamin Gregory, Samia Mujahid, Daniel Romeu and Cathy Brennan
Healthcare 2025, 13(15), 1914; https://doi.org/10.3390/healthcare13151914 - 5 Aug 2025
Abstract
Background: Eating disorders (EDs) and self-harm (SH) are both associated with distress, poor psychosocial functioning, and increased risk of mortality. Much of the literature discusses the complex interplay between SH and ED behaviours where co-occurrence is common. The onset of both is typically [...] Read more.
Background: Eating disorders (EDs) and self-harm (SH) are both associated with distress, poor psychosocial functioning, and increased risk of mortality. Much of the literature discusses the complex interplay between SH and ED behaviours where co-occurrence is common. The onset of both is typically seen during teenage years into early adulthood. A better understanding of the functions of these behaviours is needed to guide effective prevention and treatment, particularly during the crucial developmental years. An earlier review has explored the functions of self-harm, but an equivalent review for eating disorder behaviours does not appear to have been completed. Objectives: This evidence synthesis had two objectives. First, to identify and synthesise published first-hand accounts of the reasons why people engage in eating disorder behaviours with the view to develop a broad theoretical framework of functions. Second, to draw comparisons between the functions of eating disorder behaviours and self-harm. Methods: A qualitative evidence synthesis reporting first-hand accounts of the reasons for engaging in eating disorder behaviours. A ‘best fit’ framework synthesis, using the a priori framework from the review of self-harm functions, was undertaken with thematic analysis to categorise responses. Results: Following a systematic search and rigorous screening process, 144 studies were included in the final review. The most commonly reported functions of eating disorder behaviours were distress management (affect regulation) and interpersonal influence. This review identified significant overlap in functions between self-harm and eating disorder behaviours. Gender identity, responding to food insecurity, to delay growing up and responding to weight, shape, and body ideals were identified as functions more salient to eating disorder behaviours. Similarly, some self-harm functions were not identified in the eating disorder literature. These were experimenting, averting suicide, personal language, and exploring/maintaining boundaries. Conclusions: This evidence synthesis identified a prominent overlap between psychological functions of eating disorder behaviours and self-harm, specifically in relation to distress management (affect regulation). Despite clear overlap in certain areas, some functions were found to be distinct to each behaviour. The implications for delivering and adapting targeted interventions are discussed. Full article
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15 pages, 2053 KiB  
Article
Unveiling Radon Concentration in Geothermal Installation: The Role of Indoor Conditions and Human Activity
by Dimitrios-Aristotelis Koumpakis, Savvas Petridis, Apostolos Tsakirakis, Ioannis Sourgias, Alexandra V. Michailidou and Christos Vlachokostas
Gases 2025, 5(3), 18; https://doi.org/10.3390/gases5030018 - 5 Aug 2025
Abstract
The naturally occurring radioactive gas radon presents a major public health danger mainly affecting people who spend time in poorly ventilated buildings. The periodic table includes radon as a noble gas which forms through uranium decay processes in soil, rock, and water. The [...] Read more.
