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18 pages, 294 KB  
Article
Assessment of Knowledge and Attitudes of Healthcare Personnel Towards Artificial Intelligence Technologies in Greece: A Survey Study
by Dimitris Karaferis, Dimitra Balaska, Maria Eleni Karaferi and Yannis Pollalis
Hygiene 2025, 5(4), 44; https://doi.org/10.3390/hygiene5040044 - 1 Oct 2025
Viewed by 188
Abstract
Artificial intelligence (AI) is progressively being utilized in the healthcare sector to enhance efficiency, alleviate administrative burdens, and improve patient care outcomes. In the secondary healthcare sector, AI presents a range of opportunities as well as challenges. This study investigates the viewpoints of [...] Read more.
Artificial intelligence (AI) is progressively being utilized in the healthcare sector to enhance efficiency, alleviate administrative burdens, and improve patient care outcomes. In the secondary healthcare sector, AI presents a range of opportunities as well as challenges. This study investigates the viewpoints of healthcare professionals regarding the adoption of AI in Greece, emphasizing the anticipated advantages and apprehensions associated with its integration. A cross-sectional descriptive study was carried out to collect responses from healthcare professionals at the General Hospital of “Evangelismos”, which is the largest hospital in Athens, Greece. A questionnaire was utilized and distributed over a period of four months, involving 513 registered healthcare professionals (comprising 136 physicians, 235 nursing staff, and 142 other healthcare personnel). Each participant had a minimum of one year of clinical experience and was selected using a convenience sampling method. The questionnaire comprised two parts: one focused on evaluating the AI knowledge and attitudes of healthcare professionals, and the other collected demographic data. The overall comprehension of knowledge pertaining to AI among healthcare professionals was evaluated as moderate, resulting in a mean score of 3.39. A distinction exists among different personnel categories, with physicians (M = 3.73) demonstrating a greater understanding of AI and a firm conviction that AI cannot supplant human positions. Conversely, nursing personnel appear to express apprehension regarding the implications of AI on the human experience, with a notable concern about potential replacement and job loss (M = 2.63), which was identified as the lowest-ranked issue. This latter concern is also echoed by other healthcare personnel (M = 2.90). Nevertheless, the majority of participants regard the prospective use of AI favorably, demonstrate confidence in its application, and contend that the benefits outweigh the possible risks. Sufficient training and ongoing updates would enhance employees’ comprehension of AI and their awareness of its potential benefits within the healthcare sector. Full article
(This article belongs to the Section Health Promotion, Social and Behavioral Determinants)
18 pages, 1167 KB  
Article
Bridging Gaps in Occupational Respiratory Disease Management: A Comparative Survey of Pulmonologists and Occupational Physicians in Italy
by Alessandra Tortorella, Alessio Marinelli, Luigi De Maria, Silvano Dragonieri, Giuseppe Del Vecchio, Vitaliano Nicola Quaranta, Andrea Portacci, Giovanna Elisiana Carpagnano and Luigi Vimercati
Clin. Pract. 2025, 15(10), 174; https://doi.org/10.3390/clinpract15100174 - 24 Sep 2025
Viewed by 211
Abstract
Background: Themanagement of occupational respiratory diseases (ORDs) requires a multidisciplinary approach, yet collaboration between pulmonologists and occupational physicians is often fragmented, potentially compromising patient outcomes. This study aimed to systematically compare the management strategies for ORDs between these two specialties in Italy [...] Read more.
Background: Themanagement of occupational respiratory diseases (ORDs) requires a multidisciplinary approach, yet collaboration between pulmonologists and occupational physicians is often fragmented, potentially compromising patient outcomes. This study aimed to systematically compare the management strategies for ORDs between these two specialties in Italy to identify gaps and opportunities for integration. Methods: A cross-sectional survey was conducted using a structured 12-item questionnaire distributed to board-certified pulmonologists and occupational physicians across Italy. The questionnaire assessed diagnostic pathways, therapeutic strategies, preventive measures, and patterns of interdisciplinary collaboration. A total of 102 specialists (51 pulmonologists and 51 occupational physicians) completed the survey. Comparative analyses were performed using Pearson’s χ2 tests. Results: Significant divergences in practice were identified. Pulmonologists primarily focused on clinical diagnosis, utilizing pulmonary function tests (34.3%) and imaging (11.8%), and favored pharmacotherapy (27.5%) as the first-line treatment, in alignment with clinical guidelines. Conversely, occupational physicians prioritized detailed occupational and exposure histories (15.7%) and preventive interventions aimed at exposure reduction (15.7%). While both groups acknowledged the importance of collaboration, a substantial number reported that it occurred only occasionally (17.6% of pulmonologists and 12.7% of occupational physicians), indicating a significant gap in integrated care. Shared barriers included poor patient adherence and limited access to advanced diagnostic tools. Conclusions: While sharing a common foundation in diagnostic and preventive principles, pulmonologists and occupational physicians in Italy operate with distinct, complementary approaches that remain insufficiently integrated. The observed fragmentation in diagnostic and therapeutic pathways underscores an urgent need for shared national guidelines, structured interdisciplinary training, and formalized communication protocols. Bridging this disciplinary divide is essential to delivering holistic care, optimizing worker health, and preserving work ability. Full article
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14 pages, 1540 KB  
Article
Preoperative MRI Predictors for Post-Prostatectomy Urinary Incontinence
by Franco Alchiede Simonato, Guglielmo Mantica, Martina Beverini, Francesca Ambrosini, Francesco Chierigo, Veronica Giasotto, Nicola Pavan, Alchiede Simonato and Carlo Terrone
Cancers 2025, 17(18), 3004; https://doi.org/10.3390/cancers17183004 - 15 Sep 2025
Viewed by 409
Abstract
Background: We investigated the predictive role of prostatic morphology on preoperative multiparametric magnetic resonance imaging for post-prostatectomy urinary incontinence. Methods: Patients who underwent robot-assisted radical prostatectomy between February 2018 and October 2021 and who were not previously incontinent, did not undergo [...] Read more.
