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Biomedicines
Volume 13
Issue 8
10.3390/biomedicines13081877
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Article

Challenges Pertaining to the Optimization of Therapy and the Management of Asthma—Results from the 2023 EU-LAMA Survey

by
Michał Panek
1,*,
Robab Breyer-Kohansal
2,
Paschalis Steiropoulos
3,
Peter Kopač
4,
Monika Knopczyk
5,
Tomasz Dębowski
5,
Christer Janson
6 and
Maciej Kupczyk
1
1
Department of Internal Medicine, Asthma and Allergy, Medical University, 90-153 Łódź, Poland
2
Department of Respiratory and Pulmonary Diseases, Clinic Hietzing, Vienna Healthcare Group, 1130 Vienna, Austria
3
Department of Respiratory Medicine, Medical School, University General Hospital, Democritus University of Thrace, 68100 Alexandroupolis, Greece
4
Department of Allergology and Clinical Immunology, University Clinic of Pulmonary and Allergic Diseases, 4204 Golnik, Slovenia
5
Medical Department, Chiesi Poland Sp. z o.o., 02-305 Warsaw, Poland
6
Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, 751 85 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Biomedicines 2025, 13(8), 1877; https://doi.org/10.3390/biomedicines13081877 (registering DOI)
Submission received: 20 June 2025 / Revised: 24 July 2025 / Accepted: 27 July 2025 / Published: 1 August 2025
(This article belongs to the Special Issue New Insights in Respiratory Diseases)
Review Reports Versions Notes

Abstract

Background: Treatment compliant with the Global Initiative for Asthma (GINA) can promote more effective disease control. Single-inhaler triple therapy (SITT) is one method that is used to optimize therapy in this context, but TRIPLE therapy is still employed by physicians to a limited extent. Objective: This study aimed to describe the factors influencing challenges in optimizing asthma therapy. Methods: A 19-question survey, created via the CATI system, was distributed among pulmonologists, allergologists, general practitioners, and internal medicine specialists in Poland, Greece, Sweden, Slovenia, and Austria. Results: Statistically significant percentage differences in the use of TRIPLE therapy in the context of asthma management were observed among countries as well as between pulmonologists, allergists, and other specialists. Overuse of oral corticosteroids (OCSs) to treat nonsevere and severe asthma in the absence of an approach that focuses on optimizing inhalation therapy among asthma patients receiving TRIPLE therapy was observed in different countries as well as among physicians with different specialties. Twenty elements associated with the challenges involved in diagnosing and managing difficult-to-treat and severe asthma were identified. Six clinical categories for the optimization of asthma therapy via SITT were highlighted. The degree of therapeutic underestimation observed among severe asthma patients was assessed by comparing actual treatment with the recommendations of the GINA 2023 guidelines. Conclusions: Physicians of various specialties in Europe are subject to therapeutic inertia in terms of their compliance with the GINA 2023 guidelines.
Keywords: asthma management; adult; severe asthma; GINA; SITT; LAMAs; TRIPLE therapy asthma management; adult; severe asthma; GINA; SITT; LAMAs; TRIPLE therapy

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MDPI and ACS Style

Panek, M.; Breyer-Kohansal, R.; Steiropoulos, P.; Kopač, P.; Knopczyk, M.; Dębowski, T.; Janson, C.; Kupczyk, M. Challenges Pertaining to the Optimization of Therapy and the Management of Asthma—Results from the 2023 EU-LAMA Survey. Biomedicines 2025, 13, 1877. https://doi.org/10.3390/biomedicines13081877

AMA Style

Panek M, Breyer-Kohansal R, Steiropoulos P, Kopač P, Knopczyk M, Dębowski T, Janson C, Kupczyk M. Challenges Pertaining to the Optimization of Therapy and the Management of Asthma—Results from the 2023 EU-LAMA Survey. Biomedicines. 2025; 13(8):1877. https://doi.org/10.3390/biomedicines13081877

Chicago/Turabian Style

Panek, Michał, Robab Breyer-Kohansal, Paschalis Steiropoulos, Peter Kopač, Monika Knopczyk, Tomasz Dębowski, Christer Janson, and Maciej Kupczyk. 2025. "Challenges Pertaining to the Optimization of Therapy and the Management of Asthma—Results from the 2023 EU-LAMA Survey" Biomedicines 13, no. 8: 1877. https://doi.org/10.3390/biomedicines13081877

APA Style

Panek, M., Breyer-Kohansal, R., Steiropoulos, P., Kopač, P., Knopczyk, M., Dębowski, T., Janson, C., & Kupczyk, M. (2025). Challenges Pertaining to the Optimization of Therapy and the Management of Asthma—Results from the 2023 EU-LAMA Survey. Biomedicines, 13(8), 1877. https://doi.org/10.3390/biomedicines13081877

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