The naturally occurring radioactive gas radon presents a major public health danger mainly affecting people who spend time in poorly ventilated buildings. The periodic table includes radon as a noble gas which forms through uranium decay processes in soil, rock, and water. The accumulation of radon indoors in sealed or poorly ventilated areas leads to dangerous concentrations that elevate human health risks of lung cancer. The research examines environmental variables affecting radon concentration indoors by studying geothermal installations and their drilling activities, which potentially increase radon emissions. The study was conducted in the basement of the plumbing educational building at the Aristotle University of Thessaloniki to assess the potential impact of geothermal activity on indoor radon levels, as the building is equipped with a geothermal heating system. The key findings based on 150 days of continuous data showed that radon levels peak during the cold days, where the concentration had a mean value of 41.5 Bq/m3 and reached a maximum at about 95 Bq/m3. The reason was first and foremost poor ventilation and pressure difference. The lowest concentrations were on days with increased human activity with measures that had a mean value of 14.8 Bq/m3, which is reduced by about 65%. The results that are presented confirm the hypotheses and the study is making clear that ventilation and human activity are crucial in radon mitigation, especially on geothermal and energy efficient structures. Full article
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14 pages, 5448 KiB  
Article
A Study of Climate-Sensitive Diseases in Climate-Stressed Areas of Bangladesh
by Ahammadul Kabir, Shahidul Alam, Nusrat Jahan Tarin, Shila Sarkar, Anthony Eshofonie, Mohammad Ferdous Rahman Sarker, Abul Kashem Shafiqur Rahman and Tahmina Shirin
Climate 2025, 13(8), 166; https://doi.org/10.3390/cli13080166 - 5 Aug 2025
Abstract
The National Adaptation Plan of Bangladesh identifies eleven climate-stressed zones, placing nearly 100 million people at high risk of climate-related hazards. Vulnerable groups such as the poor, floating populations, daily laborers, and slum dwellers are particularly affected. However, there is a lack of [...] Read more.
The National Adaptation Plan of Bangladesh identifies eleven climate-stressed zones, placing nearly 100 million people at high risk of climate-related hazards. Vulnerable groups such as the poor, floating populations, daily laborers, and slum dwellers are particularly affected. However, there is a lack of data on climate-sensitive diseases and related hospital visits in these areas. This study explored the prevalence of such diseases using the Delphi method through focus group discussions with 493 healthcare professionals from 153 hospitals in 156 upazilas across 21 districts and ten zones. Participants were selected by district Civil Surgeons. Key climate-sensitive diseases identified included malnutrition, diarrhea, pneumonia, respiratory infections, typhoid, skin diseases, hypertension, cholera, mental health disorders, hepatitis, heat stroke, and dengue. Seasonal surges in hospital visits were noted, influenced by factors like extreme heat, air pollution, floods, water contamination, poor sanitation, salinity, and disease vectors. Some diseases were zone-specific, while others were widespread. Regions with fewer hospital visits often had higher disease burdens, indicating under-reporting or lack of access. The findings highlight the need for area-specific adaptation strategies and updates to the Health National Adaptation Plan. Strengthening resilience through targeted investment and preventive measures is crucial to reducing health risks from climate change. Full article
(This article belongs to the Section Climate and Environment)
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28 pages, 15264 KiB  
Article
Effect of Auxiliary Air-Suction Seed-Filling Structure on Seed Discharge Performance of Peanut High-Speed Seed-Metering Machine
by Peng Guo, Bin Sun, Shuqi Shang, Jialin Hou, Dongwei Wang, Zhuang Zhao, Ahmed Elshafie, Xiaoshuai Zheng and Farid Eltoum
Agriculture 2025, 15(15), 1678; https://doi.org/10.3390/agriculture15151678 - 2 Aug 2025
Viewed by 208
Abstract
Aiming to resolve the problem of the poor peanut seed-filling effect under high-speed operation when developing high-speed peanut sowing with precision, a peanut precision seed-metering machine with an auxiliary air-suction seed-filling device was designed. Focusing on the force analysis of peanuts in the [...] Read more.