Background: We investigated the predictive role of prostatic morphology on preoperative multiparametric magnetic resonance imaging for post-prostatectomy urinary incontinence. Methods: Patients who underwent robot-assisted radical prostatectomy between February 2018 and October 2021 and who were not previously incontinent, did not undergo radiotherapy, hormone therapy, or transurethral resection of the prostate, and who had a follow-up longer than 12 months were selected. For each patient, a radiology physician evaluated the preoperative magnetic resonance imaging, measuring prostatic and membranous urethral length, classifying prostatic apex according to the Lee Type, and estimating the presence of the median lobe and its intravesical protrusion. Multivariate logistic regression models evaluated the influence of anatomic features measured in magnetic resonance imaging on urinary continence recovery, defined as daily pad usage less than or equal to one, considering age, body mass index, prostate volume, International Prostatic Symptoms Score, the usage of a nerve sparing technique, and the International Society of Urological Pathology classification. Results: A total of 95 patients who underwent robot-assisted radical prostatectomy were enrolled. Median age, median body mass index, and median PSA density were respectively 66 years (62, 70), 26.12 kg/m2 (23.88, 28.09), and 0.16 ng/mL/cc (0.10, 0.26). Patients with urinary continence ranged from 32 (33.7%) at baseline to 93 (97.8%) after one year from surgery. At preoperative magnetic resonance, Lee Type was almost equally distributed, but Type C was less represented (18 patients, 18.9%) and Type D was more frequent (31 patients, 32.2%). Median prostatic urethral length, median membranous urethral length, and median intravesical prostatic protrusion were respectively 36 mm (31, 42), 15 mm (13, 16), and 0 mm (0, 0). Multivariate logistic regression models showed no statistical significance, except for Lee Type C and A comparison at vesical catheter removal after surgery (OR 0.17; 95% CI 0.04–0.71; p-value 0.01). Conclusions: The results of this study showed that patients who had Lee Type C might have higher probability of early urinary continence recovery, but no further statistically significant correlations were found. Full article
(This article belongs to the Special Issue Clinical and Translational Research of Urological Cancer)
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11 pages, 2349 KB  
Article
Understanding Patient and Physician Perspectives on Exclusive Enteral Nutrition in Adults with Crohn’s Disease: Bridging the Gap in Nutritional Therapy
by Ramit Magen-Rimon, David Mamet, Meis Assaf, Zohar Tal-Leshinsky, Oxana Libman, Matti Waterman and Haggai Bar-Yoseph
Nutrients 2025, 17(18), 2945; https://doi.org/10.3390/nu17182945 - 12 Sep 2025
Viewed by 467
Abstract
Background and Aims: Exclusive enteral nutrition (EEN) effectively induces remission in pediatric Crohn’s disease (CD), but reasons for its limited use in adults remain unclear. This study aimed to identify and compare patients’ and physicians’ perspectives on barriers to EEN use, in order [...] Read more.
