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4 Results Found

  • Article
  • Open Access
27 Citations
8,097 Views
28 Pages
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Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

  • Larissa M. Dorsch,
  • Maike Schuldt,
  • Cristobal G. dos Remedios,
  • Arend F. L. Schinkel,
  • Peter L. de Jong,
  • Michelle Michels,
  • Diederik W. D. Kuster,
  • Bianca J. J. M. Brundel and
  • Jolanda van der Velden
Cells2019, 8(7), 741;https://doi.org/10.3390/cells8070741

18 July 2019

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. It is mainly caused by mutations in genes encoding sarcomere proteins. Mutant forms of these highly abundant proteins likely stress the protein quality control (PQC) sys...

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  • Article
  • Open Access
3 Citations
4,034 Views
13 Pages
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Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells

  • Willemien F. J. Hof,
  • Miranda Visser,
  • Joyce J. de Jong,
  • Marian N. Rajasekar,
  • Jan Jacob Schuringa,
  • Inge A. M. de Graaf,
  • Daan J. Touw and
  • Bart G. J. Dekkers
Toxins2024, 16(1), 61;https://doi.org/10.3390/toxins16010061

22 January 2024

Amanita phalloides poisonings account for the majority of fatal mushroom poisonings. Recently, we identified hematotoxicity as a relevant aspect of Amanita poisonings. In this study, we investigated the effects of the main toxins of Amanita phalloide...

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  • Review
  • Open Access
384 Citations
23,095 Views
26 Pages
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Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins

  • Evangelos Zoidis,
  • Isidoros Seremelis,
  • Nikolaos Kontopoulos and
  • Georgios P. Danezis
Antioxidants2018, 7(5), 66;https://doi.org/10.3390/antiox7050066

14 May 2018

Unlike other essential trace elements that interact with proteins in the form of cofactors, selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of 21st naturally occurring amino acid, selenocysteine (Sec), encoded...

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  • Article
  • Open Access
2 Citations
2,744 Views
16 Pages
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Glucose-Dependent Insulinotropic Polypeptide and Substance P Mediate Emetic Response Induction by Masked Trichothecene Deoxynivalenol-3-Glucoside through Ca2+ Signaling

  • Zihui Qin,
  • Hua Zhang,
  • Qinghua Wu,
  • Ben Wei,
  • Ran Wu,
  • Xinyi Guo,
  • Huiping Xiao and
  • Wenda Wu
Toxins2022, 14(6), 371;https://doi.org/10.3390/toxins14060371

27 May 2022

Deoxynivalenol (DON), the most naturally-occurring trichothecenes, may affect animal and human health by causing vomiting as a hallmark of food poisoning. Deoxynivalenol-3-glucoside (D3G) usually co-occurs with DON as its glucosylated form and is ano...

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