Aiming to resolve the problem of the poor peanut seed-filling effect under high-speed operation when developing high-speed peanut sowing with precision, a peanut precision seed-metering machine with an auxiliary air-suction seed-filling device was designed. Focusing on the force analysis of peanuts in the seed chamber, the peanut seed disturbance principle in the seed-metering machine for the blowing structure of an auxiliary air-suction seed-filling device was clarified. The seed-filling process was analyzed via DEM-CFD coupled simulation, and three factors affecting the seed-filling effect were identified, namely the seed-filling chamber ‘V’ angle γ, the bottom blow-air-hole cross-sectional area S, and the bottom blow-air-hole airflow velocity vq, and the ranges of values of the three factors were determined. The Box–Behnken test was conducted using the seed-filling index and leakage index as the indexes. The results show that the seed-filling chamber ‘V’ angle γ is 56.59°, the bottom blowhole cross-sectional area S is 1088.4 mm2, and the blowhole air velocity vq is 12.11 m·s−1. At this point, the peanut seed suction qualification index and leakage index are optimal, the seed suction qualification index is 96.33%, and the seed leakage index is 2.59%. At the same time, the field test shows that a sowing operation speed of 8–12 km·h−1, a qualified index > 93%, and a leakage index < 4.5% are required to meet the agronomic requirements of peanut precision sowing. Full article
(This article belongs to the Section Agricultural Technology)
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16 pages, 1176 KiB  
Article
Evaluating the Use of Rice Husk Ash for Soil Stabilisation to Enhance Sustainable Rural Transport Systems in Low-Income Countries
by Ada Farai Shaba, Esdras Ngezahayo, Goodson Masheka and Kajila Samuel Sakuhuka
Sustainability 2025, 17(15), 7022; https://doi.org/10.3390/su17157022 - 2 Aug 2025
Viewed by 214
Abstract
Rural roads are critical for connecting isolated communities to essential services such as education and health and administrative services, as well as production and market opportunities in low-income countries. More than 70% of movements of people and goods in Sub-Saharan Africa are heavily [...] Read more.
Rural roads are critical for connecting isolated communities to essential services such as education and health and administrative services, as well as production and market opportunities in low-income countries. More than 70% of movements of people and goods in Sub-Saharan Africa are heavily reliant on rural transport systems, using both motorised but mainly alternative means of transport. However, rural roads often suffer from poor construction due to the use of low-strength, in situ soils and limited financial resources, leading to premature failures and subsequent traffic disruptions with significant economic losses. This study investigates the use of rice husk ash (RHA), a waste byproduct from rice production, as a sustainable supplement to Ordinary Portland Cement (OPC) for soil stabilisation in order to increase durability and sustainability of rural roads, hence limit recurrent maintenance needs and associated transport costs and challenges. To conduct this study, soil samples collected from Mulungushi, Zambia, were treated with combinations of 6–10% OPC and 10–15% RHA by weight. Laboratory tests measured maximum dry density (MDD), optimum moisture content (OMC), and California Bearing Ratio (CBR) values; the main parameters assessed to ensure the quality of road construction soils. Results showed that while the MDD did not change significantly and varied between 1505 kg/m3 and 1519 kg/m3, the OMC increased hugely from 19.6% to as high as 26.2% after treatment with RHA. The CBR value improved significantly, with the 8% OPC + 10% RHA mixture achieving the highest resistance to deformation. These results suggest that RHA can enhance the durability and sustainability of rural roads and hence improve transport systems and subsequently improve socioeconomic factors in rural areas. Full article
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26 pages, 1033 KiB  
Article
Internet of Things Platform for Assessment and Research on Cybersecurity of Smart Rural Environments
by Daniel Sernández-Iglesias, Llanos Tobarra, Rafael Pastor-Vargas, Antonio Robles-Gómez, Pedro Vidal-Balboa and João Sarraipa
Future Internet 2025, 17(8), 351; https://doi.org/10.3390/fi17080351 - 1 Aug 2025
Viewed by 148
Abstract
Rural regions face significant barriers to adopting IoT technologies, due to limited connectivity, energy constraints, and poor technical infrastructure. While urban environments benefit from advanced digital systems and cloud services, rural areas often lack the necessary conditions to deploy and evaluate secure and [...] Read more.