Background and Aims: Exclusive enteral nutrition (EEN) effectively induces remission in pediatric Crohn’s disease (CD), but reasons for its limited use in adults remain unclear. This study aimed to identify and compare patients’ and physicians’ perspectives on barriers to EEN use, in order to inform strategies to enhance its utilization. Methods: An online questionnaire was distributed to adult CD patients and gastroenterologists, collecting data on demographics, disease characteristics, previous EEN exposure, and attitudes toward EEN and potential barriers (Likert scale 1–5). Comparative analysis and logistic regression identified factors associated with reluctance toward EEN. Results: A total of 315 CD patients (mean age 36.7) and 42 physicians completed the survey. Previous EEN use was reported by 40%, while 20.3% of the entire cohort were reluctant to use it. The only factor that predicted reluctance was current use of advanced therapy (OR 2.06 [95%CI 1.05–4.35]). Among physicians, 71% had prescribed EEN, and 81% were willing to do so. Key barriers were lack of food variety (65% Likert score > 3) and reduced social interaction (59%) among patients and social interaction (67.3%) and taste concerns (54.7%) among physicians. Patients rated hunger sensation and lack of food variety concerns as more significant barriers than physicians. Patients identified direct communication with staff (68.6% Likert score > 3) and full cost coverage (65%) as facilitators for adherence. Notably, 87% wanted more information from their doctors. Conclusions: Most adult CD patients and physicians are open to discuss EEN. Removing barriers related to palatability and diversity of enteral nutrition, as well as shortening of EEN duration, may enhance acceptance of and adherence to EEN. Full article
(This article belongs to the Section Clinical Nutrition)
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12 pages, 698 KB  
Article
18F-FDG PET/CT Findings to Improve Confidence in Distinguishing Lung External Beam Radiotherapy Side Effects
by Dino Rubini, Valerio Nardone, Corinna Altini, Claudia Battisti, Cristina Ferrari, Alfonso Reginelli, Federico Gagliardi, Giuseppe Rubini and Salvatore Cappabianca
Life 2025, 15(9), 1392; https://doi.org/10.3390/life15091392 - 2 Sep 2025
Viewed by 571
Abstract
Modern external beam radiotherapy (EBRT) on lung cancer improved dose distribution thanks to advanced dose calculation algorithms, but side effects and relapses can occur in any case onset. Differential diagnosis of relapses and side effects is difficult, and when computed tomography (CT) is [...] Read more.
Modern external beam radiotherapy (EBRT) on lung cancer improved dose distribution thanks to advanced dose calculation algorithms, but side effects and relapses can occur in any case onset. Differential diagnosis of relapses and side effects is difficult, and when computed tomography (CT) is uncertain 18-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) can support the diagnosis, even if it can also be difficult to construe. The aim of this retrospective analysis was to evaluate 18F-FDG PET/CT qualitative patterns and semiquantitative parameters, both automatic and preceded by physicians, in interpreting lung lesions in the radiotherapy (RT) lung irradiation field. In total, 94 patients (pts) submitted to EBRT (3 months before) for stage II lung cancer were included (74 men, 20 women, mean age of 68 years old, range of 49–84 years old). CT scans were performed on pts, which showed lung lesions in the RT field. 18F-FDG-PET/CT scans were analyzed qualitatively as negative or positive, and the presence of the lung area with a high 18F-FDG uptake pattern was distinguished as the following: focal/wide, deep/shade, or homogeneous/inhomogeneous. Furthermore, the following semiquantitative parameters were collected: gSUVmax (global standardized uptake value max), MTV (tumor metabolic volume), metabolic spatial distribution (MSD) = proximal SUVmax/distal SUVmax, and intratumoral difference in spatial distribution (IDSD%) = [distal SUVmax/proximal SUVmax] × 100. 18F-FDG PET/CT was related to the pts’ outcome (biopsy and/or clinical–instrumental follow-up): positive for lung relapse, negative if the lesions were phlogistic. The following diagnostic performance parameters of 18F-FDG PET/CT were calculated: sensitivity (Sens), specificity (Spec), diagnostic accuracy (DA), positive predictive value (PPV), and negative predictive value (NPV). Qualitative variables were compared by Chi-squared test, while for semiquantitative parameters Student’s t-test was applied; p < 0.05 was considered statistically significant. Statistics tests were performed with MedCalc V.22.018 ©2024. In 76/94 (80.8%) pts, 18F-FDG uptake was higher compared to the background; in 18/94 (19.2%) no high 18F-FDG uptake areas were detected. Outcome was positive for lung relapse in 49/94 pts, while negative in 45/94, with disease prevalence of 52.13% (95%CI = 41.57–62.54%). In the 18/94 pts without high 18F-FDG uptake, the outcome was negative for lung relapse. In 49/76 pts with higher 18F-FDG uptake, the outcome confirmed the presence of relapse, while in 27/76 the lesion was phlogistic. Results about the Sens, Spec, DA, PPV, and NPV (95%CI) were, respectively: 100% (92.75–100%), 40% (25.7–55.67%), 71.28% (61.02–80.14%), 64.47% (58.84–69.73%), and 100% (81.47–100%). Chi-square test showed significant statistical difference between the positive and negative outcome for patterns focal/wide (p = 0.02) and deep/shade (p < 0.00001). A total of 35/49 (71.4%) pts with lung relapse had a focal lesion and 15/27 (55.6%) with phlogosis had a wide pattern. A total of 34/49 (69.4%) pts with lung relapse had a deep pattern and 25/27 (92.6%) with lung phlogosis had the shade one. Significant difference was observed in evaluating the three patterns (p = 0.00007), with prevalence of “focal/deep/homogeneous” patterns in lung relapse and “wide/shade/inhomogeneous” in phlogosis. gSUVmax, MTV, MSD, and IDSD% were in the following order: in the 76 pts, 5.63 (1.4–24.7), 42.49 (4.94–193), 3.61 (1–5.54), and 70.7% (18–100%); in the 49/76 true positive pts, 6.93 (1.5–24.7), 35.28 (4.94–85.99), 3.30 (1.05–5.54), and (18–95%); in the 27/76 false positive pts, 3.27 (1.4–19.2), 38.37 (4.94–193), 1.57 (1–2.13), and 78.6% (4.7–100%). The difference was statistically significant only for MSD (t = 2.779; p = 0.0069) and IDSD% (t = 2.769; p = 0.0071). 18F-FDG-PET/CT confirms its high sensitivity and NPV in evaluating lung lesions after RT. To improve physician confidence in interpreting lung 18F-FDG uptake without further support, MSD and IDSD% could be considered. Heterogeneity of lung lesions, especially in radiotreated tissue, can be turned from a drawback to a resource and analyzed for differentiating relapses from EBRT side effects. Considering the calculation of semiquantitative parameters that require “human intelligence”, even if slightly more time-consuming, can improve the nuclear physician’s confidence in interpreting 18F-FDG PET/CT images. Full article
(This article belongs to the Section Radiobiology and Nuclear Medicine)
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16 pages, 3215 KB  
Article
A Substance-Based Medical Device for Managing Hemorrhoidal Disease: Output from a Cross-Sectional Survey
by Roberto Cioeta, Paola Muti, Marta Rigoni, Roberta La Salvia, Elena Gabriele, Andrea Cossu and Emiliano Giovagnoni
J. Clin. Med. 2025, 14(17), 6069; https://doi.org/10.3390/jcm14176069 - 27 Aug 2025
Viewed by 690
Abstract
Background: Hemorrhoidal disease (HD) is a common anorectal condition characterized by symptoms such as bleeding, pain, discomfort and itching. While often underdiagnosed due to patient reluctance to seek care, HD significantly impacts quality of life (QoL). Conservative treatments are preferred for low-grade HD, [...] Read more.
Background: Hemorrhoidal disease (HD) is a common anorectal condition characterized by symptoms such as bleeding, pain, discomfort and itching. While often underdiagnosed due to patient reluctance to seek care, HD significantly impacts quality of life (QoL). Conservative treatments are preferred for low-grade HD, with increasing interest in natural substance-based therapies. Materials and Methods: A large-scale survey was conducted using a digital platform to collect real-world data (RWD) from patients, pharmacists and physicians. The research assessed perceived effectiveness, safety, tolerability, quality of life (QoL) and usage patterns of NeoFitoroid BioOintment. Quantitative analysis was also performed using a global score (GS) based on Likert scale ratings and their distribution. Results: A total of 2618 participants were included. A strong concordance across the three participating cohorts in the answers provided for all items of the questionnaire was observed. The descriptive analysis revealed high grades of effectiveness, safety and tolerability. Indeed, over 90% of respondents rated the product as “good” or “excellent” in terms of effectiveness and safety. Conclusions: These findings underscore the treatment’s effectiveness, safety, tolerability and positive influence on QoL in HD patients. Full article
(This article belongs to the Special Issue Clinical Innovations in Digestive Disease Diagnosis and Treatment)
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15 pages, 238 KB  
Article
Understanding Employees’ Attitudes and Awareness of Code of Ethics and Associated Factors: A Cross-Sectional Survey at a Public Tertiary Hospital in Croatia
by Zrinka Hrgović, Jure Krstulović, Ante Tavra, Ante Krešo, Franko Batinović, Ljubo Znaor and Ana Marušić
Healthcare 2025, 13(17), 2131; https://doi.org/10.3390/healthcare13172131 - 27 Aug 2025
Viewed by 496
Abstract
Background/Objectives: Ethical challenges in healthcare require awareness and adherence to professional codes of ethics, particularly in interdisciplinary settings such as tertiary hospitals. This study aimed to assess the attitudes and awareness of healthcare professionals regarding codes of ethics at the University Hospital [...] Read more.