Rural regions face significant barriers to adopting IoT technologies, due to limited connectivity, energy constraints, and poor technical infrastructure. While urban environments benefit from advanced digital systems and cloud services, rural areas often lack the necessary conditions to deploy and evaluate secure and autonomous IoT solutions. To help overcome this gap, this paper presents the Smart Rural IoT Lab, a modular and reproducible testbed designed to replicate the deployment conditions in rural areas using open-source tools and affordable hardware. The laboratory integrates long-range and short-range communication technologies in six experimental scenarios, implementing protocols such as MQTT, HTTP, UDP, and CoAP. These scenarios simulate realistic rural use cases, including environmental monitoring, livestock tracking, infrastructure access control, and heritage site protection. Local data processing is achieved through containerized services like Node-RED, InfluxDB, MongoDB, and Grafana, ensuring complete autonomy, without dependence on cloud services. A key contribution of the laboratory is the generation of structured datasets from real network traffic captured with Tcpdump and preprocessed using Zeek. Unlike simulated datasets, the collected data reflect communication patterns generated from real devices. Although the current dataset only includes benign traffic, the platform is prepared for future incorporation of adversarial scenarios (spoofing, DoS) to support AI-based cybersecurity research. While experiments were conducted in an indoor controlled environment, the testbed architecture is portable and suitable for future outdoor deployment. The Smart Rural IoT Lab addresses a critical gap in current research infrastructure, providing a realistic and flexible foundation for developing secure, cloud-independent IoT solutions, contributing to the digital transformation of rural regions. Full article
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28 pages, 4026 KiB  
Article
Multi-Trait Phenotypic Analysis and Biomass Estimation of Lettuce Cultivars Based on SFM-MVS
by Tiezhu Li, Yixue Zhang, Lian Hu, Yiqiu Zhao, Zongyao Cai, Tingting Yu and Xiaodong Zhang
Agriculture 2025, 15(15), 1662; https://doi.org/10.3390/agriculture15151662 - 1 Aug 2025
Viewed by 206
Abstract
To address the problems of traditional methods that rely on destructive sampling, the poor adaptability of fixed equipment, and the susceptibility of single-view angle measurements to occlusions, a non-destructive and portable device for three-dimensional phenotyping and biomass detection in lettuce was developed. Based [...] Read more.
To address the problems of traditional methods that rely on destructive sampling, the poor adaptability of fixed equipment, and the susceptibility of single-view angle measurements to occlusions, a non-destructive and portable device for three-dimensional phenotyping and biomass detection in lettuce was developed. Based on the Structure-from-Motion Multi-View Stereo (SFM-MVS) algorithms, a high-precision three-dimensional point cloud model was reconstructed from multi-view RGB image sequences, and 12 phenotypic parameters, such as plant height, crown width, were accurately extracted. Through regression analyses of plant height, crown width, and crown height, and the R2 values were 0.98, 0.99, and 0.99, respectively, the RMSE values were 2.26 mm, 1.74 mm, and 1.69 mm, respectively. On this basis, four biomass prediction models were developed using Adaptive Boosting (AdaBoost), Support Vector Regression (SVR), Gradient Boosting Decision Tree (GBDT), and Random Forest Regression (RFR). The results indicated that the RFR model based on the projected convex hull area, point cloud convex hull surface area, and projected convex hull perimeter performed the best, with an R2 of 0.90, an RMSE of 2.63 g, and an RMSEn of 9.53%, indicating that the RFR was able to accurately simulate lettuce biomass. This research achieves three-dimensional reconstruction and accurate biomass prediction of facility lettuce, and provides a portable and lightweight solution for facility crop growth detection. Full article
(This article belongs to the Section Crop Production)
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16 pages, 1947 KiB  
Article
Benthic Macrofauna in the Loukkos Estuary, Morocco: Patterns and Environmental Drivers
by Feirouz Touhami
Ecologies 2025, 6(3), 53; https://doi.org/10.3390/ecologies6030053 - 1 Aug 2025
Viewed by 167
Abstract
This study provides the first comprehensive characterization of benthic macrofaunal communities in the Loukkos estuary, highlighting their spatial and seasonal variability and the environmental factors shaping their structure. A total of 47 species were identified across 12 site–season combinations, dominated by molluscs (47%), [...] Read more.