Background/Objectives: Ethical challenges in healthcare require awareness and adherence to professional codes of ethics, particularly in interdisciplinary settings such as tertiary hospitals. This study aimed to assess the attitudes and awareness of healthcare professionals regarding codes of ethics at the University Hospital of Split in Croatia, which did not have an institutional code at the time of the study. Methods: A cross-sectional survey using a structured, anonymous questionnaire was distributed both physically across hospital departments and online via email. Welch’s t-test, ANOVA, Kruskal–Wallis, and correlation tests were used to assess associations between favourability scores and participant characteristics. Linear and logistic regression analyses further examined predictors of favourable attitudes. Results: Of 442 returned questionnaires, 377 were complete and included in the analysis, mainly from nurses (56.5%) and physicians (42.7%). The median favourability score was 83.8% (88/105; IQR 78.1–88.6), with 87.0% scoring above the favourable threshold (≥75%). Female gender and higher education were significantly associated with more favourable attitudes. Participants strongly endorsed core principles such as patient confidentiality and autonomy, yet 57.6% considered ethics education during training inadequate, and only 36.3% viewed dual practices as a conflict of interest. Most respondents reported adherence to ethical standards (85.4%), while only over half were familiar with their professional ethics code (64.5%) and the hospital Ethics Committee (56.2%); a total of 66.3% supported introducing a hospital-specific code. Awareness and support for ethical structures were higher among women and those with more education. Conclusions: This study reveals a gap between personal ethical commitment and institutional ethical infrastructure. Strengthening ethics education and implementing a hospital-specific ethics code may enhance organisational ethical culture. Full article
(This article belongs to the Special Issue Ethics of Well-Done Work and Proposals for a Better Healthcare System)
23 pages, 4540 KB  
Brief Report
Injectable Porcine Collagen in Musculoskeletal Disorders: A Delphi Consensus
by Orazio De Lucia, Federico Giarda, Andrea Bernetti, Chiara Ceccarelli, Giulia Letizia Mauro, Fabrizio Gervasoni, Lisa Berti and Antonio Robecchi Majnardi
J. Clin. Med. 2025, 14(17), 6058; https://doi.org/10.3390/jcm14176058 - 27 Aug 2025
Viewed by 1030
Abstract
Background/Objectives: Musculoskeletal disorders causing chronic pain are increasingly prevalent due to factors such as injury, overuse, and aging, leading to interest in porcine collagen injections as a potential therapeutic and conservative option. Despite promising results, evidence-based information on this treatment is scarce. To [...] Read more.
Background/Objectives: Musculoskeletal disorders causing chronic pain are increasingly prevalent due to factors such as injury, overuse, and aging, leading to interest in porcine collagen injections as a potential therapeutic and conservative option. Despite promising results, evidence-based information on this treatment is scarce. To address this gap, the authors conducted an eDelphi consensus among expert Italian physicians in musculoskeletal pain to gather their perspectives on collagen injections. Methods: A Steering Committee and a Panel of 23 physicians developed the statements list (36) including the modalities, safety, and efficacy of intra- and extra-articular collagen injections. Panelists rated their agreement with each statement on a 5-point Likert scale (5 means “Strong Agreement”). Consensus was defined as when at least 75% of the panelists voted with a score of ≥4/5 after two rounds of votes. The weighted average (WA) was calculated for each statement. As control, we elaborated a Hypothetical Parametric Distribution (HPD WA equal to 3.00), where the percent of panelists is equally distributed along each Likert Scale Value (LSV). The maximum WA for 75% of the consensus is established at 3.75. Indeed, the combination of 75% having WA > 3.75 was defined as “Strong Agreement”. While, if the consensus was under 75%, the WA vs. HPD comparison was performed using the Wilcoxon Test. Significant differences among the distribution of LSVs judged the statement as “Low Level of Agreement”. Disagreement was evaluated when the WA was under the PHD. Results: The consensus was reached “Strong Agreement” after twin rounds in 29 out of 36 (8.55%). In 5 out of 36 statements (13.89%), the panelists reached the “Low Level of Agreement” by statistical tests. In the remaining two statements, there was a “Consensus of Disagreement”. All panelists unanimously agreed on crucial points, such as contraindications, non-contraindication based solely on comorbidity, and the importance of monitoring collagen’s effectiveness. Unanimous agreement was reached on recommending ultrasound guidance and associating collagen injections with therapeutic exercise and physical modalities. Substantial consensus (concordance > 90%) supported collagen injections for osteoarthritis, chondropathy, and degenerative tendinopathies, emphasizing intra- and peri-articular treatment, even simultaneously. However, areas with limited evidence, such as the combination of collagen with other injectable drugs, treatment of myofascial syndrome, and injection frequency, showed disagreement. The potential of intra-tendinous porcine collagen injections for tendon regeneration yielded mixed results. Conclusions: Clinicians experts in musculoskeletal pain agree on using collagen injections to treat pain originating from joints (e.g., osteoarthritis) and periarticular (e.g., tendinopathies). Full article
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14 pages, 1054 KB  
Article
Impact of the 2024 Resident Physician Work Stoppage on Acute Hemorrhagic Stroke Admissions: A Single Cerebrovascular-Specialty Hospital Study in South Korea
by Youngsoo Kim, Dougho Park, Haemin Kim, Dahyeon Koo, Sukkyoung Lee, Yejin Min, Daeyoung Hong and Mun-Chul Kim
Healthcare 2025, 13(17), 2129; https://doi.org/10.3390/healthcare13172129 - 27 Aug 2025
Viewed by 660
Abstract
Background: In February 2024, a nationwide resignation of resident physicians and fellows in South Korea caused a sudden disruption in the healthcare service delivery system. This study aimed to investigate how the crisis affected hospital admission patterns, treatment timelines, and early outcomes [...] Read more.