This study provides the first comprehensive characterization of benthic macrofaunal communities in the Loukkos estuary, highlighting their spatial and seasonal variability and the environmental factors shaping their structure. A total of 47 species were identified across 12 site–season combinations, dominated by molluscs (47%), polychaetes (23%), and crustaceans (21%). Species richness varied considerably along the estuarine gradient, ranging from fewer than five species in the upstream sector to up to 30 species downstream. Overall, higher diversity was observed in the downstream areas and during the dry season. Macrofaunal density also exhibited substantial variability, ranging from 95 ind.m−2 to 14,852 ind.m−2, with a mean density of 2535 ± 4058 ind.m−2. Multivariate analyses identified four distinct benthic assemblages structured primarily by spatial factors (ANOSIM R = 0.86, p = 0.002), with negligible seasonal effect (R = −0.03, p = 0.6). Assemblages ranged from marine-influenced communities at the estuary mouth dominated by Cerastoderma edule, through rich and diverse seagrass-associated communities in the lower estuary dominated by Bittium reticulatum, and moderately enriched mid-estuary communities characterized by Scrobicularia plana and Hediste diversicolor, to species-poor upstream communities dominated by the tolerant species H. diversicolor. Canonical analysis showed that salinity and vegetation explain nearly 40% of the variation in benthic assemblages, highlighting the key role of Zostera seagrass beds as structuring habitats. Moreover, upstream anthropogenic pressures alter environmental conditions, reducing benthic diversity and favoring tolerant species. Full article
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20 pages, 10603 KiB  
Article
A Safety-Based Approach for the Design of an Innovative Microvehicle
by Michelangelo-Santo Gulino, Susanna Papini, Giovanni Zonfrillo, Thomas Unger, Peter Miklis and Dario Vangi
Designs 2025, 9(4), 90; https://doi.org/10.3390/designs9040090 (registering DOI) - 31 Jul 2025
Viewed by 141
Abstract
The growing popularity of Personal Light Electric Vehicles (PLEVs), such as e-scooters, has revolutionized urban mobility by offering compact, cost-effective, and environmentally friendly transportation solutions. However, safety concerns, including inadequate infrastructure, poor protective measures, and high accident rates, remain critical challenges. This paper [...] Read more.
The growing popularity of Personal Light Electric Vehicles (PLEVs), such as e-scooters, has revolutionized urban mobility by offering compact, cost-effective, and environmentally friendly transportation solutions. However, safety concerns, including inadequate infrastructure, poor protective measures, and high accident rates, remain critical challenges. This paper presents the design and development of an innovative self-balancing microvehicle under the H2020 LEONARDO project, which aims to address these challenges through advanced engineering and user-centric design. The vehicle combines features of monowheels and e-scooters, integrating cutting-edge technologies to enhance safety, stability, and usability. The design adheres to European regulations, including Germany’s eKFV standards, and incorporates user preferences identified through representative online surveys of 1500 PLEV users. These preferences include improved handling on uneven surfaces, enhanced signaling capabilities, and reduced instability during maneuvers. The prototype features a lightweight composite structure reinforced with carbon fibers, a high-torque motorized front wheel, and multiple speed modes tailored to different conditions, such as travel in pedestrian areas, use by novice riders, and advanced users. Braking tests demonstrate deceleration values of up to 3.5 m/s2, comparable to PLEV market standards and exceeding regulatory minimums, while smooth acceleration ramps ensure rider stability and safety. Additional features, such as identification plates and weight-dependent motor control, enhance compliance with local traffic rules and prevent misuse. The vehicle’s design also addresses common safety concerns, such as curb navigation and signaling, by incorporating large-diameter wheels, increased ground clearance, and electrically operated direction indicators. Future upgrades include the addition of a second rear wheel for enhanced stability, skateboard-like rear axle modifications for improved maneuverability, and hybrid supercapacitors to minimize fire risks and extend battery life. With its focus on safety, regulatory compliance, and rider-friendly innovations, this microvehicle represents a significant advancement in promoting safe and sustainable urban mobility. Full article
(This article belongs to the Section Vehicle Engineering Design)