Background: In February 2024, a nationwide resignation of resident physicians and fellows in South Korea caused a sudden disruption in the healthcare service delivery system. This study aimed to investigate how the crisis affected hospital admission patterns, treatment timelines, and early outcomes in patients with acute hemorrhagic stroke. Methods: We retrospectively analyzed data from prospective cohorts of patients diagnosed with intracerebral hemorrhage or subarachnoid hemorrhage admitted to a single cerebrovascular-specialty hospital between March 2023 and February 2025. Patients were categorized into two groups: those admitted before (Before crisis group, n = 130) and after (After crisis group, n = 214) the crisis. Clinical characteristics, regional distribution, time delays, and 3-month modified Rankin Scale (mRS) outcomes were compared. Results: Following the crisis, a significant increase was observed in admissions from outside the hospital’s primary coverage area (p < 0.001). Onset-to-arrival (138.0 vs. 92.0 min, p = 0.040) and onset-to-operation times (200.0 vs. 166.0 min, p = 0.046) were significantly delayed, particularly in patients who underwent surgical treatment. However, arrival-to-operation time remained stable (p = 0.694), and initial neurological severity was comparable. Functional outcomes at 3 months did not differ significantly (mRS 0–2: 53.8% vs. 50.5%, p = 0.157), indicating preserved in-hospital care quality, despite external disruption. Conclusions: The medical crisis disrupted the stroke care delivery system and delayed prehospital care in South Korea. Nevertheless, the cerebrovascular-specialty hospital maintained timely intervention and preserved outcomes. These findings support the strategic importance of decentralized specialty hospitals in ensuring the resilience of the healthcare service delivery system during a national healthcare crisis. Full article
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12 pages, 922 KB  
Proceeding Paper
FairCXRnet: A Multi-Task Learning Model for Domain Adaptation in Chest X-Ray Classification for Low Resource Settings
by Aminu Musa, Rajesh Prasad, Mohammed Hassan, Mohamed Hamada and Saratu Yusuf Ilu
Eng. Proc. 2025, 107(1), 16; https://doi.org/10.3390/engproc2025107016 - 22 Aug 2025
Viewed by 668
Abstract
Medical imaging analysis plays a pivotal role in modern healthcare, with physicians relying heavily on radiologists for disease diagnosis. However, many hospitals face a shortage of radiologists, leading to long queues at radiology centers and delays in diagnosis. Advances in artificial intelligence (AI) [...] Read more.
Medical imaging analysis plays a pivotal role in modern healthcare, with physicians relying heavily on radiologists for disease diagnosis. However, many hospitals face a shortage of radiologists, leading to long queues at radiology centers and delays in diagnosis. Advances in artificial intelligence (AI) have made it possible for AI models to analyze medical images and provide insights similar to those of radiologists. Despite their successes, these models face significant challenges that hinder widespread adoption. One major issue is the inability of AI models to generalize data from new populations, as performance tends to degrade when evaluated on datasets with different or shifted distributions, a problem known as domain shift. Additionally, the large size of these models requires substantial computational resources for training and deployment. In this study, we address these challenges by investigating domain shifts using ChestXray-14 and a Nigerian chest X-ray dataset. We propose a multi-task learning (MTL) approach that jointly trains the model on both datasets for two tasks, classification and segmentation, to minimize the domain gap. Furthermore, we replace traditional convolutional layers in the backbone model (Densenet-201) architecture with depthwise separable convolutions, reducing the model’s number of parameters and computational requirements. Our proposed model demonstrated remarkable improvements in both accuracy and AUC, achieving 93% accuracy and 96% AUC when tested across both datasets, significantly outperforming traditional transfer learning methods. Full article
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28 pages, 3308 KB  
Article
Structural Discourse Markers in German Palliative Care Interactions
by Aaron Schmidt-Riese
Languages 2025, 10(8), 195; https://doi.org/10.3390/languages10080195 - 18 Aug 2025
Viewed by 545
Abstract
The aim of this study is to provide a systematic account of structural discourse markers operating at a conversational macro-level in German Palliative Care interactions, focusing on their frequency, distribution, co-occurrence, and speaker-group-specific usage. By combining qualitative approaches from conversation analysis and interactional [...] Read more.
The aim of this study is to provide a systematic account of structural discourse markers operating at a conversational macro-level in German Palliative Care interactions, focusing on their frequency, distribution, co-occurrence, and speaker-group-specific usage. By combining qualitative approaches from conversation analysis and interactional linguistics with quantitative methods from corpus linguistics, discourse markers are analyzed together as a functional category from multiple analytical perspectives to enhance the overall understanding of the use of discourse markers. The analysis reveals a functional distribution across different transition points in conversation: Whereas the German so most frequently appears in openings and transitions to non-verbal activities, gut and okay predominate in topic shifts and conversation closings. However, gut and okay differ in their composition of discursive functions, although discourse structuring emerges as the second most frequent function in both cases, an observation that stands in contrast to the continued neglect of this function in standard dictionary entries. The institutional asymmetries inherent in medical interactions are reflected in the finding that both doctors and caregivers use significantly more structural discourse markers than patients and their relatives. Differences between physicians’ and caregivers’ use of discourse markers can be attributed to their different professional roles and communicative responsibilities. Full article
(This article belongs to the Special Issue Current Trends in Discourse Marker Research)
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15 pages, 591 KB  
Article
Patient Perceptions of Embryo Visualisation and Ultrasound-Guided Embryo Transfer During IVF: A Descriptive Observational Study
by Giorgio Maria Baldini, Dario Lot, Antonio Malvasi, Antonio Simone Laganà, Angelo Alessandro Marino, Domenico Baldini and Giuseppe Trojano
J. Pers. Med. 2025, 15(8), 374; https://doi.org/10.3390/jpm15080374 - 13 Aug 2025
Viewed by 524
Abstract
Objective: To evaluate patient perceptions regarding ultrasound-guided embryo transfer, visualisation of embryos prior to transfer, and continuity of care with the same physician during in vitro fertilisation (IVF) treatments. Setting: Between January and September 2023, this study was conducted at the IVF MOMO’ [...] Read more.
Objective: To evaluate patient perceptions regarding ultrasound-guided embryo transfer, visualisation of embryos prior to transfer, and continuity of care with the same physician during in vitro fertilisation (IVF) treatments. Setting: Between January and September 2023, this study was conducted at the IVF MOMO’ FertiLIFE centre in Bisceglie, Italy. Design: Descriptive and observational study based on an anonymous survey administered to IVF patients at the time of embryo transfer. The goal was to assess the subjective emotional and psychological response to selected procedural elements of the embryo transfer process. Participants: Out of 284 distributed questionnaires, 200 were included in the final analysis. Inclusion required fully completed responses. Questionnaires with incomplete, unclear answers or patient refusal were excluded. The study group was compared with the general IVF patient population treated at the centre over the past 5 years to ensure representativeness. Methods: Patients completed a structured questionnaire using a five-point Likert scale. Statistical analysis included descriptive statistics, Spearman’s rank correlation, Friedman test, and exploratory factor analysis. Ethical approval was obtained (CELFer no. 07/2021), and all participants provided written informed consent. Results: The majority of patients reported a heightened sense of calm and reassurance during ultrasound-guided embryo transfer. Viewing embryos on a monitor before transfer was also positively perceived. A strong preference emerged for continuity of care with the same physician throughout the IVF process. While this study did not assess objective stress levels or clinical outcomes, the findings highlight the psychological comfort associated with these patient-centred practices. Limitations: This single-centre study is based on self-reported data and lacks objective assessments of psychological well-being. Therefore, results reflect personal perceptions rather than measurable clinical outcomes. Broader, multicentre research using validated psychological tools is needed to confirm and expand these findings. Furthermore, the questionnaire used in this study was developed internally and not validated externally with standardised psychometric instruments. Conclusions: This study provides insight into IVF patients’ subjective experiences, emphasising the perceived emotional benefits of specific procedural and relational aspects of care. These findings support the integration of patient-centred strategies—such as visual engagement and physician continuity—into routine IVF practice to enhance overall patient well-being. Full article
(This article belongs to the Section Epidemiology)
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29 pages, 1132 KB  
Article
Generating Realistic Synthetic Patient Cohorts: Enforcing Statistical Distributions, Correlations, and Logical Constraints
by Ahmad Nader Fasseeh, Rasha Ashmawy, Rok Hren, Kareem ElFass, Attila Imre, Bertalan Németh, Dávid Nagy, Balázs Nagy and Zoltán Vokó
Algorithms 2025, 18(8), 475; https://doi.org/10.3390/a18080475 - 1 Aug 2025
Viewed by 783
Abstract
Large, high-quality patient datasets are essential for applications like economic modeling and patient simulation. However, real-world data is often inaccessible or incomplete. Synthetic patient data offers an alternative, and current methods often fail to preserve clinical plausibility, real-world correlations, and logical consistency. This [...] Read more.