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16 pages, 1477 KiB  
Article
Co-Inoculation Between Bacteria and Algae from Biological Soil Crusts and Their Effects on the Growth of Poa annua and Sandy Soils Quality
by Lin Peng, Xuqiang Xie, Man Chen, Fengjie Qiao, Xingyu Liu, Yutong Zhao, Xiawei Peng and Fangchun Liu
Microorganisms 2025, 13(8), 1778; https://doi.org/10.3390/microorganisms13081778 - 30 Jul 2025
Viewed by 219
Abstract
Microorganisms (bacteria and algae) are important components of biological soil crusts, which exhibit crucial functions in promoting plant growth, maintaining soil structure, and improving soil nutrient content. To determine the effects of combined inoculation on the growth of Poa annua and sandy soils, [...] Read more.
Microorganisms (bacteria and algae) are important components of biological soil crusts, which exhibit crucial functions in promoting plant growth, maintaining soil structure, and improving soil nutrient content. To determine the effects of combined inoculation on the growth of Poa annua and sandy soils, four species of bacteria and algae were isolated and identified from biological soil crusts (during different developmental stages in a karst rocky desertification area). The soil quality was evaluated based on a soil quality index (SQI), growth indicators of Poa annua, soil physicochemical properties, and a stability analysis of aggregates. With the application of nutrient-poor sandy soils as the substrate, different treatment inoculation solutions were inoculated onto Poa annua. The results revealed that bacteria–algal co-inoculation reduces soil acidity, enhances soil nutrient content and aggregate stability, improves soil quality, and protects plant growth. Notably, compared with the single application of bacterial solution and algal solution, the combined application of bacteria–algal solution significantly improves the sandy soil quality. Full article
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59 pages, 3467 KiB  
Review
Are Hippocampal Hypoperfusion and ATP Depletion Prime Movers in the Genesis of Alzheimer’s Disease? A Review of Recent Pertinent Observations from Molecular Biology
by Valerie Walker
Int. J. Mol. Sci. 2025, 26(15), 7328; https://doi.org/10.3390/ijms26157328 - 29 Jul 2025
Viewed by 259
Abstract
Alzheimer’s dementia (AD) is a disease of the ageing brain. It begins in the hippocampal region with the epicentre in the entorhinal cortex, then gradually extends into adjacent brain areas involved in memory and cognition. The events which initiate the damage are unknown [...] Read more.
Alzheimer’s dementia (AD) is a disease of the ageing brain. It begins in the hippocampal region with the epicentre in the entorhinal cortex, then gradually extends into adjacent brain areas involved in memory and cognition. The events which initiate the damage are unknown and under intense investigation. Localization to the hippocampus can now be explained by anatomical features of the blood vessels supplying this region. Blood supply and hence oxygen delivery to the area are jeopardized by poor flow through narrowed arteries. In genomic and metabolomic studies, the respiratory chain and mitochondrial pathways which generate ATP were leading pathways associated with AD. This review explores the notion that ATP depletion resulting from hippocampal hypoperfusion has a prime role in initiating damage. Sections cover sensing of ATP depletion and protective responses, vulnerable processes with very heavy ATP consumption (the malate shuttle, the glutamate/glutamine/GABA (γ-aminobutyric acid) cycle, and axonal transport), phospholipid disturbances and peroxidation by reactive oxygen species, hippocampal perfusion and the effects of hypertension, chronic hypoxia, and arterial vasospasm, and an overview of recent relevant genomic studies. The findings demonstrate strong scientific arguments for the proposal with increasing supportive evidence. These lines of enquiry should be pursued. Full article
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14 pages, 1906 KiB  
Article
Integrating CT-Based Lung Fibrosis and MRI-Derived Right Ventricular Function for the Detection of Pulmonary Hypertension in Interstitial Lung Disease
by Kenichi Ito, Shingo Kato, Naofumi Yasuda, Shungo Sawamura, Kazuki Fukui, Tae Iwasawa, Takashi Ogura and Daisuke Utsunomiya
J. Clin. Med. 2025, 14(15), 5329; https://doi.org/10.3390/jcm14155329 - 28 Jul 2025
Viewed by 360
Abstract
Background/Objectives: Interstitial lung disease (ILD) is frequently complicated by pulmonary hypertension (PH), which is associated with reduced exercise capacity and poor prognosis. Early and accurate non-invasive detection of PH remains a clinical challenge. This study evaluated whether combining quantitative CT analysis of [...] Read more.