Large, high-quality patient datasets are essential for applications like economic modeling and patient simulation. However, real-world data is often inaccessible or incomplete. Synthetic patient data offers an alternative, and current methods often fail to preserve clinical plausibility, real-world correlations, and logical consistency. This study presents a patient cohort generator designed to produce realistic, statistically valid synthetic datasets. The generator uses predefined probability distributions and Cholesky decomposition to reflect real-world correlations. A dependency matrix handles variable relationships in the right order. Hard limits block unrealistic values, and binary variables are set using percentiles to match expected rates. Validation used two datasets, NHANES (2021–2023) and the Framingham Heart Study, evaluating cohort diversity (general, cardiac, low-dimensional), data sparsity (five correlation scenarios), and model performance (MSE, RMSE, R2, SSE, correlation plots). Results demonstrated strong alignment with real-world data in central tendency, dispersion, and correlation structures. Scenario A (empirical correlations) performed best (R2 = 86.8–99.6%, lowest SSE and MAE). Scenario B (physician-estimated correlations) also performed well, especially in a low-dimensions population (R2 = 80.7%). Scenario E (no correlation) performed worst. Overall, the proposed model provides a scalable, customizable solution for generating synthetic patient cohorts, supporting reliable simulations and research when real-world data is limited. While deep learning approaches have been proposed for this task, they require access to large-scale real datasets and offer limited control over statistical dependencies or clinical logic. Our approach addresses this gap. Full article
(This article belongs to the Collection Feature Papers in Algorithms for Multidisciplinary Applications)
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12 pages, 676 KB  
Article
Challenges Pertaining to the Optimization of Therapy and the Management of Asthma—Results from the 2023 EU-LAMA Survey
by Michał Panek, Robab Breyer-Kohansal, Paschalis Steiropoulos, Peter Kopač, Monika Knopczyk, Tomasz Dębowski, Christer Janson and Maciej Kupczyk
Biomedicines 2025, 13(8), 1877; https://doi.org/10.3390/biomedicines13081877 - 1 Aug 2025
Viewed by 469
Abstract
Background: Treatment compliant with the Global Initiative for Asthma (GINA) can promote more effective disease control. Single-inhaler triple therapy (SITT) is one method that is used to optimize therapy in this context, but TRIPLE therapy is still employed by physicians to a limited [...] Read more.
Background: Treatment compliant with the Global Initiative for Asthma (GINA) can promote more effective disease control. Single-inhaler triple therapy (SITT) is one method that is used to optimize therapy in this context, but TRIPLE therapy is still employed by physicians to a limited extent. Objective: This study aimed to describe the factors influencing challenges in optimizing asthma therapy. Methods: A 19-question survey, created via the CATI system, was distributed among pulmonologists, allergologists, general practitioners, and internal medicine specialists in Poland, Greece, Sweden, Slovenia, and Austria. Results: Statistically significant percentage differences in the use of TRIPLE therapy in the context of asthma management were observed among countries as well as between pulmonologists, allergists, and other specialists. Overuse of oral corticosteroids (OCSs) to treat nonsevere and severe asthma in the absence of an approach that focuses on optimizing inhalation therapy among asthma patients receiving TRIPLE therapy was observed in different countries as well as among physicians with different specialties. Twenty elements associated with the challenges involved in diagnosing and managing difficult-to-treat and severe asthma were identified. Six clinical categories for the optimization of asthma therapy via SITT were highlighted. The degree of therapeutic underestimation observed among severe asthma patients was assessed by comparing actual treatment with the recommendations of the GINA 2023 guidelines. Conclusions: Physicians of various specialties in Europe are subject to therapeutic inertia in terms of their compliance with the GINA 2023 guidelines. Full article
(This article belongs to the Special Issue New Insights in Respiratory Diseases)
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14 pages, 228 KB  
Article
Impact of Japan’s 2024 Physician Work Style Reform on Pediatricians’ Working Hours and Associated Factors
by Masatoshi Ishikawa, Ryoma Seto, Michiko Oguro and Yoshino Sato
Healthcare 2025, 13(15), 1815; https://doi.org/10.3390/healthcare13151815 - 25 Jul 2025
Viewed by 2299
Abstract
Background/Objectives: Long working hours among pediatricians negatively affect their health and patient safety. In Japan, the Ministry of Health, Labour and Welfare launched the “Work Style Reform for Physicians” in 2024. However, whether these reforms have effectively reduced pediatricians’ working hours remains unclear. [...] Read more.
Background/Objectives: Long working hours among pediatricians negatively affect their health and patient safety. In Japan, the Ministry of Health, Labour and Welfare launched the “Work Style Reform for Physicians” in 2024. However, whether these reforms have effectively reduced pediatricians’ working hours remains unclear. We surveyed pediatricians and pediatric residents working in hospital pediatric departments to assess whether the reform has reduced their long working hours. Methods: A questionnaire was distributed to pediatricians in hospitals, collecting data on demographics, working hours, night shifts, and other working conditions. A multivariate logistic regression analysis identified factors associated with working ≥60 and ≥80 h on a weekly basis. Results: Questionnaires were sent to 835 hospitals, with valid responses from 815 pediatricians across 316 hospitals. Among them, 31.7% worked 50–60 h per week, 18.4% worked 60–70 h, 7.7% worked 70–80 h, and 4.9% worked >80 h. Factors associated with working >60 h included being <30 years old and working in a department with five or more physicians. Pediatricians working >80 h were more likely to have a cardiology subspecialty and work in a department with five or more physicians. Conclusions: Although the “Work Style Reform for Physicians” has reduced long working hours among pediatricians, many still experience excessive workloads. Full article
(This article belongs to the Special Issue Job Satisfaction and Mental Health of Workers: Second Edition)
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