Background/Objectives: Interstitial lung disease (ILD) is frequently complicated by pulmonary hypertension (PH), which is associated with reduced exercise capacity and poor prognosis. Early and accurate non-invasive detection of PH remains a clinical challenge. This study evaluated whether combining quantitative CT analysis of lung fibrosis with cardiac MRI-derived measures of right ventricular (RV) function improves the diagnostic accuracy of PH in patients with ILD. Methods: We retrospectively analyzed 72 ILD patients who underwent chest CT, cardiac MRI, and right heart catheterization (RHC). Lung fibrosis was quantified using a Gaussian Histogram Normalized Correlation (GHNC) software that computed the proportions of diseased lung, ground-glass opacity (GGO), honeycombing, reticulation, consolidation, and emphysema. MRI was used to assess RV end-systolic volume (RVESV), ejection fraction, and RV longitudinal strain. PH was defined as a mean pulmonary arterial pressure (mPAP) ≥ 20 mmHg and pulmonary vascular resistance ≥ 3 Wood units on RHC. Results: Compared to patients without PH, those with PH (n = 21) showed significantly reduced RV strain (−13.4 ± 5.1% vs. −16.4 ± 5.2%, p = 0.026) and elevated RVESV (74.2 ± 18.3 mL vs. 59.5 ± 14.2 mL, p = 0.003). CT-derived indices also differed significantly: diseased lung area (56.4 ± 17.2% vs. 38.4 ± 12.5%, p < 0.001), GGO (11.8 ± 3.6% vs. 8.65 ± 4.3%, p = 0.005), and honeycombing (17.7 ± 4.9% vs. 12.8 ± 6.4%, p = 0.0027) were all more prominent in the PH group. In receiver operating characteristic curve analysis, diseased lung area demonstrated an area under the curve of 0.778 for detecting PH. This increased to 0.847 with the addition of RVESV, and further to 0.854 when RV strain was included. Combined models showed significant improvement in risk reclassification: net reclassification improvement was 0.700 (p = 0.002) with RVESV and 0.684 (p = 0.004) with RV strain; corresponding IDI values were 0.0887 (p = 0.03) and 0.1222 (p = 0.01), respectively. Conclusions: Combining CT-based fibrosis quantification with cardiac MRI-derived RV functional assessment enhances the non-invasive diagnosis of PH in ILD patients. This integrated imaging approach significantly improves diagnostic precision and may facilitate earlier, more targeted interventions in the management of ILD-associated PH. Full article
(This article belongs to the Section Nuclear Medicine & Radiology)
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21 pages, 727 KiB  
Article
Cost-Effective Energy Retrofit Pathways for Buildings: A Case Study in Greece
by Charikleia Karakosta and Isaak Vryzidis
Energies 2025, 18(15), 4014; https://doi.org/10.3390/en18154014 - 28 Jul 2025
Viewed by 191
Abstract
Urban areas are responsible for most of Europe’s energy demand and emissions and urgently require building retrofits to meet climate neutrality goals. This study evaluates the energy efficiency potential of three public school buildings in western Macedonia, Greece—a cold-climate region with high heating [...] Read more.
Urban areas are responsible for most of Europe’s energy demand and emissions and urgently require building retrofits to meet climate neutrality goals. This study evaluates the energy efficiency potential of three public school buildings in western Macedonia, Greece—a cold-climate region with high heating needs. The buildings, constructed between 1986 and 2003, exhibited poor insulation, outdated electromechanical systems, and inefficient lighting, resulting in high oil consumption and low energy ratings. A robust methodology is applied, combining detailed on-site energy audits, thermophysical diagnostics based on U-value calculations, and a techno-economic assessment utilizing Net Present Value (NPV), Internal Rate of Return (IRR), and SWOT analysis. The study evaluates a series of retrofit measures, including ceiling insulation, high-efficiency lighting replacements, and boiler modernization, against both technical performance criteria and financial viability. Results indicate that ceiling insulation and lighting system upgrades yield positive economic returns, while wall and floor insulation measures remain financially unattractive without external subsidies. The findings are further validated through sensitivity analysis and policy scenario modeling, revealing how targeted investments, especially when supported by public funding schemes, can maximize energy savings and emissions reductions. The study concludes that selective implementation of cost-effective measures, supported by public grants, can achieve energy targets, improve indoor environments, and serve as a replicable model of targeted retrofits across the region, though reliance on external funding and high upfront costs pose challenges. Full article
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20 pages, 3560 KiB  
Article
Study on Vibration Effects and Optimal Delay Time for Tunnel Cut-Blasting Beneath Existing Railways
by Ruifeng Huang, Wenqing Li, Yongxiang Zheng and Zhong Li
Appl. Sci. 2025, 15(15), 8365; https://doi.org/10.3390/app15158365 - 28 Jul 2025
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Abstract
With the development of underground space in urban areas, the demand for tunneling through existing railways is increasing. The adverse effects of cut-blasting during the construction of tunnels under crossing existing railways are investigated. Combined with the principle of blasting seismic wave superposition, [...] Read more.
With the development of underground space in urban areas, the demand for tunneling through existing railways is increasing. The adverse effects of cut-blasting during the construction of tunnels under crossing existing railways are investigated. Combined with the principle of blasting seismic wave superposition, LS-DYNA numerical simulation is used to analyze the seismic wave superposition law under different superposition methods. This study also investigates the vibration reduction effect of millisecond blasting for cut-blasting under the different classes of surrounding rocks. The results show that the vibration reduction forms of millisecond blasting can be divided into separation and interference of waveform. Based on the principle of superposition of blasting seismic waves, vibration reduction through wave interference is further divided. At the same time, a new vibration reduction mode is proposed. This vibration reduction mode can significantly improve construction efficiency while improving damping efficiency. The new vibration reduction mode can increase the vibration reduction to 80% while improving construction efficiency. Additionally, there is a significant difference in the damping effect of different classes of surrounding rock on the blasting seismic wave. Poor-quality surrounding rock enhances the attenuation of seismic wave velocity and peak stress in the surrounding rock. In the Zhongliangshan Tunnel, a tunnel cut-blasting construction at a depth of 42 m, the best vibration reduction plan of Class III is 3 ms millisecond blasting, in which the surface points achieve separation vibration reduction. The best vibration reduction plan of Class V is 1 ms millisecond blasting, in which the surface points achieve a new vibration reduction mode. During the tunnel blasting construction process, electronic detonators are used for millisecond blasting of the cut-blasting. This method can reduce the vibration effects generated by blasting. The stability of the existing railway is ultimately guaranteed. This can improve construction efficiency while ensuring construction safety. This study can provide significant guidance for the blasting construction of the tunnel through the railway. Full article
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